Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Doetzlhofer, Angelika
Assistant Professor
eRA COMMONS USER NAME (credential, e.g., agency login)
ADOETZLHOFER
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
M.S.
Ph.D.
1996
2000
University of Vienna, Austria
University of Vienna, Austria
FIELD OF STUDY
Biochemistry
Molecular Biology
A. Positions and Honors.
Positions
1995-2000
Assistant, Medical University of Vienna, Inst. of Molecular Biology
2000-2007
Post-Doctoral Fellow, House Ear Institute, Dept. of Cell and Molecular Biology
2007-2008
Senior Research Associate, House Ear Institute, Dept. of Cell and Molecular Biology
2008-present
Assistant Professor, Johns Hopkins University School of Medicine, Dept. of
Neuroscience
B. Peer-reviewed publications (in chronological order).

Sutterluety H, Bartl S, Doetzlhofer A, Khier H, Wintersberger E, Seiser C. Growth-regulated antisense
transcription of the mouse thymidine kinase gene. Nucleic Acids Res. 1998 Nov 1;26(21):4989-95.

Doetzlhofer A, Rotheneder H, Lagger G, Koranda M, Kurtev V, Brosch G, Wintersberger E, Seiser C.
Histone deacetylase 1 can repress transcription by binding to Sp1. Mol Cell Biol. 1999 Aug;19
(8):5504-11.

Schuettengruber B, Doetzlhofer A, Kroboth K, Wintersberger E, Seiser C. Alternate activation of two
divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone
modification. J Biol Chem. 2003 Jan 17;278(3):1784-93

Lagger G, Doetzlhofer A, Schuettengruber B, Haidweger E, Simboeck E, Tischler J, Chiocca S, Suske
G, Rotheneder H, Wintersberger E, Seiser C. The tumor suppressor p53 and histone deacetylase 1
are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene. Mol Cell
Biol. 2003 Apr;23(8):2669-79.

Lumpkin EA, Collisson T, Parab P, Omer-Abdalla A, Haeberle H, Chen P, Doetzlhofer A, White P,
Groves A, Segil N, Johnson JE. Math1-driven GFP expression in the developing nervous system of
transgenic mice. Gene Expr Patterns. 2003 Aug;3(4):389-95.
PHS 398/2590 (Rev. 11/07)
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Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle):

Doetzlhofer A*, White PM*, Johnson JE, Segil N, Groves AK. In vitro growth and differentiation of
mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme. Dev Biol.
2004 Aug 15;272(2):432-47. *These authors contributed equally to this work.

Doetzlhofer A*, White PM*, Lee YS, Groves A, Segil N. Prospective identification and purification of
hair cell and supporting cell progenitors from the embryonic cochlea. Brain Res. 2006 May
26;1091(1):282-8. *These authors contributed equally to this work.

White PM*, Doetzlhofer A*, Lee YS, Groves AK, Segil N. Mammalian cochlear supporting cells can
divide and trans-differentiate into hair cells. Nature. 2006 Jun 22;441(7096):984-7. *These authors
contributed equally to this work.

Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel MF, Segil N, Pirvola U. p19(Ink4d)
and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion
leading to DNA damage and p53-mediated apoptosis. J Neurosci. 2007 Feb 7;27(6):1434-44.

Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF
provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell.
2009 Jan;16(1):58-69
C. Research Support
Ongoing Research Support
2007-2010 – NIDCD Small Grant Program (R03)
“The function of Hes and Hey genes in maintaining a supporting cell state”
R03 DC008689
PHS 398/2590 (Rev. 11/07)
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Biographical Sketch Format Page