PUBLICATIONS:
Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., de Waal Malefyt, R. (2004). IL-22 activates
STAT3 and induces IL-10 by colon epithelial cells. Intl. Immunopharmacology 4 679-691.
Hurst,H. D., Muchamel,T., Gorman,D., Gilbert,J.M., Clifford,T,, Kwan, S., Menon, S., Seymour, B.,
Jackson, C., Kung, T.T., Brieland, J.K., Zurawski, S., Chapman, R.W., Zurawski, G. and Coffman,
R.,L (2002).New Il-17 family members promoteTh1 or Th2 responses in the lung: In vivo function of
the novel cytokine Il-25. J. Immunol 169: 443-453.
Debets,R.,Timans,J.C. , Homey,B., Zurawski,S., Sana,T.R., Lo,S., Wagner,J,Edwards,G.,
Cifford,T., Menon,S.,Bazan,J.F. and Kastelein, R.A.(2001) Two novel IL-1 family members, IL-1
delta and Il-1epsilon,function as an antagonist and agonist of NF-kappa b activation through the
orphan IL-1 receptor-related protein 2. J.Immunol 167:1440-1446.
Fort, M.M.,Lesley, R., Davidson,N.J., Menon, S., Brombacher,F., Leach, M.W.and Rennick,
D.M.(2001) Interleukin 4 exacerbates disease in aTH1 T cell transfer model of colitis. J. Immunol
166:2793-2800.
Fort M.M.,Cheung,J., Yen,D.,Li,J., Zurawski,S.M., Lo,S., Menon,S., Clifford,T., Hunte,B., Lesley,R.,
Muchamel,T., Hurst,S.D., Zurawski,G., Leach,M.W., Gorman,D.M. and Rennick,D.M.(2001) Mouse
Il17E: a unique member of the IL17 family that induces TH2-associated responses in vivo.Immunity
50: 985-995.
Rossi, D. L., Hurst, S. D., Xu,Y.,Wang, W., Menon, S., Coffman, R. L. and Zlotnik, A. (1999)
Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells.
J.Immunol 162 : 5490-5497.
Namikawa, R., Muench, M. O., Firpo,M. T., Humeau, L.,Xu, Y., Menon,S. and Roncarolo,M.G.
(1999)
Administration of Flk2/Flt3 ligand induces expansion of human highly-Proliferative
potentialcolony-forming cells in the SCID hu mouse. Exp. Hematology 27: 1029-1037.
Hoover,D. M., Schalk-Hihi,C., Chou, C-C, Menon, S., Wlodawer, A. and Zadanov, A. Purification of
receptor complexes of Interleukin-10.(1999) Eur. J. Biochem.262, 134-141.
Boyaka, P. N., Marinaro, M., Jackson, R.J., Menon, S., Kiyono, H., Jirillo,E., and McGhee, J. R.
(1999) IL-12 is an effective adjuvant for induction of mucosal immunity . J. Immunol. (1999)
162:122-128.
Halfon,S., Ford, J., Foster,J., Dowling, L., Lucian, L., Sterling, M., Xu, Y.,Weiss, M., Ikeda, M.,
Ligget,D.,Helms,A., Caux, C., Lebecque,S., Hannum,C., Menon,S., McClanahan, T., Gorman, D.,
and Zurawski, G. (1998) Leukocystatin, a new class II cystatin expressed selectively by
hematopoitic cells. J. Biol. Chem. 273(26): 16400-08.
Davidson, N. J., Hudak, S. A., Lesley, R.E., Menon,S., Leach, M.W. and Rennick, D. I L-12, but not
IFN -g, plays a major role in sustaining the chronic phase of colitis in IL-10 deficient mice. (1998) J
Immmunol 161:3143-3149.
Hunter, C.A., Timans,J., Piscane,P., Cai, G., Walker, W., Aste-Amezaga, R., Bazan,J.F. and
Kastelein, R. (1997) Comparison of the effects of interleukin-1alpha, interleukin-1 beta and I
interferon-gamma -inducing factor on the production of interferon gamma by natural killer cells.
Eur.J Immunol 27(11): 2787-92.
Hudak, S.,Leach, M.W., Xu, Y., Menon, S. and Rennick, D. (1998) Radioprotective effects of the
FLK2/FLK3 ligand. J. Exp Hematol. 26:515-522.
Robinson,D., Shibuya, K., Zonin, F., Murphy, E., Sana, T., Hartley, S., Menon, S. Kastelein, K.,
Bazan, F. and O'Garra, A. (1997). IGIF does not drive Th1 development, but synergizes with IL-12
for Interferon gamma production through activation of IRAK and NF- B. Immunity 7(4):1533-40.
Bernardini, G. Hedrick, J., Sozzani, S., Luini, W., Spinetti, G., Weiss, M., Menon, S., Zlotnik, A.,
Mantovani, A., Santoni, A. and Napolitano, M. (1997). Identification of C-C chemokine TARC,
Macrophage inflammatyory protein -1 beta as novel functional ligands for the CCR8 receptor. Eur.
J. Immunol. 1998 28:582-588
Vicari, A. P., Figueroa, D. J., Hedrick, J. A., Foster, J. F., Singh, K. P., Menon, S., Copeland, N. G.,
Gilbert, D. J., Jenkins, N. A., Bacon, K. B. and Zlotnik, A. (1997). TECK: A novel CC chemokine
specifically expressed by thymic dendritic cells and potentially involved in T cell development.
Immunity 7:1-20.
Adema G. J., Hartgers, F., Verstraten, R., de Vries, E., Marland, G., Menon, S., Foster, J., Xu, Y.,
Nooyen, P., McClanahan, T., Bacon, K. and Figdor, C. G. (1997) A dendritic-cell-derived C-C
chemokine that preferentially attracts naive T cells. Nature 387 (6634): 713-717.
Zadnov, A., Schalk-Hihi, C., Menon, S., Moore, K. and Wlodawer, A. (1996). Crystal structure of
Epstein-Barr virus protein BCRF1, a homolog of cellular Interleukin-10. (1997) J. Mol. Biol. 268 (2):
460-467.
Berg, D.J., Davidson, N., Kuhn, R., Muller, W., Holland, G., Thompson-Snipes, L., Leach, M. W. and
Rennick, D. (1996). Enterocolitis and colon cancer in Interleukin-10-deficient mice are associated
with abberant cytokine production and CD4+ TH1-like responses. J. Clin. Invest. 98 (4): 1010-1020.
Hedrick, J.A. Saylor,V., Figueroa, D. Mizoue, L. Xu, Y., Menon,S., Abrams, J., Handel, T. and
Zlotnik, A. (1997). Lymphotactin attracts NK cells and T cells in vivo. J. Immunol 158 (4): 15331540.
Muchamuel, T., Menon, S., Pisacane, P.,Howard, M. C. and Cockayne, D. (1997). Interleukin-13
protects mice against lipopolysaccharide-induced lethal endotoxemia: Correlation with downmodulation of TNF- , IFN- , and IL-12 production. J. Immunol 158 (6): 2898-2903.
Hudak, S., Hunte, B., Culpepper, J., Menon, S., Hannum, C., Thomson-Snipes, L. and Rennick, D.
(1995). FLT3/FLK2 ligand promotes the growth of murine stem cells and spleen colony forming
units. Blood 85 (15): 2774-2955.
Berg, D.J., Kuhn, R., Rajewsky, K., Muller, W., Menon, S., Davidson, N., Grünig, G. and Rennick, D.
(1995). Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic
shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96: 2339-2347.
Muench, M.O., Roncarolo, M.G., Menon, S., Xu, Y., Kastelein, R., Zurawski, S., Hannum, C.H.,
Culpepper, J., Lee, F. and Namikawa, R. (1995). Flt-2/Flt-3 ligand regulates the growth of early
myeloid progenitors isolated from human fetal liver. Blood 84 (4): 963-972.
Powrie, F., Leach, M.W., Mauze, S., Menon, S., Caddle, L.B., Coffman, R.L. (1994). Inhibition of
Th1 responses prevents inflammatory bowel-disease in SCID mice reconstituted with CD45RB(HI)
CD4+ T-cells. Immunity 1 (7): 553-562.
Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Zurawski, S., Bazan, F., Kastelein, R.,
Hudak, S., Wagner, J., Mattson, J., Luh, J., Duda, G., Martina, N., Peterson, D., Menon, D.,
Shanafelt, A., Muench, M., Kelner, G., Namikawa, R., Rennick, D., Roncarolo, M.G., Zlotnik, A.,
Rosnet, O., Dubreuil, P., Birnbaum, D. and Lee, F. (1994) Ligand for FLT3/FLK2 receptor tyrosine
kinase regulates growth of hematopoietic stem-cells and is encoded by variant RNAs. Nature 368
(6472): 643-648.
Culpepper, J., Hannum, C., Mattson, J., Luh, J., McClanahan, T., Campbell, D., Zurawski, S.,
Wagner, J., Hudak, D., Martina, N., Rennick, D., Peterson, D., Kastelein, R., Menon, S., Dang, W.,
Bazan, F., Muench, M., Kelner, G., Roncarolo, M.G., Zlotnik, A., Rosnet, O., Dubreuil, P., Birnbaum,
D. and Lee, F. (1994). Characterization of the ligand for FLT3/FLK2 receptor. FASEB Journal 8 (5):
963. Abstract.
Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Duda, G., Zurawski, S., Rennick, D.,
Wagner, J., Martina, N., Kastelein, R., Shanafelt, A., Peterson, D., Menon, S., Dang, W., Mattson,
J., Luh, J., Bazan, F., Rosnet, O., Dubreuil, P., Birnbaum, D. and Lee, F. (1994). The ligand for
FLT3/FLK2. J. Cell. Biochem. S18A: 19. Abstract.
Muench, M., Menon, S., Kastelein, R., Hannum, C., Culpepper, J., Zurawski, S., Cupp, J., Lee, F.,
Roncarolo, M.G. and Namikawa, R. (1994). FLT3/FLK2-ligand stimulates the growth of human fetal
liver progenitors. Experimental Hematology (Charlottsville) 22 (8): 737. Abstract.
Hunte, B., Hudak, S., Menon, S., Hannum, C., Lee, F., Campbell, D., Culpepper, J. and Rennick, D.
(1994). The effects of FLT3 ligand on the growth of myeloid and lymphoid progenitor cells.
Experimental Hematology (Charlottsville) 22 (8): 720. Abstract.
Doherty, T.M., Kastelein, R., Menon, S., Andrade, S. and Coffman, R.L. (1994). Modulation of
murine macrophage function by Interleukin-13. J. Cell. Biochem. Suppl 0 (18D): 301. Abstract.
Ishida, H., Muchamel, T., Sakaguchi, S., Andrade, S., Menon, S. and Howard, M. (1994).
Continuous administration of anti-IL-10 antibodies delays onset of autoimmunity in NZB/W F1 mice.
J. Exp. Med. 179 (1): 305-310.
Powrie, F., Menon, S. and Coffman, R.L. (1993). Cooperation between IL-4 and IL-10 results in
inhibition of DTH responses. J. Immunol. 150 (8 part 2): 203A. Abstract.
Bean, A., Freiberg, R., Andrade, S., Menon, S., and Zlotnik, A. (1993). IL-10 and/or IL-4 protect
mice against staphylococcal enterotoxin B SEB-induced lethal shock. J. Immunol. 150 (8 part 2):
173A. Abstract.
Grimaldi, C., Menon, S., Muchamuel, T., Santos, L.and Howard, M. (1993). Production of soluble
murine CD38 for studying its biological functions. J. Cell Biochem. Suppl. 0 (17 part B): 213.
Abstract.
Doherty, T.M., Kastelein, R., Menon, S., Andrade, S. and Coffman, r.L. (1993). Modulation of
murine macrophage function by IL-13. J. Immunol. 151 (12): 7151-7160.
Powrie, D., Menon, S., and Coffman, R.L. (1993). Interleukin-4 and interleukin-10 synergize to
inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23 (11) 3043-3049.
Bean, A.G., Freiberg, R.A., Andrade, S., Menon, S. and Zlotnik, A. (1993). Interleukin 10 protects
mice against staphylococcal enterotoxin B-induced shock. Infect. Immunol. 61 (11): 4937-4939.
McKenzie, A.N., Culpepper, J., de Waal Malefyt, R., Briere, F., Punnonen, J., Aversa, G., Sato, A.,
Dang, W., Cocks, B.G., Menon, S. et al. (1993). Interleukin 13, a T-cell-derived cytokine that
regulates human monocyte and B-cell function. Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3735-3739.
Punnonen, J., Aversa, G., Cocks, B.G., McKenzie, A.N., Menon, S., Zurawski, S., de Waal Malefyt,
R. and de Vries, J.E. (1993). Interleukin-13 induces interleukin- 4-independent IgG4 and IgE
synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3730-3734.
Howard, M., Muchamuel, T., Andrade, S. and Menon, S. (1993). Interleukin-10 protects mice from
lethal endotoxemia. J. Exp. Med. 177 (4): 1205-1208.
Menon, A.S., Driscoll, J. Chung, C.H. and Goldberg, A.L. (1988). ATP-dependent proteases in
bacterial and mammalian cells. In: Ubiquitin Systems (M. Schlesinger and A. Hershko, eds.) Cold
Spring Harbor Laboratories Press, Cold Spring Harbor, New York.
Goldberg, A.L., Menon, A.S., Goff, S.A. and Chin, D.T. (1987). The mechanism and regulation of
the ATP-dependent protease La. From Escherchia coli Biochem. Soc. Trans. UK 15: 809-811.
Menon, A.S. and Goldberg, A.L. (1987). Protein substates activate the ATP- dependent protease
La by promoting nucleotide binding and release of bound ADP. J. Biol. Chem. 262: 14929-14934.
Menon, A.S. and Goldberg, A.L. (1987). The binding of nucleotides to the ATP-dependent protease
La. From Escherchia coli. J. Biol. Chem. 262: 14921-14928
Menon, A.S., Waxman, L. and Goldberg, A.L. (1987). The energy utilized in protein breakdown by
the ATP-dependent protease La. From Escherchia coli. J. Biol. Chem. 262: 722-726.
Menon, A.S. and Goldberg, A.L. (1987). Proteins activate their own degradation by protease La by
promoting nucleotide binding and ADP release. Fed. Proc. 46: 2087. Abstract.
Goldberg, A.L., Menon, A.S., Chin, S.T., Waxman, L., Edmunds, T.E. and Goff, S.A. (1987). The
mechanism and regulation of the ATP-dependent protease La. From E. coli. Fed. Proc. 46: 2056.
Abstract.
Goldberg, A.L., Voellmy, R., Chung, C.H., Menon, A.S., Desautels, M., Meixsell, T. and Waxman, L.
(1985). The ATP-dependent pathway for protein breakdown in bacteria and mitochondria. Prog.
Clin. Biol. Res. 180: 33-45.
Goldberg, A.L., Waxman, L., Menon, A.S. and Goff, S.A. (1985). ATP-dependent proteases and
their role in intracellular protein degradation. International Union of Biochemistry Congress,
Amsterdam. Abstract
Menon, A.S. and Goldberg, A.L. (1985). Studies on the role of ATP in protein degradation by
protease La, the lon gene product. Fed. Am. Soc. Exp. Biol. 44: 1092. Abstract.
Menon, A.S., Usha Devi, S. and Ramasarma, T. (1984). Purification and characterisation of
Fermodulin, an Fe2+-dependent inhibitor protein of 3-Hydoxy 3-Methylglutaryl CoA reductase. Arch.
Biochem. Biophys 239: 342-351.
Menon, A.S., Usha Devi, S. and Ramasama, T. (1984). Fe2+-dependent modulation of HMGCoA
reductase by a cytosolic protein-Fermodulin. Indian J. Biochem. Biophys. 21: 27-38.
Goldberg, A.L., Waxman, L., Menon, A.S. and Goff, S.A. (1984). The role of protease La (the lon
gene product) and ATP in protein degradation in E. coli. American Society for Microbiology,
Conference on Genetics and Molecular Biology of Industrial Micro-organisms. Abstract.
Ramasarma, T., Menon, A.S. and Usha Devi, S. (1983). Fermodulin, a protein that inhibs HMGCoA
reductase in the presence of Fe2. Proceeding of the HMGCoA Reductase III Meeting, San
Francisco, CA, USA. J. Lipid. Res. 24(10): 1412. Abstract.
Menon, A.S., Usha Devi, S. and Ramasarma, T. (1982). Inhibition of HMGCoA reductase by
cytosolic proteins: Real or artifact. Biochem. Biophys. Res. Comm. 109: 619-625.
Usha Devi, S. and Menon, A.S. (1982). Nature of the inhibition of hepatic HMGCoA reductase by
Fe2+ and a cytosolic protein factor: Purification of the protein factor. Proc. Soc. Biol. Chem. (India)
41: 156. Abstract.
Vijaya, S., Rau, M., Manjunath, R., Menon, A.S., Kurup, C.K.R. and Ramasarma, T. (1980).
Changes in the activities of two membrane-bound enzymes. Current Science 49 (16): 620-622.
Menon, A.S. and Ramasarma, T. (1980). Adriamycin treatment increases HMGCoA reductase and
isoprene biosynthesis in the rat liver. Biochem. Biophys. Res. Comm. 99: 939-949.
Menon, A.S., Rau, M. and Ramasama, T. (1980). Vandadate inhibits mevalonate synthesis and
stimulates NAD(P)H oxidase. FEBS Letts. 114: 139-142.
George, R., Menon, A.S. and Ramasarma, T. (1979). Regulation of HMGCoA reductase by
adenosine compounds and fatty-acyl CoA. Indian J. Biochem. Biophys. 17: 1-8.
George, R., Menon, A.S. and Ramasarma, T. (1979). Desensitization of HMGCoA reductase to
ATP-Mg by heat treatment of microsomes. Biochem. Biophys. Res. Comm. 84: 544-549.
Ramasama, T., George, R. and Menon, A.S. (1979). Prevention of the ATP-Mg inhibition of
HMGCoA reductase by adenosine compounds. J. Lipid. Res. 20: 1046. Abstract.
Menon, A.S. (1979). Desensitization of HMGCoA reductase by heat treatment of microsomes.
Proc. Soc. Biol. Chem. (India) Indian J. Biochem. Biophys. 16 (Supplement): 62. Abstract