Online appendix B: Excluded publications Studies withdrawn due to unusable data Data not extractable: Bauwens O, Dusart M, Pierard P, Faber J, Prigogine T, Duysinx B, et al. Endobronchial ultrasound and PET mediastinal hot spots in lung cancer patients. European Respiratory Journal 2007:E3202. Gilbert S, Wilson DO, Christie NA, Luketich JD, Schuchert MJ. Does endobronchial ultrasonography have a place in the thoracic surgeon's armamentarium? AATS Annual Meeting Abstracts 2008. Kennedy MP, Jimenez CA, Morice RC, Mhatre AD, Ravella S, Sarkiss M, et al. The diagnosis of mediastinal lymphadenopathy by endobronchial ultrasound guided needle aspiration in an academic cancer. Chest 2007;132(4):591b-. Krasnik M, Herth F, Vilmann P, Skov BG, Larsen SS. A comparison of endobronchial ultrasound guided biopsy and positron emission tomography with integrated computer tomography in lung cancer staging. Chest 2005;128(4):323S-b-. Wallace MB, Pascual JMS, Raimondo M, Woodward TA, McComb BL, Crook JE, et al. Minimally invasive endoscopic staging of suspected lung cancer. JAMA : the journal of the American Medical Association 2008;299(5):540-6. Overlapping/repeat data: Annema JT, Versteegh MIM, Veselic M, Rabe KF. EBUS-TBNA vs mediastinoscopy for the staging of lung cancer. European Respiratory Journal 2006:Abstract 3091. Herth FJ, Eberhardt R, Vilmann P, Ernst A, Krasnik M. EBUS guided biopsy for the diagnosis of mediastinal lymph nodes in a radiologically normal mediastinum.. Chest 2005;128(4):211S-. Herth FJ, Eberhardt R, Krasnik M, Ernst A. Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration of Lymph Nodes in the Radiologically and PET Normal Mediastinum in Patients with Lung Cancer. Chest 2008;133:887-891. Krasnik M, Herth F, Eberhardt R, Vilmann P, Ernst A. EBUS guided biposy for the diagnosis of mediastinal lymph nodes in a radiologically normal mediastinum. 4th EACTS-ESTS Joint Meeting, September 25, 2005-September 28, 2005, Barcelona Spain 2005. Krasnik M, Herth F, Ernst A, Eberhardt R, Vilmann P. EBUS-TBNA: a new method of endoscopic transbronchial real time ultrasound guided biposy for diagnosis of mediastinal lymph nodes. 4th EACTS-ESTS Joint Meeting, September 25, 2005-September 28, 2005 2005. Nakajima T, Yasufuku K, Iyoda A, Yoshida S, Suzuki M, Sekine Y, et al. The evaluation of lymph node metastasis by endobronchial ultrasound- guided transbronchial needle aspiration: crucial for selection of surgical candidates with metastatic lung tumors. The Journal of thoracic and cardiovascular surgery 2007;134(6):1485-90. Nakajima T, Yasufuku K, Sherif M, Suzuki H, Nagato K, Yamada Y, et al. Evaluation of Mediastinal Lymph Node Metastasis by Endobronchial Ultrasound Guided Transbronchial Needle Aspiration in Patients with Metastatic Lung Tumors. American journal of respiratory and critical care medicine 2007:Board #G44, Page: A619. Rintoul R, Buttery R, Hardy C, Rassl D, Carroll N. Endobronchial and endoscopic ultrasound for assessment of pet positive mediastinal lymph nodes. European Respiratory Journal 2007:Abstract P3875. Yasufuku K, Nakajima T, Wong M, Ishibashi F, Yamada Y, Suzuki H, et al. Systematic Mediastinal and Hilar Lymph Node Sampling in Lung Cancer Patients Using Endobronchial Ultrasound Guided Transbronchial Needle Aspiration. Proceedings of the American Thoracic Society 2006:A542 [Poster Board #916]. Yasufuku K, Chiyo M, Sekine Y, Chhajed PN, Shibuya K, Iizasa T, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes. Chest 2004;126(1):122-8. Excluded after detailed review of content Not about EBUS: Bernasconi M, Chhajed PN, Gambazzi F, Bubendorf L, Rasch H, Kneifel S, et al. Combined transbronchial needle aspiration and positron emission tomography for mediastinal staging of NSCLC. European Respiratory Journal 2006;27(5):889-894. Review articles: Eberhardt R, Herth FJF. Endosonography in diagnosis and staging of lung cancer. Pneumologie (Stuttgart Germany) 2006;60(9):562-7. Herth F, Hecker E, Hoffmann H, Becker HD. Endobronchial ultrasound for local tumour and lymph node staging in patients with centrally growing lung cancer. Ultraschall in der Medizin (Stuttgart Germany : 1980) 2002;23(4):251-5. Herth FJ, Krasnik M, Vilmann P. EBUS-TBNA for the diagnosis and staging of lung cancer. Endoscopy 2006;38(Suppl 1):S101-5. Lennon AM, Rintoul RC, Penman ID. Competition for EUS/ EBUS-TBNA/ video assisted thoracoscopy. Endoscopy 2006;38(Suppl 1):S80-3. Ogita S, Robbins DH, Blum RH, Harris LJ. Endoscopic ultrasound fine-needle aspiration in the staging of non- small-cell lung cancer. Oncology (Williston Park N.Y.) 2006;20(11):141925. Trisolini R, Agli LL, Patelli M. Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration of the mediastinum (8). Chest 2004;126(3):1005-1006. Woelke K, Rausch V, Granetzny A. Mediastinal lymph node staging with endobronchial ultrasound (EBUS) and mediastinoscopy - A comparison of both methods. Atemwegs- und Lungenkrankheiten 2006;32(8):343-344. Not solely about lung cancer: Herth FJ, Eberhardt R, Vilmann P, Krasnik M, Ernst A. Real-time endobronchial ultrasound guided transbronchial needle aspiration for sampling mediastinal lymph nodes. Thorax 2006;61(9):795-8. Kotsianos-Hermle D, Scherr M, Wirth S, Rieger J, Huber RM, Reiser M, et al. Visualization of bronchial lesions using multidetector CT and endobronchial ultrasound (EBUS). Eur J Med Res 2007;12(2):84-9. Krasnik M, Skov B, Eberhardt R, Herth F. Ebus TBna compared to mediastinoscopy. European Respiratory Journal 2007:Abstract 210. Patel NM, Pohlman A, Husain A, Noth I, Hall JB, Kress JP. Conventional transbronchial needle aspiration decreases the rate of surgical sampling of intrathoracic lymphadenopathy. Chest 2007;131(3):773-8. Vincent BD, El BE, Hoffman B, Doelken P, De Rosimo J, Reed C, et al. Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration. The Annals of thoracic surgery 2008;85(1):224-30. Not about mediastinal staging: Gomez S, Andreo F, Castella E, Llatjos M, Perez-Izquierdo J, Astudillo J, et al. Real-time needle aspiration with endobronchial ultrasound (rtna-ebus) for lung cancer staging in patients without enlarged mediastinal lymphadenopathy on computed tomography. European Respiratory Journal 2007:Abstarct 1282. Herth F, Becker HD, Ernst A. Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial. Chest, 2004:322-5. Herth FJ, Eberhardt R. Actual role of endobronchial ultrasound (EBUS). Eur Radiol 2007;17(7):1806-12. Kanoh K, Miyazawa T, Kurimoto N, Iwamoto Y, Miyazu Y, Kohno N. Endobronchial ultrasonography guidance for transbronchial needle aspiration using a double-channel bronchoscope. Chest, 2005:388-93. Koh MS, Tee A, Wong P, Antippa P, Irving LB. Advances in lung cancer diagnosis and staging: endobronchial ultrasound. Intern Med J 2007. Krasnik M, Vilmann P, Skov B, Eberhardt R, Herth F. Combined endoscopic transbronchial transbronchial and transoesophageal ultrasound-guided biopsy of centrally located lung tumours following a nondiagnostic bronchoscopy. European Respiratory Journal 2007:Abstract E3203. Pascual J, Wallace M, Raimondo M, Woodward T, Johnson M. A prospective double blind comparison of endoscopic ultrasound, endobronchial ultrasound and bronchoscopic fine needle aspiration for malignant mediastinal lymph nodes. European Respiratory Journal 2007:Abstract E3185. Rintoul RC, Buttery RC, Stewart S, Wallace WA, Walker WS, Skwarski KM. Endobronchial Ultrasound Guided Transbronchial Needle Aspiration Can Avoid the Need for Mediastinoscopy in Lung Cancer Staging. Proceedings of the American Thoracic Society 2006:A609 [Poster Board #H37] Rintoul RC, Skwarski KM, Murchison JT, Hill A, Walker WS, Penman ID. Endoscopic and endobronchial ultrasound real-time fine-needle aspiration for staging of the mediastinum in lung cancer. Chest 2004;126(6):2020-2. Shannon JJ, Bude RO, Orens JB, Becker FS, Whyte RI, Rubin JM, et al. Endobronchial ultrasound-guided needle aspiration of mediastinal adenopathy. American journal of respiratory and critical care medicine 1996;153(4 Pt 1):1424-30. Williams WL, Naseer R, Mills J, Edwards J, Howells J, Munavvar M. Comparative yield of transbronchial needle aspiration (conventional and endobronchial ultrasound guided) and PET-CT in the evaluation of mediastinal malignancy. Thorax 2007;62(Supplement 3):72 (Abstract P196). Re-staging: Herth FJF, Krasnik M, Annema J, Ernst A, Eberhardt R, Rintoul R. Endobronchial ultrasound-TBNA for mediastinal restaging after neoadjuvant chemotherapy. European Respiratory Journal 2007:Abstract 1280. Herth F, Yasufuku K, Eberhardt R, Krasnik M, Annema J, Anantham D, et al. EBUS-TBNA for mediastinal restaging after induction chemotherapy for non-small cell lung. Chest 2007;132(4):466-. Herth FJF, Yasufuku K, Eberhardt R, Ernst A, Krasnik M. EBUS-TBNA for Mediastinal Restaging. Proceedings of the American Thoracic Society 2006:A610 [Poster Board #H44]. Krasnik M, Ernst A, Eberhardt R, Yasufuku K, Herth F. EBUS-TBNA FOR MEDIASTINAL RESTAGING. Chest 2006;130(4):115S-c-. Krasnik M, Ernst A, Eberhardt R, Yasufuku K, Herth F. EBUS-TBNA for Mediastinal Restaging. The American Association for Thoracic Surgery, 87th Annual Meeting, 2007 Program and Abstracts 2007. Reports excluded on basis of abstract or title Not about EBUS: Al-Haddad M, Wallace MB. EUS-FNA and biomarkers for the staging of non-small cell lung cancer. Endoscopy 2006;38(Suppl 1):S114-7. Anandasabapathy S. Endoscopic ultrasound: indications and applications. The Mount Sinai journal of medicine New York 2006;73(4):702-7. Annema JT, Hoekstra OS, Smit EF, Veseliç M, Versteegh MIM, Rabe KF. Towards a minimally invasive staging strategy in NSCLC: analysis of PET positive mediastinal lesions by EUS-FNA. Lung cancer (Amsterdam Netherlands) 2004;44(1):53-60. Annema JT, Versteegh MI, Veseliç M, Welker L, Mauad T, Sont JK, et al. Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. JAMA : the journal of the American Medical Association 2005;294(8):931-6. Annema JT, Veseliç M, Rabe KF. Analysis of subcarinal lymph nodes in (suspected) nonsmall-cell lung cancer after a negative transbronchial needle aspiration - What's next? A preliminary report. Respiration 2004;71(6):630-634. Annema JT, Veseliç M, Rabe KF. EUS-FNA in diagnosing lung cancer after a non-diagnostic brochoscopy and its impact on preventing surgery. Proceedings of the American Thoracic Society 2005;2(Abstracts issue):A912. Barawi M, Gress F. EUS-guided fine-needle aspiration in the mediastinum. Gastrointestinal endoscopy 2000;52(6 Suppl):S12-7. Bhutani MS. Endoscopic ultrasound. Endoscopy 2005;37(11):1084-1088. Bhutani MS, Suryaprasad S, Moezzi J, Seabrook D. Improved technique for performing endoscopic ultrasound guided fine needle aspiration of lymph nodes. Endoscopy 1999;31(7):550-3. Brakel K, van OH. Oesophageal endoscopic ultrasound with fine-needle aspiration biopsy in the staging of non-small-cell lung carcinoma; results from 43 patients. Nederlands tijdschrift voor geneeskunde 2006;150(15):878. Caddy G, Conron M, Wright G, Desmond P, Hart D, Chen RY. The accuracy of EUS-FNA in assessing mediastinal lymphadenopathy and staging patients with NSCLC. The European respiratory journal : official journal of the EuropeanSociety for Clinical Respiratory Physiology 2005;25(3):410-5. Caddy GR, Chen RY. Current clinical applications of endoscopic ultrasound. ANZ journal of surgery 2007;77(3):101-11. Cerfolio RJ, Bryant AS, Eloubeidi MA. Routine mediastinoscopy and esophageal ultrasound fine-needle aspiration in patients with non-small cell lung cancer who are clinically N2 negative: a prospective study. Chest 2006;130(6):1791-5. Cerfolio RJ, Bryant AS, Scott E, Sharma M, Robert F, Spencer SA, et al. Women with pathologic stage I, II, and III non-small cell lung cancer have better survival than men. Chest 2006;130(6):1796-802. Chang YL, Lee YC, Shih JY, Wu CT. Pulmonary pleomorphic spindle cell carcinoma: peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma. Lung cancer (Amsterdam Netherlands) 2001;34(1):91-7. Craanen ME, Comans EFI, Paul MA, Smit EF. Endoscopic ultrasound guided fine-needle aspiration and 18FDG-positron emission tomography in the evaluation of patients with nonsmall cell lung cancer. Interactive cardiovascular and thoracic surgery 2007;6(4):433-6. De Luca L, Di Bella S, D'Amore E. Mediastinal and gastric EUS: indications and technique of examination. Minerva medica 2007;98(4):423-9. Dooms C, Vansteenkiste J. Positron emission tomography in nonsmall cell lung cancer. Current opinion in pulmonary medicine 2007;13(4):256-60. Eloubeidi MA. Endoscopic ultrasound-guided fine-needle aspiration in the staging and diagnosis of patients with lung cancer. Semin Thorac Cardiovasc Surg 2007;19(3):206-11. Fritscher-Ravens A, Petrasch S, Reinacher-Schick A, Graeven U, Konig M, Schmiegel W. Diagnostic value of endoscopic ultrasonography-guided fine-needle aspiration cytology of mediastinal masses in patients with intrapulmonary lesions and nondiagnostic bronchoscopy. Respiration 1999;66(2):150-5. Fukui T, Shimizu Y, Takanashi S, Nishizawa K, Minamimura H, Ishikawa T, et al. Acute pulmonary thromboembolism with a floating right-heart thrombus. 4 surgical cases. Jpn J Thorac Cardiovasc Surg 2001;49(2):113-6. Fusaroli P, Caletti G. Endoscopic ultrasonography. Endoscopy 2005;37(1):1-7. Fusaroli P, Caletti G. Endoscopic ultrasonography. Endoscopy 2007;39(1):17-20. Gavril'ev SS, Nikolaev VP, Vinokurova MK, Petukhova N, Gavril'eva LP, Malogulova I. Improved technology of chemotherapy of pulmonary tuberculosis complicated by other diseases. Probl Tuberk 2001(2):8-11. Ghaye B, Dondelinger RF. Imaging guided thoracic interventions. Eur Respir J 2001;17(3):507-28. Gill KRS, Wallace MB. Endoscopic ultrasound and staging of non-small cell lung cancer. Minerva medica 2007;98(4):323-30. Gress FG, Savides TJ, Sandler A, Kesler K, Conces D, Cummings O, et al. 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