北京协和医学院研究生导师简介 姓名 高友鹤 性别 男 技术职称 教授 行政职务 无 √理学学位(博) □医学学位(博) 招生类型 √理学学位(硕) □医学学位(硕) 招生专业 病理与病理生理学 电子信箱 gaoyouhe@pumc.edu.cn 研究方向 及目前进 展简介 研究方向: 尿蛋白质组 器官功能 蛋白质相互作用 生物信息学 社会任职 国务院学位委员会基础医学组成员 近期电子照片一张 起止年月 所在学校及科研院所 学位、职称或 职务 1982.9-1990.7 中国协和医科大学 医学博士 美国康涅狄格大学 生物学博士 美国哈佛医学院 博士后,讲师 中国医学科学院基础医学研究所 教授 主 1990.7-1997.1 要 学 1997.1-2001.7 习 2001.7及 工 作 简 历 1. A strategy for studying the liver secretome on the organ level Yang Zhang, Yan Wang, Wei Sun, Lulu Jia, Sucan Ma and Youhe Gao* Journal of Proteome Research a) http://pubs.acs.org/doi/abs/10.1021/pr901057k?prevSearch=youhe%2Bgao&searchHist oryKey 2. Siqi Hu, Eli Song, Rui Tian, Sucan Ma, Tao Yang, Yi Mu, Yuan Li, Chen Shao, and Youhe Gao (2009)Systematic analysis of a simple adaptor protein PDZK1: ligand identification, interaction and functional prediction of complex. Cellular Physiology and Biochemistry 24:231–242 3. Lulu Jia1, Ling Zhang1, Chen Shao1, Eli Song1, Wei Sun1, Mingxi Li2, and Youhe Gao1§ (2009)An attempt to understand kidney’s protein handling function by comparing plasma and urine proteomes Plos One 4(4) :e5146 4. Yong Chen, Bei Gu, Shuzhen Wu, Wei Sun, Sucan Ma, Yuqin Liu* and Youhe Gao* (2009) Using Enrichment Index for Quality Control of Secretory Protein Sample and Identification of Secretory Proteins Journal of Mass Spectrometry 44(3) :397-403 5. Chen Shao, Wei Sun, Fuxin Li, Ruifeng Yang, Ling Zhang and Youhe Gao (2009)Oscore: a combined score to reduce false negative rate for peptide identification in tandem mass spectrometry analysis 6. Journal of Mass Spectrometry 44(1):25-31 Wei Sun1,5, Yong Chen1,5, Fuxin Li2, Ling Zhang3, Ruifeng Yang4, Zhi Zhang4, Dexian Zheng1, Youhe Gao1 (2009)Dynamic urinary proteomic analysis reveals stable proteins to be potential biomarkers 7. 代表性学 术论文 Proteomics- clinical application 3(3) :370-382 Wei Sun, Ruifeng Yang, Ling Zhang, Chen Shao, Zhengguo Zhang and Youhe Gao (2009) Improve peptide identification by empirical peptide retention time database Rapid Communication in Mass Spectrometry 23(1) :109-118 8. Yan Wang; Yong Chen; Yang Zhang; Shuzhen Wu; Sucan Ma; Siqi Hu; Ling Zhang; Chen Shao; Mingxi Li and Youhe Gao (2008) Differential ConA-enriched Urinary Proteome in Rat Experimental Glomerular Diseases Biochemical and Biophysical Research Communications 4;371(3):385-90. 9. Eli Song, Shijuan Gao, Rui Tian, Sucan Ma, Haiming Huang, Jiayan Guo, Yingna Li, Ling Zhang, and Youhe Gao ( 2006 ) A high-efficiency strategy for binding property characterization of peptide-binding domains. Molecular & Cellular Proteomics 5:1368-1381 10. Ling Zhang*, Chen Shao*, Dexian Zheng and Youhe Gao (2006)An integrated machine learning system to computationally screen protein databases for Protein binding peptide ligands with generalization capability Molecular & Cellular Proteomics 5: 1224-1232. 11. Wei Sun, Shijuan Gao, Linjie Wang, Yong Chen, Shuzhen Wu, Xiaorong Wang, Dexian Zheng, and Youhe Gao (2006)Microwave-assisted protein preparation and enzymatic digestion in proteomics Molecular & Cellular Proteomics 5:769-776 12. Linjie Wang, Fuxin Li, Wei Sun, Shuzhen Wu, Xiaorong Wang, Ling Zhang, Dexian Zheng, Jue Wang and Youhe Gao (2006)Concanavalin A captured glycoproteins in healthy human urine Molecular & Cellular Proteomics 5: 560-562. 13. Wei Sun, Shuzhen Wu, Xiaorong Wang, Fuxin Li, Jue Wang, Dexian Zheng, and Youhe Gao (2005) Human urine proteome analysis with three different separation approaches Proteomics 5(18)4994-5001 14. Haiming Huang and Youhe Gao (2005) A method for the generation of arbitrary peptide libraries. Molecular Biotechnology 30(2):135-142 15. Wei Sun, Fuxin Li, Jue Wang, Dexian Zheng and Youhe Gao (2004) AMASS: Software for automatically validating the quality of MS/MS spectrum from SEQUEST results. Molecular & Cellular Proteomics, 3: 1194 - 1199. 16. Fuxin Li 1*, Wei Sun 2, Youhe Gao 2* Jue Wang1 (2004)RScore: A Peptide Randomicity Score For Evaluating MS/MS Spectra. Rapid Communication in Mass Spectrometry 18(14): 1655-9 名称 主编或副 主编的著 作/译著 Renal and Urinary Proteomics Methods and Protocols 名称 美国生物化学分子生物学学 会(ASBMB) 主编(或 副主编) 出版社 日期 Thongboo nkerd, Wiley 2009 Visith 奖项 学生旅行奖 获奖日期 2006 两人 2007 四人 2009 两人 国际生物化学与分子生物学 学生旅行奖 联盟(IUBMB) 2006 重要奖项 第七届国际健康与生命科学 中 的 质 谱 ( Seventh International Symposium on 会议旅行奖 Mass Spectrometry in the Health and Life Sciences) 2005 全国优秀博士学位论文 2007 亚 太 蛋 白 质 组 学 大 会 学生旅行奖 (AOHUPO) 2008