BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Lin, Ming-Fong
Professor and Vice-Chair
eRA COMMONS USER NAME
Lin.MING-FONG
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Kaohsiung Med. College, Kaohsiung, Taiwan
B.S.
1974
Pharmacy
National Tsing Hua Univ., HsinChu, Taiwan
M.S.
1976
Mol. Biology
Roswell Park Graduate Div., SUNY, Buffalo, NY
Ph.D.
1983
Exptl. Pathology
Professional Positions:
1983-1985
Postdoc., Cancer Biology, Louisiana State University Medical Center, New Orleans, LA
1986-1986
Res. Asst. Professor, Dept. of Biochem. and Mol. Biology, LSU Med. Ctr., New Orleans, LA
1987-1988
Res. Asst Professor, Dept. of Biochemistry, Oregon Health Sciences University, Portland, OR
1988-1995
Assistant Professor, Department of Urology, and Member of Basic Science Division, Norris
Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
1995-2000
Associate Professor, Biochemistry/Molecular Biology, Surgery/Urology, and Eppley Cancer
Institute, University of Nebraska Medical Center, Omaha, NE
1997-present Coordinator, UNMC Prostate Cancer Research Focus Group, UNMC, Omaha, NE
2000-2006
Professor of Surgery/Urology, UNMC, Omaha, NE.
2000-present Professor of Biochemistry/Molecular Biology and Eppley Cancer Institute, UNMC
2004-present Vice-Chairman, Department of Biochemistry and Molecular Biology, UNMC
Professional Activities:
1995, Memb., Mol. Biol. SS, Army BCa Program, DOD; 1996-97, Reviewer, VA Merit Grants, Dept. of
Veterans Affairs; 10/98, Ad Hoc Memb., BCE SS, NIH; 7/99, Memb., Epidemiology and Disease Control-2
Special Review Panel in PCa, NIH; 8/00, Memb., NIDDK Diseases Special Emphasis Panel, NIH; 3/02,
Reviewer, LA Cancer and Lung Trust Fund Board, LA; 3/02, Reviewer, VA Merit Grants, Dept. of Veterans
Affairs; 7/02, Memb., Endo. Panel, Army PCa Program, DOD; 1/03 & 11/03, Memb., P01 PPG, NIEHS, NIH;
11/03, Memb., Flexible System for Cancer Drug Discovery by Small Business (FLAIR) - SBIR/STTR
Initiative, NCI, NIH; 7/98-6/06, Ad Hoc Memb. & Memb., TBE SS, ACS; 7/01-2/04, Memb., BCE SS, NIH;
9/04, Memb., Cancer Therapeutics Cluster, P01 PPG, NCI, NIH; 6/04 – 6/05, Memb., & 10/06, Ad Hoc
Memb., TCB SS, NIH; 11/06, Memb., In Vivo Cellular and Molecular Imaging Centers (ICMICs), ZCA1
SRRB-9 (J1), NCI, NIH; 11/06, Memb., Program Project Review Panel, NCI, Canada; 6/07, Ad Hoc Memb.,
MCE SS, NIH; 10/07, Memb., NCI P01 Clinical Studies Special Emphasis Panel, NCI, NIH; 11/07, Memb., In
Vivo Cellular and Molecular Imaging Centers (ICMICs), ZCA1 SRRB-9 (J1), NCI, NIH; 6/2008, Memb.,
NIH Teleconference Review ONC-X(03); 9/11-12/2008, Memb., Mol. Biol & Genetic-3 panel, Army PCa
Program, DOD; 11/12-13/2008 NCI SEP: ZCA1 SRRB-3 J1 B, SBIR Phase II “Bridge Awards to Accelerate
the Development of New Cancer Therapies and Cancer Imaging Technologies Toward Commercialization”
(SBIR[R44]), NIH
Relevant Publications (Total of 89 publications: 83 peer-reviewed and 6 non-peer-reviewed articles)
Spruck, CH, III, Gonzalez-Zulueta, M, Shibata, A, Simoneau, AR, Lin, M-F, Gonzales, F, Tsai, YC, and
Jones, PA. p16 gene in uncultured tumours. Nature 370:183-184, 1994. PMID: 8028660
Garcia-Arenas, R, Lin, FF, Lin, D, Jin, LP, Shih, CCY, Chang, CS, and Lin, M-F. The expression of prostatic
acid phosphatase is transcriptionally regulated in human prostate cells. Mol Cell Endocrinol 111:2937,1995. PMID: 764350
Lin, M-F, Kawachi, M, Stallcup, M, Grunberg, S, and Lin, FF. Growth inhibition on androgeninsensitive
human prostate carcinoma cells by a 19-Norsteroid derivative agent, mifepristone. The Prostate 26:194204, 1995. PMID: 7716084
Lin, M-F, Meng, TC, Rao, PS, Chang, CS, Schonthal, AH, and Lin, FF. Expression of human prostatic acid
phosphatase correlates with androgen stimulated cell proliferation in prostate cancer cell lines. J Biol Chem
273:5939-5947, 1998. PMID: 9488733
Zelivianski, S, Comeau, D, and Lin, M-F. Cloning and analysis of the promoter activity of the human prostatic
acid phosphatase gene. Biochem Biophys Res Commun 245:108-112, 1998. PMID: 9535792
Meng, TC, and Lin, M-F. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic
acid phosphatase in human prostate cancer cells. J Biol Chem 273:22096-22104, 1998. PMID: 9705354
Yeh, SY, Lin, HK, Kang, HY, Thin, TH, Lin, M-F, and Chang, CS. From HER2/Neu signal cascade to
androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through
MAP kinase in prostate cancer cells. Proc Natl Acad Sci USA 96:5458-5463, 1999. PMID: 21881
Zelivianski, S, Larson, C, Seberger, J, Taylor, R, and Lin, M-F. Expression of prostate acid phosphatase is
regulated by upstream negative and positive elements. Biochem Biophys Acta 1491:123-132, 2000.
PMID: 10760575
Meng, TC, Lee, MS, and Lin, M-F. Interaction between protein tyrosine phosphatase and protein tyrosine
kinase is involved in androgen-promoted growth of prostate cancer cells. Oncogene 19:2664-2677, 2000.
PMID: 10851066
Zhang, XQ, Lee, MS, Zelivianski, S, and Lin, M-F. Characterization of a prostate-specific tyrosine
phosphatase by mutagenesis and expression in human prostate cancer cells. JBC 276:2544-2550, 2001.
PMID: 11067847
Lin, M-F, Lee, MS, Zhou, XW, Andressen, JC, Meng, TC, Johansson, SL, West, WW, Taylor, RJ, Anderson,
JR, and Lin, FF. Decreased expression of cellular prostatic acid phosphatase increases tumorigenicity of
human prostate cancer cells. J Urology 166:1943-1950, 2001. PMID: 11586265
Igawa, T, Lin, FF, Lee, MS Karan, D, Batra, SK, and Lin, M-F. Establishment and characterization of
androgen-independent human prostate cancer LNCaP cell model. The Prostate 50:222-235, 2002.
PMID: 11870800
Zelivianski, S, Igawa, T, Lim, S, Taylor, R, and Lin, M-F. Identification and characterization of regulatory
elements of the human prostatic acid phosphatase promoter. Oncogene 21:3696-3705, 2002.
PMID: 12032838
Lee, MS, Igawa, T, Yuan, TC, Zhang, XQ, Lin, FF, Lin, M-F. ErbB-2 signaling is involved in regulating PSA
secretion in androgen independent prostate cancer LNCaP C-81 cells. Oncogene 22:781-796, 2003. PMID:
12569372
Igawa, T, Lin, FF, Rao, P, and Lin, M-F. Suppression of LNCaP prostate cancer xenograft tumors by a
prostate-specific protein tyrosine phosphatase, prostatic acid phosphatase. Prostate 55:247-258, 2003.
PMID: 12712404
Zhang, XQ, Kondrikov, D, Yuan, TC, Lin, FF, Hansen, J, and Lin, M-F. Receptor protein tyrosine
phosphatase alpha signaling is involved in androgen depletion-induced neuroendrocrine differentiation of
androgen-sensitive LNCaP human prostate cancer cells. Oncogene 22:6704-6716, 2003. PMID: 14555984
Lee, MS, Igawa, T, Chen, SJ, Van Bemmel, D, Lin, JS, Lin, FF, Johansson, SL, Christman, JK, and Lin, M-F.
p66Shc protein is up-regulated by steroid hormones in hormone-sensitive cancer cells and in primary
prostate carcinomas. Int J Cancer 108:672-678, 2003. PMID: 14696093
Lee, MS, Igawa, T, and Lin, M-F. Tyrosine-317 of p52Shc mediates androgen-stimulated proliferation signals
in human prostate cancer cells. Oncogene 23:3048-3058, 2004. PMID: 14990987
Zelivianski, S, Glowacki, R, and Lin, M-F. Transcriptional activation of the human prostatic acid phosphatase
gene by NF-κB via a novel hexanucleotide-binding site. NAR 32:3566-3580, 2004. PMID: 4841168
Veeramani, S, Igawa, T, Yuan, TC, Lin, FF, Lee, MS, Lin, JS, Johansson, SL, and Lin, M-F. Expression of
p66Shc protein correlates with proliferation of human prostate cancer cells. Oncogene 24:7203-7212, 2005.
PMID: 16170380
Veeramani, S, Yuan, TC, Chen, SJ, Lin, FF, Petersen, JE, Shaheduzzaman, S, Srivastava, S, MacDonald,
RG, and Lin, M-F. Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in
androgen-independent proliferation of prostate cancer. Endo-Related Cancer 12:805-822, 2005. PMID:
16322323
Mimeault, M, Moore, E, Moniaux, N, Henichart, J-P, Depreux, P, Lin, M-F, and Batra, S K. Cytotoxic effects
induced by a combination of cyclopamine and Gefitinib, the selective hedgehog and epidermal growth
factor receptor signaling inhibitors, in prostate cancer cells. Int. J. Cancer 118: 1022-1031, 2006. PMID:
16108016
Yuan, TC, Veeramani, S, Lin, FF, Kondrikou, D, Zelivianski, S, Igawa, T, Karan, D, Batra, SK, and Lin, M-F.
Androgen deprivation induces human prostate epithelial neuroendocrine differentiation of androgensensitive LNCaP cells. Endocrine-Related Cancer 13:151-167, 2006. PMID: 16601285
Singh, AP, Chauhan, SC, Bafna, S, Johansson, SL, Smith, LM, Moniaux, N, LIn, M-F, and Batra, SK.
Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. The
Prostate 66:421-429, 2006. PMID: 16302265
Cao, X, Qin, J, Xie, Y, Khan, O, Dowd, F, Scofield, M, Lin, M-F, and Tu, Y. Regulator of G-protein Signaling
2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells.
Oncogene 25:3719-3734, 2006. PMID: 16449965
Mimeault, M, Venkatraman, G, Johansson, SL, Moore, E, Henichart, J-P, Depreux, P, Lin, M-F, and Batra,
SK. Novel combination therapy against metastatic and androgen-independent prostate cancer by using
gefitinib, tamoxifen and etoposide. Int. J. Cancer 120:160-169, 2006. PMID: 17013895
Chen, SJ, Karan, D, Johansson, SL, Lin, FF, Zeckser, J, Singh, AP, Batra, SK, and Lin, M-F. Prostatederived factor as a paracrine and autocrine factor for the proliferation of androgen receptor-positive human
prostate cancer cells. The Prostate 67:557-571, 2007. PMID: 17221842
Mimeault, M, Johansson, SL, Venkatraman, G, Moore, E, Henichart, J-P, Depreux, P, Lin, M-F, and Batra,
SK. Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and
cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells.
Mol. Cancer Ther. 6:967-978, 2007. PMID: 17363490
Yuan, TC, Lin, FF, Veeramani, S, Chen, SJ, Earp, HS III, and Lin, M-F. ErbB-2 via PYK2 up-regulates the
adhesive ability of androgen receptor-positive human prostate cancer cells. Oncogene 26:7552-7559,
2007. PMID: 17563746
Yuan, TC, Veeramani, S, and Lin, M-F. Neuroendocrine-like prostate cancer cells: Neuroendocrine
transdifferentiation of prostate adenocarcinoma cells. Endocrine-related Cancer 14: 531-547, 2007.
PMID: 17914087
Mimeault, M, Mehta, PP, Hauke, R, Henichart, J-P, Depreux, P, Lin, M-F, and Batra, SK. Improvement of
cytotoxic effects induced by mitoxantrone on metastatic prostate cancer cells by co-targeting epidermal
growth factor receptor and hedgehog signaling cascades. Growth Factor 25:400-416, 2007. PMID:
18365871
Singh, AP, Bafna, S, Chaudhary, K, Venkatraman, G, Smith, L, Eudy, JD, Johansson,SL, Lin, M-F, and
Batra, SK. Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks
in androgen-dependent and androgen-independent prostate cancer cells. Cancer Letters 259:28-38, 2008.
PMID: 17977648
Veeramani, S, Yuan, TC, Lin, FF, and Lin, M-F. Mitochondrial Redox Signaling by p66Shc is involved in
regulating androgenic growth stimulation of human prostate cancer cells. Oncogene 27:5057-5068, 2008.
PMID: 18504439
Dillard, PR, Lin, M-F, and Khan, SA. Androgen-independent prostate cancer cells acquire the complete
steroidogenic potential of synthesizing testosterone from cholesterol. Mol. Cellu. Endo. 295:115-120, 2008.
PMID: 18782595
Radhakrishnan, P, Lin, M-F, and Cheng, PW. Elevated expression of L-selectin ligand in lymph node-derived
human prostate cancer cells correlates with increased tumorigenicity. Glycoconjugate J. 26:75-81, 2009.
PMID: 18670876
Ye, CJ, Stevens, JB, Liu, G, Bremer, SW, Jaiswal, AS, Ye, KJ, Lin, M-F, Lawrenson, L, Lancaster, WD,
Kurkinen, M, Liao, JD, Gairola, CG, Shekhar, MPV, Narayan, S, Miller, FR, and Heng, HH. Genome based
cell population heterogeneity promotes tumorigenicity - the evolutionary mechanism of cancer. J. of
Cellular Physiology 219:288-300, 2009. PMID: 19115235
Alam, SM, Rajendran, M, Ouyang, S, Veeramani, S, Zhang, L, Lin, M-F. A novel role of Shc adaptor proteins
in steroid hormone-regulated cancers. Endocrine-Related Cancer 16:1-16, 2009. PMID: 19001530
Qin, J, Sie, Y, Wang, B, Hoshino, M, Wolff, DW, Zhano, J, Scofield, MA, Dowd, FJ, Lin, M-F, and Tu, Y.
Upregulation of PIP3-dependent Rac Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis.
Oncogene (2009, in press) PMID: 19305425
Veeramani, S, Lee, MS, and Lin, M-F. Opinion in “Revisiting Histidine-dependent Acid Phosphatases: A
Distinct Group of Tyrosine Phosphatases”. Trends in Biochemical Science (2009) In press.
ONGOING
2R01 CA88184 (Lin)
NIH/NCI
7/1/2006 - 6/30/2011
“Signaling in Androgen-Refractory Prostate Cancer”
The major goal of this proposal is to investigate the role of ErbB-2 tyrosine phosphorylation signaling in the
progression of prostate cancer cells. Overlapping: None.
PC074289 (Lin, PI; Batra, co-PI)
DOD Prostate Cancer Synergistic Idea Development Award, 7/15/2008 - 7/14/2011
“Aberrant expression of protein phosphatases during androgen-independent growth in human prostate
cancer cells”
The major goal of this proposal is to investigate the effect of aberrant expression of protein phosphatases
involving in prostate cancer progression, leading to advanced hormone-refractory growth.
Overlapping: None.
PC050769, Idea Development Award (Lin)
2005 PCa Research Program, DOD
10/15/2005 – 10/14/2009 (No cost extension)
“Oxidative Stress in Human Prostate Cancer Progression”
This project is investigating Redox signaling involving in prostate carcinogenesis. Overlapping: None.
R01 CA125661 (Tu, Creighton University, Omaha, NE)
NCI, NIH
10/1/2007-9/30/2012
Co-investigator: Lin
“Regulator of G-protein Signaling (RGS) Proteins in prostate cancer”
This project is investigating GPCR signaling involving in prostate carcinogenesis. Overlapping: None.
R01 CA1139303-01 (Mehta)
NIH/NCI
4/1/2005 - 3/31/2010
Co-investigator: Lin
“Intercellular Communication and Chemoprevention of Prostate Cancer”
The major goal of this project is investigating the gap junction proteins in prostate cancer cells. I serve as a
co-investigator involving in cell biology. Overlapping: None.
5T32 CA009476-18 (Rizzino, UNMC Eppley Cancer Center)
NCI, NIH
7/1/08 - 6/30/2013
Co-Investigators/Mentors: Lin
"Cancer Biology Training Grant"
This is a training grant for post-doctoral fellows and graduate students. There is no support to me or my lab
whatsoever. Overlapping: None.
COMPLETED (within the last 3 years)
1R01 CA88184 (Lin)
NIH/NCI
7/1/00 - 6/30/06
“Signaling in Androgen-Refractory Prostate Cancer Cells”
PC040502, Idea Development Award (Batra)
2004 PCa Research Program, DOD
10/15/2004 – 8/31/2007
Co-investigator: Lin
“Molecular studies on MIC-1/PDF Gene in Human Prostate Cancer”