Curriculum Vitae
Bizhan Malaekeh-Nikouei (Pharm.D, Ph.D.)
Associate Professor in Pharmaceutics,
School of Pharmacy and Nanotechnology Research Center,
Mashhad University of Medical Sciences (MUMS),
Mashhad, Iran
P.O. Box: 91775-1365
Phone: +98 511 8823255-6 or +98 511 7112611
E-mail: malaekehb@mums.ac.ir
Gender: male
Date of birth: June 24th, 1976
Place of birth: Mashhad, Iran
Residence: Mashhad, Iran
Marital status: Married
Number of Children: 2
Education:
- Research fellowship (6 month) in University of Queensland, Australia
(2005)
- Ph.D. in Pharmaceutics from School of Pharmacy, Mashhad University
of Medical Sciences (2001-2006)
- Pharm.D. from School of Pharmacy, Tabriz University of Medical
Sciences (1994 -1999)
Workshops:
- "Electronic databases", Mashhad University of Medical Sciences,
Mashhad, 2007, (1 day).
- "Teaching Methods", Mashhad University of Medical Sciences,
Mashhad, 2007, (2 days).
- "Education Planning", Mashhad University of Medical Sciences,
Mashhad, 2007, (2 days).
- "MCQ", Mashhad University of Medical Sciences, Mashhad, 2007, (1
day).
- "SPSS", Mashhad University of Medical Sciences, Mashhad, 2007, (3
days).
- "EndNote", Mashhad University of Medical Sciences, Mashhad,
2007, (1 day).
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- "Peer Review", Mashhad University of Medical Sciences, Mashhad,
2007, (1 day).
- "Nanostructures", Kish University, Kish Island, 2006, (3 days).
- "Application of Nanotechnology in Drug Delivery", Tehran
University of Medical Sciences, Tehran, 2007, (1 day).
- "Biomedical writing", Mashhad University of Medical Sciences,
Mashhad, 2008, (3 days).
- "Medical Journalism", Mashhad University of Medical Sciences,
Mashhad, 2008, (1 day).
Research interests:
Particulate drug delivery systems including Microspheres and
Nanospheres, Liposomes, Solid lipid nanoparticles (lipospheres),
Nanobiotechnology, Designing of non-viral vectors, Targeted drug
delivery, Peptide and protein formulation, Instrumental analysis
Current research projects:
1) Preparation and evaluation of nano-sized galactosylated lipoplexes
effect on transfection efficiency
2) Preparation and characterization of microspheres encapsulated with
triamcinolone for intravitreal administration
3) Preparation and in vitro and in vivo evaluation of liposomal
Avastin (Anti-VEGF IgG) for intravitreal administration:
comparison with soluble form
4) Preparation, characterization and transfection evaluation of peptide
coupled lipoplexes as non-viral vectors for gene therapy
5) Formulation of foluorometholone ophthalmic solution using
cyclodextrins
6) Synthesis of PEGylated fatty acids as carrier for targeted solid lipid
nanoparticles (lipospheres)
7) Preparation and characterization of topical liposomes encapsulated
with total extract and fractions of Platycladus orientalis
8) Preparation, characterization and evaluation of tumoricidal effects
of solid lipid nanoparticles (lipospheres) containing docetaxel in
tumor-bearing mice
9) Preparation, characterization and evaluation of transfection efficiency of
nanoliposomes modified with polyethylenimine
10) Preparation and characterization of liposomes encapsulated with
clindamycin and tretinoin
11) Study of cytotoxic and apoptogenic properties of Crocin, Safranal
and their nanoliposomes in various cancer cell lines
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12) Preparation and evaluation of transfection efficiency of cationic
liposome-PEI-plasmid nanocomplexes
13) Preparation and study of phase solubility of inclusion complexes of
beclomethasone with cyclodextrins to enhance water solubility of
the drug for inhalation
14) Evaluation of diclofenac release from its molecularly imprinted
polymer in aqueous and organic solvents
15) Preparation, characterization and in vitro evaluation of siRNA
delivery efficiency of nanoliposomes modified with linear
polyethylenimine
16) Preparation and characterization of nanoliposomes containing
cyclosporine for ophthalmic application and evaluation of their
safety in the rabbit eye
17) The effect of nanoliposomes containing vancomycin and rifampin
on Staphylococcus epidermidis biofilm
18) Preparation and evaluation of transfection efficiency of nucleus
targeted nano-liposomes containing PEI-Dexamethasone
19) Evaluation the amount of cyclosporine penetration into the
posterior segment of eye after liposomal and conventional form
administration in animal model
20) Preparation, characterization and antitumor effects of mesoporous
silica nanoparticles containing epirubicin and Bcl-2 siRNA in
animal model
21) The effect of polyallylamine molecular weight on transfection
efficiency of nanocomplexes composed of cationic liposomespolyallylamine-plasmid
22) Preparation and in vivo evaluation of nanoliposomes containing
melphalan after intravitreal administration
23) Cytotoxic effects of mesoporous silica nanoparticles in PC12 cells
24) Preparation, characterization of A26 aptamer conjugated
mesoporous silica nanoparticles containing epirubicin for in-vitro
targeted delivery to cancer cells
Publications:
1) Hasanzadeh D., Malaekeh-Nikouei B., 1997, Quantitative analysis
of H2-blockers by FT-IR: comparison with HPLC method,
Pharmaceutical Sciences (Journal of Tabriz Faculty of Pharmacy),
3, 25-32. (Persian)
2) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., 2004,
Preparation and characterization of biodegradable microspheres
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encapsulated with cyclosporine A using different grades of PLGA,
Iranian Journal of Basic Medical Sciences, 7, 4, 240-249 (Persian).
3) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Samiee A.,
2005, Preparation of fusogenic liposomes encapsulated with
cyclosporine A and evaluation of its immunosuppressive effects on
human T-cells, Pharmaceutical Sciences (Journal of Tabriz Faculty
of Pharmacy), 2, 1-9 (Persian).
4) Jaafari M. R., Malaekeh-Nikouei B., Nasirli H., Hosseinzadeh H.,
2005, Formulation of topical liposomes encapsulated with
triamcinolone and comparison of their anti-inflammatory effects
with available conventional topical ointment in mice, Iranian
Journal of Basic Medical Sciences, 8, 3, 195-201 (English).
5) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., Davies N. M.,
2005, Preparation and characterization of PLGA microspheres
loaded by cyclosporine-cyclodextrin complex, Iranian Journal of
Pharmaceutical Sciences, 1, 4, 195-201 (English).
6) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., 2006, The
effect of different grades of PLGA on characteristics of
microspheres encapsulated with cyclosporine A, Current Drug
Delivery, 3, 4, 343-349 (English).
7) Malaekeh-Nikouei B., 2006, Liposomes as novel drug delivery
system, Razi, 211, 59-64 (Persian).
8) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., Davies N. M.,
2006, The effect of complexation on characteristics and drug
release of PLGA microspheres loaded by cyclosporinecyclodextrin complex, Journal of Drug Delivery Science and
Technology, 16(5), 345-350 (English).
9) Malaekeh-Nikouei B., Nassirli H., Davies N. M., 2007,
Enhancement of cyclosporine aqueous solubility using α- and
hydroxypropyl β-cyclodextrin mixtures, Journal of Inclusion
Phenomena and Macrocyclic Chemistry, 59 (3-4), 245-250
(English).
10) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., 2007,
Preparation, characterization and mucoadhesive evaluation of
chitosan coated liposomes containing cyclosporine A, Saudi
Pharmaceutical Journal, 15, 3-4, 176-182 (English).
11) Malaekeh-Nikouei B., Abrishami M., Zarei S., 2008, Liposomal
formulation of bevasizuamb for intravitreal administration: increased
half-life, decreased side effects, Iranian Journal of Medical
Hypotheses and Ideas, 2:4, (Persian).
12) Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R., 2008,
Preparation, characterization and mucoadhesive properties of chitosan
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coated microspheres encapsulated with cyclosporine A, Drug
Development and Industrial Pharmacy, 34, 5, 492-498 (English).
13) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Samiee A.,
2008, The Enhancement of Immunosuppressive Effects of
Cyclosporine A on Human T-Cells Using Fusogenic Liposomes,
Colloids and Surfaces B:Biointerfaces, 67, 238-244 (English).
14) Abrishami M., Zarei-Ghanavati S., Soroush D., Rouhbakhsh M.,
Jaafari M. R., Malaekeh-Nikouei B., 2009, Preparation,
characterization and in vivo evaluation of nanoliposomes
encapsulated bevacizuamb for Intravitreal administration, Retina, 29,
5, 699-703 (English).
15) Malaekeh-Nikouei B., Davies N. M., 2009, Double loading of
cyclosporine A in liposomes using cyclodextrin complexes, PDA
Journal of Pharmaceutical Science and Technology, March-April,
63(2), 139-148 (English).
16) Ramezani M., Khoshhamdam M., Dehshahri A., MalaekehNikouei B., 2009, The influence of size, lipid composition and
bilayer Tm on the transfection efficiency of nanolipoplexes, Colloids
and Surfaces B:Biointerfaces, 72(1), 1-5 (English).
17) Malaekeh-Nikouei B., Malaekeh-Nikouei M., Kazemi Oskuee
R., Ramezani M., 2009, Preparation, characterization and transfection
efficiency of nanoliposomes modified with oligoamines as gene
carrier, Nanomedicine: Nanotechnology, Biology, and Medicine, 5,
457–462 (English).
18) Malaekeh-Nikouei B., Sajadi Tabassi S.A., Ashari H.,
Gholamzadeh A., 2009, Evaluation the effect of cyclodextrin
complexation on aqueous solubility of fluorometholone to achieve
ophthalmic solution, Journal of Inclusion Phenomena and
Macrocyclic Chemistry, 65, 335-340 (English).
19) Ramezani M., Khakshoor T., Malaekeh-Nikouei M., MalaekehNikouei B., 2010, The effect of linear PEI on characteristics and
transfection efficiency of PEI-based cationic nanoliposomes, Iranian
Journal of Basic Medical Sciences, 4,1, 82-88 (English).
20) Motaharinia J., Ramezani M., Malaekeh-Nikouei M., MalaekehNikouei B., 2011, Liposome-linear polyethyleneimine-DNA
Nanocomplexes for Gene Delivery: Preparation, Characterization and
In Vitro Transfection Activity, Current Nanoscience, 7, 587-593
(English).
21) Malaekeh-Nikouei B., et al, 2011, Improvement of cytotoxic and
apoptogenic properties of crocin in cancer cell lines by its
nanoliposomal form, Pharmaceutical Biology, 49(10): 1039–1045,
(English).
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22) Malaekeh-Nikouei B., Banaee T., Aghamohammadian J.,
Mosallaei N., Mohajeri SA., 2011, Quantitative LC Analysis of
Cyclosporine A in Ocular Samples, Chromatographia, 73:817–821,
(English).
23) Malaekeh-Nikouei B., Golmohammadzadeh S., Hosseini M.,
Nassirli H., 2011, Preparation and characterization of liposomes
encapsulated with clindamycin and tretinoin, Pharmacie Globale
(IJCP), 6 (03), (English).
24) Asili J., Mosallaei N., Shaterzadeh A., Malaekeh-Nikouei B.,
2011, Preparation and characterization of liposomes containing
methanolic extract of aerial parts of Platycladus orientalis (L.)
Franco, Avicenna Journal of Phytomedicine, 2, 1, 17-23 (English).
25) Ramezani M., Malaekeh-Nikouei B., Motaharinia J., MalaekehNikouei M., 2011, Glactosylated liposome-polyethyleneimine-DNA
nanocomplexes as a non-viral vector, Pharmacie Globale (IJCP), 10
(03) (English).
26) Tavallaie S., Zobeiri M., Haghighat-Khazaee Z., HassanzadehKhayyat M., Nassirli H., Malaekeh-Nikouei B., Sahebkar A.,
Ghayour-Mobarhan M., 2012, Serum vitamin E concentration in
Iranian population with angiography defined coronary artery disease,
Asian Biomedicine, 6, 1, 19-25 (English).
27) Mohajeri SA, Malaekeh-Nikouei B., Sadegh H., 2011,
Development of a pH-responsive drug delivery system for diclofenac
using molecularly imprinted polymers, Drug Development and
Industrial Pharmacy, 38(5):616-22 (English).
28) Malaekeh-Nikouei B., Sajadi Tabassi S.A., Gerayeli G., Arab
Salmani M., Gholamzadeh A., 2012, The effect cyclodextrin mixtures
on the aqueous solubility of beclomethasone dipropionate, Journal of
Inclusion Phenomena and Macrocyclic Chemistry, 72, 383-387
(English).
29) Rafiee E., Eavani S., Malaekeh-Nikouei B., 2012, 12Tungstophosphoric Acid Immobilized on γ-Fe2O3@SiO2 Core–Shell
Nanoparticles: An Effective Solid Acid Catalyst for the Synthesis of
Indole Derivatives in Water, Chemistry Letters, 41, 4, 438 (English).
30) Malaekeh-Nikouei B., Abbasi Ghaeni F., Motamedshariaty V.,
Mohajeri SA, 2011, Controlled release of prednisolone acetate from
molecularly imprinted hydrogel contact lenses, Journal of Applied
Polymer Science (English) (In press).
31) Mosallaei N., Banaee T., Farzadnia M., Abedini E, Ashraf H,
Malaekeh-Nikouei B., 2012, Safety evaluation of nanoliposomes
containing cyclosporine A after ocular administration, Current Eye
Research, 37, 6, 453-456 (English).
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32) Ramezani M., Malaekeh-Nikouei B., Malekzadeh S.,
Baghayeripour M.R., Malaekeh-Nikouei M., 2011, The effect of
lipopolymer structure on the transfection efficiency of hydrophobic
PEI-based cationic nanoliposomes, Current Nanoscience (English)
(Accepted).
33) Zarei-Ghanavati S., Malaekeh-Nikouei B., Pourmazar R., Seyedi
S., Preparation, Characterization and In Vivo Evaluation of
Microspherical Triamcinolone acetonide after Intravitreal
Administration, Journal of Ocular Pharmacology and Therapeutics,
(English) (In press).
34) Hosseinzadeh H., Ramezani M., Tavakoli Anaraki N., MalaekehNikouei B., Mohammadpour A.H., Development and validation of
extraction and HPLC method for determination of crocetin in human
serum samples, Iranian Journal of Basic Medical Sciences (English)
(Submitted).
35) Malaekeh-Nikouei B., et al, Assessment of cytotoxic and
apoptogenic properties of safranal and nanoliposomal safranal in
various cancer cell lines, Phytotherapy Research (English)
(Submitted).
36) Moghadas Sharif N., Fazly Bazzaz B.S., Khameneh Bagheri B.,
Malaekeh-Nikouei B., The effect of nanoliposomes containing
vancomycin and rifampin on Staphylococcus epidermidis biofilm,
International Journal of Antimicrobial Agents (English) (Submitted).
Presentations:
1) Malaekeh-Nikouei B., Ramezani M., Arabi L., Transfection
efficiency of hydrophobic polyethyleneimine-based cationic
nanoliposomes, Nanoscience and Nanotechnology Conference,
September 19-23, 2011, Italy.
2) Malaekeh-Nikouei B., Zarei-Ghanavati S., Pourmazar R., Seyedi
S., Microspheres containing triamcinolone acetonide for
intravitreal administration: preparation, characterization and in
vivo evaluation, 5th Iranian Controlled Release Conference,
October 4-6, 2011, Mashhad, Iran.
3) Malaekeh-Nikouei B., Ramezani M., and Malaekeh-Nikouei M.,
Galactosylated liposmes-polyethyleneimine-DNA Nanocomplexes
for gene delivery, Nano Thailand 2010, November 18-20, 2010,
Thailand.
4) Malaekeh-Nikouei B., Ramezani M., Motaharinia J., and
Malaekeh-Nikouei M., The Cationic Liposome-PolyethyleneimineDNA Complexes for Gene Delivery: Preparation, Characterization,
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and Transfection In Vitro, 12th Iranian Pharmaceutical Sciences
Conference, August 2-5, 2010, Zanjan, Iran.
5) Malaekeh-Nikouei B., Ramezani M., and Malaekeh-Nikouei M.,
Preparation, Characterization and Transfection Efficiency of
Galactosylated Nanolipoplexes as a Gene Carrier, 2010 Singapore
Symposium on Drug Delivery Systems, January 20-24, 2010,
Singapore.
6) Malaekeh-Nikouei B., Abrishami M., Zarei-ghanavati S., Soroush
D., Majid Rouhbakhsh M., Jaafari M. R.,
Preparation,
characterization and in vivo evaluation of nanoliposomes
encapsulated bevacizuamb (Avastin) for intravitreal administration,
The Specialized Congress of Nanomedicine, Nanobiotechnology,
Nanobiosensors and Nanomaterials, July 14-16, 2009 , Mashhad,
Iran.
7) Malaekeh-Nikouei B., Ramezani M., Nazari S., Khakshour T.,
Preparation, characterization and transfection efficiency of
nanoliposmes modified with lipopolymers constructed from
polyethyleneimine and acrylate derivatives, 4th Iranian Controlled
Release Conference, October 6-8, 2009, Zanjan, Iran
8) Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Afshin Samiei,
The effect of phospholipid type and size on immunosuppressive
activities of liposomes encapsulated with cyclosporine A, 11th
Liposome Research Days Conference, July 2008, Yokohama, Japan.
9) Malaekeh-Nikouei B., Ramezani M., Malaekeh-Nikouei M.,
Kazemi Oskuee R., Preparation, characterization and transfection
efficiency of nanoliposomes modified with oligoamines as gene
carrier, 11th Iranian Pharmaceutical Sciences Conference, Aug
2008, Kerman, Iran.
10)
Gholamzadeh A., Ashari H., Malaekeh-Nikouei B., Sajadi
Tabassi S.A., Evaluation of sulphobutylether β-cyclodextrin and
hydroxypropyl γ-cyclodextrin complexation on aqueous solubility of
fluorometholone, 11th
Iranian
Pharmaceutical
Sciences
Conference, Aug 2008, Kerman, Iran.
11)
Shahsavand S., Mehri S., Moallem S.A., Mosavi S.H.,
Malaekeh-Nikouei B., Assessment of cytotoxic and apoptogenic
properties of crocin and its nanoliposomes in various cancer cell
lines, 11th Iranian Pharmaceutical Sciences Conference, Aug 2008,
Kerman, Iran.
12)
Mehri S., Shahsavand S., Moallem S.A., Mosavi S.H.,
Malaekeh-Nikouei B., Assessment of cytotoxic and apoptogenic
properties of safranal and its nanoliposomes in various cancer cell
lines, 11th Iranian Pharmaceutical Sciences Conference, Aug 2008,
Kerman, Iran.
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13)
Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A.,
Preparation, characterization and mucoadhesive evaluation of
chitosan coated liposomes containing cyclosporine A, The Third
Iranian Conference of Novel Drug Delivery Systems, June 2007,
Tehran, Iran.
14)
Sajadi S. A., Malaekeh-Nikouei B., Jaafari M. R., Davies
N. M., The effect of complexation on characteristics of and drug
release from PLGA microspheres loaded by cyclosporinecyclodextrin complex, 33rd Annual Meeting and Exposition of the
Controlled Release Society, July 2006, Vienna, Austria.
15)
Malaekeh-Nikouei B., Sajadi S. A., Jaafari M. R.,
Preparation and characterization of chitosan coated microspheres
encapsulated with cyclosporine A, 10th Iranian Pharmaceutical
Sciences Conference, Aug 2006, Tehran, Iran.
16)
Malaekeh-Nikouei B., Jaafari M. R., Sajadi S. A., Samiei
A., The enhancement of immunosuppressive effects of
cyclosporine A on human T-cells using fusogenic liposomes, 10th
Iranian Pharmaceutical Sciences Conference, Aug 2006, Tehran,
Iran.
17)
Sajadi S. A., Malaekeh-Nikouei B., Jaafari M. R.,
Preparation and characterization of biodegradable microspheres
encapsulated with Cyclosporine A using different grades of PLGA,
1ST Pharmaceutical Sciences Fair & Exhibition, June 2005, Nice,
France.
18)
Malaekeh-Nikouei B., et al., Formulation of topical
liposomes encapsulated with triamcinolone and comparison of their
anti-inflammatory effects with available conventional topical
ointment in mice, 9th Seminar of Pharmaceutical Sciences, Aug
2004, Tabriz, Iran.
19)
Malaekeh-Nikouei B., et al., Preparation and
characterization of biodegradable microsphere encapsulated with
Cyclosporine A using different grades of PLGA, 9th Seminar of
Pharmaceutical Sciences, Aug 2004, Tabriz, Iran.
20)
Malaekeh-Nikouei B., et al., Comparison of different
physicochemical analysis methods of H2-blockers, 1st Seminar of
Pharmaceutical Methodology, Sep 2001, Mashhad, Iran.
21)
Hasanzadeh D., Malaekeh-Nikouei B., Development of
quantitative FT-IR analysis of H2-blockers: comparison with the
HPLC methodology, Proc. 3rd World Meeting APV/APGI, April
2000, Berlin, Germany.
Book:
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1) Stuart S., Modern Infrared Spectroscopy, 2002, Tabriz University
of Medical Sciences (Translation to Persian).
2) Malaekeh-Nikouei B., Hanafi-Bojd M.Y., Aghebati T., Mosallaei
N., 2011, Nanoparticulate drug delivery systems, Mashhad
University of Medical Sciences, (Writing in Persian).
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