Principal Investigator/Program Director (Last, First, Middle):
Braun, Werner
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
T. David Power, Ph.D.
Postdoctoral Fellow
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
B.S.
M.S.
Ph.D.
Fellow
Fellow
1988-1992
1992-1995
1995-1999
2000 -2001
2001-2003
Elon University, Elon, NC
Miami University, Oxford, OH
Miami University, Oxford, OH
University of North Texas, Denton, TX
University of Texas Med Branch, Galveston, TX
FIELD OF STUDY
Chemistry
Biochemistry
Organic Chemistry
Organic Chemistry
Biochemistry
Please refer to the application instructions in order to complete sections A, B, and C of the Biographical
Sketch.
A. Positions and Honors
2005
Postdoctoral Poster Award (2nd Place), Sealy Center for Molecular Science & Sealy Center for
Cancer Cell Biology: 13th Annual Science Forum, University of Texas Medical Branch,
Galveston, TX.
2004
Postdoctoral Poster Award, Annual McLaughlin Fellowship Colloquium on Infection and
Immunity, University of Texas Medical Branch, Galveston, TX.
2002-2003
Postdoctoral Fellowship, Keck Center for Computational and Structural Biology of the Gulf
Coast Consortia through the National Library of Medicine (NLM Grant No. 5T15LM07093),
University of Texas Medical Branch, Galveston, TX.
2002-2003
Taught 2 Medical Student Facilitation Courses, University of Texas Medical Branch, Galveston,
TX.
2001
Invited Speaker, International Lecture Series funded by the National Research Foundation
(NRF), South Africa in conjunction with the University of KwaZulu-Natal, Department of Pure &
Applied Chemistry, Durban, South Africa: June 22 (University of Pretoria, Pretoria), June 29
(University of Natal, Pietermaritzburg), July 16 (Stellenbosh University, Stellenbosh), and July
18 (University of Witswaterstrand, Johannesburg). “Determination of the Interaction Energy
Contribution of Picrate Anion Toward Stabilization of a K+ bis-Cage-Annulated 20-Crown-6”.
2001
Poster Award, American Chemical Society Meeting in Miniature, Tarleton State University,
Stephenville, TX.
2000
Guest Lectured Organic Chemistry Classes, Fall Semester, University of North Texas, Denton,
TX.
1996 -1999 Advanced Organic Chemistry Teaching Assistant and Course Coordinator, Miami University,
Oxford, OH.
1993
Outstanding Graduate Student Teaching Award, General Chemistry, Miami University, Oxford,
OH.
1992-1995
General Chemistry Teaching Assistant, Miami University, Oxford, OH.
1991-1992
General Chemistry Teaching Assistant, Elon College, Elon, NC.
1990
Assistant to the Associate Dean of Student Affairs, Jana Lynn Fields Patterson, Elon College,
Elon, NC.
1989-1990
Learning Resource Center (LRC) Mathematics Tutor, Elon College, Elon, NC.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
Page
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
B.
Braun, Werner
Selected peer-reviewed publications
1. Adams, EL, Rice, PJ, Graves, B, Ensley, HE, Yu, H., Brown, GD, Gordon, S, Monteiro, MA, PappSzabo, E, Lowman, DW, Power, TD, Wempe, MF, Williams, DL J. Pharmacol. Exp. Ther., 2008, 325,
115-123, Differential High Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans is
Dependent upon Primary Structure and is Influenced by Polymer Chain Length and Side Chain
Branching.
2. Negi, SS, Schein, CH, Oezguen, N, Power, TD, Braun, W Bioinformatics, 2007, 23, 3397-3399,
InterProSurf: a Web Server for Predicting Interacting Sites on Protein Surfaces.
3. Oezguen, N, Schein, CH, Power, TD, Izumi, T, Braun, W Proteins, 2007, 68, 313-323, A “Moving Metal
Mechanism” for Substrate Cleavage by the DNA Repair Endonuclease APE 1.
4. Chen, D, Menche, G, Power, TD, Peterson, JW, Schein, CH Proteins, 2007, 67, 593-605, Accounting
for Ligand-bound Metal Ions in Docking Small Molecules on Adenylyl Cyclase Toxins.
5. Kruger, HG, Mdluli, P, Power, TD, Raasch, T, Singh, A J. Mol. Struct. (THEOCHEM), 2006, 771, 165170, Experimental and Computational Studies of the Regioselective Protection of Hydantoins using
Anhydride.
6. Gokul V, Kruger HG, Govender T, Fourie L, Power TD J. Mol. Struct. (THEOCHEM), 2004, 672, 119125, An Ab Initio Mechanistic Understanding of the Regioselective Acetylation of 8,11-dihydroxypentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-lactam.
7. Marchand AP, Hazlewood A, Huang Z, Vadlakonda SK, Rocha J-DR, Power TD, Majerski KM, Klaic L,
Kragol G, Bryan JC Struct. Chem., 2003, 14, 279-288, Stabilization of a K+-(bis-Cage-annulated 20Crown-6) Complex by Bidentate Picrate.
8. Volk DE, Power TD, Gorenstein DG, Luxon BA Tetrahedron Lett. 2002, 43, 4443-4447, An Ab Initio
Study of Phosphorothioate and Phosphorodithioate Interactions with Sodium Cation.
9. Marchand AP, Kruger HG, Power TD, Segal, C Kem. Ind. 2002, 51, 51-67, Synthesis and Properties of
Polycyclic Cage Hydrocarbons (High Energy Density Fuels) and of Polycyclic Cage Organonitro
Compounds (Insensitive High-Energy Explosives).
10. Marchand AP, Keith JM, Alihodzic S, Ganguly B, Somers AW, Hariprakasha HK, Power TD Struct.
Chem. 2001, 12, 313-322, Stereo-Electronic Control of Grignard Additions of Vinylmagnesium Bromide
to 1-Methyl- and 3- Methylpentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-diones and to 1Methylhexacyclo [10.2.1.0.02,11.04,9.04,14.09,13]pentadeca-5,7-diene-3,10-dione.
11. Bryan JC, Levitskaia TG, Giacovazzo C, Cascarano G, Marchand AP, Huang Z, Kumar VS, Power TD
Struct. Chem. 2001, 12, 275-282, Synthesis, Alkali Metal Picrate Extraction Properties, and X-ray
Crystal Structure of a Novel, Cage-annulated Monoaza-18-Crown-6 Host.
12. Marchand AP, Power TD, Kruger HG Croat. Chem. Acta 2001, 74, 265-270, Ab Initio Theoretical
Investigation of a Formal Alkene-Enedione Intramolecular [2 + 2] Photocycliazation.
13. Marchand AP, Chong H-S, Shukla R, Dong EZ, Ganguly B, Hazlewood A, Power TD, Watson WH, Bott
SG Tetrahedron 2001, 57, 8629-8635, p-Facial Selectivity and Proximal/Distal Regioselectivity in a
Diels-Alder Reaction of an Unsymmetrical, Cage-Annulated 1,3-Cyclohexadiene.
14. Marchand AP, Chong H-S, Takhi M, Power TD Tetrahedron 2000, 56, 3121-3126, Synthesis and Alkali
Metal Picrate Extraction Studies of p-tert-Butylcalix[4]arene Crown Ethers Bridged at the Lower Rim
with Pyridyl Units.
15. Power TD, Sebastian JF Tetrahedron Lett. 1999, 40: (34) 6149-6152, A DFT Proton Affinity Study of
Vinyl and Allyl Anions of Cyclic Vinyl Ethers and Cycloalkenes.
16. Chan K, Power TD, Jai-nhuknan J, and Cybulski SM J. Chem. Phys. 1999, 110: (2) 860-869 An Ab
Initio study of HeF2, NeF2, and Ar-F2 Van der Waals Complexes.
17. Power TD, Sebastian JF Tetrahedron 1998, 54: (29) 8371-8392 Relative Anion Stabilities and
Transition State Energies Regarding Vinylic vs Allylic Deprotonation of Cyclic Vinyl Ethers by
Organolithium Reagents: An Ab Initio Study.
18. Johnson RC, Power TD, Holt JS, Immaraporn B, Monat JE, Sissoko AA, Yanik MM, Zagorodny AV,
Cybulski SM J. Phys. Chem. B 1997 101: (40) 8040-8040 Electron-Correlated Calculations of Electric
Properties of Nucleic Acid Bases - Reply.
19. Johnson RC, Power TD, Holt JS, Immaraporn B, Monat JE, Sissoko AA, Yanik MM, Zagorodny AV,
Cybulski SM J. Phys. Chem. 1996, 100: (48) 18875-18881 Electron-Correlated Calculations of Electric
Properties of Nucleic Acid Bases.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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Principal Investigator/Program Director (Last, First, Middle):
Braun, Werner
20. Power TD, Sebastian JF Tetrahedron Lett. 1996, 37: (51) 9127-9130 Vinylic vs Allylic Deprotonation:
An Ab Initio Molecular Orbital Study of 2,3-dihydrooxepin and 1,3-cycloheptadiene.
C. Research Support
Active
None
Completed
2005
National Computational Science Alliance CHE050029 (18,000 su advance) “Thermodynamic
and Kinetic Ab Initio Calculations of Novel Cage Compound and Cyclohexadiene” with H.G.
Kruger.
2004
National Computational Science Alliance CHE000039N converted to CHE010004 (40,000 su)
“Thermodynamic and Kinetic Ab Initio Study of Novel Cage Compound and Highly Strained
Systems” with H.G. Kruger.
2003
National Computational Science Alliance MCB030067 (10,000 su) “Computational Elucidation of
the Human apurinic/apyrimidinic Endonuclease 1-DNA Mechanism”.
2003
National Computational Science Alliance CHE020024 (10,000 su) “Interaction Energies of
Biologically Relevant Cations and DNA Phosphate and r-Monothiophosphate Backbones”
2002
National Computational Science Alliance CHE020024 (45,700 su) “Interaction Energies of Alkali
Metals and DNA Phosphate and Thiophosphate Backbones”.
2001
National Computational Science Alliance MCB020004N (10,000 su) “Forcefield Parameter
Development for Monothio and Dithiophosphate Dinucleotides” with D.J. King and D.E. Volk.
2000
National Computational Science Alliance CHE000010N (10,000 su), CHE000036N (10,000 su),
NCSA University of Kentucky (10,000 su) “Through-Bond vs Through-Space Transmission of
Electronic Effects in an Unusual Intramolecular [2+2] Photocyclization” with H.G. Kruger.
2000
National Computational Science Alliance-Boston University (10,000 su) “I. Determination of
Binding Energies Between Diaza-crown ethers and Alkali Metals. II. Vinylic vs. Allylic
Deprotonation of Cyclic Vinyl Ethers with Methyllithium” with A. Hazlewood.
2000
National Computational Science Alliance CHE000031N (40,000 su) “Intramolecular Wurtz-Type
Reactions in Dihaloadamantanes” with H.G. Kruger.
2000
National Computational Science Alliance CHE000032N (10,000 su) “Steric Control of Grignard
Additions” with H.K. Hariprakasha.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006)
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