THE LABORATORY OF ORGANIC SYNTHESIS
Institute of Chemistry, Academy of Sciences of Moldova,
Academiei str. 3, MD-2028 Chisinau, Moldova
Phone: + 373(22)73 97 54; Fax: +373(22)73 99 54;
e-mail: flmacaev@cc.acad.md
Founded in 1958.
RESEARCH INTERESTS
Our laboratory is specializing in various aspects of organic and medicinal chemistry and
currently engaged in projects directed at the discovery of new catalysts (metal-mediated and metalfree) for asymmetric synthesis, mechanistic investigations of reactions which proceed with high
levels of regio- and stereoselectivity, ionic liquids as green alternatives to solvents and the total
synthesis of biologically active products by use computer-aided molecular design and structureactivity analysis.
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Our current projects are summarized below:
Computer-assisted combinatorial design, synthesis and testing of new anti-tubercular agents;
A new generation of stereoselectors for metal complex catalysis;
Design, synthesis and study of co-ordination compounds of 3d- and 4f-metals using
functionalized macro- and heterocyclic ligands for possible medicinal and therapeutic
applications;
Asymmetric catalytic synthesis of amines using terpenoid-derived chiral phosphates.
SCIENTIFIC CONTACT
Prof. Dr. A. Börner, Leibniz-Institut für Organische Katalyse, Rostock, Germany
Armin.Boerner@catalysis.de
Prof. Dr. A. Malkov, Joseph Black Building, University of Glasgow, Glasgow, UK
amalkov@chem.gla.ac.uk
Prof. Dr. A. Alexakis, Université de Genève, Genève, Suisse
Alexandre.Alexakis@chiorg.unige.ch
Prof. Dr. W. Dehaen Leuven University, Belgium
wim.dehaen@chem.kuleuven.be
Prof. Dr. A. Geronikaki, Aristotelian University of Thessaloniki, Greece
geronik@pharm.auth.gr
Prof. Dr. A. De Groot, Wageningen University, Deijenplein 8, 6703HB Wageningen, the
Netherlands
Aede.deGroot@wur.nl
Prof. Dr. K. Gavrilov, Ryazan State University, Ryazan, Russia
k.gavrilov@rsu.edu.ru
Prof. Dr. V. Davankov, Institute of Organoelement Compounds, Moscow, Russia
davank@ineos.ac.ru
Prof. Dr. I. Beletskaya, Lomonosov Moscow State University, Moscow, Russia
beletska@org.chem.msu.ru
Prof. Dr. V. Poroikov, Institute of Biomedical Chemistry, Moscow, Russia
Vladimir.Poroikov@ibmc.msk.ru
Prof. Dr. F. Galin, Institute of Organic chemistry, Ufa, Russia.
galin@anrb.ru
Prof. Robert Reynolds, Southern Research Institute, Birmingham, AL, U.S.A.
reynolds@sri.org
SELECTED PUBLICATIONS
1. F. Macaev, K. Gavrilov, V. Munteanu, E. Stingaci, L. Vlad, L. Bet, S. Pogrebnoi, A. Barba.
Synthesis of 4-substituted 2-carenes utilising newly imidazolinic ionic liquids. Chem. Nat.
Comps. 2007, 43, 114-116.
2. Benetsky E.B., Zheglov S.V., Grishina T.B., Macaev F.Z., Bet L.P., Davankov V.A., Gavrilov
K.N. Various P*-chiral phosphite-type ligands: their synthesis, stereochemistry and use in the
Pd-catalysed allylation. Tetrahedron Lett. 2007, 48, 8326-8330.
3. Gavrilov K.N., Benetsky E.B., Grishina T.B., Zheglov S.V., Rastorguev E.A., Petrovskii P.V.,
Macaev F.Z., Davankov V.A., Diastereomeric P*-chiral diamidophosphites with terpene
fragments in asymmetric catalysis. Tetrahedron: Asymmetry. 2007, 18, 2557-2564.
4. F.Z. Macaev, O.M. Radul, I.N. Sterbet, S.I. Pogrebnoi, N.S. Sucman, S.T. Malinovskii, A.N.
Barba, M. Gdaniec. Synthesis and structure of new oxoindoles. Chem. Heterocycl. Comps.
2007, 3, 374-383.
5. Gavrilov K.N., Benetskii E.B., Macaev F.Z., Davankov V.A. The First P*-Monodentate
Phosphite Based on Vicinal Diol of Monoterpene Series. Russ. J. Coord. Chem., 2007, 33, 230231.
6. Macaev F., Munteanu V., Stingaci E., Barba A., Pogrebnoi S. New room temperature liquids:
Synthesis and characterization. Chem. J. Moldova. 2007, 2, 119-122.
7. F. Makaev, E. Styngach, V. Muntyanu, S. Pogrebnoi, Z. Rybkovskaya, A. Barba. New Catalysts
of Biginelli Reaction. Russ.J Org. Chem. 2006, 46, 849-854.
8. F.Z. Macaev, A.V. Malkov Use of monoterpenes, 3-carene and 2-carene, as synthons in the
stereoselective synthesis of 2,2-dimethyl-1,3-disubstituted cyclopropanes. Tetrahedron. 2006,
62, 9-26.
9. F. Macaev, L. Vlad, А.Gudima. Selective synthesis of carvone and cryptomerlone from apinene. Chem. Nat. Comps. 2006, 42, 301-303.
10. Pogrebnoi S., Saraber F.C.E., Jansen B.J.M., Groot A. Synthesis of a chiral steroid ring D
precursor starting from carvone. Tetrahedron, 2006, 62, 1743-1748.
11. F.C.E. Saraber, S.V. Drach, A.Baranovsky, T.Charnikhova, S.Pogrebnoi, B. J.M. Jansen,
A.Groot. Mukaiyma and Torgov Chemistry in the synthesis of (D-homo) Steroids Skeletons.
Polish J. Chem., 2006, 80, 535-548.
12. F.Makaev, L.Bets, L.Vlad, S.Pogrebnoi, A.Barba, A.Besolov, S.Malinovskii, R.Lyubodarskii.
Stereoselective synthesis of new (+)-1-{(1R,3R,6S)-4,7,7-trimethylbicyclo[4.1.0]hept-4-en-3yl}ethan-1-one derivatives. Russ.J Org. Chem. 2006, 46, 849-854.
13. Macaev F. What can be done with the acetyl group of aryl-1-ethanones? Chem. J. Moldova.
2006, 1, 43-60.
GROUP MEMBERS
Head of the Laboratory - Fliur Macaev, Doctor Habilitate of Chemistry
1. Pogrebnoi Serghei, Doctor of Chemistry, Senior Scientist
e-mail: richserg@moldnet.md
2. Stingaci Eugenia, Doctor of Chemistry, Senior Scientist
3. e-mail: estingaci@mail.md
4. Sepeli Felix, Doctor of Chemistry, Senior Scientist
e-mail:validol@mail.md
5. Vlad Liudmila, Doctor of Chemistry, Senior Scientist e-mail:lvlad@mail.md
6. Radul Oleg, Researcher
7. Gudima Alexandru, Engineer, e-mail: gap0400@mail.ru
8. Munteanu Viorica, Engineer
9. Bet Liudmila, PhD Student, e-mail:major@mail.md
10. Ribkovskaia Zinaida, PhD Student, e-mail:zinka123@mail.ru
11. Sucman Natalia, PhD Student, e-mail:nicheli@yandex.ru