CURRICULUM VITAE – EXPERT WITNESS IN NEPHROLOGY, KIDNEY DISEASES AND HYPERTENSION Stanley Goldfarb, M.D., F.A.C.P. January, 2000 HOME ADDRESS: 801 Muirfield Road Bryn Mawr, PA 19010 OFFICE ADDRESS: Department of Medicine 100 Centrex Hospital of the University of Pennsylvania 3400 Spruce Street Philadelphia, PA 19103 Telephone: Office – 215 614 0904 Email: sgoldfar@mail.med.upenn.edu SOCIAL SECURITY NUMBER: 084-34-1223 CITIZENSHIP: USA DATE OF BIRTH: December 18, 1943 PLACE OF BIRTH: Brooklyn, New York MARITAL STATUS: Married: Rayna Lynn Block Children: Rachael Fay, 1977 Michael Louis, 1980 EDUCATION: Secondary Education: Poly Prep Country Day School Princeton University B.A. 1961-1965 University of Rochester School of Medicine M.D. 1965-1969 University of Pennsylvania M.A.(hon.) 1985 POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: 1966-1967 Student Research Fellow - American Cancer Society, Department of Pathology, College of Physicians and Surgeons, Columbia University 1969-1970 Intern in Medicine, Hospital of the University of Pennsylvania 1970-1972 Residency in Medicine, Hospital of the University of Pennsylvania 1972-1974 Postdoctoral Fellow in Nephrology- Hospital of the University of Pennsylvania 1974-1975 Chief Medical Resident, University of Pennsylvania - VA Hospital MILITARY SERVICE: 1970-1976 Captain, Pennsylvania Army National Guard FACULTY APPOINTMENTS: 1974-1975 Clinical Instructor in Medicine, University of Pennsylvania School of Medicine 1975-1981 Assistant Professor of Medicine, University of Pennsylvania School of Medicine 1981-1990 Associate Professor of Medicine, University of Pennsylvania School of Medicine (Tenure) 1990- 1992 Professor of Medicine (Tenure), University of Pennsylvania School of Medicine 1993- 1996 Clinical Professor of Medicine University of Pennsylvania School of Medicine 1996- Professor of Medicine University of Pennsylvania School of Medicine ADMINISTRATIVE, ACADEMIC AND HOSPITAL APPOINTMENTS: 1975-78 Consultant in Nephrology, Wilmington Veterans Administration Hospital 1975- Staff Physician, Renal Electrolyte Section and Department of Medicine, Hospital of the University of Pennsylvania 1975-1978 Research and Education Associate of the Veterans Administration Hospital 1978-1988 Coordinator of ID 205 Course in Clinical Physiology Renal Section, University of Pennsylvania School of Medicine 1978-1981 Co-Director, Stone Evaluation Center Hospital of the University of Pennsylvania 1987-1988 Acting Chief, Renal Electrolyte Section 1988-1990 Associate Director- Clinical Research CenterUniversity of Pennsylvania 1988- 1992 Co-Chief, Renal-Electrolyte Section, Hospital of the University of Pennsylvania 1990-1992 Program Director- General Clinical Research Center- University of Pennsylvania 1992-1996 Senior Vice President for Medical Affairs - Graduate Health System 1996- Vice Chairman for Network Development- Department of Medicine- University of Pennsylvania School of Medicine 1997- Senior Vice Chair for Clinical Affairs- Department of Medicine- University of Pennsylvania Health System MEMBERSHIP ON NATIONAL COMMITTEES 1978-1986 Secretary, Subspecialty Committee on Nephrology American Board of Internal Medicine (Nephrology Board) 1983-1985 Member Nephrology Subcommittee for MKSAP VII - American College of Physicians 1986-1988 Member Nephrology Subcommittee for MKSAP VIII -American College of Physicians 1986-1987 Member (representing National Kidney Foundation) Committee on Clinical PrivilegesNephrology - American College of Physicians 1980-1981 Member Medical Sciences Task Force for the Comprehensive Qualifying Examination National Board of Medical Examiners 1987-1992 Representative of the National Kidney Foundation to the Council of Subspecialty Societies 1988-1994 Member - Subspecialty Committee on Nephrology - American Board of Internal Medicine (Nephrology Board) 1989- 1991 Representative of the American Society of Nephrology to the Intersociety Council for Research in Kidney and Urological Diseases 1989- Member Health and Public Policy CommitteeAmerican Society of Nephrology 1989- Member Health and Public Policy CommitteeNational Kidney Foundation 1989- 1991 Member National Medical Advisory Board of the National Kidney Foundation 1990- Member National Scientific Advisory Board of the National Kidney Foundation 1991-1993 Chairman, Council on Diabetic Nephropathy, National Kidney Foundation 1992- Secretary, American Board of Internal Medicine Committee on Recertification in Nephrology 1992- Member Dean's Ad Hoc Advisory Committee on Appointment and Promotion, Harvard Medical School 1992- Chair, Nominating Committee, American Society of Nephrology 1992- Representative of the American Society of Nephrology to the Council of Subspecialty Societies of the American College of Physicians Council Chairman- 1992-1995 1993-1996 Member of the Board of Regents of the American College of Physicians 1994- Pre-Reviewer for the ACGME- Nephrology Subspecialty Programs 1994-1996 Member Scientific Program Subcommittee of the American College of Physicians 1994-1996 Member Career Change Task Force of the American College of Physicians 1994- Member Nephrology Coalition Task Force: Defining the Nephrologist 1996- Member Publication Policy Committee of the American College of Physicians 1997- 1998 Member Managed Care Advisory Group- The American College of Physicians 1998 Member Scientific Program Subcommittee of the American College of Physicians 1998- Chair- Managed Care Subcommittee- American College of Physicians/American Society of Internal Medicine SPECIALTY CERTIFICATION: 1972 Diplomate, American Board of Internal Medicine 1974 Diplomate, American Board of Internal Medicine (Nephrology) LICENSURE: 1971 1994 1995 Pennsylvania New Jersey Delaware # MD012132E # 61009 # C10004490 MAJOR TEACHING AND CLINICAL RESPONSIBILITIES AT THE UNIVERSITY OF PENNSYLVANIA: 1975-1992 Ward Rounds: General Medicine (4 weeks) Renal-Electrolyte Service - Renal Rounds (8 weeks) Morning Report - (4 weeks) Interdepartmental 205 - Lecturer in Renal Component 1997Attending Physician- Renal Service MAJOR TEACHING AND CLINICAL RESPONSIBILITIES AT THE GRADUATE HOSPITAL: 1993-1996 Ward Rounds: General Medicine (4 weeks) Morning Report - (4 weeks) LECTURES, SEMINARS, RESEARCH: CONFERENCES, WORKSHOPS, SUPERVISED Interdepartmental 205 - Course Director for Renal- 1980-1988 ACADEMIC COMMITTEES AT THE UNIVERSITY OF PENNSYLVANIA: 1976-1979 Housestaff Training Program Review Committee 1978-1983 Procedure Utilization Review Committee 1983-1992 Intern Selection Committee, Department of Medicine 1985-1992 Quality Assurance Committee, Department of Medicine 1987-1989 Member Medical School Committee on Continuing Medical Education 1987-1991 Member Department of Medicine Capitol Resources Allocation Committee 1987-1988 Member Search Committee - Chairman of Medicine Presbyterian University of Pennsylvania Medical Center 1987-1988 Member Review Committee for Neural Science Institute, University of Pennsylvania 1987-1989 Member, Institutional Animal Care and Use Committee 1988-1990 Member, Evaluation Subcommittee Committee; Medical School of Curriculum 1988-1992 Member, Executive Committee, Diabetes Center 1997- Member - CME Council 1997- Member- UPHS Medical Directors Council 1998- Chair- Department of Medicine Quality Improvement Committee ACADEMIC AND ADMINISTRATIVE COMMITTEES AT THE GRADUATE HOSPITAL 1993-1996 Member, The Medical Board 1993-1995 Chairman, Corporate Rehabilitation Committee 1993-1996 Member, Education Committee GRADUATE HEALTH SYSTEM Board Directorships 1993-1996 Member Board of Directors Parkview Hospital City Avenue Hospitals President 1993-1996 Founder’s Medical Group AWARDS AND HONORS: 1961 New York State Regents Scholar 1965 Cum Laude, Princeton University 1969 Student Cancer Research Award, Monroe County Medical Center 1978-81 Recipient, Clinical Investigator Award, National Institute of Arthritis, Metabolic and Digestive Disease 1981 Who's Who in American Jewry 1981 Who's Who in World Jewry 1983 Who's Who in Frontier Science and Technology 1986,1987,1988Achievement Award, National Kidney Foundation of the Delaware Valley 1990- National Volunteer Award- National Kidney Foundation 1993- Who's Who in the East 1993 Who's Who Science and Engineering 1995 Who's Who in America 1996 Who’s Who in Medicine MEMBERSHIP IN PROFESSIONAL AND SCIENTIFIC SOCIETIES: 1972 Associate, American College of Physicians 1976 Membrane Transport Workers Union 1976 American Federation for Clinical Research 1976 American Society of Nephrology 1977 American College of Clinical Pharmacology (Fellow) 1977 New York Academy of Sciences 1978 Fellow, American College of Physicians 1978 American Society of Mineral Research 1981 International Society of Nephrology 1982 John Morgan Society 1986 American Society for Clinical Investigation 1994- Fellow, College of Physicians of Philadelphia 1994 American Medical Association EDITORIAL BOARDS American Journal of Kidney Disease -1992-1996 SCIENTIFIC REVIEWER FOR THE FOLLOWING: Annals of Internal Medicine American Journal of Physiology Journal of Clinical Investigation Archives of Internal Medicine Journal of Laboratory and Clinical Medicine Mineral and Electrolyte Metabolism Kidney International Veterans Administration European Journal of Medicine New England Journal of Medicine Metabolism American Journal of Digestive Diseases Life Sciences Proceedings National Academy of Sciences Circulation Research American Journal of Digestive Disease Journal of Critical Illness Journal of the American Society of Nephrology Journal of the American Medical Association ` PRINCIPAL INVESTIGATOR OF THE FOLLOWING GRANTS: 1) Hypocalcemic and PTH inhibitory actions of WR 2721 American Cancer Society, IN135C, 1982 2) Hypocalcemic and PTH-inhibitory mechanisms of WR 2721 NIH, NAIM DDK, AM31826, 1983-1986 3) Pathogenesis of altered renal function in juvenile diabetes, Juvenile Diabetes Foundation, 1986-1988 4) Polyol pathway and Glomerular Filtration in Diabetes, 1987-1990- DK39727 5) Characteristics of Uropontin Metabolism in Normals and in Patients with Urolithiasis, DCI Joint Clinic Voluntary Research and Development Fund- 1992, CO-INVESTIGATOR OF THE FOLLOWING RESEARCH GRANTS: 1) Regulation of Renal Calcium and Phosphate Excretion, NIH, 32R01HL00340, 1984-1987 2) Nephrology Training Grant, NIH, S-T 32-AM 07006, 1982-1987 3) NIH IROl-DK-44513 " Tubulointerstitial Kidney Cells and the Response to Glucose" 12/1/91; 4) Molecular Mediators of Renal Cell Growth- Project 3 in George M. O'Brien Renal Research Center Application NIH DK-45191: Project Period: 12/1/91; P.I.: Eric G. Neilson M.D. Project Leaders: Stanley Goldfarb, M.D. Fuad N. Ziyadeh, M.D; NATIONAL STUDY SECTIONS: 1) VA Merit Review Board in Nephrology, 1988-1991 Member-1988-1990 Chairman-1990-1992 SPECIAL STUDY SECTIONS AND REVIEW COMMITTEES: 1) Member, Special Study Section- National Institutes of Health, 1983,1989,1991 2) Reviewer, Abstract Selection International Society of Nephrology IXth Congress, Los Angeles, CA 1984 3) Reviewer, Abstracts - American Society of Nephrology Washington, 1984 4) Head, Ca-PO4 Program - American Society of Nephrology - 1985 5) Member, National Program Committee - American Society of Nephrology - 1988-89 6) Head, Clinical Nephrology Program - American Society of Nephrology 1991 7) Scientific Reviewer for the National Osteoporosis Society COMMUNITY, CIVIC AND CHARITABLE ACTIVITIES: 1) Member, Organizing Committee - National Kidney Foundation of the Delaware Valley - Annual Ball, 1985 2) Member, Medical Advisory Board - National Kidney Foundation of the Delaware Valley, 1985 - 1991 3) Chairman, Medical Advisory Board - National Kidney Foundation of the Delaware Valley, 1989-1991 4) Member, Board of Directors-National Kidney Foundation of the Delaware Valley, 1989-1991 5) Co-Chair, Annual National Kidney Foundation of the Delaware Valley Golf Outing, 1985 -1990 6) 1994- Wharton Health Care Program Mentor- Graduate Program in Health Care Management . Wharton School of the University of Pennsylvania 7) Member- Program CommitteePhiladelphia 1995-1998 College of Physicians of 8) Councilor - College of Physicians of Philadelphia 1998 BIBLIOGRAPHY: Original Publications 1) Goldfarb, S., Richart RM, Okagaki T: Nuclear DNA content in endolymphatic stromal myosis. Am. J. Obstet. and Gynec. 106: 524-529, 1970. 2) Goldfarb S, Richart RM, Okagaki T: A cytophotometric study of nuclear DNA content of cyto- and syncytiotrophoblast in trophoblastic disease. Cancer 27: 83-91, 1971. 3) Feldman HA, Goldfarb S, McCurdy DK: Recurrent radiographic dyeinduced renal failure. JAMA 229: 72, 1974. 4) Goldfarb S, Beck LH, Agus ZS and Goldberg M: Tubular sites of action of cyclic AMP on renal PO4 reabsorption. Proc. 1st International Conf. on Phosphate, Paris, France, June 1975. 5) Goldfarb S, Cox M, Singer I and Goldberg M: Acute hyperkalemia induced by hyperglycemia: hormonal mechanisms. Ann. Int. Med. 84:426-432, 1976. 8) Eisenberg J and Goldfarb S: The clinical use of prothrombin time as a screening test. Clin. Chem. 22: 1644, 1976. 9) Westby GR, Goldfarb S, Agus ZS and Goldberg M: The acute effects of growth hormone on renal calcium and phosphate excretion in the dog. Metabolism 26: 525-530, 1977. 10) Goldfarb S, Westby GR, Agus ZS and Goldberg M: Renal tubular effects of chronic phosphate depletion. J. Clin. Invest. 59: 770-779, 1977. 11) Emmett M, Goldfarb S, Agus ZS and Narins RG: The pathophysiology of acid-base change in chronically phosphate-depleted rats: bone-kidney interaction. J. Clin. Invest. 59: 291, 1977. 12) Goldfarb S, Bosanac P, Goldberg M and Agus ZS: Effects of calcium on renal phosphate reabsorption. Am. J. Physiol. 234: F22-F28, 1978. 13) Goldfarb S, Strunk B, Singer I, Goldberg M: Paradoxical glucoseinduced hyperkalemia: combined aldosterone-insulin deficiency. Am. J. Med. 59: 901, 1975. 14) Goldfarb S, Beck LH, Agus ZS and Goldberg M: Dissociation of tubular sites of action of saline, PTH and DbCAMP on renal tubular phosphate reabsorption. Nephron 21:221-229, 1978. 15) Lau K, Goldfarb S, Grabie M, Agus ZS and Goldberg M: Mechanism of lithium induced hypercalciuria in rats. Am. J. Physiol. 234:E294E300, 1978. 16) Grabie M, Lau K, Agus ZS, Goldberg M and Goldfarb S: Role of parathyroid hormone in the hypercalciuria of chronic phosphate depletion. J. Min. and Electrolyte Metab. 1:279-287, 1978. 17) Cowgill LD, Goldfarb S, Lau K, Slatopolsky E and Agus ZS: Evidence for an intrinsic renal tubular defect in mice with familial hypophosphatemic rickets. J. Clin. Invest. 63:1203-1210, 1979. 18) Lau K, Wolf C, Nussbaum P, Weiner, B, DeOreo P, Agus ZS and Goldfarb S: Differing effects of acid versus neutral phosphate therapy of hypercalciuria. Kidney Int. 16:736-742, 1979. 19) Mitnick P, Goldfarb S and Agus ZS: Calcium and phosphate metabolism in tumoral calcinosis. Ann. Int. Med. 92:482-487, 1980. 20) Lau K, Agus ZS, Goldberg M and Goldfarb S: Renal tubular sites of altered Ca and PO4 transport in phosphate depleted rats. J. Clin. Invest. 64:1681-1687, 1979. 21) Goldfarb S: Juxtamedullary and superficial nephron phosphate reabsorption in the cat. Am. J. Physiol. 239:F336-F332, 1980. 22) Grabie M, Nussbaum P, Goldfarb S, Walker BR, Goldberg M, Agus ZS: Effects of a-methyldopa on renal hemodynamics and tubular function in man. Clin. Pharm. and Therap. 27:522-527, 1980. 23) Wasserstein A, Hill G, Goldfarb S, and Goldberg M: Recurrent TTP after viral infection: clinical and histological simulation of chronic glomerulonephritis. Arch. Int. Med. 141:685-688, 1981. 24) Goldfarb S: Phosphate transport in superficial and juxtamedullary nephrons in the cat: evidence for nephron heterogeneity. Adv. Exp. Med. Biol. 128:67-70, 1980. 25) Mitnick PD, Greenberg A, DeOreo PB, Weiner BM, Coffman TM, Walker BR, Agus ZS, Goldfarb S: Differing renal effects of two nonsteroidal anti-inflammatory agents, indomethacin and oxaprozin, in man. Clin. Pharm. Therap. 28:680-689, 1980. 26) Lau K, Goldfarb S, Goldberg M and Agus ZS. Effects of PO4 administration of tubular calcium transport. J. Lab Clin. Med. 99:317324, 1982. 27) Mitnick PD, Greenberg A, Coffman T, Kelepouris E, Wolf CJ and Goldfarb S. Effects of two models of hypercalcemia on renal acid base metabolism. Kid. Int. 21:613-620, 1982. 28) Goldfarb S: Effects of calcium on ADH action in the cortical collecting tubule perfused in vitro. Adv. Expt. Med. Biol. 151:111-115, 1982. 29) Jorkasky D and Goldfarb S: Abdominal wall hernia complicating chronic ambulatory peritoneal dialysis. Am. J. Nephrol. 2:323-325, 1982. 30) Lau YK, Wasserstein A, Westby GR, Bosanac P, Grabie M, Mitnick P, Slatopolsky E, Goldfarb S and Agus ZS: Proximal tubular defects in idiopathic hypercalciuria: resistance to phosphate administration. Min. Elect. Metab. 7:237-250, 1982. 31) Goldfarb S: Effects of calcium on ADH action in the cortical collecting tubule perfused in vitro. Am. J. Physiol. 243 (Renal Fluid Electrolyte Physiol. 12): F481-F486, 1982. 32) Goldstein C, Braunstein S and Goldfarb S. Idiopathic syndrome of inappropriate antidiuretic hormone release. Ann. Int. Med., 99: 185-189, 1983. 33) Glover D, Riley L, Carmichael K, Spar B, Glick J, Kligerman MM, Agus, ZS, Slatopolsky E, Attie M, and Goldfarb S: Hypocalcemia and inhibition of parathyroid hormone secretion after administration of WR2721 (a radioprotective and chemoprotective agent). N. Engl. Journ. Med., 309: 1137-1142, 1983. 34) Kimmel P, Goldfarb S. Effect of isoproterenol, cyclic AMP and antidiuretic hormone on potassium transport in cortical collecting tubule. Am. J. Physiol., 246 :F804-F810, 1984. 35) Goldstein C, Walker B, Goldfarb S. Comparative effects of oxaprozin on renal hemodynamic and electrolyte excretion. Seminars in Rheumatology, 15 suppl. 27-35, 1985. 36) Goldfarb S, Walker BR, Agus ZS. The uricosuric action of oxaprozin. J. Clin. Pharm. 25 :144-149, 1985. 37) Attie MF, Spar BM, Wolf J, Fallon M, Slatopolsky E, and Goldfarb S. Studies of the hypocalcemic action of WR2721. Journ. Clin. Inves. 75:1191-1197, 1985. 38) Glover D, Shaw L, Glick JM, Slatopolsky E, Weiler C, Attie M, and Goldfarb S. Treatment of hypercalcemia associated with parathyroid cancer with WR2721: A unique hypocalcemic agent and inhibitor of PTH secretion. Annals Intern. Med. 103:55-58, 1985. 39) Garrick R, Ziyadeh F, Jorkasky D, Goldfarb S: Bartter's Syndrome - a unifying hypothesis. Am. J. Nephrology, 5:379-384, 1985. 40) Morrison G, Spar B, Walker B, Goldfarb S. The renal effects of indoramin. J. Cardiovascular Pharm. 8 (Supl 2): 525-532, 1986. 41) Weiss J, Walker ST, Fallon M, and Goldfarb S. In Vivo and in vitro effect of WR-2721 in experimental hypercalcemia in the rat. J. Pharm. and Exp. Ther. 238: 969-973, 1986. 42) Goldfarb S, Simmons D and Kern E.O. Amelioration of glomerular hyperfiltration in experimental diabetes by myo-inositol supplementation and Sorbinil. Trans. Assoc. Amer. Phy. 99:67-72, 1986. 43) Wasserstein A, Stolley P, Goldfarb S, and Agus ZS. Case control study of risk factors for calcium nephrolithiasis. Mineral Elect. Metab. 13:85-95, 1987. 44) Webster GD, Goldfarb S, Norcini JJ, Shea JA, and Murray LN. Performance of a dangerous answer subtest within a subspecialty certifying examination. Medical Education, 21, 426-431, 1987. 45) Weaver ME, Morrissey J, McConkey C, Goldfarb S, Slatopolsky E, Martin KJ. WR2721 inhibits parathyroid adenylate cyclase. Am. J. Physiol. 252: E197-E201, 1987. 46) Goldfarb S. Nephrology Forum: The role of diet in the pathogenesis and prophylaxis of calcium nephrolithiasis - Kidney Int. 34: 544-555, 1988. 47) Goldfarb S, Kern EFO, Simmons D: The role of polyol pathway activation in the pathogenesis of altered glomerular hemodynamic function in experimental diabetes mellitus in the rat. Proceedings, Second Workshop on Animal Models of Diabetes, ed. Shafrir E and Renold A., 517-522, 1988. 48) Baker L, Dahlem S, Goldfarb S, Kern E, Stanley CA, Egler J, and Heyman S. Hyperfiltration and renal disease in glycogen storage disease, Type I. Kidney Int. 35,1345-1350, 1989. 49) Garrick R, Goldfarb S. The differential diagnosis and renal pathophysiologic effects of hypercalcemia. Am. J. Kid. Dis. 12, 160163,1989 50) Attie MF, Goldfarb S, Fallon M, Shaker J, and Carmichael K. Effects of WR-2721 on parathyroid hormone secretion and bone. Proceedings First International Conference on Alternative Action of PTH. In press, 1990. 51) Shaker J, Attie MF, Goldfarb S, Fallon M. WR-2721 attenuates bone loss after hindlimb tenotomy in rats. J. Bone & Min Res. 4. 885-90, 1989 52) Ziyadeh FN, Snipes ER, Watanabe M, Alvarez RJ, Goldfarb S, Haverty TP. The effects of high glucose on cell growth and matrix production in mouse proximal tubule cells in culture: Inhibition of cell proliferation, stimulation of cell hypertrophy and increased transcription of procollagens Type IV and Type I. American Journal of Physiology. 259 (Renal Fluid Electrol. Physiol. 28) F704-F714,1990 53) Goldfarb S, Ziyadeh FN, Kern EFO, Simmons DA, Ziyadeh FN. Effects of polyol pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats . Diabetes 40: 465-472, 1991. 54) Ziyadeh FN, Simmons DA, Snipes EA, Goldfarb S. Effect of myoInositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose. J Am Soc Nephrology, 1, 1220-1229,1991. 55) Wolf G, Neilson EG, Goldfarb S, Ziyadeh FN. The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture. Biochemical and Biophysical Research Communications. 176, 902-909 1991. 56) Spinler S and Goldfarb S. Nephrotoxicity of contrast media following cardiac angiography: pathogenesis, clinical course, and preventive measures, including the role of low osmolality contrast media. Annals of Pharmacotherapy. 26: 56-72, 1991. 57) Rudnick MR, Goldfarb S, Murphy M.The role of mannitol and other prophylactic regimens in contrast media induced acute renal failure Coronary Artery Disease 2 1047-1052,1991. 58) Rocco MV, Chen Y, Goldfarb S, and Ziyadeh FN. Elevated glucose levels stimulate transforming growth factor beta expression and bioactivity in murine proximal tubule cell culture. Kidney Int. 41, 107115,1992. 59) Lemann J, Bidani AK, Bain RP, and the Collaborative Study of Angiotensin-Converting Enzyme Inhibition in Diabetic Nephropathy (S Goldfarb, Site PI). Use of the serum creatinine to estimate glomerular filtration rate in health and early diabetic nephropathy. Am J Kid Dis 16: 236-243, 1990 60) Rodby R, Amjad A, Rohde R and the Collaborative Study of Angiotensin-Converting Enzyme Inhibition in Diabetic Nephropathy (S Goldfarb, Site PI). Renal scanning 99mTc DTPA glomerular filtration rate determination compared with iothalamate clearance GFR in diabetics. Am J Kid Dis 20: 569-573, 1992 61) Goldfarb S, Spinler S, Berns JS, and Rudnick R. Low osmolality contrast media and the risk of contrast media associated nephrotoxicity. Investigative Radiology. 28 Suppl 5:S7-10; discussion S11-2, 1993. 62)Dawson P. Goldfarb S Latchaw RE. Hill JA. Cohen, MD. Low osmolality contrast media and the risk of nephrotoxicity- - DISCUSSION. Investigative Radiology. 28(Suppl 5):S 11-S 12, 1993 Nov 63)Goldfarb S. Morris TW. Latchaw RE. Hill JA. Cohen MD. Enge IP. The physiologic effects of contrast media on the heart- discussion. Investigative Radiology. 28(Suppl 5):S 47, 1993 Nov 64) Hill J, Winniford M, Cohen B, Van Fossen D, Murphy M, Halpren E, Ludbrook PA, Wexler L, Rudnick M, and Goldfarb S, for the Iohexol Cooperative Group. Multicenter trial of Ionic vs Non-ionic contrast media for cardiac angiography. American Journal of Cardiology, 72: 770-775, 1993. 65) Sasse , E A, Doumas, B T, Lemann Jr, J and The Collaborative Study Group (S Goldfarb, Site PI). Urinary Albumin in Relation to Urinary Total Protein in Patients with Established Diabetic Nephropathy. Annals of Internal Med. (1989) Vol III, No. 4 pp 343. 66) Bain R, Rohde R, Hunsicker L G, McGill J, Korbin S, Lewis E J, and The Collaborative Study Group (S Goldfarb, Site PI). A Controlled Clinical Trial of Angiotensin Converting Enzyme Inhibition in Type 1 Diabetic Nephropathy: Study Design and Patient Characteristics. J. Am. Soc. Nephrol. (1992) Vol 3: S97-S103. 67) Bleyer AJ, Fumo P, Snipes EA, Goldfarb S, Simmons DA, Ziyadeh FN. Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule. Kidney International. 45(3):659-66, 1994 68) Lewis MD Edmund J, Hunsicker MD Lawrence G, Bain Raymond P, Rohde BS Richard D, for Collaborative Study Group (S Goldfarb, Site PI), The Effect of Angiotensin Converting Enzyme Inhibition in Diabetic Nephropathy. New England Journal of Medicine, 329, 1456-1463,1993. 69) Rudnick, MR, Berns JS, Cohen RM, and Goldfarb, S. Nephrotoxic risks of renal angiography: Contrast media-associated nephrotoxicity and atheroembolism. A critical review. American Journal of Kidney Diseases. 24(4):713-27, 1994. 70) Breyer, JA, , Hunsicker LG, Bain RP, Lewis EJ, Rohde RD, for Collaborative Study Group (S Goldfarb, Site PI)Angiotensin Converting Enzyme Inhibition in Diabetic Nephropathy. Kidney Int, 45, S-156-S-160, 1994 71) Rudnick M, Goldfarb S, Wexler L, et al. Nephrotoxicty following cardiac angiography. A double-blind multicenter trial of ionic and nonionic contrast media in 1194 patients. Kidney International. 47(1):254261, 1995 72) Berns, JS, Imperiale A, Goldfarb S. Are cytotoxic agents beneficial in idiopathic membranous nephropathy ? Journal of the American Society of Nephrology. 5(8):1553-1558, 1995 73) Hebert, L, Bain RP, Verme, D et al for Collaborative Study Group (S Goldfarb, Site PI) Remission of nephrotic range proteinuria in type I diabetes. Kidney International, 46, 1688-1693, 1994. 74) Cheng, JWM, Charland S, Goldfarb S, Spinler S. Effects of renal function on recainam pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther , 57, 492-498, 1995. 75) Goldfarb, S. Brailer, D. And Katz, F. Proving the link between outcomes and resource utilization. Medical Interface. 8, 79-84, 1995. 76) Brailer, D, Goldfarb S, Katz, F, and Horgan, M. Improving performance with clinical decision support. Journal on Quality Improvement. 22, 443-456 1996. 77) Rodby, R, Firth L, Lewis E J, and The Collaborative Study Group (S Goldfarb, Site PI). An economic analysis of Captopril in the treatment of diabetic nephropathy. Diabetes Care 19, 1051-1061, 1996 78) Cheng JW, Charland SL, Shaw L, Kobrin S, Goldfarb S, Stanek E, and Spinler S. Is the volume of distribution of digoxin reduced in patients with renal dysfunction? Determination of pharmacokinetics by fluoresence polarization assay. Pharmacotherapy 17, 584-590, 1997. 79)Mange K, Matsuura D, Cizman B, Soto H, Ziyadeh FN, Goldfarb S, Neilson EG Language guiding therapy: The case of dehydration versus volume depletion Annals of Internal Medicine 127: (9) 848-853 1997 80) Rudnick MR, Berns JS, Cohen RM, Goldfarb S. Contrast mediaassociated nephrotoxicity Seminars in Nephrology 17: (1) 15-26 1997 81) Goldfarb S and Henrich W. Update in nephrology. Annals of Internal Medicine. 128,49-56,1998 82) Min W, Shiraga H, Chalko C, Goldfarb S, Krishna GG, Hoyer JR. Quantative studies of human urinary uropontin excretion. Kidney International 53, 189-193, 1998 83) Spinler SA. Nawarskas JJ. Boyce EG. Connors JE. Charland SL. Goldfarb S. Predictive performance of ten equations for estimating creatinine clearance in cardiac patients. Iohexol Cooperative Study Group. Annals of Pharmacotherapy. 32:1275-83, 1998 84) Goldfarb, S. The utility of decision support, clinical guidelines, and financial incentives as tools to achieve improved clinical performance. The Joint Commision Journal on Quality Improvement. 25, 137-144,1999 Manuscripts In Preparation Goldfarb, S, Brailer D, Kim L. A new from of clinical knowledge for bedside evaluation: The role of hospital cohort analysis in clinical care Books Hormones, Autacoids, and the Kidney Contemporary Issues in Nephrology.Vol 23 ed. by Goldfarb, S. and Ziyadeh, F.N., Churchill Livingstone, Philadelphia, 1991. Workshops in Disorders of Fluid and Electrolytes ed by S. Goldfarb and H. Szerlip. Churchill Livingstone, New York, 1993. Symposia Mini-symposium on Diabetic Nephropathy ed by S. Goldfarb. American Journal of Kidney Disease. 22, 721-736,1993 Editorial Reviews, Chapters, Letters: 1) Goldberg M, Agus ZS and Goldfarb S: Renal handling of calcium, phosphate and magnesium. In The Kidney, ed. by Brenner and Rector, Saunders and Co., Philadelphia, PA, 1976. 2) Goldberg M, Agus ZS and Goldfarb S: Renal handling of calcium and phosphate. In Perspective in Renal Physiology, ed. by K. Thurau. MTP Publishing Co., Baltimore, MD, 1976. 3) Goldberg M, Agus ZS and Goldfarb S: Renal handling of calcium and phosphate. In Kidney and Urinary Tract Physiology II, ed. K. Thurau. (International Review of Physiology, vol. II), University Park Press, 1976. 4) Goldfarb S and Agus ZS: The kidney in adrenal and pituitary diseases. In The Kidney in Systemic Diseases, ed. by W. Suki and G. Eknoyan, 1981. 5) Lau K, Goldfarb S and Goldberg M: The effects of PTH on phosphate transport. In Renal Handling of Phosphate, ed. by S. Massry, Plenum Press, 1980. 6) Agus ZS, Goldfarb S and Wasserstein A: Disturbances in calcium phosphate and magnesium balance. In The Kidney, ed. by B. Brenner and F. Rector, 2nd ed., W.B. Saunders Co., 1981. 7) Agus ZS, Wasserstein A and Goldfarb S: PTH, calcitonin, cyclic nucleotides and the kidney. In Annual Review of Physiology, Andreoli TE, ed., Ann. Rev., Inc., 1981. 8) Agus ZS, Goldfarb S and Wasserstein A: Mineral metabolism in health and disease, in Contemporary Nephrology, ed. by S. Klahr S. Massry, Plenum Pub. Corp., New York, NY, 1981. 9) Greenberg A and Goldfarb S: Acid base disturbances in the surgical patient, in Medical Care of the Surgical Patient, ed. by Division of General Medicine, University of Pennsylvania, School of Medicine, Lippincott, 1982. 10) Agus ZS, Goldfarb S and Wasserstein A: Calcium transport in the kidney, in Reviews of Physiology, Biochemistry and Experimental Pharmacology, Ullrich K, ed., Springer-Verlag, Heidelberg, 1980. 11) Agus ZS, Goldfarb S and Wasserstein A: Renal tubular transport defects, in Internal Medicine, Stein, J., ed., Elsevier North-Holland, 1982. 12) Agus ZS, Goldfarb S and Wasserstein A: Diagnosis and treatment of disorders of the serum calcium and phosphate, in Essentials of Nephrology for Primary Care Physicians, Schrier RW, ed., W.B. Saunders, Co., March, 1981. 13) Agus ZS, and Goldfarb S: Disorders of calcium and phosphate metabolism, in Medical Clinics North America, L. Beck ed., W.B. Saunders, Co., March, 1981. 14) Agus ZS, Wasserstein A, Goldfarb S: Clinical disorders of calcium and magnesium metabolism, in Symposium on Fluid and Electrolyte Metabolism, ed. by B. Brenner, American Journal of Medicine 72:473488, 1982. 15) Agus ZS, Goldfarb S, and Wasserstein A: Renal regulation of calcium balance. In Physiology and Pathology of Electrolyte Metabolism, eds. Seldin DW and Giebisch G. Raven Press, NY, 1985. 16) Goldfarb S, Kelepouris E: Disorders of Calcium and Phosphate Metabolism, in Pathophysiology of Electrolyte and Renal Disorders. ed. H. David Humes. Churchhill Livingstone, Inc., 1985. 17) Goldfarb S, Goldstein C. Renal and electrolyte disorders in, Text Book of Medicine. ed. A.R. Myers, Harwal Publishing Co., Philadelphia, 1986. 18) Goldfarb S, Agus ZS. On the mechanism of polyuria hypercalcemia. Invited editorial. Am. J. Nephrol. 4:69-76, 1984. in 19) Agus ZS and Goldfarb S: Disorders of calcium metabolism, in Disorders of Fluid and Electrolyte Metabolism. Ed. by DeFronzo R, and Arieff A. Churchill Livingstone Inc., 1984. 20) Goldfarb S, Ntoso KA. Disorders of Magnesium Metabolism, in Internal Medicine. Stein, J., Ed. Little Brown Co. Boston, 1986. 21) Goldfarb S, Ziyadeh F. Disorders of Phosphate Metabolism, in, Internal Medicine. Stein, J. Ed. Little Brown Co., Boston, 1986. 22) Garrick R and Goldfarb S. Hypo and Hypercalcemia, in Manual of Renal Therapeutics. Ed. by R.J. Glassock, Churchill Livingstone Inc., 1987. 23) Goldfarb S and Garrick R. Nephrolithiasis, in Textbook of Internal Medicine. Ed. by Kelly, W. Lippincott, Phila, 1989. 24) Ziyadeh, FN, Kern EFO, Goldfarb S. Metabolic and Biochemical Abnormalities in the Pathogenesis of Diabetic Nephropathy in the Kidney in Diabetes Mellitus. Ed. by Brenner BM and Stein JH, vol 20, p 87114,1989. 25) Goldfarb, S. Dietary factors in the pathogenesis of osteoporosis. CPC Series in Metabolic Bone Disease. vol 3,#2,1989. ed. by D. Zackson, Triclinica, New York. 26) Goldfarb S, Ziyadeh, FN. Renal and electrolyte disorders (2nd ed.)in, Text Book of Medicine. ed. A.R. Myers, Harwal Publishing Co., Philadelphia, in press, 1993 27) Goldfarb S and Garrick R. Nephrolithiasis, in Textbook of Internal Medicine. Ed. by Kelly, W. (2nd edition) In press, 1990 28) Ziyadeh F.N., and Goldfarb, S. The role of the renal interstitium in Diabetic Nephropathy. Kidney International, 39:464-476, 1991. 29) Goldfarb S, Ziyadeh FN- Letter to the Editor, New England J. Medicine, Glomerular lesions and microalbuminuria in diabetes. 321,759,1989 30) Goldfarb, S. Diet and Nephrolithiasis. in Endocrine and Metabolism Clinics of North America. Nephrolithiasis ed. by Lynwood H. Smith. Saunders and Co., in press 1990. 31) Goldfarb S, Ntoso KA. Disorders of Magnesium Metabolism, in Internal Medicine. Stein, J., Ed. 3rd Edition Little Brown Co. Boston, 1990. 32) Goldfarb S, Ziyadeh F. Disorders of Phosphate Metabolism, in, Internal Medicine. Stein, J. Ed. 3rd Edition Little Brown Co., Boston, 1991. 33) Kobrin S, Goldfarb S. Common consultative problems in nephrology: Magnesium Deficiency. Seminars in Nephrology. 1991. 34) Kobrin S, Goldfarb S. Hypocalcemia and hypercalcemia, in Acid Base and Electrolyte Disorders. ed. by HJ Androgue. Contemporary Mangement in Critical Care. Churchill Livingstone NY. 1991. 35) Goldfarb S, Ziyadeh F. Nephrolithiasis. in Scientific American Medicine. Rubinstein E, and Federman D. ed. Scientific American, NY 1993 36) Goldfarb S. Kidney Complications of Diabetes Self-Study Unit. Pennsylvania Academy of Diabetes. in press 1994 37) Goldfarb S, Sharma K. Diabetic Nephropathy. in Current Practice in Medicine. ed. by R. Glassock. Current Medicine. in press 1994. 38) Goldfarb S, Ziyadeh F. Disorders of Phosphate Metabolism, in, Internal Medicine. Stein, J. Ed. 4th Edition C.V. Mosby Co., St. Louis 1994. 39) Goldfarb S, Ziyadeh F. The Kidney in Diabetes in, Internal Medicine. Stein, J. Ed. 4th Edition C.V. Mosby Co., St. Louis 1994. 40) Goldfarb, S. The approach to the patient with diabetic nephropathy, in A Primer in Nephrology. ed by A Greenberg. National Kidney Foundation. NY in press 1994. 41) Goldfarb S, Kobrin, S. Disorders of Magnesium Metabolism in, Internal Medicine. Stein, J. Ed. 4th Edition C.V. Mosby Co., St. Louis 1994. 42) Goldfarb S, Kobrin, S. Renal tubular transport defects, in, Internal Medicine. Stein, J. Ed. 4th Edition C.V. Mosby Co., St. Louis 1994.. 43) Ziyadeh F.N., and Goldfarb, S. The role of the renal interstitium in Diabetic Nephropathy. in Current Topics in Pathology; Tubulointerstitial and Cystic Diseases of the Kidney. Ed by S. Dodd and C.L. Berry. In press, 1994 44) Goldfarb S. Diet and nephrolithiasis. [Review] Annual Review of Medicine. 45:235-43, 1994. 45) Goldfarb, S. Patient Management Problem in Diabetic Nephropathy. Scientific American, NY. 1994. 46) Ziyadeh FN and Goldfarb S. The Diabetic Renal Tubulointerstitium. In Tubulointerstitial and Cystic Disdeases of the Kidney. Dodd, SM (ed). Springer, 1995. 175-202, 47) Goldfarb S .Invited editorial. Physicians in control of the capitated dollar- do unto others. Annals of Internal Medicine. 123(7):546-547, 1995 48) Rudnick M, Berns J, Cohen R, and Goldfarb S. New concepts in the pathogenesis and therapy of Contrast Media Induced Nephropathy. Current Concepts in Nephrology and Hypertension. In press 1996 49) Goldfarb S, Kobrin S. Disorders of Magnesium Metabolism, in Internal Medicine. Stein, J., Ed. Little Brown Co. Boston, 1996. 50) Goldfarb S, Ziyadeh F. Disorders of Phosphate Metabolism, in, Internal Medicine. Stein, J. Ed. Little Brown Co., Boston, 1996. 51)Goldfarb S, Kobrin, S. Renal Tubular Disorders, in Internal Medicine. Stein, J., Ed. Little Brown Co. Boston, 1996. 52) Goldfarb S. Nephrolithiasis, in, Internal Medicine. Stein, J. Ed. Little Brown Co., Boston, 1996. 53) Goldfarb S, Ziyadeh F. Diabetic Nephropathy, in, Internal Medicine. Stein, J. Ed. Little Brown Co., Boston, 1996. 54) Invited Book Review. New England Journal of Medicine, in press 1996: Goligorsky and Stein Acute Renal Failure, new concepts and therapeutic strategies 55) Sharma K, and Goldfarb, S. Acid Base Disorders in. Pulmonary Medicine. Ed by, Fishman, AP. In press 1996. 56) Goldfarb S, Ziyadeh F. Nephrolithiasis. in Scientific American Medicine. Section 10, topic XII, p 1-10. Rubinstein E, and Federman D. ed. Scientific American, NY 1996 Goldfarb S, Kobrin S. Disorders of Magnesium Metabolism, in Internal Medicine. Stein, J., Ed. Mosby & Co., Baltimore, 1998. 57) Goldfarb S, Ziyadeh F. Disorders of Phosphate Metabolism, in, Internal Medicine. Stein, J. Ed. Mosby & Co., Baltimore, 1998 58) Goldfarb S, Kobrin, S. Renal Tubular Disorders, in Internal Medicine. Stein, J., Ed. Mosby & Co., Baltimore, 1998. 59) Goldfarb S. Nephrolithiasis, in, Internal Medicine. Stein, J. Ed. Mosby & Co., Baltimore, 1998 60) Goldfarb S, Ziyadeh F. Diabetic Nephropathy, in, Internal Medicine. Stein, J. Ed. Mosby & Co., Baltimore, 1998 LECTURES BY INVITATION: October 23, 1976 "Workshop in electrolytes and acid base balance" Pascack Valley Hospital Annual Symposium March 10, 1977 "Tubulo-interstitial renal disease" Hazelton General Hospital November 1979 Chairman, Scientific Session-American Society Clinical Research, Annual Meeting, 1980 May 1980 Chairman, Scientific Session-American Federation of Clinical Research, Annual Meeting, 1980 October 1980 Medical Grand Rounds University of Connecticut School of Medicine Hartford, Conn November 1980 Special Seminar University of Utah School of Medicine Salt Lake City, Utah March 1982 Research Seminar Albert Einstein School of Medicine Bronx, New York April 1982 Clinical Pathologic Conference Temple University Hospital Philadelphia, PA October 1982 Research Conference Jefferson Medical College Philadelphia, PA November 1982 Research Conference Department of Physiology New York Medical College New York, NY December 1982 Chairman, Scientific Session American Society of Nephrology Annual Meeting December 1982 Guest Speaker, Annual Meeting of Ohio National Kidney Foundation Toledo, Ohio December 1982 Visiting Professor Medical Grand Rounds Medical College of Ohio Toledo, Ohio March 1983 Visiting Professor S.U.N.Y. - Stony Brook New York March 1983 Visiting Professor University of Texas - Health Sciences Center San Antonio, Texas January 1984 Visiting Professor LSU School of Medicine New Orleans, LA March 1984 Visiting Professor Medical College of Virginia Richmond, VA May 1984 Visiting Professor George Washington University School of Medicine Washington, DC November 1984 Visiting Professor Baystate Medical Center Springfield, MA February 1985 Research Seminar Albert Einstein School of Medicine Bronx, NY September 1985 International Symposium: Developments in the Use of Alpha-Receptor Antagonism in Cardiovascular Disease. Cologne, West Germany October 1985 Lecturer - Update in Nephrology Course Cleveland Clinic Cleveland, Ohio August 1986 Visiting Professor University of Texas Health Science Center San Antonio, TX December 1986 Guest Lecturer Vanderbilt University Nashville, TN January 1987 Medical Grand Rounds Medical College of Pennsylvania Philadelphia, PA September 1987 Second International Workshop on Animal Models in Diabetes Geneva, Switzerland February 1988 Invited Lecturer Polyol Pathway and Diabetic Complications Juvenile Diabetes Foundation Symposium -San Diego, CA June 1988 Visiting Professor Medical College of New York Valhalla, New York January 1989 Visiting Professor University of Alabama at Birmingham Birmingham, Ala. February 1989 Medical Grand RoundsRutgers-NJ Medical School Department of Medicine Camden, N.J. March 1989 Invited Speaker NIH Symposium on Diabetic Nephropathy Bethesda, Md. October 1989 Invited Speaker Update in Nephrology Course Harvard Medical School Boston, Mass. October 1989 Invited Speaker Annual Meeting Pennsylvania Society of Nephrology Pittsburgh, PA December 1989 Visiting Professor Albert Einstein School of Medicine Bronx, New York March 1991 Visiting Professor Renal Division Johns Hopkins School of Medicine Baltimore, MD April 1991 Invited Speaker American College of Physicians Annual Meeting New Orleans, LA April 1991 Visiting Professor Tulane University School of Medicine Renal Division New Orleans, LA October 1991 Invited Speaker Update in Nephrology Course Harvard Medical School Boston, Mass. February 1992 Invited Speaker Reading Hopsital Reading, PA September 1992 Invited Speaker Duke University Medical Center Durham, NC November 1992 Invited Speaker Annual Meeting American Society of Nephrology Baltimore, Md. January 1993 Visiting Professor Temple University Residency Program in Internal Medicine Scranton, PA March 1993 Visiting Professor Henry Ford Hospital Detroit, Michigan May 1993 Visiting Professor University of Iowa School of Medicine Iowa City, Iowa October 1993 Official American College of Physicians Representative Pennsylvania Chapter of the American College of Physicians Pittsburgh, PA November 1993 Invited Lecturer National Meeting American Society of Nephrology Annual Meeting Boston, Mass November 1993 Invited Lecturer Annual Graduate Symposium University of Santo Domingo Santo Domingo, Dominican Republic February 1994 Official American College of Physicians Representative Delaware Chapter of the American College of Physicians Wilmington, DE. August 1994 Visiting Speaker University of Oklahoma Seminar "Nephrology and Cardiology Update for the Practicing Physician" Tulsa, Oklahoma November 1994 Official American College of Physicians Representative Minnesota Chapter of the American College of Physicians Minneapolis, MN February 1995 Invited Lecturer Team Rounds (Medical Grand Rounds) ìBetween a rock and a hard place - Stone Disease in the 90’sî Columbia-Presbyterian Medical Center New York, NY April, 1995 Invited Lecturer 1995 Healthinfo Managed Health Care Congress Washington, DC May 1995 Update in Nephrology Annual Scientific Session American College of Physicians Atlanta, GA July 1995 Invited Lecturer AHCPR-ACP Conference Defining Healthcare at the Specialist-Generalist Interface Chicago, Ill November, 1995 Invited speaker National meeting of the American Society of Nephrology New therapeutic options in Acute Renal Failure San Diego, CA November, 1995 Invited speaker Measuring Outcomes Across Integrated Delivery Systems Zitter Group Conference San Francisco, CA April 1996 Update in Nephrology Annual Scientific Session American College of Physicians San Fransisco, CA August, 1996 Invited speaker Measuring Outcomes Across Integrated Delivery Systems Zitter Group Conference Washington, DC December, 1996 Invited Speaker USC Graduate Internists Society 44th Annual Session Los Angeles, CA December, 1996 Invited Speaker Wharton Symposium on Health Care Delivery University of Pennsylvania Philadelphia, PA March, 1997 Invited speaker 17th International Symposium on Critical Care Medicine Brussels, Belgium March, 1997 Update in Nephrology Annual Scientific Session American College of Physicians Philadelphia, PA August, 1997 Invited Lecturer American Society of Nephrology Board Review Course San Francisco, CA March, 1998 Update in Nephrology Annual Scientific Session American College of Physicians San Diego, CA June, 1998 Update in Nephrology Annual Scientific Session American Diabetes Assoc. Chicago, ILL August, 1998 Invited Lecturer American Society of Nephrology Board Review Course San Francisco, CA Abstracts Singer I, Relman AS, Strunk B and Goldberg M. Hyperglycemia induced hyperkalemia, diabetes, and hypoaldosteronism. Proc. 6th Ann. Mtg. Society of Nephrology, November 1973, p.42. Goldfarb S, Strunk B, Relman AS, Singer I and Goldberg M. Paradoxical glucose-induced hyperkalemia: combined aldosterone-insulin deficiency. Clin. Res. 23:469A, 1974. Goldfarb S, Beck LH, Agus ZS and Goldberg M. Dissociation between the sites of action of PTH and saline on renal phosphate reabsorption. Clin. Res. 23:528A, 1974 (presented at National Mtg AFCR, Atlantic City, May 4, 1974). Goldfarb S, Agus ZS and Goldberg M. The acute effects of growth hormone on renal Ca++ and PO4 reabsorption. ASN Abstracts 33:1974. Goldfarb S, Agus ZS and Goldberg M. Tubular sites of action of cyclic AMP on renal PO4 reabsorption. ASN Abstracts 33:1974 (presented at National Meeting of the American Society of Nephrology, Washington, DC, November 24, 1974). Goldfarb S, Cox M, Singer I and Goldberg M. Paradoxical glucose induced hyperkalemia: combined aldosterone and insulin deficiencies. Abstracts of American College of Physicians. (Presented at National Mtg, American College of Physicians. (Presented at National Mtg, American College Physicians, April 8, 1975, San Francisco, CA). Beck L, Goldfarb S, Goldberg M and Agus ZS. Renal PO4 reabsorptive capacity (TmP) in the acute vs. chronic parathyroidectomized dog. Clin. Res. 23:355A, 1975. Eisenberg J and Goldfarb S. Clinical utility of prothrombin time: a model for evaluating screening tests. Abstracts of American College of Physicians. (Presented at National Meeting, American College of Physicians, April 8, 1975, San Francisco, CA). Goldfarb S, Westby GR, Goldberg M and Agus ZS. Chronic phosphate depletion (CPD): proximal tubular function and hypercalciuria. Clin. Res. 24:401, 1976. (Presented at National Mtg - American Federation of Clinical Research Atlantic City, May 1, 1976). Emmett M, Goldfarb S, Agus ZS and Narins RG. The pathophysiology of acid-base changes in phosphate depletion (PD): bone-kidney interactions. ASN Abstracts, 1976. Goldfarb S, Bosanac P, Goldberg M and Agus ZS. Enhancement of phosphate reabsorption by calcium: a micropuncture study. Clin. Res. 25:433A, 1977. (Presented at National Mtg. AFCR, Washington, DC, May 4, 1977.) Cowgill L, Goldfarb S, Goldberg M, Slatopolsky E, and Agus ZS. Nature of the renal defect in familial hypophosphatemic rickets. J. Clin. Invest. 1977. (Presented at National Mtg, AFCR, Washington, DC, May 4, 1977). Grabie M, Goldfarb S, Lau K, Agus ZS and Goldberg M. Enhancement of the hypercalciuria (HC) of phosphate depletion by parathyroidectomy (PTX). Clin. Res. 25:433A, 1977. Lau K, Goldfarb S, Agus ZS and Goldberg M. Chronic lithium (Li) treatment in the rat: a model for post-absorptive hypercalciuria (HC). Clin. Res. 25:399A, 1977. Goldfarb S, Bosanac P, Goldberg M and Agus ZS. Enhancement of phosphate (PO4) reabsorption by calcium (Ca++): a micropuncture study. Clin. Res. 25:433A, 1977. Lau K, Agus ZS, Goldberg M and Goldfarb S. Chronic phosphate depletion: change in segmental calcium and phosphate reabsorption. Kidney Int. 12:485A, 1977. (Presented at the National Mtg, ASN, Washington, D.C., Washington, D.C., November 21, 1977). Lau K, Nussbaum P, Goldberg M, Goldfarb S and proximal tubular dysfunctions underlying the absorptive hypercalciuria. Kidney Int. 12:469A, National Mtg, ASN, Washington, DC, November 21, Agus ZS. Evidence of "phosphate leak" in 1977. (Presented at 1977). Lau K, Wolf C, Nussbaum P, Agus ZS and Goldfarb S. Acid vs phosphate therapy in idiopathic hypercalciuria (IHC): effects on calcium and acid excretion. Kidney Int. 12:457A, 1977. (Presented at National Mtg, ISN, Montreal Canada, June 14, 1978). Nussbaum P, De Fronzo R, Agus ZS, Goldberg M and Goldfarb S. Dissociation of proximal tubular (PTR) sodium (Na) and phosphate (PO4) transport by phlorizin (PHZ). Kidney Int. 12:459A, 1977. (Presented at National Mtg, ASN, Washington, DC November 21, 1977). Lau K, Agus ZS, Goldberg M and Goldfarb S. Effect of phosphate on calcium reabsorption: tubular sites of action. Clin. Res. 26:468A, 1978. (Presented at National Mtg, AFCR, San Francisco, CA, May 1, 1978). Nussbaum P, De Fronzo R, Lau K, Goldberg M, Agus ZS and Goldfarb S. Interactions of insulin, phlorizin, and PTH on renal tubular phosphate transport. Clin. Res. 26:472A, 1978. Nussbaum P, Grabie M, Walker B, Goldfarb S, Goldberg M, and Agus ZS. The acute and chronic effect of -methyldopa on renal tubular function. Clin. Res. 26:292A, 1978. Nussbaum P, Lau K, DeFronzo R, Goldberg M, Agus ZS and Goldfarb S. Interactions of insulin, phlorizin and PTH on renal tubular phosphate transport. (Presented at the National Meeting ASN, New Orleans, LA, November 21, 1978.) Goldfarb S. Evidence for heterogeneity of PO4 transport between superficial (S) and juxtamedullary (J) nephrons: combined A-V extraction, micropuncture and clearance studies in the cat. Clin. Res. 27:415A, 1979. Mitnick PD, DeOreo P, Weiner B, Walker B, Goldberg M, Agus ZS and Goldfarb S. Renal effect of oxaprozin (WY2173), a non-steroidal antiinflammatory agent in man. Clin. Res. 27:425A, 1979. Wasserstein A, Lau K, Mitnick PD, Slatopolsky E, Goldfarb S and Agus ZS. Renal functional characteristics of idiopathic hypercalciuria (IH). Clin. Res. 27:433A, 1979. Mitnick PD, Wolf C and Goldfarb S. Acid-base effects of hypercalcemia primary hyperparathyroidism (HCHP) in rats. Clin. Res. 27:425A, 1979. (Presented, National Meeting, 1979). Mitnick PD, Goldfarb S and Agus ZS. On the mechanism of hyperphosphatemia in tumoral calcinosis (TC). Clin. Res. 27:425A, 1979. Lau K, Stom MC, Goldberg M, Goldfarb S, Gray RW, Lemann J Jr and Agus ZS. Evidence for a humoral phosphaturic factor in oncogenic hypophosphatemic osteomalacia. Clin. Res. 27:421A, 1979. Kimmel P, and Goldfarb S. Effect of isoproterenol, cyclic AMP and antidiuretic hormone on potassium transport in cortical collecting tubule. Clin. Res. 30:453A, 1982 (Presented, National Meeting, 1982). Glover D, Riley LJ, Agus ZS, Slatopolsky E, Glick J and Goldfarb S. Hypocalcemia and inhibition of PTH release after WR2721 (WR) -a radio and chemotherapy protective agent. Clin. Res. 30:448A, 1982. Glover D, Riley LJ, Agus ZS, Slatopolsky E, Glick J and Goldfarb S. Hypocalcemia and inhibition of PTH release after WR2721 (WR) - A radio and chemoprotective agent. Abstracts American Society of Nephrology, 1982 (Selected for presentation at National Meeting, 1982). Shareghi GR, Goldfarb S, Agus ZS. Characterization of Mg++ transport in medullary thick ascending limb of Henle. (Selected for presentation, National Meeting, American Federation Clinical Research, May 1983.). Shareghi GR, Goldfarb S, Agus ZS: Characterization of magnesium transport in medullary thick ascending limb of Henle (Presented - VIth International Workshop on phosphate and other minerals. Verona, Italy, June, 1983). Spar B, Riley L, Wolf J, Slatopolsky E, Attie M, and Goldfarb S: The mechanism of the hypocalcemia induced by WR2721 (selected for presentation, National Meeting of the American Society of Nephrology, Washington, DC, 1983. Wolfe J, Attie M, Goldfarb S: Studies of the hypocalcemic action of WR2721 (Selected for presentation, National Meeting to American Federation of Clinical Research, Washington, DC, 1984). Weiss J, Wolf J, Slatopolsky E, Fallon M, Attie M, and Goldfarb S. Chronic inhibition of PTH secretion and correction of Vit D induced hypercalcemia by WR2721. (Selected for oral presentation, American Society of Nephrology National Meeting, Washington, DC, 1984). Weiss J, Fallon M, Goldfarb S. In Vivo and In Vitro effects of WR-2721 in experimental Humoral Hypercalcemia of Malignancy (Selected for presentation, plenary poster session, National Meeting, American Federation of Clinical Research, Washington, DC, 1985). Goldfarb S, Walker ST, Weiss J, Fallon M, Shaw L, and Attie M. In Vivo and In Vitro evidence the sulfur (S) group activity mediates the bone and parathyroid inhibitory and hypocalcemic action of WR2721. (Selected for presentation, National Meeting, American Society of Nephrology, New Orleans, LA, 1985). Goldfarb S, Simmons D, Kern EFO. Amelioration of the hyperfiltration of experimental diabetes by myo-inositol supplementation and Sorbinil. (Selected for presentation, National Meeting, Association of American Physicians, Washington, DC, 1986). Kern EFO, Simmons P, Goldfarb S. Effects of dietary myo-inositol, supplementation on renal hemodynamics in experimental diabetes (selected for oral presentation, National Meeting, American Society of Nephrology, Washington DC, 1986). Goldfarb S, Kern EFO, and Simmons D. Differential effects of supplementary dietary inositol on glomerular hyperfiltration due to early diabetes and high protein diet. (Selected for oral presentation - American Society for Clinical Investigation National Meeting, San Diego, CA 1987). Goldfarb S, Kern EFO, and Simmons D. Evidence for a role for polyol pathway in the glomerular hyperfiltration of early diabetes. Selected for oral presentation, 10th Congress of the International Society of Nephrology. London, Great Britain, 1987). Kern EFO and Goldfarb S. Medium myo-inositol deprivation inhibits rat glomerular Na/K ATPase activity. Presented, American Society of Nephrology, 1988.Kidney Int.35 431,1989. Ziyadeh F, Haverty T, Watanabe M, Goldfarb S .Glucose and myo-Inositol modulate collagen biosynthesis by proximal tubular cells in culture . Presented, American Society of Nephrology, 1988 Kidney Int.35 322,1989. Goldfarb S, Ziyadeh, F, , Haverty T. Effects of hyperglycemia on proliferation in renal proximal tubular cells in culture-role of altered cellular myo-inositol metabolism.Presented, American Society of Nephrology, 1988.Kidney Int.35 428,1989. Perlmutter J, Senesky D, Simmons D, Goldfarb S. Resistance to vasoconstrictive response to adenosine in experimental diabetes. Submitted, American Society of Nephrology, 1988.Kidney Int.35 436,1989. Snipes, ER, Haverty TP, Goldfarb S, Ziyadeh F. Glucose-induced transcription and secretion of collagens type IV and I in mouse proximal tubules in culture: modulation by insulin. Clin Res.37,502A,1989 Perlmutter, J, Jacobs, J, Ziyadeh, F, Senesky, D, Simmons, D, Kern EFO, Goldfarb, S. Reduced renal vasoconstrictive response to adenosine and reversal by aldose reductase inhibition in acute experimental diabetes. Clin Res.37,583A,1989 Ziyadeh F. Snipes, ER, Watanabe M, Alvarez RJ,Goldfarb S., Haverty TP. Glucose-induced transcriptional control of cytoskeletal b-actin and basement membrane procollagen type IV in proximal tubule: a cell culture model of diabetic renal hypertrophy. Submitted to American Society of Nephrology, 1989. Snipes, ER,Ziyadeh F., Watanabe M, Alvarez RJ,Goldfarb S., Haverty TP. High ambient glucose stimulates biosynthesis by cultured proximal tubule cells of interstitial procollagen type I: Transcriptional control and activation of an enhancer sequence. Submitted to American Society of Nephrology, 1989. F.N. Ziyadeh, E.R. Snipes, M. Watanabe, R.J. Alvarez, S. Goldfarb, & T.P. Haverty.High Glucose Induces Cell Hypertrophy and Stimulates Transcription of Basement Membrane Procollagen Type IV in Cultured Proximal Tubule Cells. Presented XI Meeting International Society of Nephrology, Tokyo, 1990 E Snipes, M. Watanabe, DA Simmons, S. Goldfarb and FN Ziyadeh.Polyol Pathway activation in high glucose stimulation of procollagen transcription and secretion in proximal tubule cells. Presented, American Society of Nephrology, 1990. JASN 1:642, 1990 MV Rocco, S Goldfarb and FN Ziyadeh. Transforming Growth Factor-fl in Proximal Tubule Cells: Production,Glucose-Induced Transcriptional Control and Autocrine Role In Cell Proliferation. Presented, American Society of Nephrology, 1990, JASN 1:448, 1990 FN Ziyadeh. J Perlmutter, M Watanabe, J Hoyer, J Tomaszewski, D Senesky, S Goldfarb.Experimental Diabetes in the Rat is Characterized by Tubulo-interstitial Collagen Type III Accumulation Prior to Appearance of Glomerular Lesions. American Society of Nephrology, 1990, JASN 1:556,1990 Chalko, C, Krishna, G, Hoyer, J, Goldfarb, S. Characterization of urinary Uropontin excretion in humans. Selected for presentation American Society of Nephrology, 1992, in press. Anand, S, Krishna, G, Grossman, R, Kapoor, S, Goldfarb,S. Pentoxifylline ameliorates cyclosporine nephrotoxicity in humans. Selected for presentation American Society of Nephrology, 1992, in press. Sharma,K, Ericksen,M, Goldfarb,S, Ziyadeh,FN. Up -regulation of kidney transforming growth factor gene expression in two rodent models of spontaneous diabetes mellitus. Selected for presentation American Society of Nephrology, 1992, in press. Lewis EJ, Rhode RD, Bain RP, Lemann Jr J, and The Collaborative Study Group (S. Goldfarb, Site P.I.), Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, the George Washington University, Rockville, MD, and the Medical College of Wisconsin, Milwaukee, WI.Some Characteristics of Patients Entering the Double-Blind Trial of Angiotensin Converting Enzyme Inhibition to Slow the Progression of Diabetic Nephropathy. Diabetes, Vol. 40, Supplement 1, 505A, 1991. Bain RP, Lewis EJ, McGill JB, Hunsicker LG, Rohde RD and The Collaborative Study Group (S. Goldfarb, Site P.I.), Baseline Characteristics of 325 IDDM Patients Entered in Diabetic Nephropathy Trial of Captopril vs Placebo. Bethesda, MD. Presented; 14th International Diabetes Federation Congress, June 23-28, 1991. Diabetes, Vol. 40, Supplement 1, 505A, 1991. Lewis EJ, Bain R, Hunsicker LG and The Collaborative Study Group (S. Goldfarb, Site P.I.) A Controlled Clinical Trial of Angiotensin-Converting Enzyme Inhibition in Type 1 Diabetic Nephropathy. , Rush Medical College, Chicago, IL, George Washington University, Washington, DC, University of Iowa, Iowa City, IA. Presented to the Congress of the International Society of Nephrology, June 13-16, 1993. Hunsicker Lawrence, Lewis Edmund, Bain Raymond, McGill Janet and The Collaborative Study Group (S. Goldfarb, Site P.I.) Outcome of A Multi-Center Clinical Trial of ACE-Inhibition in Diabetic Nephropathy. Iowa City, IA, Chicago, IL, Washington, DC and St. Louis, MO, Diabetes Vol. 42, Supplement 1:98A, 1993. Rodby R, Rohde R, Sharon Z, Pohl M, Lewis E and The Collaborative Study Group (S. Goldfarb, Site P.I.), The Urine Protein to Creatinine (P/C) Ration as a Predictor of the 24 Hour Urine Protein (24 up) Excretion in Type 1 Diabetics with Overt Nephropathy. Rush Medical Center, Chicago, IL. Submitted to American Society of Nephrology Conference, 11/93. Breyer Julie, McGill Janet, Nahman N Stanley, Lewis Edmund, Bain Raymond, Cooper Melissa, Berl Tomas and The Collaborative Study Group (S. Goldfarb, Site P.I.), Predictors of the Rate of Progression of Renal Insufficiency in Patients with Insulin-Dependent Diabetes and Overt Diabetic Nephropathy. Rush Medical College, Chicago, IL and George Washington University, Washington, DC. Submitted to American Society of Nephrology Conference, 11/93. Herbert L, Lewis E, Tolchin N, Cattran D, Whittier F and The Collaborative Study Group (S. Goldfarb, Site P.I.). Remission of Nephrotic Range Proteinuria (NRP) in Patients with Type 1 Diabetes and Nephropathy: Experience of the NIH Multicenter Controlled Clinical Trial of Captopril (CAP) Therapy in Diabetic Nephropathy. Submitted to American Society of Nephrology Conference, 11/93. Lewis EJ, Bain RP, Rohde RD, Hunsicker LG and The Collaborative Study Group (S. Goldfarb, Site P.I.), A Controlled Clinical Trial of Angiotensin Converting Enzyme (ACE) Inhibition in Type 1 Diabetic Nephropathy. Rush Medical College, Chicago, George Washington University, Washington, DC, University of Iowa, Iowa City, IA. Submitted to American Society of Nephrology Conference, 11/93. Nawarskas J J, Boyce, EG., Connors, JE., Charland, SL, Goldfarb, S, Spinler, S A. for the Iohexol Cooperative Study. Predictive performance of eleven methods for calculating creatinine clearance in cardiac patients with stable renal function: effects of age Submitted to 1997 Spring Practice and Research Forum American College of Clinical Pharmacy Spinler, S A.,Nawarskas J J, Boyce, EG., Connors, JE., Charland, SL, Goldfarb, S, for the Iohexol Cooperative Study... Predictive performance of eleven methods for calculating creatinine clearance in cardiac patients with stable renal function: effects of low serum albumin. Submitted to 1997 Spring Practice and Research Forum American College of Clinical Pharmacy Spinler, S A.,Nawarskas J J, Boyce, EG., Connors, JE., Charland, SL, Goldfarb, S, for the Iohexol Cooperative Study for the Iohexol Cooperative Study. Predictive performance of nine methods for calculating creatinine clearance in cardiac patients with stable renal function: effects of age: effects of renal insufficiency Submitted to 1997 Spring Practice and Research Forum American College of Clinical Pharmacy Spinler, S A.,Nawarskas J J, Boyce, EG., Connors, JE., Charland, SL, Goldfarb, S, for the Iohexol Cooperative Study. Predictive performance of eleven methods for calculating creatinine clearance in cardiac patients with stable renal function: effects of serum creatinine Submitted to 1997 Spring Practice and Research Forum American College of Clinical Pharmacy Spinler, S A.,Nawarskas J J, Boyce, EG., Connors, JE., Charland, SL, Goldfarb, S, for the Iohexol Cooperative Study. Predictive performance of nine methods for calculating creatinine clearance in cardiac patients with stable renal function: effects of obesity . Submitted to 1997 Spring Practice and Research Forum American College of Clinical Pharmacy