CURRICULUM VITAE
OF
DR LALJI SINGH
DIRECTOR, CCMB, HYDERABAD
Centre for Cellular & Molecular Biology
Hyderabad 500007
INDIA
FAX
International
91-40-27160252 or 27160591
India
040-27160252 or 27160591
CCMB Website: http://www.ccmb.res.in
E-mail: lalji@ccmb.res.in
Updated 21st April 2008
Telephones
Off:
Res:
040-27160789
040-27160555 or 27160556
Name
:
LALJI SINGH
Father’s Name
:
Sri Surya Narain Singh
Date of Birth
:
5th July 1947
Place of Birth :
Jaunpur, Uttar Pradesh, India
Current Position &
Address
Present
:
DIRECTOR, CCMB, Hyderabad
:
Permanent
:
Centre for Cellular and Molecular Biology
Hyderabad 500 007 (A.P.)
India
Village: Kalwari, Post Office: Sikrara,
District: Jaunpur, Uttar Pradesh, India
Educational Qualifications
:
B.Sc. with Zoology, Botany and Chemistry, (1964),
M.Sc. in Zoology with thesis in Cytogenetics (1966)
Ph.D in Cytogenetics, 1971, Banaras Hindu University
(Thesis: Evolution of Karyotypes in Snakes)
Research Interests:
1.
2.
3.
4.
5.
Molecular Basis of Sex-determination
DNA Fingerprinting
Wildlife Conservation
Human Genome Analysis
Human Genetic Diversity
Publications:
Dr Lalji Singh has more than 150 research papers published in
internationally reputed journals.
Please see Annexure ‘D’ for complete list of Publications
2
Social Impact of some of the research work carried out by
Dr Lalji Singh
1.
Development of a universal probe for DNA Fingerprinting:
Dr Lalji Singh and his colleagues at the Centre for Cellular & Molecular Biology (CCMB)
developed a probe called Bkm-derived probe for DNA fingerprinting as a fallout of their
earlier internationally well-known work on the mechanisms of the determination of sex. Their
probe is being extensively used for forensic investigation, paternity determination and seed
stock verification. DNA fingerprinting evidence was presented in the court and for the first
time in the annals of the history of Indian Judiciary DNA fingerprinting was accepted as an
infallible evidence in the court of law; this verdict was upheld by the Kerala High Court. Since
then, they have used this indigenous technique in 500 cases such as paternity disputes,
identification of missing children identification of mutilated bodies, exchange of babies in
maternity wards and cases of rape and murder, etc. These include sensational cases of
assassination of the late Prime Minister Shri Rajiv Gandhi, assassination of Punjab Chief
Minister and the famous tandoor case of Naina Sahni.
DNA Fingerprinting technology has reached to common man all over India and is providing
them a justice which otherwise would not have been possible for them to obtain.
Based on Dr Singh’s above findings a separate autonomous “Centre for DNA Fingerprinting
and Diagnostics” has been set up by the Department of Biotechnology, Government of India.
2.
Conservation of wildlife
Although our country is endowed with a tremendous wealth of megadiversity in plant and
animal wildlife, their very existence is at stake owing to destruction of forests following
industrialization, agricultural activities as well as poaching of wildlife for reasons of sports
and money. There was therefore an urgent need to arrest this phenomena and work out
strategies to tackle these problems by using innovative techniques. CCMB is, therefore,
setting up a laboratory for the Conservation of Endangered Species (LaCONES) at Attapur
village near Nehru Zoological Park. The potential utility of molecular techniques in the study
of evolutionary relationships of plants and animals is already established. Dr Lalji Singh is
presently using this technique for wild life preservation and better management of
endangered species in our zoos and also for identification and isolation of genes for useful
characters in silkworm races.
3.
Species identification for forensic applications
Crimes related to the killing of animals are a serious threat in India. In such a case, we need
to establish whether a drop of blood, or tiny piece of meat, bunch of hair or some other
mutilated biological sample confiscated by the wildlife curators and/or investigating agencies
belongs to human or animal, and if animal, to which species of animal. Such investigations
have become very important in recent past with our increased awareness towards threats of
extinction of many animal species due to human intervention. The law enforcement requires
strong evidences in such matters which could be provided by establishing exact identity of
confiscated animal(s) or parts and products thereof. The team of researchers headed by Dr
Lalji Singh from the CCMB has recently developed, for the first time anywhere in the world, a
novel DNA based approach which, without knowing the history of a forensic sample, is able
3
to establish whether a drop of blood or tiny piece of meat belongs to human or animal, and if
animal, to which species of the animal. CCMB has already using this approach in providing
the service to the society and has resolved more than 50 cases forwarded by various wildlife
curators and crime investigation agencies.
4.
DNA based molecular Diagnostics
There are several genetic disorders prevalent in our country. The problem has become
much more serious because there are no adequate facilities for diagnosing these disorders.
Dr Lalji Singh and his group have set up diagnostic services for many genetic disorders such
as sickle cell anemia, Alzheimer’s disease, BCD, male infertility, pancreatitis, Robert’s
syndrome, etc. Research by Dr Lalji Singh and his colleagues further helped in better
understanding of the role played by genetic factors in these diseases and the possibility of
developing better diagnostic tools for the detection and the management of such diseases.
These services will be of tremendous help to common man in reducing their agonies
whenever therapeutic intervention is possible.
5.
Genetic affinities of Andaman Islanders
Dr Lalji Singh and his group have undertaken the study on genetic diversity in primitive tribes
of India including the tribal populations of Andaman and Nicobar Islands using Ychromosomal markers and mtDNA sequences. Data indicates that the Andamanese have
closer affinities to Asian than to African population and suggests that they are the
descendants of the early Paleolithic colonizers of Southeast Asia – the hunter gatherers and
the first migrants moved out of Africa about 60,000-100,000 years ago. These findings have
revolutionized the ways of thinking about the origin of man in terms of their evolution and
migration from place to place.
6.
Genome Foundation and its activities
Human disease and suffering are as old as humanity and genetic disorders are most
distressing since there is no cure available for them and the diseases get transmitted across
the generations. The problem of genetic disorders in India is enormous. Indians are also
genetically susceptible to common diseases, such as, diabetes and heart diseases. Thus,
prevention of disability is the only option for these disorders. However, the diagnostic
services for them are mostly focused to cater the urban India.
A group of intellectuals with high professional integrity have come together to establish this
Foundation under Dr Lalji Singh as its Managing Director, which will provide such diagnostic
services to both rural and urban populations of the country. The Foundation will function with
people’s participation and utilize the voluntary services of retired scientists and
professionals. The Foundation will establish various centres across the length and breadth
of India to take these services to the masses through networking with various NGOs and
socially committed organizations. The Foundation is already registered under Section 25 of
the Companies Act, 1956. A Foundation stone was laid recently by Dr Lalji Singh for a
building complex for “Establishing a Rural Centre of Genome Foundation in Northern India”
in Jaunpur, UP, India.
4
Annexures:
A.
B.
C.
D.
E.
F.
G.
H.
I.
J.
K.
L.
M.
N.
O.
Honours, Awards and Endowment Lectures
Academic and Service Affiliations
Research Interests
List of Publications
List of Patents and Popular Articles
Information on and Relevance of Research Contributions
Teaching Experience
Organisation of Courses
Administrative Experience
Sponsored Research/Collaborations
International meetings attended
Membership of Professional Societies
Fellowship of Indian/Foreign Academies
Membership of Editorial Boards
Membership of Professional Committees
5
A. HONOURS, AWARDS AND ENDOWMENT LECTURES
2008
2008
2008
2007
2007
2007
2007
2006
2006
2nd University Foundation Oration
KLE University, Belgaum
Kakatiya University, Warangal (A.P.)
18th Convocation of Kakatiya
University
8th Dharma Vira Oration
Sir Gangaram Hospital, New Delhi
Dehradun
Rajbhasha Shri Samman by
Bharatiya Rajbhasha Vikas
Sansthan
Rashtriya Ekta Samman 2007
National Unity Conference, New
Delhi
Central Drug Research Institute,
Lucknow
Deendayal Upadhyay Gorakhpur
University, Gorakhpur
Indian Society of Human Genetics
Sir Edward Mellanby Memorial
Lecture
Honorary D.Sc. degree
Dr L D Sanghvi Oration Award
2006
2006
Father of DNA Fingerprinting
Award
J C Bose National Fellowship
Honorary D.Sc. degree
2006
2005
Honorary Professor
ISWA Honorary Fellowship (2005)
2005
2003
Honorary Fellow, Biotech Research
Society of India
Swami Sukhdevanand Rishi
Samman in the field of Genetics
Intellectuals’ Honour – The Great
Son of the Soil
Honorary D.Sc. degree
Awarded Padma Shri by the
President
FICCI Award 2002-03 for R&D in
Life Sciences
Biotechnologist of the year 2002
2003
Vigyan Gaurav Award
2003
The Honorary D.Sc. degree
2003
Purvanchal Ratna
2002
ISHEER AWARD
2002
TWAS Fellowship
2002
Sixth Prof. S. P. Ray-Chaudhuri
Memorial Lecture Award
New Millennium Plaques of Honour
- 2001-2002 award for outstanding
services in the field of Biological
Sciences
K N Bhal Memorial Gold Medal for
2001
The D.A.E. – C.V. RAMAN
2005
2004
2004
2004
2004
2002
2001
2001
Jaunpur Journalists Assocation
6
Department of Science & Technology
Uttar Pradesh Rajarshi Tandon Open
University, Allahabad
Sri Venkateswara University, Tirupati
Indian Science Writers’ Association
(ISWA)
Biotech Research Society of India
Mumukshu Ashram Siksha Sankul,
Shahjahanpur
All India Conference of Intellectuals,
Meerut
Banaras Hindu University, Varanasi
Government of India
Federation of Indian Chambers of
Commerce and Industry, New Delhi.
Metro Vision Business & Technology
Magazine, Hyderabad
Council of Science & Technology,
Government of Uttar Pradesh
Mahatma Gandhi Kashi Vidyapeeth,
Varanasi
Veer Bahadur Singh Poorvanchal
University, Jaunpur
Indian Society of Health Environment
Education and Research (ISHEER),
Jodhpur Centre, Jodhpur
Third World Academy of Sciences
Trieste, Italy
Prof. S. P. Ray-Chaudhuri Foundation,
BHU, Varanasi
By the Prime Minister of India at the 89th
Session of the Indian Science
Congress-2002
Society of Biosciences, Muzaffarnagar
Indian Physics Association, Mumbai
2001
2001
2001
Lecturership-2000
Goyal Prize in Life Sciences-2000
CRI Foundation Day Oration
Lecture
Late Sri Damodaram Sanjivayya
Endowment Lecture
Kurukshetra University, Haryana
Cancer Research Foundation, Mumabi
Sri Venkateswara University, Tirupati
2001
Dr Y Nayudamma Memorial
Extension Lecture on
Biotechnology-1999
Dr Y Nayudamma Memorial Turst,
Tenali
2001
2000
2000
2000
Kothari Memorial Endowment
Lecture
Visesha Puraskaaram
The Honorary D.Sc., degree
Fellow
2000
IMTECH Foundation Day Lecture
1999
1999
II Mansi Ram Memorial Lecture
Professional Excellence Award in
Science & Technology - for
Expertise in DNA Fingerprinting
IV Endowment Lecture
Pondicherry University,
Pondicherry
Dr Ramineni Foundation, USA
Purvanchal University, Jaunpur, U.P.
Andhra Pradesh Akademi of Sciences,
Hyderabad
Institute of Microbial Technology,
Chandigarh
University of Delhi, Delhi
Viswabharathy Academy, Hyderabad
1999
1998
1998
1998
1998
1997
1997
1996
1996
1995
1995
1995
1994
1994
1992
197476
The Indian Instrumentation Society,
Hyderabad Chapter, Hyderabad
Scroll of Honour: Outstanding
Forensic Expert Award - for
Indianization of DNA Fingerprinting
Technology
Honorary Professor
Indian Academy of Neurology
Oration
Dr Yellapragada Subbarow
Memorial Oration
Joy Govind Law Memorial Medal
Padma Bhushan Dr P S Siva Reddy
Endowment Award
Shri Om Prakash Bhasin Award –
in the field of Biotechnology
Haldane Oration Medal
The VASVIK Research Award – for
Biological Sciences & Technology
for the year 1992
Professor Vishwanath Memorial
Lecture Award
Jagdish Chandra Bose Award – for
Research in Life Sciences
Ranbaxy Research Award – in the
field of basic medical sciences
Prof S P Ray-Chaudhuri 75th
Birthday Endowment Lecture
Award
CSIR Technology Award – for
biological sciences
Commonwealth Scholarship – for
Postdoctoral Research in
Molecular Biology
7
The Medico Legal Society, All India
Institute of Medical Sciences, New
Delhi.
School of Animal Sciences, University of
Hyderabad, Hyderabad
Indian
Academy
of
Neurology,
Bangalore
The Indian Medical
Association,
Vijayawada
The Asiatic Society, Calcutta
Dr P Siva Reddy Founda-tion,
Hyderabad
Shri Om Prakash Bhasin Foundation for
Science & Technology, Delhi
Society for Bionaturalists, India
Vividhlaxi Audyogik Samshodhan Vikas
Kendra, Bombay
Indian National Science Academy, New
Delhi.
Hari Om Ashram Trust, Delhi
Ranbaxy
Research
Foundation,
Ranbaxy, New Delhi
Banaras Hindu University, Varanasi
Council of Scientific &
Research, New Delhi
Edinburgh University, UK
Industrial
1974
INSA Medal for Young Scientists
1973
Dr S P Basu Memorial Medical - for
outstanding contribution in the
field of Cytogenetics
1966
Banaras Hindu University Gold
Medal – for standing first in order
of merit in M.Sc (Zoology)
B.
Indian National Science Academy, New
Delhi
Zoological Society, Calcutta
Banaras Hindu University, Varanasi
ACADEMIC AND SERVICE AFFILIATIONS
Designation
Organization
& Place
Dept. of Zoology,
BHU
Dept. of Zoology,
BHU
Dept.of Zoology
Calcutta Univ.
From
To
Nature of
duties
Research &
Training
Research
1974
Mode of
Appointment
U.G.C.
Fellowship
CSIR
Fellowship
Permanent Post
1966
1970
1970
1972
1972
Pool Officer
Dept.of Zoology
Calcutta Univ.
April
1974
Sept
1974
CSIR
Appointment
Research
Postdoctoral
Research Fellow
Edinburgh Univ.
U.K.
1974
1976
Commonwealth
Fellowship
Research
Guest Scientist
Dept.of Zoology
Calcutta Univ.
Oct
1976
April
1977
On leave from
U.K.
Research
Research
Associate
Edinburgh Univ.
U.K.
1977
1979
Medical
Research
Council
Fellowship
Research
Visiting Fellow
Austr. National
Univ., Canberra
Edinburgh Univ.
U.K.
July
1979
Oct
1979
Sept
1979
May
1987
Research
CCMB
Hyderabad
CCMB
Hyderabad
CCMB
Hyderabad
CDFD
Hyderabad
June
1987
June
1990
June
1995
Oct
1995
May
1990
June
1995
July
1998
Feb
1999
Welcome
Foundation
Medical
Research
Council
Fellowship
CSIR
Appointment
CSIR
Appointment
CSIR
Appointment
DBT
Appointment
CCMB
Hyderabad
July 1998-to-date
CSIR
Appointment
Research
Jr. Research
Fellow
Sr. Research
Fellow
Research
Associate
Research
Associate
Scientist EII
Scientist F
Scientist G
Officer on
Special Duty
(OSD)
Director
8
Research &
Training
Research
Research
Research
Research
Setting up of
Centre for
DNA
Fingerprinting
& Diagnostics
C.
Research Interests
1.
Molecular Basis of Sex Determination
2.
DNA Fingerprinting
3.
Wildlife Conservation
4.
Human Genome Studies
5.
Ancient DNA Studies
9
Research Theses guided for the Doctoral degree (Ph.D)
Recognised Guide for Ph.D in Jawaharlal Nehru University, New Delhi and
University of Hyderabad, Hyderabad
S.No. Name of the Student
Title of the thesis
Year
1.
Shirly George Panicker
Isolation and characterization of 1994
Bkm-satellite DNA from snake
(Bungarus fasciatus) and a Bkmassociation Y chromosomespecific clone M34 from mouse
2.
K R Rajyashri
Molecular mechanism of sex1994
determination: Isolation and
characterization of an unusually
conserved testis determining gene
3.
Raghavender Nagaraj Studies on sex and tissue-specific 1995
Bkm-binding protein in mouse
4.
Narendra Pathak
5.
Sanjay Sachdev
6.
Anju Singh
7.
S. Subramanian
Molecular Analysis of Y Chromosome DNA in Human
8.
B Jyotsna
Genetic studies of wild populations 2008
Of tiger Panthera tigris tigris
Molecular characterization of
1998
gene(s) expressed specifically in
snake oocytes
Molecular analysis of Bkm1998
associated DNA sequences in
Drosophila.
___________________________________________________________________
Identification and Characterization 2000
of a Highly Conserved Gene, which
is Predominantly Expressed in the
Human, Testis, in Silkworm
Bombyx mori
___________________________________________________________________
2003
________________________________________________________________________
9.
V V Suryanarayana
Molecular status of detoxification
2008
genes and functional Proteomics
in recurrent early pregnancy loss
__________________________________________________________________
10
Postdoctoral Fellows worked/working with Dr Lalji Singh
1.
Dr Sridevi Naidu
2.
Dr P Manickam
3.
Dr Prabhjeet Singh
4.
Dr Sokka Reddy
5.
Dr Qurratulain Hasan
6.
Dr Saswati Ghosh
7.
Dr C S Shashikant
8.
Dr Vanya Shah
9.
Dr Sanjeev Shangary
10
Dr Bhupendra Narain Singh
11.
Dr Divyendu Saha
12.
Dr Moinak Banerjee
13.
Dr G V Rao
14.
Dr G R Chandak
15.
Dr Milind P Niphadkar
16.
Dr Abhay Sharma
17.
Dr Jose Jacob
18.
Dr Shriram Shetty
19.
Dr Franscina Celestina
20.
Dr Rekha Rai
21.
Dr Shalini Ratan
22.
Dr Shamsunder Chaurasia
23.
Dr Anju Singh
24.
Dr Ajay Gaur
25.
Dr Nandita Singh
26.
Dr L V K S Bhaskar
11
D.
Research Papers Published
(1968-2008)
1.
Singh, L., Sharma, T. and Ray-Chaudhuri, S.P.: W. chromosome in the Indian
water snake (checkered keel back) Natrix piscator (Colubridae). Experientia,
(Basel) 24, 79-80 (1968).
2.
Singh, L., Sharma, T. and Ray-Chaudhuri, S.P.: Chromosomes and classification
of the snakes of the family Boidae. Cytogenetics, 7, 161-168 (1968).
3.
Ray-Chaudhuri, S.P., Sharma, T., Pathak, S. and Singh, L.: Chromosomes and
the karyotype of the Pangolin, Manis pentadactyla L. (Pholidota Mammalia).
Experientia, (Basel) 26, 1167-1168 (1969).
4.
Ray-Chaudhuri, S.P., Singh, L. and Sharma, T.: Sexual dimorphism in somatic
interphase nuclei of snakes. Cytogenetics, 9, 410-423 (1970).
5.
Singh, L., Sharma, T. and Ray-Chaudhuri, S.P.: Multiple sex chromosomes in the
common Indian krait, Bungarus caeruleus Schneider. Chromosoma (Berl.), 31,
386-391 (1970).
6.
Singh, L., Sharma, T. and Ray-Chaudhuri, S.P.: Chromosome numbers and sex
chromosomes in few Indian species of amphibian and reptiles. Mammal. Chrom.
Newslett. 11, 91-94 (1970).
7.
Ray-Chaudhuri, S.P., Singh, L. and Sharma, T.: Evolution of sex chromosomes
and formation of W-chromatin in snakes. Chromosoma (Berl.), 33, 239-251
(1971).
8.
Singh, L.: Multiple W chromosome in a sea snake, Enhydrina schistosa Daudin.
Experientia (Basel), 28, 95-97 (1972).
9.
Ray-Chaudhuri, S.P. and Singh, L.: DNA replication pattern in sex chromosome
of snakes. Nucleus (Calcutta), 15, 200-210 (1972).
10.
Singh, L.: Evolution of karyotypes in snakes. Chromosoma (Berl.), 38, 185-236
(1972).
11.
Singh, L.: Karyological study of three species of turtles from India. Indian
Biologist, 4, 64-69 (1972).
12.
Singh, L. and Ray-Chaudhuri, S.P.: DNA replication pattern in the chromosomes
of Crocodylus palustris (Lesson). Nucleus (Calcutta), 16, 33-37 (1973).
13.
Singh, L.: The present status of sex chromosomes in amphibians. Nucleus
(Calcutta), 17, 17-27 (1974).
14.
Singh, L.: Study of mitotic and meiotic chromosomes in seven species of lizards.
Proc. Zool. Soc., Calcutta, 27, 57-79 (1974).
15.
Singh, L.: Chromosomes of six species of Indian snakes. Herpetologica, 30,
419-429 (1974).
12
16.
Gupta, P., Singh, L. and Ray-Chaudhuri, S.P.: Chromosomes of Indian breeds of
cattle. Nucleus (Calcutta), 17, 129-132 (1974).
17.
Singh, L. and Ray-Chaudhuri, S.P.: Localization of C-band in the W sex
chromosome of Common Indian krait, Bungarus caeruleus Schneider. Nucleus
(Calcutta), 18, 163-166 (1975).
18.
Singh, L., Purdom, I.F. and Jones, K.W.: The chromosomal localization of
satellite DNA in Ptyas mucosus (Ophidia), Colubridae). Chromosoma (Berl.),
57, 177-184 (1976).
19.
Singh, L., Purdom, I.F. and Jones, K.W.: Satellite DNA and evolution of sex
chromosomes. Chromosoma (Berl.), 59, 43-62 (1976).
20.
Singh, L., Purdom, I.F. and Jones, K.W.: Effect of different denaturing agents on
the detectability of specific DNA sequences of various base compositions by in
situ hybridization. Chromosoma (Berl.), 60, 377-389 (1977).
21.
Singh, L., Purdom, I.F. and Jones, K.W.: Behaviour of sex chromosomes
associated satellite DNAs in somatic and germ cells in snakes. Chromosoma
(Berl.), 71, 167-181 (1979).
22.
Singh, L., Ray-Chaudhuri, S.P., Majumdar, K., Purdom, I.F. and Jones, K.W.:
Sex specific chromosome polymorphisms in the Common Indian krait, Bungarus
caeruleus schneider (Ophidia, Elapidae). Chromosoma (Berl.), 73, 93-108
(1979).
23.
Singh, L., Purdom, I.F. and Jones, K.W.: Sex chromosome associated satellite
DNA: Evolution and conservation. Chromosoma (Berl.), 79, 137-157 (1980).
24.
Singh, L., Purdom, I.F. and Jones, K.W.: Conserved sex chromosome-associated
nucleotide sequences in eukaryotes. Cold Spring Harbor Symp. Quant. Biol.,
45, 805-813 (1981).
25.
Jones, K.W. and Singh, L.: Conserved repeated DNA sequences in vertebrate
sex chromosomes. Hum. Genet. 58, 46-53 (1981).
26.
Jones, K.W. and Singh, L.: Conserved sex-associated repeated DNA in
vertebrates. In: “Genome Evolution” (Eds. G. Dover and R. Flavell), Academic
Press, London, pp.135-154 (1982).
27.
Singh, L. and Jones, K.W.: Sex reversal (Sxr) in the mouse (Mus musculus) is
caused by a recurrent non-reciprocal crossover involving the X and an aberrant Y
chromosome. Cell 28, 205-216 (1982).
28.
Muller, U., Singh, L. Grund, S. and Jones, K.W.: Ovarian cells participate in the
formation of tubular structures in mouse/rat heterosexual gonadal cocultures.
Differentiation, 22, 136-138 (1982).
29.
Jones, K.W., Singh, L. and Phillips, C.: Conserved Nucleotide sequences on sex
chromosomes. Proc. John Inn’s Symp. 265-287 (1983).
13
30.
Singh, L., Phillips, C. and Jones, K.W.: The conserved nucleotide sequences of
Bkm, including those, which define Sxr in the mouse, are transcribed. Cell 36,
111-120 (1984).
31.
Singh, L. and Jones, K.W. : The use of heparin as a simple cost-effective means
of controlling background in nucleic acid hybridization procedures. Nucl. Acids
Res., 8, 5627-5637 (1984).
32.
Jones, K.W. and Singh, L.: Snakes and the evolution of sex chromosomes.
Trends Genet. 1, 55-61 (1985).
33.
Singh, L. and Jones, K.W.: Bkm sequences are polymorphic in humans and are
clustered in pericentric regions of various acrocentric chromosomes including the
Y. Hum. Genet. 73, 304-308 (1986).
34.
Singh, L., Matsukuma, S. and Jones, K.W.: Testis development in a mouse with
10% of XY cells. Dev. Biol., 122, 287-290 (1987).
35.
Jones, K.W., Singh, L. and Edwards, R.G.: The use of probes for the Y
chromosome in preimplantation embryo cells. Hum. Reprod. 2, 439-445 (1987).
36
Jones, K.W., Olszewska, E., and Singh, L.: Rapidly evolving Bkm DNA is
associated with hypervariable domains. In: “Chromosomes Today”, 9, 22-29.
(Eds. A. Stahl, J.M. Luciani & A.M. Vagner - Capodano. Allen & Unwin Suffolk,
G.B.) (1987).
37.
Matsukuma, S., Singh, L., and Jones, K.W.: Microinjection of Bkm related male
specific mouse DNA into autologous zygotes. J. Genet. 66, 163-176 (1987).
38.
Singh, L., Matsukuma, S., and Jones, K.W.: The use of Y chromosome specific
repeated DNA sequences in the analysis of testis development in an XX/XY
mouse. Development, 101 (supplement), 143-150 (1987).
39.
Singh, L., Winking, H., Jones, K.W., and Gropp, A.: Restriction fragment
polymorphism in the sex-determining region of the Y chromosomal DNA of
European wild mice. Mol. Gen. Genet. 212, 440-449 (1988).
40.
Singh, L.: DNA profiling and its applications. Curr. Sci., 60, 580-585 (1991).
41.
Aggarwal, R.K., Lang, J.W., Singh, L.: Isolation of high molecular weight DNA
from small samples of blood having nucleated erythrocytes, collected,
transported and stored at room temperature. Genetic Analysis: Techniques
and Applications, 9(2), 54-57 (1992).
42.
Singh, L. and Majumdar, K.C.: Striking similarity in molecular organization of sex
chromosomes is a reflection of their common mode of action. In: "Sex
Chromosomes and Sex-determining Genes" (Eds. Ken C Reed and Jennifer A
Marshall Graves), pp. 337-356 (1993).
43.
Lang, J.W., Aggarwal, R.K., Majumdar, K.C. and Singh, L.: Individualisation and
estimation of relatedness in crocodilians by DNA fingerprinting with Bkm derived
probe. Mol. Gen. Genet. 238, 49-58 (1993).
44.
Bhargava, P.M. and Singh, L.: What should India be doing on the human
genome? Curr. Sci., 65(9), 663-664 (1993).
14
45.
Panicker, S.G. and Singh, L.: Banded krait minor satellite (Bkm) contains sex and
species-specific repetitive DNA. Chromosoma, 103, 40-45 (1994).
46.
Singh, L., Panicker, S.G., Nagaraj, R. and Majumdar, K.C.: Banded krait minorsatellite (Bkm)-associated Y chromosome-specific repetitive DNA in mouse.
Nucl. Acids Res., 22(12), 2289-2295 (1994).
47.
Aggarwal, R.K., Majumdar, K.C., Lang, J.W. and Singh, L.: Generic affinities
among crocodilians as revealed by DNA fingerprinting using a Bkm-derived
probe. Proc. Natl. Acad. Sci., (USA) 91, 10601-10605 (1994).
48.
Singh, L. and Majumdar, K.C.: Behaviour of microchromosome associated
satellite DNA in Bungarus fasciatus (Ophidia, Elapidae). J. Genet. 73(1),1-15
(1994).
49.
Singh, L., Wadhwa, R., Naidu, S., Nagaraj, R. and Ganesan, M.: Sex and tissuespecific Bkm (GATA)-binding Protein in the Germ Cells of heterogametic sex. J.
Biol. Chem., 269, 25321-25327 (1994).
50.
Singh, L., Panicker, S.G., Nagaraj, R. and Majumdar, K.C.: Functional
Significance of Molecular organization of sex chromosomes. Proc. Indian Natl.
Sci. Acad., 360, 455-470 (1994).
51.
Aggarwal, R.K., Singh, P. and Singh, L.: Genetic fingerprinting: an overview with
special reference to its application in agriculture. In: Proc. Golden Jubilee
Symp. Genetic Research and Education: Current Trends and Next Fifty
Years. (Eds. B. Sharma et al.), Ind. Soc. Genet. & Plant Breeding, 4, pp: 19091925 (1995).
52.
Singh, L., and Rajyashri, K.R.: Molecular basis of sex determination and
differentiation in mammals. Molecular Genetics & Gene Therapy: The New
Frontier, Scientific Communications, Amsterdam, pp 21-44 (1995).
53.
Singh, L.: Biological significance of minisatellites. Electrophoresis, 16, 15861595 (1995).
54.
Nagaraju, J., Sharma, A., Sethuraman, B. N., Rao, G. V. and Singh, L.: DNA
fingerprinting in silkworm Bombyx mori using banded krait minor satellite DNAderived probe. Electrophoresis, 16, 1639-1642 (1995).
55.
Rajyashri, K.R. and Singh, L.: A Bkm-associated human Y-chromosomal DNA is
conserved and transcribed in the testis of mouse. Chromosoma, 104, 274-281
(1995).
56.
Majumdar, K.C., Shetty, S., Wadhwa, R., Bhaskar, S., Ganesan, M. and Singh,
L.: Detection and purification of sequence specific DNA binding protein. Anal.
Biochem., 241, 23-29 (1996).
57.
Jobling, M.A., Samara, V., Pandya, A., Fretwell, N., Bernasconi, B., Mitchell, R.J.,
Gerelsaikhan, T., Dashnyam, B., Sajantila, A., Salo, P.J., Nakahori, Y., Disteche,
C.M., Thangaraj, K., Singh, L., Crawford, M.H. and Tyler-Smith, C.: Recurrent
duplication and deletion polymorphisms on the long arm of the Y chromosome in
normal males. Hum. Mol. Gen., 5, 1767-1775 (1996).
15
58.
Nagaraju, J.G. and Singh, L.: Assessment of genetic diversity by DNA profiling
and its significance in improvement of silkworm, Bombyx mori. Electrophoresis,
18, 1676-1681 (1997).
59.
Shankaranarayanan, P., Banerjee, M., Kackar, R.K., Aggarwal, R.K. and Singh,
L.: Genetic variation in Asiatic lions and Indian tigers. Electrophoresis, 18, 16931700 (1997).
60.
Thangaraj, K., Nalini J Gupta, Chakravarty, B., and Singh, L.: XXY Female: An
unique case of sex reversal. THE LANCET, 352 (9134), 1121 (1998).
61.
Shankaranarayanan, P. and Singh, L.: A rapid and simplified protocol for isolation
of DNA from Scat samples. Curr. Sci., 75 (9), 883-884 (1998).
62.
Shankaranarayanan, P. and Singh, L.: Mitochondrial DNA sequences divergence
among big cats and their hybrids. Curr. Sci., 75(9), 919-923 (1998).
63.
Vanaja, D.K., Sivakumar, B., Rachel, A.J., Singh, L., Janardhanasarma, M.K. and
Habibullah, C.M.: In vivo identification, survival and functional efficacy of
transplanted hepatocytes in acute liver failure mice model by FISH using Ychromosome probe. Cell Transplantation 7(3), 267-273 (1998).
64.
Arpita Pandya, Turi E. King, Fabricio R. Santos, Paul G. Taylor, Kumarasamy
Thangaraj, Lalji Singh, Mark A. Jobling and Chris Tyler-Smith: A polymorphic
human Y-chromosomal G to A transition found in India. Ind. J. Hum. Genet. 4,
52-61 (1998).
65.
Parmar, S.N.S., Singh, L., Rao, G.V., Mishra, S.K. and Reddy, A.R. DNA
fingerprinting in poultry using multilocus probe Bkm-2(8). Indian Veterinary
Journal, 75, 371-374 (1998).
66.
Singh, L.: DNA fingerprinting technology and emerging legal and ethical issues.
In: Human Genome Research: Emerging Ethical, Legal, Social and Economic
Issues (Eds. M G K Menon, P N Tandon, S S Agarwal and V P Sharma), pp.116135 (1999).
67.
Siva Kumar, S., Subramanian, V., Walimbe, S.R. and Singh, L.: Current Trends
in 'Ancient DNA studies' - A Review. Curr. Sci., 76(7), 101-107 (1999).
68.
Narendra Kumar, A., Chandak, G.R., Rajasekhar, A., Reddy, N.C.K., and Singh,
L.: Fetus-in-Fetu: A case report with molecular analysis. J. Ped. Surg., 34 (4), 15 (1999).
69.
Niranjan, Y., Chandak, G.R., Veerraju, P and Singh, L.: Some Atypical and Rare
Sickle Gene Haplotypes in Populations of Andhra Pradesh, India. Hum. Biol., 71
(3), 335-342 (1999).
70.
Sharma, A., Niphadkar, M.P., Kathirvel, P., Nagaraju, J. and Singh, L.: DNA
fingerprint variability within and among the Silkworm Bombyx mori genotypes and
estimation of their genetic relatedness using Bkm-derived probe. J. Hered. 90,
315-319 (1999).
71.
Thangaraj, K., Ramana, G.V. and Singh, L.: Y-chromosome and mitochondrial
DNA polymorphisms in Indian populations. Electrophoresis, 20, 1743-1747
(1999).
16
72.
Hurles, M.E., Veitia, R., Arroyo, E., Armenteros, M., Betranpetit, J., PerezLezaun, A., Bosch, E., Shlumukova, M., Cambon-Thomsen, A., McElreavey, K.,
Lopez de Munian, A., Rohl, A., Wilson, I.J., Singh, L., Pandya, A., Santos, F.R.,
Tyler-Smith, C. and Jobling, M.A.: Recent male-mediated gene flow over a
linguistic barrier in Iberia suggested by analysis of a Y-chromosomal DNA
polymorphism. American Journal of Human Genetics, 65, 1437-1448 (1999).
73.
Singh, L., Pathak, N.H., Rachel, A.J. and Thangaraj, K.: Snake's Eye View of
Adam and Eve in Reproductive Immunology (Ed. Satish K Gupta) pp. 132-148
(1999).
74.
Tatiana Zerjal, Arpita Pasndya, Fabricio R. Santos, Raju Adhikari, Eduardo
Tarazona, Lars Beckman, Manfred Kayser, Oleg Evgrafov, Lalji Singh,
Kumaraswamy Thangaraj, Giovanni Destro-Bisol, Mark G. Thomas, Rahell
Qamar, Qasim Mehdi, Zoe H. Rosser, Matt E. Hurles, Mark A. Jobling and Chris
Tyler-Smith: The use of Y-chromosomal DNA variation to investigate population
history: recent male spread in Asia and Europe. In: Genomic Diversity:
Applications in Human Population Genetics (Ed. Papiha, Deka and
Chakraborty) pp.91-101 (1999).
75.
Hema, M.G., Zeenath, J., Ahuja, Y.R., Singh, L. Analysis of SRY : the testis
determining factor in individuals with 46XY gonadal dysgenesis. Medical
Science Research, 27, 95-97 (1999).
76.
Fabricio R. Santos, Arpita Pandya, Manfred Kayser, R. John Mitchell, Aiping Liu,
Lalji Singh, Giovanni Destro-Bisol, Andrea Novelletto, Raheel Qamar, S. Qasim
Mehdi, Raju Adhikari, John Clegg and Chris Tyler-Smith: A polymorphic L1
retroposon insertion in the centromere of the human Y chromosome. Hum. Mol.
Gen., 9, 421-430 (2000).
77.
G.V. Ramana, G.R. Chandak and Lalji Singh: Sickle Cell Gene Haplotypes in
Relli and Thurpu Kapu Populations of Andhra Pradesh. Human Biology, 72,
535-540 (2000).
78.
Anil K Mandal, Amar Pal Singh, Laxmi Rao, Lalji Singh, Stella Hornby and Barry
Jones: Robert’s Pseudothalidomide Syndrome. Arch Ophthalmol 118, 14621463 (2000).
79.
P. K. Rout, K. Thangaraj, A Mandal, L Singh: DNA Finger Printing of Indian goats
with a BKM-derived probe. 7th International Conference on Goats, France, 15-21 May
2000.
80.
G.V. Ramana, L.Singh, R Chakraborty: The SRY-1532 site of the Human Y
chromosome is subject to recurrent single nucleotide mutations. Human
Biology, 73, 71-80, (2001).
81.
G.V. Ramana, Bing Su, Li Jin, Lalji Singh, Ning Wang, Peter Underhill and Ranajit
Chakraborty: Y-chromosome SNP haplotypes suggest evidence of gene flow among
caste, tribe, and the migrant Siddi populations of Andhra Pradesh, South India.
European J. Hum. Genetics, 9, 695-700 (2001).
82.
Thangaraj, K., Reddy, A.G. and Singh, L. Is amelogenin gene reliable for gender
identification in forensic casework and prenatal diagnosis? Intl. J. Legal Med., 116,
121-123 (2002).
17
83.
GR Chandak, MM Idris, DN Reddy, S Bhaskar, PVJ Sriram, L Singh. “Mutations
in pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than cationic
trypsinogen gene (PRSS1) are significantly associated with tropical calcific
pancreatitis.” J Med. Genet., 39, 347-351 (2002).
84.
David B. Everman, Cynthai F. Bartels, Yue Yang, Niranjan Yanamandra, Frances
R. Goodman, J. Roberto Mendoza-Londono, Ravi Savarirayan, Susan M. White,
John M. Graham Jr., Robert Peter Gale, Eva Svarch, William G. Newman, Albert
R. Kleckers, Clair A. Francomano, Vinukonda Govindaiah, Lalji Singh, Stuart
Morrison, J. Terrig Thomas and Mathew L. Warman. “The mutational spectrum of
brachydactyly type C”. American Journal of Medical Genetics, 112, 291-296
(2002).
85.
R. K. Aggarwal, V V Shenoy, J. Ramadevi, R. Rajkumar, L. Singh. Molecular
characterization of some Indian Basmati and other elite rice genotypes using
fluorescent-AFLP. Thero Appl Genet., 105, 680-690 (2002).
86.
K. Thangaraj, M. Joshi, A.G. Reddy, N.J. Gupta, B. Chakravarty, L. Singh: CAG
repeat expansion in the androgen receptor gene is not associated with male
infertility in Indian Populations. J. Andrology, 23, 815-818 (2002).
87.
A. Singh, K. Shaijala, A. Gaur and L. Singh: Development and characterization of
novel microsatellite markers in the Asiatic lion (Panthera leo persica). Molecular
Ecology Notes, 2, 542-543 (2002).
88.
G.R. Chandak, M. Uma Sridevi, C.J. Vas, D.M. Panikker and L. Singh:
Apolipoprotein E and Presenilin-1 Allelic Variation and Alzheimer’s Disease in
India. Human Biology, v.74, no.5, pp. 683-693 (2002).
89.
Subbaya Subramanian, Vamsi M Madgula, Ranjan George, Rakesh K Mishra,
Madhusudhan W Pandit, Chandrashekar S Kumar and Lalji Singh: MRD: a
microsatellite repeats database for prokaryotic and eukaryotic genomes. Genome
Biology 3, 11.1-11.13 (2002).
90.
Christopher N. Balakrishnan, Steven L. Monfort, Ajay Gaur, Lalji Singh and
Michael D. Sorenson: Phylogeography and conservation genetics of Eld’s deer
(Cervus eldi). Molecular Ecology, 12, 1-10 (2003).
91.
Thangaraj, K., Subramanian S., Reddy A.G., Singh L.: Unique Case of Deletion
and Duplication in the Long Arm of the Ychromosome in an Individual with
Ambiguous Genitalia. Am. J. Med. Genet., 116A, 205-207 (2003).
92.
Kumarasamy Thangaraj, Lalji Singh, Alla G. Reddy, V Raghavendra Rao,
Subhash C Sehgal, Peter A Underhill, Melanie Pierson, Ian G.Frames and Erika
Hagelberg: Genetic Affinities of the Andaman Islanders, a Vasnishing Human
Population. Current Biology, 13, 68-93 (2003)
93.
Subbaya Subramanian, Rakesh K Mishra and Lalji Singh: Genome-wide analysis
of microsatellite repeats in human: Abundance and their density in specific
genomic regions. Genome Biology, 4, R13.1-R1310 (2003).
94.
S.K. Verma and L. Singh: Novel universal primers establish identity of an
enormous number of animal species for forensic application. Molecular Ecology
Notes, 3,28-31 (2003).
18
95.
Priyadarshini, P., Murthy, B. S., Nagaraju, J., Singh, L.: A GATA-binding protein
expressed predominantly in the pupal ovary of the silkworm, Bombyx mori.
Insect Biochemistry & Molecular Biology, 33, 185-195 (2003)
96.
Subbaya Subramanian, Vamsi M Madgula, Ranjan George, Rakesh K Mishra,
Madhusudhan W Pandit, Chandrashekar S Kumar and Lalji Singh: Triplet repeats
in human genome: distribution and their association with genes and other
genomic regions. Bioinformatics,19, 549-552 (2003).
97.
Subbaya Subramanian, Rakesh K Mishra and Lalji Singh: Genome-wide analysis
of Bkm sequences (GATA repeats): predominant association with sex
chromosomes and potential role in higher order chromatin organization and
function. Bioinformatics, 19, 6, 681-685 (2003).
98.
Kumarasamy Thangaraj, Manjunath B. Joshi, Alla G. Reddy, Avinash A Rasalkar,
and Lalji Singh: Sperm Mitochondrial Mutations as a Cause of Low Sperm
Motility. Journal of Andrology, 24, No.3, 388-392 (2003)
99.
Bhupendra N. Singh, Amritha Suresh, Gogineni Uma Prasad, Subbaya
Subramanian, Mehar Sultana, Sandeep Goel, Satish Kumar and Lalji Singh: A
highly conserved human gene encoding a novel member of WD-repeat family of
proteins (WDR13), Genomics, 81, 315-328 (2003).
100.
Kumarasamy Thangaraj, Nalini J Gupta, K Pavani, Alla G. Reddy, Subbaya
Subramanian, Deepa Selvi Rani, Bibaswan Ghosh, Baidyanath Chakravarty and Lalji
Singh: Y Chromosome Deletions in Azoospermic Men in India. Journal of
Andrology, 24, 588-597 (2003).
101.
Subramanian S, Vamsi M Madugula, Ranjan George, Satish Kumar, Madhusudhan W Pandit
and Lalji Singh: SSRD: simple sequence repeat database for human genome. Comp Funct
Genom., 4, 342-345 (2003).
102.
Shivaji, S., Kholkute, S.D., Verma, S. K., and Lalji Singh (19 authors). Conservation
of wild animals by assisted reproduction and molecular marker technology. Indian
Journal of Experimental Biology, 2003, 41, 710-723.
103.
Verma, S.K., Prasad K., Nagesh, N., Sultana, M., Singh, L. Was elusive carnivore a
panther? DNA typing of faeces reveals the mystery. Forensic Science
International, 137, 16-20 (2003).
104.
A. Gaur, A. Singh, V. Arunabala, G. Umapathy, K Shailaja and L. Singh.
Development and characterization of 10 novel microsatellite markers from Chital
deer (Cervus axis) and their cross-amplification in other related species. Molecular
Ecology Notes, 3, 607-609 (2003).
105.
MW Pandit and Lalji Singh. Science of establishing identity – Past, present and
future. Palaeobotanist, 52, 1-11 (2003).
106.
Raghavendra V Rao, Kumarasamy Thangaraj, Alla G Reddy, V Sridhar, Lalji Singh.
Pairwise MtDNA-HVRII sequence differences and geographic maternal distances
among Korku, an Austro-Asiatic tribe in Central India. Indian Journal of Human
Genetics, 9, 25-28 (2003).
19
107.
Aggarwal, R. K., J. Ramadevi, L. Singh). Ancient origin and evolution of the Indian
wolf: evidence from mitochondrial DNA typing of wolves from Trans-Himalayan
region and Pennisular India. Genome Biology, 4: P6 (2003).
108.
Lakshmi Rao, Arvind Babu, Murthy Kanakavalli, Venkata Padmalatha, Amar Pal
Singh, Prashant Kumar Singh, Mamata Deenadayal and Lalji Singh. Chromosomal
abnormalities and Y-chromosome microdeletions in infertile men with varicocele and
idiopathic infertility of South Indian origin. Journal of Andrology, 25, 147-153 (2004)
109.
Kumarasamy Thangaraj, Alla G Reddy and Lalji Singh. Mutation in STR Locus D21S11 of
Father Causing Allele Mismatch in the Child. Journal of Forensic Science, 49, (2004)
110.
Manjunatha B Joshi, Pramod K Rout, Ajoy K Mandal, Chris Tyler-Smith, Lalji Singh and
Kumarasamy Thangaraj. Phylogeography and Origin of Indian Domestic Goats. Molecular
Biology and Evolution, 21(3), 454-462 (2004).
111.
Ramesh K Aggarwal, T P Velavan, D Udaykumar, P S Hendre, Kartik Shanker, B C
Choudhury and Lalji Singh. Development and characterization of novel microsatellite markers
from the olive ridley sea turtle (Lepidochelys olivacea). Molecular Ecology Notes, 4, 77-79
(2004).
112.
Anju Singh, Ajay Gaur, K. Shailaja, B. Satyare Bala, Lalji Singh. A novel
microsatellite (STR) marker for forensic identification of big cats in India. Forensic
Science International, 141, 143-147 (2004).
113.
G.R. Chandak, M.M. Idris, D.N. Reddy, K.R. Mani, S. Bhaskar, G.V. Rao, L. Singh. Absence of
PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and nonheriditary chronic pancreatitis. Gut, 53, 723-728 (2004).
114.
K Arvind Babu, K Lakshmi Rao, M K Kanakavalli, W Surayanarayana, Mamata Deenadayal,
Lalji Singh. CYP1A1, GSTM1 and GSTT1 genetic polymorphism is associated with
susceptibility to polycystic ovaries in South Indian women. Reproductive BioMedicine, Vol.9.
No.2, 194-200 (2004).
115.
Ramesh K Aggarwal, D. Udaykumar, P.S. Hendre, A. Sarkar and Lalji Singh. Isolation and
characterization of six novel microsatellite markers for mulberry (Morus indica). Molecular
Ecology Notes, 4, 477-479 (2004).
116.
H. Dixit, M. Deendayal and L. Singh. Mutational analysis of mature peptide region of
inhibin genes in Indian women with ovarian failure. Human Reproduction, Vol.19(8),
1760-1764 (2004).
117.
Sunil Kumar Verma, Ravindra Kumar Sinha and Lalji Singh. Phylogenetic position of
Platanista gangetica: insights from the mitochondrial cytochrome b and nuclear
interphotoreceptor
retinoid-binding
protein
gene
sequences.
Molecular
Phylogenetics and Evolution, Vol 33, 280-288 (2004).
118.
Langstiesh BT, Reddy BM, Thangaraj K, Singh L. Genetic Diversity and
Relationships among the tribes of Meghalaya compared to other Indian and
Continental Populations. Hum Biol. 76:569-590 (2004).
119.
Venkata Suryanarayana, Mamata Deenadayal and Lalji Singh. Association of
CYO1A1 gene polymorphism with recurrent pregnancy loss in the South Indian
population. Human Reproduction, Vol. 19, No.11 2648-2652 (2004).
20
120.
K. Shanker, J. Ramadevi, B.C. Choudhury, L. Singh, R.K. Aggarwal. Phylogeography
of olive ridley turtles (Lepidochelys olivacea) on the east coast of India: implications
of conservation theory. Molecular Ecology 13(7) 1899-1909 (2004).
121.
Lakshmi Rao, Arvind Babu, Venkata Padmalatha, Murthy Kanakavalli, Mamata
Deenadayal and Lalji Singh. Novel X-chromosomal defect associated with abnormal
ovarian function. J. Obstet. Gynaecol. Res. Vol. 31 (1), 12-15 (2005).
122.
Kumarasamy Thangraj, Vempati Sridhar, Toomas Kivisild, Alla G. Reddy,
Gyaneshwer Chaubey, Vijay Kumar Singh, Suminder Kaur, Pooja Agarwal, Amit Rai,
Jalaj Gupta, Chandana Basu Mallick, Niraj Kumar, Thrimulaisamy P Velavan,
Rajanbabu Suganthan, Divi Udaykumar, Rashmi Kumar, Rachana Mishra, Arif Khan,
Chitikineni Annapurna, Lalji Singh. Different population histories of the Mundari- and
Mon-Khmer-speaking Austro-Asiatic tribes inferred from the mtDNA 9-bp
deletion/insertion polymorphism in Indian populations. Hum. Genet. Vol. 116, 507517 (2005).
123.
Reddy BM., Naidu VM, Madhavi VK, Thangaraj K, Langtieh BT, Venkataramana P,
Kumar V, Singh L. STR Data for the Amp FlSTR Profiler Plus Loci Among 27
Populations of Different Social Hierarchy from Southern Part of Andhra Pradesh,
India. Forensic Sci. Intl. 149: 81-97 (2005).
124.
K Thangaraj, Gyaneshwar, Thomas Kivisile, A.G. Reddy, Vijay Singh, Avinash
Rasalkar and Lalji Singh. Reconstructing the origin of Andaman Islanders. Science
Vol. 308; 996 (2005).
125.
M. Sachdev, R. Sankaranarayanan, P. Reddanna, K. Thangaraj, L. Singh. Major
histocompatibility complex class I polymorphism in Asiatic lions. Tissue Antigens
Vol. 66: 9-18 (2005).
126.
K Lakshmi Rao, K Arvind Babu, M K Kanakavalli, V V Padmalatha, Mamata
Deenadayal and Lalji Singh. Prevalence of chromosome defects in azoospermic and
oligoasthenoteratozoospermic South Indian infertile men attending infertility clinic,
Reproductive Biomedicine Online Vol. 10, No. 4. 467–472 (2005).
127.
Sandeep Kumar Gupta, Sunil Kumar Verma and Lalji Singh. Molecular insight into a
wildlife crime: the case of peafowl slaughter, Forensic Science International Vol.
154 No.2-3. 214-217 (2005).
128.
K Anil Kumar, K Lakshmi Rao, Suryanarayana V Vedula, Kanakavalli M K,
Padmalatha V Vaddamani, Mamta Deendayal and Lalji Singh. Screening of
Galactose-1-Phosphate Uridyltransferase gene in Indian women with ovarian failure,
Reproductive Bio Medicine Online Vol.11.No 4. 44-448 (2005).
129.
Hridesh Dixit, Lakshmi K. Rao, Venkata Padmalatha, Murthy Kanakavalli, Mamatha
Deenadayal, Nalini Gupta, Baidyanath N. Chakravarty, Lalji Singh (2005). Mutational
screening of coding region of Growth Differentiation Factor 9 gene in Indian women
with ovarian failure, Menopause Vol 12 No.6. 749-754 (2005).
130.
K Lakshmi Rao, M K Kanakavalli, K Arvind Babu, V V Padmalatha, Mamata
Deenadayal and Lalji Singh. Chromosome inversions and a novel chromosome
insertion associated with recurrent miscarriages in South India, Archives of
Obstetrics and Gynecology 272(4) 273-7 (2005).
21
131.
Lalji Singh, Thangaraj, G R Chandak, et al from CCMB: The Indian Genome
Variation Consortium. Human Genet (2005) Vol. 1-11
132.
Rajender Singh, Selvi R. Deepa, Sakhamuri Madhavi, Nalini J. Gupta, Baidyanath
Chakravarty, Lalji Singh, Kumarsamy Thangaraj. Male infertility: No Evidence of
Involvement of Androgen Receptor Gene among Indian Men. J. Androl. 27(1) 102105 (2006).
133.
Kumarasamy Thangaraj, Gyaneshwer Chaubey, Toomas Kivisild, Alla G Reddy,
Vijay Kumar Singh, Avinash A Rasalkar and Lalji Singh: Response to Comment on
“Reconstructing the Origin of Andaman Islanders”. Science: Vol. 311. 470b (2006).
134.
Singh Rajender, Vutukuri Rajani, Nalini J. Gupta, Baidyanath Chakravarty, Lalji
Singh, Kumarasamy Thangaraj: SRY negative 46,XX male with normal genitals,
complete
masculinization
and
infertility.
Mol
Hum
Reprod.
doi:10.1093/molehr/gal030).
135.
Thangaraj K, Deepa SelviRani, Pavani K, Gupta NJ, Reddy P, Reddy AG,
Chakravarty BN, Singh L (2006) A to G transitions at 260, 386 and 437 in DAZL gene
are not associated with spermatogenic failure in Indian population. Intl. J. Androl.
(doi:10.1111/j.1365-2605.2006.00685.x)
136.
Thangaraj K, Chaubey G, Singh VK, Reddy AG, Pavate PP, Singh L Genetic Profile
of Nine Autosomal STR Loci Among Halakki and Kunabhi Populations of Karnataka,
India. J. Forensic Sci. 51: 190-192 (2006).
137.
Vikrant Kumar, Banrida T. Lasngstieh, Komal V Madhavi, Vegi M. Naidu, Hardeep
Pal Singh, Silpak Biswas, Kumarasamy Thangaraj, Lalji Singh, B. Mohan Reddy
Global patterns in Human mtDNA Versus Y-chromosome Variation Caused by
Spatial Instability of the Local Cultural Processes. PloS Genetics Vol.2, Issue 4 e53
(2006).
138.
Golla N. Prasad Prasad, Ayyasamy Vanniarajan, Cyril Emmanuel, Kotturathu
Mammen Cherian, Lalji Singh, Kumarasamy Thangaraj K. Novel mitochondrial DNA
mutations in a rare variety of hypertrophic cardiomyopathy. Intl. J. Cardiol.
109: 432-433 (2006).
139.
Vanniarajan A, Nayak D, Reddy AG, Singh L, Thangaraj K. Clinical and genetic
uniqueness in an individual with MELAS. Am. J. Med. Genet 141B: 440-444 (2006)
140.
Kumarasamy Thangaraj, Gyaneshwer Chaubey, Vijay Kumar Singh, Ayyasamy
Vanniarajan, Ismail Thanseem, Alla G. Reddy, Lalji Singh In situ origin of deep
rooting
lineages
of
mitochondrial
Macrohaplogroup
M
in
India
BMC Genomics 7:151 (2006)
141.
Vanniarajan A, Rajshekher GP, Joshi MB, Reddy AG, Singh L, Thangaraj K (Novel
mitochondrial mutation in the ND4 gene associated with Leigh Syndrome. Acta
Neurol Scand DOI: 10.1111/j.1600-0404.2006.00673.x (2006).
142.
Venkata Suryanarayana, Lakshmi Rao, Murthy Kanakavalli, Venkata Padmalatha,
Mamata Deenadayal, Lalji Singh. Recurrent early pregnancy loss and endothelial
nitric oxide synthase gene polymorphisms. Arc. Gynecol. Obstet. 274, 119-124
(2006).
22
143.
Rajender Singh, Prabhakar K Shastry, Avinash A Rasalkar, Lalji Singh and K
Thangaraj. A novel androgen receptor mutation resulting in complete androgen
insensitivity syndrome and bilateral Leydig cell hyperplasia. Journal of Andrology
(2006)
144.
Gupta SK, Thangaraj K, Singh L. A Simple and Inexpensive Molecular Method for
Sexing and Identification of the Forensic Samples of Elephant Origin. J. Forensic
Sci.
51
(2006).
http://www.blackwell-synergy.com/doi/abs/10.1111/j.15564029.2006.00154.x
145.
Singh Rajender, Kumarasamy Thangaraj, Nalini J. Gupta, N. Leelavathy, Deepa
Selvi Rani, Renjini G Nambiar, Vadivelu Kalavathy, Sathiyavedu T Santhiya, Sayee
Rajangam, Puthiya M. Gopinath, Baidyanath Chakravarty, Lalji Singh. A Novel
human sex-determining gene linked to Xp11.21-11.23. J. Clin. Endocrin. Metab.
(2006) 4028-4036.
146.
Kumar V, Langsiteh BT, Biswas S, Babu JP, Rao TN, Thangaraj K, Reddy AG, Singh
L, Reddy BM. Asian and Non-Asian Origins of Mon-Khmer and Mundari Speaking
Austro-Asiatic populations of India. Am. J. Hum. Biol. 18: 461-469 (2006)
147.
Thanseem I, Thangaraj K, Chaubey G, Singh VK, Bhaskar LVKS, Reddy BM, Reddy
AG, Singh L. Genetic Affinities Among the Lower Castes and Tribal Groups of India:
Inference from Y Chromosome and Mitochondrial DNA. BMC Genetics 7:42 (2006).
148
Hridesh Dixit, Lakshmi Rao, Venkata V Padmalatha, Murthy Kanakavalli,
Mamata Deenadayal, Nalini Gupta, Baidyanath Chakrabarty, Lalji Singh.
Missensemutations in the BMP15 gene are associated with overrian failure.Human
Gennet (2006) 119: 408-417
148.
H.Dixit, Lakshmi Rao, V V Padmalatha, Murthy Kanakavalli, Mamata Deenadayal,
Nalini Gupta, B.N. Chakrabarty, Lalji Singh Missence Mutations in the BMP15 gene
ara associated with ovarian, Human Gennet (2006 ) 119: 408 - 415
149.
H.Dixit, Lakshmi Rao, V V Padmalatha, Murthy Kanakavalli, Mamata Deenadayal,
Nalini Gupta, B.N. Chakrabarty, Lalji Singh. Mutational analysis of the betaglycan
gene-coding region in susceptibility for overian failure Human Reproduction (2006)
1-6
150.
H. Dixit, M. Deendayal and Lalji singh. Mutational analysis of the mature peptide
region of inhibin genes in Indian women with ovarian failure Human Reproduction
Vol.19,No.8 pp.1760-1764,(2004)
151.
Ramana Gutala, Denise R. Carvalho-Silva, Li Jin, Bryndis Yngvadottir, Vasanthi
Avadhanula, Khaja Nanne, Lalji Singh, Ranajit Chakraborty and Chris Tyler-Smith: A
shared Y-chromosomal heritage between Muslims and Hindus in India. Hum Genet
(2006) DOI 10.1007/s00493-006-0234-x
152.
Nikita Thakur, Nageshwar D Reddy, Venkateshwar G Rao, Mohan P Krishna,,Lalji
Singh and Giriraj R Chandak : A novel mutation in STK11 gene is associated with
Peutz-Jeghers Syndrome in Indian patients. BMC Medical Genetics (2006)
doi:10.1186/1471/-2350-7-73.
153.
Tatiana Zerjal, Arpita Pandya, Kumarasamy Thangaraj, Edmund Y. S. Ling, Jennifer
Kearley, Stefania Bertoneri, Silvia Paracchini, Lalji Singh, Chris Tyler-Smith: Ychromosomal insights into the genetic impact of the caste system in India" Human
Genet (2007) 121:137-144 (DOI 10.1007/s00439-006-0282-2).
23
154.
Swapna Mahurkar, Mohammed M Idris, Nageshwar D Reddy, Seema Bhaskar,
Venkateshwar G Rao, Varghese Thomas, Lalji Singh and Giriraj Ratan Chandak:
Association of cathepsin B gene polymorphisms with tropical Calcific pancreatitis.
Gut (2006) doi:10.1136/gut.2005.087403.
155.
Deepa-SelviRani, Vanniarajan A, Gupta NJ, Chakravarty BN, Singh L, Thangaraj K:
A novel missense mutation C11994T in the mitochondrial ND4 gene as a cause of
low sperm motility in the Indian subcontinent. Fertility and Sterility (2006)
doi:10.1016/j.fertnstert.2006.04.044.
156.
Bhagavatula J, Singh L. Genotyping faecal samples of Bengal tiger Panthera tigris
tigris for population estimation: a pilot study. BMC Genet. 2006 Oct 17;7:48.
http://www.biomedcentral.com/1471-2156/7/48
157.
Ajay Gaur, Kesaraju Shailaja, Anju Singh, Veluri Arunabala, Borusu Satyarebala & Lalji Singh:
Twenty polymorphic microsatellite markers in the Asiatic lion (Panthera leo persica).
Conservation Genetics (2006) 7:1005-1008. DOI 10.1007/s10592-006-9121-1.
158.
Singh Rajender, Lalji Singh, Kumarasamy Thangaraj: Phenotypic heterogeneity of mutations
in androgen receptor gene. Asian J Androl (2007); 9:147-149.
159.
Zeenath Jehan, Sambandam Vallinayagam, Shrish Tiwari, Suman Pradhan, Lalji Singh,
Amritha Suresh, Hemakumar M. Reddy, Y.R. Ahuja and A. Jesudasan: Novel noncoding
RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric
CDC21_2. Genome Research (2007), 17: 433-440.
160.
Seema Bhaskar, DN Reddy, Swapna Mahurkar, GV Rao, Lalji Singh and Giriraj Chandak:
Lack of significant association of an insertion/deletion polymorphism in the angiotensin
converting enzyme (ACE) gene with tropical calcific pancreatitis. BMC Gastroenterology
published online December 12, 2006. doi:10.1186/1471-230X-6-42.
161.
Mala Ganesan, Khanderao R. Paithankar, Medicharla V. Jagannadham, Curam S.
Sundaram, Bulusu S. Murthy, Lalji Singh: Characterization of novel DNA-binding
proteins expressed in snake oocyte cDNA library. J. Protein Expression and
Purification 53 (2007)164-178; doi: 10.1016/j.pep.2006.11.007.
162.
R K Aggarwal, T Kivisild, J Ramadevi and L Singh: Mitochondrial DNA coding region
sequences support the phylogenetic distinction of two Indian wolf species. J Zool
Syst Evol Res (2007) 45(2), 163-172; doi: 10.1111/j.1439-0469.2006.00400.x.
163.
Vikrant Kumar, Arimanda N S Reddy, Jagadish P Babu, Tipirisetti N Rao, Banrida T
Langstieh, Kumarasamy Thangaraj, Alla G Reddy, Lalji Singh and Battini M Reddy:
Y-chromosome evidence suggests a common paternal heritage of Austro-Asiatic
populations. BMC Evolutionary Biology (2007) 7:47; doi:10.1186/1471-2148-7-47
164.
A. Khattri, R.K. Pandey, N.J. Gupta, B. Chakravarty, M. Deendayal, L. Singh and K.
Thangaraj: CA repeat and Rsal polymorphisms in ER gene are not associated with
infertility in Indian men. International Journal of Andrology, 30, 1-7 (2007).
165.
V. R. Rao, L.V.K.S.Bhaskar, C Annapurna, A.G.Reddy, K Thangaraj, A.Papa Rao,
Lalji Singh: Single Nuceotide Polymorphisms in Alcohol Dyhydrogenase Genes
24
Among Some Indian Population. American Journal of Human Biology 338-344
(2007)
166.
K. Thangaraj, G. Chaubey, A.G. Reddy, V.K. Singh, L. Singh. Autosomal STR data
on the enigmatic Andaman Islanders. Forensic Sci. Intl. 169, 247-251 (2007).
167.
Venkata V Suryanarayana, Lakshmi Rao, Murthy K Kanakavalli, Venkata V Padmalatha,
Mamata Deenadayal, Lalji Singh. Role of CYP17 and CYP19 polymorphisms in idiopathic
recurrent miscarriages among South Indian Women. Reproductive BioMedicine Online. 14,
341-347 (2007)
168.
Thangaraj K, Chaubey G, Singh VK, Reddy AG, Chauhan P, Malvee R, Pavate PP,
Singh L:.Y-Chromosomal STR Haplotypes in Two Endogamous Tribal Populations of
Karnataka, India. J Forensic Sci. 52(3):751-3 (2007).
169.
Singh Rajender, Nalini J Gupta, Baidyanath Chakravarty, Lalji Singh, Kumarasamy
Thangaraj: Androgen insensitivity syndrome: Do trinucleotide repeats in androgen
receptor gene have any role? Asian Journal of Androl. Dec 20 (Epub ahead of
print)
170.
Dhandapany PS, Sakthivel S, Vanniarajan A, Karthikeyan B, Nagaraj C,
Gowrishankar K, Selvam GS, Singh L, Thangaraj K (2006) Novel mitochondrial DNA
mutations implicated in Noonan syndrome. Intl. J. Cardiol. 120: 284-285 (2007).
171.
Stephan M Funk, Sunil K Verma, Greger Larson, Kasturi Prasad, Lalji Singh, Goutam
Narayan and John E Fa (2007) The pygmy hog is a unique genus: 19th century
taxonomists got it right first time round. Molecular Phylogeny and Evolution. DOI:
10.1016/j.ympev.2007.08.007.
172.
Rajender S, Singh L, Thangaraj K. L859F Mutation in Androgen Receptor Gene Results
in Complete Loss of Androgen binding to the Receptor. J Androl. 28:772-776 (2007).
173.
Aggarwal R. K., P. S. Hendre, R. K. Varshney, P. R. Bhat, V. Krishnakumar and L.
Singh (2007) Identification, characterization and utilization of EST-derived genic
microsatellite markers for genome analyses of coffee and related species.
Theoretical & Applied Genetics, 114: 359-372; DOI 10.1007/s00122-006-0440-x.
174.
Bhaskar LVKS, Thangaraj K, Shah AM, Pardhasarahi G, Kumar LP, Reddy AG, Rao
AP, Mulligan CJ, Singh L, Rao VR (2007). Allelic variation in the NPY gene in 14
Indian populations. J. Hum. Genet. 52:592-598.
175.
B. Mohan Reddy, B. T. Langstieh1, Vikrant Kumar, T. Nagaraja, A. N. S. Reddy,
Aruna Meka, A. G. Reddy, K. Thangaraj, Lalji Singh. Austro-Asiatic Tribes of
Northeast India Provide Hitherto Missing Genetic Link between South and Southeast
Asia. PloS ONE 2: e1141 (2007)
176.
Aggarwal, R. K., Albert Lalremruata, T. P. Velavan, Ayyadevara Pavani Sowjanya,
Lalji Singh (2007). Development and characterization of ten novel microsatellite
markers from olive ridley sea turtle (Lepidochelys olivacea). Conservation
Genetics. DOI: 10.1007/s10592-007-9421-0.
177.
K. Praveen Karanth, Lalji Singh, Randall V Collura, Caro-Beth Stewart: Molecular
phylogeny and biogeography of langurs and leaf monkeys of South Asia (Primates:
Colobinae). Molecular Phylogeny and Evolution 46:683-694(2008).
25
178.
Kumarasamy Thangaraj, Gyaneshwer Chaubey, Toomas Kivisild, Deepa Selvi Rani,
Vijay Kumar Singh, Thanseem Ismail, Denise Carvalho-Silva, Mait Metspalu, LVKS
Bhaskar, Alla G. Reddy, Sharat Chandra, Veena Pande, B. Prathap-Naidu, Niharika
Adarsh, Abhilasha Verma, Inaganti Amara Jyothi, Chandana Basu Mallick, Nidhi
Shrivastava, Ragala Devasena, Babita Kumari, Amit Kumar Singh, Shailendra
Kumar Dhar Diwedi, Shefali Singh, Geeta Rao, Pranav Gupta, Vartika Sonvane,
Kavita Kumar, Afsar Basha, K. R Bhargavi, Albert Lalremruata, Aravind Kumar
Gupta, Gurukamal Kaur, K. K. Reddy. A. Papa Rao, Richard Villems, Chris TylerSmith, Lalji Singh: Maternal Footprints of Southeast Asians in North India. Human
Heredity 66(1):1-9 (2007).DOI: 10.1159/000114160.
179.
Pramod K Rout, Manjunath B Joshi, Ajoy Mandal, D Laloe, Lalji Singh and
Kumarasamy Thangaraj: Microsatellite-based phylogeny of Indian domestic goats.
BMC Genetics 9:11 (2008) doi: 10.1186/1471-2156-9-11.
180.
Rajender S, Pandu G, Annapurna Ch, Sharma JD, Gandhi KPC, Sing L, Thangaraj
K: Reduced CAG repeats length in androgen receptor gene is associated with
violent criminal behavior. Intl. J. Legal Med (Published online: 26 March 2008).
181. Bhaskar LVKS, Thangaraj K, Mulligan CJ, Rao AP, Pardhasaradhi G, Kumar KP, Shah
AM, Sabeera B, Reddy AG, Singh L, Rao VR (2008) Allelic variation and haplotype
structure of the Dopamine receptor gene DRD2 in 9 Indian populations. Genet.
Testing 12:153-160
Research Papers (In press)
1.
Rani DS, Carlus JS, Poongothai J, Jyothi A, Pavani K , Gupta NJ, Reddy AG, Rajan
MM, Chakravarty BN, Singh L, Thangaraj K (2008) CAG repeat variation in the
mtDNA polymerase  (POLG) is not associated with oligoasthenozoospermia. Intl. J.
Androl. (in press).
2.
Suryavathi V, Khattri A, Gopal K, Rani DS, Panneerdoss S, Gupta NJ, Chakravarty BN,
Deendayal M, Singh L, Thangaraj K (2008) Novel variants in UBE2B gene and idiopathic
male infertility. J. Androl. (in press)
Research Report
1.
Shanker Kartik, B. C. Choudhary, R. K.Aggarwal, Lalji Singh (2000) Conservation
genetics of the Olive Ridley sea turtle (Lepidochelys olivacea) on the east coast of
India- a report. Wildlife Institute of India, Dehradun, India.
Research Papers in Conference Proceedings
1.
Aggarwal, Ramesh K., R. Rajkumar, P. Rajendrakumar, Prasad S. Hendre, A.
Baruah, R. Phanindranath, V. Annapurna, N. S. Prakash, A. Santaram, C. S.
Srinivasan, Lalji Singh (2004). Fingerprinting of Indian Coffee Selections and
26
Development of Reference DNA Polymorphism Panels for creating Molecular IDs for
Variety Identification. In: Proceedings of ASIC 2004: 20th International Conference
on Coffee Sciences, Banglore, India, 11 –15 October 2004.
2.
Aggarwal, Ramesh K., A. Baruah, V. Naik, Prasad S. Hendre, A. Ashraf, P.
Rajendrakumar, R. Rajkumar, V. Annapurna, R. Phanindranath, N. S. Prakash, C. S.
Srinivasan, Lalji Singh (2004). Development and Characterization of Coffee Specific
Microsatellite Markers for use as Potential Genetic Markers. In: Proceedings of ASIC
2004: 20th International Conference on Coffee Sciences, Banglore, India, 11–15
October 2004.
3.
Bhat, Prasanna R., V. Krishnakumar, P. S. Hendre, P. Rajendrakumar, Lalji Singh,
Ramesh K. Aggarwal (2004). Identification of Putative Resistance Gene Analogues
in Coffea and related Psilanthus taxa. In: Proceedings of ASIC 2004: 20th
International Conference on Coffee Sciences, Banglore, India, 11 –15 October 2004.
E.
LIST OF PATENTS AND POPULAR ARTICLES
Patents:
1.
Verma, S.K., and Singh L,: Universal primers to establish the identity of animal parts
and products 2003/7489 dated 24.11.2004 (South Africa – Granted)
The US patent was granted on November 28, 2006. Its number is 7,141,364
2.
Indian patent on Bkm and Bkm-derived probes has been filed (Application No. 1000
DEL 88), CSIR, New Delhi.
Popular Articles:
1.
“Breakthroughs in Bio-Technology” presented at the seminar at CCMB on the
theme – “Leadership in scientific endeavour for human development: the Indian
experience” on April 7, 2000.
2.
“Human Genome: Decoding the genetic code” published in Chartered Financial
Analyst – August 2000.
3.
“DNA Testing, Evidence Act and Expert Witness” published in The Indian Police
Journal – December 2000
4.
Science for Children: an Interview at the Indian Science Congress: 88th Session.
In: Food Nutrition and Environmental Security: The Road Ahead. A publication
brought out by the National Institute of Science Communication, New Delhi
pp.371-375, 2001.
5
Human Genome: A Gift of 20th Century and Challenge for 21st Century by M W
Pandit and Lalji Singh – Defence Science Journal Vol. 51 October 2001 No 4
(Special Issue on Recent Advances in Biotechnology).
6.
Human Genome and Beyond– published in CSIR News Vol. 51 No. 8 April 2001.
7.
An article on “The story of a village where birth of identical twins is common”
published in EENADU Telugu daily, July 31, 2003.
27
8.
Several articles in Hindi in “Jigyasa’ a periodical brought out by CCMB.
9.
Book titled “You Deserve, We Conserve: A Biotechnological Approach to Wildlife
Conservation” (by Dr Lalji Singh and Dr M W Pandit) unveiled by H.E. Dr A P J Abdul
Kalam, Hon’ble President of Indian on the occasion of dedication of LaCONES to the
nation on 1st February 2007.
10.
Book Titled “Scientoonic Tell-Tale of Genome and DNA” (by Dr Lalji Singh, Dr M W
Pandit and Dr Pradeep Srivastava)
28
F.
INFORMATION ON AND RELEVANCE OF RESEARCH CONTRIBUTIONS
1.
Development of a universal probe for DNA fingerprinting
Dr Singh and his colleagues in the CCMB, at Hyderabad, developed a probe
called Bkm-derived probe for DNA fingerprinting, as a fall out of their earlier
internationally well-known work on the mechanisms of determination of sex.
This indigenously developed probe is being extensively in use for forensic
investigations, paternity determinations and seed stock verifications. DNA
fingerprinting evidence was presented in the court and for the first time in the
annals of Indian history this result was accepted as an infallible evidence in the
court of law. This verdict was upheld by the Kerala High Court. Since then, this
technology was used in 500 cases of paternity disputes, identification of
missing children, identification of mutilated bodies, identification of exchanged
babies in hospitals and rape and murder cases, etc. These include sensational
cases of assassination of the late Prime Minister Shri Rajiv Gandhi,
assassination of Punjab Chief Minister, Swami Premananda case and the
famous tandoor case of Naina Sahni.
Setting up of CDFD
A separate autonomous "Centre for DNA Fingerprinting and Diagnostics"
(CDFD) has been set up by the Department of Biotechnology, Government of
India to apply and further develop this technology for the benefit of the country.
Dr Lalji Singh, as the First In-Charge Officer on Special Duty to this Centre, had
immensely contributed to its present status (From Oct.1995 to Feb.1999) in
addition to his research and other responsibilities in the CCMB.
The Centre is already providing DNA diagnostic services for many genetic
disorders such as Thalassemia, Sickle Cell Anemia, Mental Retardation,
Fragile-X Syndrome, Duchenne Muscular Dystrophy, Huntington's Disease,
Azoospermia, etc. The ultimate aim of the Centre is to develop, acquire and
standardize the protocols for carrier detection, prenatal diagnosis and genetic
counseling for all the genetic disorders prevalent in our country. This is an
important achievement for CCMB and CSIR. In recognition of this contribution,
Dr Singh and his group have recently been awarded the CSIR Technology
Award.
2.
DNA fingerprinting using indigenously developed Bkm-derived probe
for phylogenetic analyses
DNA Fingerprinting has so far been used only in individual identification and
establishment of biological relationships owing to its extreme power of resolving
individual specific variation present in the genome.
At the CCMB, Dr Singh and his colleagues by using the indigenously developed
Bkm-derived probe, which is successfully used for human DNA fingerprinting,
have shown, for the first time, that DNA fingerprinting can effectively be used to
infer the generic affinities among related group of animals like crocodilians. This
was hitherto thought not to be feasible largely because the fingerprint profiles
are believed to evolve too rapidly to be informative over large time intervals.
Based on qualitative differences in the fingerprints and quantitative differences
in the copy number of Bkm-related sequences in the genomes, they have been
29
able to infer generic affinities among different species/genera of crocodilians,
which are in agreement with the consensus phylogeny reconstructed using
various other approaches together. This observation is of great importance as it
establishes, for the first time, the potential utility of this molecular technique in
the study of evolutionary relationships of plants and animals. Dr Lalji Singh is
presently using this for wild life preservation and better management of
endangered species in our zoos and also for identification and isolation of
genes for useful characters in silkworm races. This technology is also being
used for medical diagnosis.
3.
Studies on molecular basis of sex determination
Isolation of highly conserved sex chromosome-specific satellite DNA, 'Bkm', from the
female Indian snake, the Banded Krait, made the beginning of the understanding of
the molecular basis of sex-determination, which is one of the most important
unsolved problems in modern biology. Now, this has also become the basis of our
understanding of sex-reversal in humans. For the first time, Dr Lalji Singh and his
colleagues have reported a unique case of sex reversal of an individual who has the
47,XXY chromosome constitution but a female phenotype. This finding of the
occurrence of XXY female with normal SRY, ZFY and SOX9 genes testifies the
involvement of other gene(s) in sex determination.
4.
Sex and germ cell-specific Bkm-binding protein
Bkm sequences in snakes, Bkm-associated Y-specific sequences p102d(2) in
human and M34 in mouse, are interspersed amongst other sequences along the
entire length of the sex-determining chromosomes. The consensus sequence in
these sex chromosome specific repeats is the conserved tetranucleotide repeat
GATA component of Bkm. Dr Singh and his associates have purified a sex- and
germ-cell-specific protein from snake ovary, which specifically binds GATA repeats
of Bkm. This may be the potential signal responsible for the decondensation
(activation) of the sex-determining chromosome. In silkworm Bombyx mori BKMbinding protein (BBP) is expressed predominantly in pupal ovary suggesting its
probable role in bringing about coordinated conformational changes in chromatin to
activate genes present in associated chromosomal domains.
5.
Wildlife Conservation- Genetic variation in Asiatic lions and Indian tigers
Previous reports suggested that Asiatic lions and tigers in India are highly inbred and
exhibit very low levels of genetic variation. Dr Singh and his colleagues' analyses on
these species have shown much higher degree of polymorphism than reported.
Analysis of 38 Asiatic lions, which exist as a single population in the Gir Forest
Sanctuary in India, revealed an average heterozygosity of 25.82%. In Indian tigers,
microsatellite analysis and multilocus fingerprinting on a population of 22 individuals
revealed a heterozygosity of 22.65%. Microsatellite analysis has enabled the
identification of the pure Asiatic lions from the hybrids. Similar analysis of hair
samples enabled them to identify hybrids of Indian and Siberian tigers. Microsatellite
analysis was performed on 50-125 years old skin samples from museum specimens.
Their results show similar levels of genetic variability as in the present population
(21.01%). Studies of Asiatic lions and tigers have further helped in identifying
individuals with high genetic variability which can be used for conservation breeding
programmes. Recently Dr Singh’s group isolated highly polymorphic microsatellite
loci from a partial genomic library of the Asiatic lion, which show much higher levels
of variation.
30
Setting up of LaCONES
Based on the studies of Dr Lalji Singh and his colleagues on Wildlife Conservation,
Government of India has taken a decision to set up a “Laboratory for the
Conservation of Endangered Species (LaCONES)” in Hyderabad close to the
Nehru Zoological Park in collaboration with the Central Zoo Authority of India, New
Delhi; the Dept. of Forests, Govt. of A.P, Hyderabad; the Centre for Cellular &
Molecular Biology (CCMB), Hyderabad and the Dept. of Biotechnology (DBT),
New Delhi. The civil construction of the facility is now complete to the extent of 8090%. The scientists have already developed a semen cryobank of tigers, lions, and
leopards and hope to create egg, embryo and cell banks for future use.
6.
A novel universal approach of species identification for forensic
applications
A PCR-based approach has been established which, without knowing the history of a
forensic sample, can reveal whether the source of the sample is human or animal,
and if animal, which of the 221 animal species. Primers used in these studies are
universal, and thus can be used for number of other species. This approach could be
an ultimate solution for the identification of species for forensic applications.
7.
Conservation genetics of Eld’s deer
Eld’s deer is a highly endangered cervid distributed historically throughout much of
South Asia and Indo-China. Mitochondrial DNA control region was analyzed in these
species to get better understanding of genetic population structure and evolutionary
history. The results suggest a strong degree of phylogeographic structure, both
between subspecies and among population within subspecies, indicating that
dispersal of individuals between populations has been very limited historically. These
findings will be useful for continued managements of these species.
8.
Genetic affinities of Andaman Islanders
Dr Lalji Singh and his group have undertaken the study on genetic diversity in
primitive tribes of India including the tribal populations of Andaman and Nicobar
islands using Y-chromosomal markers and mtDNA sequences. Data indicates that
the Andamanese have closer affinities to Asian than to African populations, and
suggests that they are the descendants of the early Paleolithic colonizers of
Southeast Asia – the hunter gatherers and the first migrants moved out of Africa
about 60,000-100,000 years ago.
9.
DNA based molecular diagnostics
During the studies on various patients from Andhra Pradesh, Dr Lalji Singh and his
group came across several interesting cases which many a times become the basis
for further clinical research in terms of their genetic association and allelic variation.
Sickle cell anemia, Alzheimer’s disease, BCD, male infertility, pancreatitis, and
Robert’s syndrome are some such examples. These studies have further helped in
better understanding of the role played by genetic factors in these diseases, and the
possibility of developing better diagnostic tools for the detection and the
management of such diseases.
31
10.
A highly conserved novel human gene implicated in testicular development
Dr Lalji Singh and his group identified and characterized a novel human gene, which
is predominantly expressed in testis showing two special variants. The overexpressed GFP fusion protein localizes to the nucleus, suggesting a regulatory
function to the protein. The knock out of the gene resulted in sterility in male mice
with abnormal testis completely devoid of germ cells; this testifies involvement of this
gene in testicular development.
11.
Mystery of Our Own Origins
India represents 1/6th of the world population and largest human biodiversity in the
world. Dr Singh and his group at the Centre for Cellular & Molecular Biology,
Hyderabad undertook the genetic biodiversity study of human populations with
special emphasis on the vanishing tribes of Andaman and Nicobar Islands, using Ychromosomal markers and mitochondrial DNA sequencing. Their study has revealed
that two tribes in Andamans are the descendants of the people who migrated 70,000
years ago from Africa. This is considered to be the path breaking work showing that
Onge and Great Andamanese (negreto tribes) have evolved in the Andaman Islands
in genetic isolation independently. For the first time, they provided genetic evidence
in support of out-of-Africa theory and proposed that there was only one wave of
migration out of Africa through the Southern sea route via India. It looks likely that the
first humans crossed the Red sea and spread to Australia via India and Southeast
Asia through the Southern Coastal route. This is in contrast to the prevailing concept
of Northern route of migration. It is really the first time that in less than a year of the
original finding by Dr Singh and his group, the world has accepted a novel finding as
possible answer to how humans migrated. It is indeed a major breakthrough rewriting
the history of human migration. Most recent findings by Dr Singh and his group
indicate that Indian mtDNA pool consists of several deep rooting lineages of
macrohaplogroup ‘M’ suggesting in situ origin of these haplogroups in India and its
subsequent migration to Southeast Asia. These studies further support one wave of
rapid dispersal theory of modern humans along the Asian Coast.
These findings will have deeper implications in relation to disease susceptibility and
individualized medicine. Very rarely such breakthroughs are made which change the
course of history and find immediate international acceptance. Their above finding
has been published in the most prestigious journal, ‘Science’ (with Impact Factor 30)
in the year 2005 and there is a write-up on his work in News and Views of many
journals including Science, New Scientist and many papers published by scientists
abroad have supported his findings. The latest finding in support of his work is titled
“Going East” appeared in Science in 2006.
G.
TEACHING EXPERIENCE
1.
Took B.Sc. and M.Sc. classes in the Zoology Department, Banaras Hindu
University, India, during 1966-1971.
2
Took in situ hybridization practical classes of honours students with Dr K
W Jones, in the Institute of Animal Genetics, University of Edinburgh from
1978-1987.
32
H.
ORGANIZATION OF CONFERENCES & TRAINING COURSES
1.
European Molecular Biology course on in situ hybridization with (Dr J O
Bishop and Dr K W Jones), September 1978, University of Edinburgh,
UK.
2.
International Workshop on Molecular techniques in cytogenetics, with Dr
K W Jones and Prof T Sharma. February-March, 1986, Banaras Hindu
University, Varanasi.
3.
The 3rd International Conference on DNA Fingerprinting, December 1316, 1994, Hyderabad.
4.
A one-day symposium on 'Genome Analysis: Recent Trends and
Applications' on 16th January and 3 weeks hands-on training course on
DNA Fingerprinting from 17th January to 4th February, 1996, Hyderabad.
5.
1st ADNAT Convention “DNA Fingerprinting” on 12th and 13th April, 1997,
Hyderabad
6.
A two-week International Hands-On Training Course
Fingerprinting from 6-19 November, 1997, Hyderabad.
7.
Guha Research Conference, Dec., 1998, Andaman and Nicobar Islands,
India.
8.
2nd ADNAT Convention - two-day symposium and a two-week hands-on
training course on "DNA Technologies: Forensic and Other Applications",
23rd February - 10th March, 1998, Hyderabad.
9.
3rd ADNAT Convention - one-day symposium on "Emerging DNA
Technologies for the next Millennium" on 23rd February, 1999 and twoweek hands-on training course on "Emerging Trends in DNA-based
Diagnosis", February 24 to March 7, 1999, Hyderabad.
10.
XXIII All India Cell Biology Conference during November 27-29, 1999.
11.
4th ADNAT Convention – A Two-day symposium on “DNA Technologies
in the Management of Biodiversity” on 20th and 21st February, 2000 at
MSSRF, Chennai and hands-on residential training course on
“Microsatellite Markers in Genome Diversity” from 23rd February to 5th
March, 2000 at CCMB, Hyderabad.
12.
ISHG 2001 – XXVI Annual Conference of the Indian Society of Human
Genetics – “Human Genome and Beyond” from 20th to 22nd February
2001 in CCMB, Hyderabad
13.
5th ADNAT Convention – A Two-day Symposium on “Perspectives in
Genome Analysis” on 23rd and 24th February 2001 and A Hands-on
Residential Training Course on “Bioinformatics: The Hand-Maiden of
Future Biology” from 25th February to 11th March 2001 in CCMB,
Hyderabad.
14.
6th ADNAT Convention – A Two-day Symposium on “Functional
Genomics” on 23rd and 24th February 2002 and an International Hands-on
33
on
DNA
Training Course on DNA Sequencing and Genotyping from 25th February
to 10th March 2002 in CCMB, Hyderabad.
15.
Silver Jubilee Celebrations (1977-2002 of CCMB – A Six-day Symposium
on “The Current Excitement in Biology” from 24th to 29th November 2002
in CCMB, Hyderabad on the occasion of the Silver Jubilee Celebrations of
CCMB.
16.
7th ADNAT Convention – A Two-day Symposium on Proteomics on 23rd
and 24th February 2003 and Two Simultaneous Hands-On Training
Courses on Proteomics and DNA Microarrays from 25th February to 10th
March 2003.
17.
8th ADNAT Convention – A Two-day Symposium on Comparative and
Functional Genomics Febraury 23 & 24, 2004 and Two Simultaneous
Hands-On Training Courses on DNA Markers: Development and
Applications February 25 to March 12, 2004 and Transgenic and Gene
Knockout Mice Technologies February 25 to March 16, 2004.
18.
9th ADNAT Convention & 30th ISHG – A Two day Symposium on
Molecular Medicine & Health during 20-23 February 2005 and Hands-on
Training Course on Chromosomal & Molecular Diagnostics February 24 –
March 10, 2005.
19.
71st Anniversary General Meeting of Indian National Science Academy –
Symposium on “Stem Cell Research: Technological, Ethical and Social
Issues” during 26-28 December 2005 jointly organized by CCMB, IICT
and NGRI at IICT Auditorum.
20.
10th ADNAT Convention – A Two day Symposium on RNAi and microRNA
in Development and Health during February 23 & 24, 2006 and Hands-on
Training Courese on RNAi in Gene Knockdown & Viral Resistance during
February 25 – March 10, 2006.
21.
The dedication of LaCONES to the Nation by Bharat Ratna, Dr A P J
Abdul Kalam, The Hon’be Presidnet of India on 1st February 2007.
22.
11th ADNAT Convention - A three-day Symposium on Advances in
Structural Biology & Structure Prediction February 23, 24 & 25, 2007 and
Hands-on Training Course on Protein Structure Prediction & Structure
Determination February 26 – March 8, 2007.
23.
The Foundation Stone Laying Ceremony of: Clinical Research Facility for
Stem Cells & Regenerative Medicine (CRF) and National Bio-Safety Level
4 Containment Facility for Human Infectious Diseases (NBCF) by Shri
Kapil Sibal, Hon’ble Union Minister for Science & Technology & Earth
Sciences, Government of India.
24.
12th ADNAT Coonvention – A two-day Symposium on Biology of
Embryonic and Adult Stem Cells February 23 & 24, 2008 and Hands-on
Training Course on Basic Techniques in Stem Cell Biology: Isolation,
Maintenance, and Differentiation February 25 – March 10, 2008.
34
I.
ADMINISTRATIVE EXPERIENCE
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Has been the First In-Charge Officer on Special Duty for the Centre for
DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, since its
inception in 1995 and has been closely involved in planning and setting it
up.
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Since July 1998, has been working as the Director of the Centre for
Cellular & Molecular Biology, Hyderabad, India
J.
SPONSORED RESEARCH/COLLABORATIONS
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Laboratory for conservation of endangered species (LaCONES)
Molecular genetic analysis of Archaeological human specimens:
Taxonomic and health perspectives.
Genomic diversity in the caste, tribal and religious populations of Andhra
Pradesh and its border areas in the broader context of the peopling of
India
Genetic diversity in primitive Indian tribes
Genome diversity in the caste and tribal populations of Himalayan region
Identification of susceptibility genes associated with Type-2 Diabetes
Mellitus in Indian population
Genome diversity in the tribal population of Kumaon region
Molecular epideomiology of alcoholism: The Kota tribe in Niligiri Hlls. The
unique opportunity to study total population.
Cytogenetic and molecular evaluation of infertile males
DNA profiling of tribal populations of Andhra Pradesh
Genome diversity in the selected tribal populations of Maharashtra
Setting up a clinical research facility to develop Stem Cell Technologies
and Regenerative Medicine
National Facility for Real time Imaging of live samples.
Conservation of Endangered Big cats
K.
INTERNATIONAL MEETINGS ATTENDED AFTER RETURNING TO
INDIA IN 1987
1.
First International Conference on DNA Fingerprinting, University of Berne,
Switzerland, 1-3 October, 1990
2.
Boden Conference on Mammalian Sex Chromosomes and Sex
Determination Genes, Sydney, Australia, 3-5 February, 1992
3.
Technology Showcase-1995, Singapore, 12-16 September, 1995
4.
4th International DNA Fingerprinting Conference, Melbourne, Australia, 27 December, 1996
5.
Visit to CNRS, Paris, France, 11-18 May, 1997 to develop a collaboration
in Genome sequencing and analysis including bioinformatics
6.
International meeting on Ethics and Human Genome, UNESCO, Paris,
France, 22-25 July, 1997
35
7.
Meeting of European Centre for Control of Infectious Diseases (ECCID),
Montpellier, France, 10-13 September, 1998
8.
5th International Conference on DNA Fingerprinting, Port Elizabeth, South
Africa, 13-23 January, 1999.
9.
Participated in the Scientific & Technical Advisory Panel of the Global
Environment Facility (GEF) workshop on “Green Certifiers” under United
National Environment Programme at Unidad de Seminarios “Ignacio Chavez”
UNAM, Cd. Universitaria, Mexico on 13th and 14th October, 1999.
10.
To participate in the Twenty-sixth session of the WHO South-East Asia
Advisory Committee on Health Research (WHO/SEA/ACHAR), as a special
invitee, at Thimphu, Bhutan during 18-21 April 2001.
11.
To participate in the in the Joint WHO-THAI Health Research Forum MultiRegional Consultative meeting on “Genomics & Health” during 23-25 July
2001, at Bangkok, Thailand.
12.
To participate in the PAHO-WHO sponsored Conference on “Biotechnology &
Genomics for Improvement of Health in Developing Countries” during 25-27
March 2002 at Havana, Cuba
13.
To participate in the 4th HUGO Pacific Meeting and 5th Asia-Pacific
Conference of Human Genetics during October 27th to 30th, 2002 at Pattaya,
Thailand.
14.
To visit various institutions in Germany as a Leader of the CSIR delegation
during 13-21 September 2003.
15.
To have discussions on possible collaborations and to deliver lectures in
different institutions in UK during 22 August to 7 September 2004 under
INSA-Royal Society International Collaboration Exchange Programme.
16.
Visit to Lyon, France to see their P4 facility during 16th to 20th October 2004.
17.
Visit to USA and Canada to see the BSL4 facilities along with CSIR-DST-ICMR
Delegation during 24 July to 4th August 2005.
18.
Visit to USA to see the Stem Cell facilities along with CSIR CCMB)-DST-NIMS during
4th to 13th August 2006.
19.
To participate and deliver a lecture at the Symposium on “New Challenges in the Life
Sciences: Prioritizing European Research in Molecular Systems Biology, Florence,
Italy during October 18-19, 2007.
L.
MEMBERSHIP OF PROFESSIONAL SOCIETIES
1.
2.
3.
4.
5.
Member (Past President) of Indian Society of Cell Biology
Member of Society of Biological Chemists of India
Past President of Indian Society of Human Genetics
Member (Past President) of P M Bhargava Foundation
Founder Member and President (formerly Secretary) of the Association for
the Promotion of DNA Fingerprinting and Other DNA Technologies
Member, Indian Academy of Social Sciences
6.
36
7.
8.
9.
Member, Professor S P Ray-Chaudhuri Memorial Foundation
Secretary, The Medically Aware and Responsible Citizens of Hyderabad
(MARCH)
Member, Guha Research Conference
M.
FELLOWSHIP OF INDIAN/FOREIGN ACADEMIES
1.
2.
3.
4.
5.
6.
7.
Fellow of Indian Academy of Sciences, elected in 1989
Fellow of National Academy of Sciences, elected in 1991
Fellow of Indian National Science Academy, elected in 1993
Fellow of Andhra Pradesh Akademi of Sciences, elected in 2000
Fellow of the National Academy of Agricultural Sciences, elected in 2001
Fellow of the National Academy of Medical Sciences, elected in 2002
Fellow of the Third World Academy of Sciences, elected in 2002
N.
MEMBERSHIP OF THE EDITORIAL BOARDS
1.
2.
3.
4.
5.
6.
7.
8.
9.
Journal of Biosciences (former member)
Journal of Basic & Applied Biomedicine
Journal of Genetics
Journal of Forensic Medicine and Toxicology
International Journal of Human Genetics
Indian Journal of Biotechnology
Proceedings of Andhra Pradesh Akademi of Sciences
ICFAI Journal of Science & Technology
Journal of Intellectual Property Rights
O.
MEMBERSHIP OF PROFESSIONAL COMMITTEES
Scientific Advisory Committees
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General Body of Bihar Council on Science & Technology (BCST), Patna
Osmania University, Hyderabad
Department of Biotechnology, New Delhi
Institute of Cytology & Preventive Oncology (ICMR), New Delhi
National Institute of Virology, Pune
Dr B R Ambedkar Centre for Biomedical Research, New Delhi
Institute of Immunohaemotology (ICMR), Mumbai
National Institute of Nutrition (ICMR), Hyderabad
Genome Research Centre, M S University, Baroda
C-MMACS, Bangalore
Dabur Research Foundation
Research Advisory Committees
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National Bureau of Fish Genetic Resources (ICAR), Lucknow
National Bureau of Animal Genetic Resources (ICAR), Karnal, Haryana
Seribiotech Research Laboratories, Bangalore
A.P. State Sericulture Research and Development Institute, Hindupur, A.P.
Indian Agricultural Research Institute (IARI), New Delhi (2001-2004)
Chairman, Research Advisory Committee, Biomedical Research Unit, Manovikas
Kendra, Calcutta.
Member, Research Council of Institute of Genomics and Integrative Biology
(IGIB), Delhi (2004-2007)
37
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Member, Animal Sciences and Biotechnology Research Committee of HRDG,
CSIR (2004-2007)
Member, Committee on Gene Patenting, DBT
Member, Advisory Committee of MAGENE Life Sciences Pvt. Ltd.
National-level Committees
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Member, Research & Development Advisory Committee for Gujarat State
Biotechnology Mission, Gujarat
Member, Academic Council, Central Institute of Fisheries Education (CIFE) (20062008)
Co-Chairman, DBT Task Force on Animal Biotechnology
Member, CSIR Sectoral Group on Biology and Biotechnology
Member, Sub-Group of Experts on Jarawa Tribes, Planning Commission.
Member, Life Sciences Research Development Board (LSRDB), Department of
Science & Technology, New Delhi
Member, National Advisory Committee for establishing the National Repository on
Human Genetic Resources and Data, Anthropological Survey of India, Kolkata
Steering Committee for Establishment of National Institute of Animal
Biotechnology, Department of Biotechnology, New Delhi
The Scientific Advisory Group, the Division of Basic Medical Sciences, Indian Council
of Medical Research, New Delhi
Programme Advisory Committee, DST, New Delhi
NABL Technical Committee for Accreditation of DNA Fingerprinting Laboratories,
DST, New Delhi
Sectional Committee, Indian National Science Academy, New Delhi
Management Council, Centre for Biotechnology (CSIR), New Delhi
Biotechnology Research Promotion Committee, DBT, New Delhi
Task Force on Human Genetics, DBT, New Delhi
Academic Council, Central Institute of Fisheries Education (ICAR), Mumbai
ICAR-NATP Project, New Delhi
Committee on Plant Genetic Resources, Indian Council of Agricultural Research
(ICAR), New Delhi
Task Force on New Initiative in Genome Analysis, ICMR, New Delhi
Central Ethical Committee on Human Research of ICMR
Scientific Panel on Horticulture Division of ICAR
Animal Sciences and Biotechnology Research Committee, HRDG, CSIR
Member, CSIR Governing Body (2004-2007)
Member, CSIR Society (2004-2007)
Member, National Advisory Committee of the Anthropological Survey of India
Member, Gujarat Council of Biotechnology (2005-)
Member, National Advisory Committee for establishing a National Repository on
Human Genetic Resource and Data (October 2005-)
Member, National Police Mission, Home Secretary, Govt. of India
Member, National Biotechnology Regulatory Authority of DBT
Chairman, Advisory Committee on Biological Toxins, Ministry of Environment of
Forests.
Chairman, Setting up of a World Class Drug Research Institute of CSIR
Member, General Body of the Bihar Council on Science & Technology, Bihar
State-level Committees
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Academic Senate, Osmania University, Hyderabad
Advisory Committee of Andhra Pradesh Technology Development & Promotion
Centre (APTDC)
38
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School Board of School of Life Sciences, University of Hyderabad
Biotechnology Committee, Acharya N G Ranga Agricultural University, Hyderabad
Governing Body, Osmania University, Hyderabad
State Biotechnology Co-ordination Committee, Govt. of Andhra Pradesh,
Hyderabad
Chief Minister’s Pharma Task Force, Government of Andhra Pradesh, Hyderabad
District Level Advisory Committee, Hyderabad District for Pre-Natal Diagnostic
Techniques Act-1994
Chairman, Governing Body for the Osmania University College of Science, OU,
Hyderabad.
Honorary Advisor of the Center for Stem Cells Sciences, Hyderabad
Other Committees
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FICCI Working Group on Knowledge Trade Initiative: Sub-Group on New Bio
Technology
Executive Committee, All India Biotech Association, New Delhi.
Scientific Review Committee, National Institute of Biologicals (Ministry of Health and
Family Welfare), New Delhi
Board of Trustees, Hyderabad Eye Research Foundation, Hyderabad
Advisory Council (for setting up a research centre for stem cells and tissue
engineering), Reliance Industries Limited, Mumbai
Member, National Committee for establishing Molecular Medicine, Sanjay Gandhi
Postgraduate Institute of Medical Sciences, Lucknow
Advisory Committee, Biotechnology Dept., University of Pune
Institutional Biosafety Committee (IBSC), (Transgene Vaccine Limited,
Hyderabad), M/s Serum Institute of India Limited (SIIL), Pune
Council of the Society of Biosciences, Muzaffarnagar, U.P
Advisory Committee, UGC-Special Assistance to MCB Department of IISc,
Bangalore
Amity Science and Technology Congress Foundation, New Delhi
FICCI Pharmaceuticals and Biotechnology Committee
President, Indian Society of Cell Biology (2001-2003)
President, Indian Society of Human Genetics (2003-2006)
Vice-Chairman, Advisory Committee of the Avanthi Group of Institutions
DBT Representative of the Institutional Biosafety Committee of Dr. Reddy’s
Laboratories Limited, Hyderabad
Date Safety Monitoring Board, Dr Reddy’s Laboratories Limited, Hyderabad
Member of the Board of Management of the Sri Devaraj Urs Academy of Higher
Education & Research, Kolar, Karnataka (2007-2009)
Member of the Executive Council of the National Academy of Agricultural
Sciences (NAAS) (2007-2010)
39