Provided by:
Medical Grand Rounds
Academic Year 2014-2015
“Reprogramming the Human Immune System to Treat Leukemia”
February 24, 2015
12:00 p.m. – 1:00 p.m.
Flyers/76er’s Theatre, White Building, Ground Floor
David L. Porter, M.D.
Jodi Fisher Horowitz Professor in Leukemia Care Excellence
Director, Blood and Marrow Transplantation
Division of Hematology/Oncology and Abramson Cancer Center
Target Audience
This program has been designed for departmental/institutional faculty, fellows, residents, medical
students, nurses, community physicians, and other health professionals in the medical specialties of
cardiovascular medicine, endocrinology diabetes & metabolism, gastroenterology, general internal
medicine, geriatrics, hematology/oncology, infectious disease, pulmonary, allergy & critical care, renalelectrolyte & hypertension, rheumatology, sleep medicine, translation medicine and human genetics.
Educational Objectives
After completing this activity, participants should be able to:
 Learn from master clinicians about clinical problem-solving techniques
 Review topics of important ethical or public policy implications
 Discuss the latest advances in basic research as they relate to various clinical diseases
 Discuss new treatment modalities for all types of diseases in internal medicine
 Improve understanding of the pathogenesis of disease to be better able to identify adverse drug
events and treatment complications
Accreditation
The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation
Council for Continuing Medical Education (ACCME) to provide continuing medical education for
physicians.
Designation of Credit
The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a
maximum of 1 AMA PRA Category 1 Credit ™. Physicians should claim only the credit commensurate
with the extent of their participation in the activity.
Acknowledgement of Commercial Support*
NONE
For more information, please contact
Denise Arnieri
215-662-3924
Denise.Arnieri@uphs.upenn.edu
Check your CME online at www.penncmeonline.com
Disclosure of Relevant Financial Relationships and Unapproved Uses of Products
It is policy at the Perelman School of Medicine at the University of Pennsylvania for individuals who are in a position to
control the content of an educational activity to disclose to the learners all relevant financial relationships that they have
with any commercial interest that provides products or services that may be relevant to the content of this continuing
medical education activity. For this purpose we consider relationships of the person involved in the CME activity to
include financial relationships of a spouse or partner.
The intent of this policy is not to prevent expert faculty with relevant relationship(s) with commercial interest(s) from
involvement in CME, but rather to ensure that Penn CME-certified activities promote quality and safety, are effective in
improving medical practice, are based on valid content, and are independent of control from commercial interests and
free of commercial bias. Peer review of all content was conducted for all faculty presentations whose disclosure
information provided to the Penn Office of CME was found to contain relationships that created a conflict of interest
relative to the topic of their presentation. In addition, all faculty were instructed to provide balanced, scientifically
rigorous and evidence-based presentations.
The staff in the Office of CME at the Perelman School of Medicine at the University of Pennsylvania, Mila Kostic,
Director of CME and the peer reviewer Zalman Agus, MD, Associate Dean for CME, have disclosed that they have
no relevant financial relationships with any commercial interests related to the content of this educational activity.
The following individuals have disclosed that they have no relevant financial relationships with any commercial interests
related to the content of this educational activity:
PLANNING COMMITTEE MEMBER NAME
LISA M. BELLINI, MD
MICHAEL S. PARMACEK, MD
DANIEL KISS, MD
LESLIE STEWART, MD
HANNY AL-SAMKARI, MD
ELAINA TULLY, MD
PRESENTER NAME
The following individuals have reported the listed relevant financial relationships with commercial interests related to
the content of this educational activity.
PRESENTER NAME
DAVID L PORTER MD
DAVID L PORTER MD
NAME OF COMMERCIAL INTEREST
RELATIONSHIP
NOVARTIS
GENENTECH
IP
SPOUSE EMPLOYMENT
Relevant Financial Relationships: Financial relationships are those relationships in which the individual benefits by receiving a salary,
royalty, intellectual property rights, consulting fee, honoraria, ownership interest (e.g., stocks, stock options or other ownership
interest, excluding diversified mutual funds), or other financial benefit. Financial benefits are usually associated with roles such as
employment, management position, independent contractor (including contracted research), consulting, speaking and teaching,
membership on advisory committees or review panels, board membership, and other activities from which remuneration is received
or expected
DISCLOSURE OF UNAPPROVED USES OF PRODUCTS
PRESENTER NAME
DAVID L PORTER MD
DAVID L PORTER MD
PRODUCT
CTL019 CELLS
TOCILIZUMAB
INVESTIGATIONAL AND/OR OFF-LABEL USE
TREATMENT OF LEUKEMIA
TREATMENT OF CYTOKINE RELEASE SYNDROME