Hematology and Clinical Oncology
MED/06- Medical Oncology
MED/15- Blood diseases
Academic/Subject Sector
V
Year
Semester
1
5
Total number of credits
Professor. Mantovani G. (mantovan@pacs.unica.it)
Even student numbers:
Professor Mantovani G. (mantovan@pacs.unica.it)
Cossu F.
La Nasa(giorgiolanasa@pacs.unica.it)
Massa E. (emassa@unica.it)
Madeddu C. (clelia_md@yahoo.it)
Odd student numbers:
Professor Massidda B.(masbru@pacs.unica.it)
Cossu F.
La Nasa(giorgiolanasa@pacs.unica.it)
Integrated Course coordinator
Integrated Course lecturers
Aims of the course
The aim of the course is to enable students to assess the state of health of an individual in
preventive, diagnostic, therapeautic and rehabilitative terms. Students should also be able
to integrate their informed judgements from knowledge of systematic pathologies and
specialist medicine with a holistic, unitary vision of the patient as a human being. During
the course students will be provided with basic tools for understanding the pathogenetic
mechanisms and their use in diagnostics and treatment; the relationship between
hematology and other branches of Clinical Medicine will also be focused on. These
objectives will be achieved partly through formal teaching and partly by the direct
examination of clinical cases, either in the presence of a patient or by studying clinical
documents.
Syllabus
Subject area: Medical Oncology: :
Disciplina: Oncologia Medica: :
Common terminology " in Clinical Oncology. Epidemology and prevention: Incidence and
mortality in neoplasms; Risk factors in the most common types of tumour; Primary and
secondary prevention. Clinical Methodology in Oncology: Suspected signs and symptoms
of neoplasm, characteristic manoeuvres of semeiotics in clinical oncology, ways and means
of the spreading of tumours, metastasis processes and staging: meanings and methods,
general factors in the prognosis of tumours; assessment of patient response to therapy;
principles for the conducting of controlled clinical experiments: stages, follow-up, aspects
of relationship with cancer patient, informed consent for diagnostic and therapeutic
procedures:
Principles of treatment: Cell proliferation and resistance to drug treatment: multidrug
resistance; Anti-proliferous drugs: classes, action mechanism, side- and toxic effects:
methods of prevention and treatment, cases requiring chemotherapy treatment:
neoadjuvant, adjuvant, remedial and palliative therapies; Support therapies, Oncological
complications and emergencies and their treatment: superior vena cava syndrome, bone
marrow compression syndrome, paraneoplastic hypercalcemia, primary end points in
Oncology, objective clinical response; quality of life; "elderly" or "frail" cancer patients:
methods of assessment and principles of treatment; Specific area: principles of diagnosis
and treatment staging, treatment applications and expected results for the following
neoplasms, chosen on the basis of frequency of occurrence,exemplary nature and
feasibilty of treatment; Pulmonary neoplasm; Colon and rectum neoplasm; Breast
neoplasm, gynecological neoplasms: Ovary neoplasm, cervical and endometrium
neoplasm; Prostate and testicle cancers; head and neck neoplasms; Hodgkins and nonHodgkins lymphomas.
Subject area: Oncological radiotherapy
Radiosensitivity and curability of tumours; Choice of total and single dosages; Combination
of radiotherapy with surgery and chemotherapy; Choice of treatment techniques (external
beam irradiation and curietherapy); Radiotherapy treatment programme; Function and
role of relations with hypertemia; Indications for the use of heavy particles; Sequence of
treatment and therapy in radio-induced lesions; The role of radiotherapy in common
localised tumours (skin, pharynx, larynx, oral cavity, breast, lung, oesophagus, bladder,
prostate, testicle, uterine cervix, endometrium, malignant lymphomas, central nervous
system, radiotherapy for metastases).
Subject area: Hematology
Hematopoiesis; Kinetic classification of anemias: Megaloblastic Anemias, Iron-deficiency
anemia, Protein-deficiency anemia, Anemia from chronic phlogosis, Vit.B6 deficiency
anemia; Hemolytic diseases: spherocytosis, Elliptocytosis, G6PD deficiency. Anemias from
metabolic malfunction (G-6-PD deficiency), Post-infection anemias, Immunohemolytic
anemias; Beta-thalassemia, Alfa-thalassemia, Structural hemoglobinopathies. Chronic
myeloproliferative disorders: polycythemia vera, essential thrombocythemia, idiopathic
myelofibrosis; Chronic myeloid leukemia; Primary and secondary myelodysplasias. Acute
leukemias; Chronic lymphoproliferative disorders: chronic lymphatic leukemia,
tricholeukemia, lymphomas, Hodgkin's disease, Myeloma, Immunocytomas, Monoclonal
gammopathy; Bone marrow aplasia and peripheral cytopenias; Hemostasis pathology,
Coagulation and Fibrinolysis; Blood transfusion and Bone marrow transplants.
Reference texts
Bonadonna-Robustelli della Cuna "Medicina Oncologica" - Editore Masson; Cavalli, Hansen,
Kaye "Texbook of medical oncology", 2nd Edition, Dunitz - Sante Tura, Lezioni di
Ematologia, Ed. Esculapio.
Teaching methods
Assessments methods
Multiple choice test followed by an oral exam
Requirements to take the exam
Language of instruction
Reference texts
Interactive teaching centre:
Cattedra di Oncologia Medica, Policlinico Universitario
Further information