Provided by: Medical Grand Rounds Academic Year 2014-2015 “Reprogramming the Human Immune System to Treat Leukemia” February 24, 2015 12:00 p.m. – 1:00 p.m. Flyers/76er’s Theatre, White Building, Ground Floor David L. Porter, M.D. Jodi Fisher Horowitz Professor in Leukemia Care Excellence Director, Blood and Marrow Transplantation Division of Hematology/Oncology and Abramson Cancer Center Target Audience This program has been designed for departmental/institutional faculty, fellows, residents, medical students, nurses, community physicians, and other health professionals in the medical specialties of cardiovascular medicine, endocrinology diabetes & metabolism, gastroenterology, general internal medicine, geriatrics, hematology/oncology, infectious disease, pulmonary, allergy & critical care, renalelectrolyte & hypertension, rheumatology, sleep medicine, translation medicine and human genetics. Educational Objectives After completing this activity, participants should be able to: Learn from master clinicians about clinical problem-solving techniques Review topics of important ethical or public policy implications Discuss the latest advances in basic research as they relate to various clinical diseases Discuss new treatment modalities for all types of diseases in internal medicine Improve understanding of the pathogenesis of disease to be better able to identify adverse drug events and treatment complications Accreditation The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Designation of Credit The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Acknowledgement of Commercial Support* NONE For more information, please contact Denise Arnieri 215-662-3924 Denise.Arnieri@uphs.upenn.edu Check your CME online at www.penncmeonline.com Disclosure of Relevant Financial Relationships and Unapproved Uses of Products It is policy at the Perelman School of Medicine at the University of Pennsylvania for individuals who are in a position to control the content of an educational activity to disclose to the learners all relevant financial relationships that they have with any commercial interest that provides products or services that may be relevant to the content of this continuing medical education activity. For this purpose we consider relationships of the person involved in the CME activity to include financial relationships of a spouse or partner. The intent of this policy is not to prevent expert faculty with relevant relationship(s) with commercial interest(s) from involvement in CME, but rather to ensure that Penn CME-certified activities promote quality and safety, are effective in improving medical practice, are based on valid content, and are independent of control from commercial interests and free of commercial bias. Peer review of all content was conducted for all faculty presentations whose disclosure information provided to the Penn Office of CME was found to contain relationships that created a conflict of interest relative to the topic of their presentation. In addition, all faculty were instructed to provide balanced, scientifically rigorous and evidence-based presentations. The staff in the Office of CME at the Perelman School of Medicine at the University of Pennsylvania, Mila Kostic, Director of CME and the peer reviewer Zalman Agus, MD, Associate Dean for CME, have disclosed that they have no relevant financial relationships with any commercial interests related to the content of this educational activity. The following individuals have disclosed that they have no relevant financial relationships with any commercial interests related to the content of this educational activity: PLANNING COMMITTEE MEMBER NAME LISA M. BELLINI, MD MICHAEL S. PARMACEK, MD DANIEL KISS, MD LESLIE STEWART, MD HANNY AL-SAMKARI, MD ELAINA TULLY, MD PRESENTER NAME The following individuals have reported the listed relevant financial relationships with commercial interests related to the content of this educational activity. PRESENTER NAME DAVID L PORTER MD DAVID L PORTER MD NAME OF COMMERCIAL INTEREST RELATIONSHIP NOVARTIS GENENTECH IP SPOUSE EMPLOYMENT Relevant Financial Relationships: Financial relationships are those relationships in which the individual benefits by receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as employment, management position, independent contractor (including contracted research), consulting, speaking and teaching, membership on advisory committees or review panels, board membership, and other activities from which remuneration is received or expected DISCLOSURE OF UNAPPROVED USES OF PRODUCTS PRESENTER NAME DAVID L PORTER MD DAVID L PORTER MD PRODUCT CTL019 CELLS TOCILIZUMAB INVESTIGATIONAL AND/OR OFF-LABEL USE TREATMENT OF LEUKEMIA TREATMENT OF CYTOKINE RELEASE SYNDROME