C. ANDREW CHAPMAN
ADDRESS:
Center for Studies in Behavioral Neurobiology,
Department of Psychology,
Concordia University
7141 Sherbrooke St. W., Room SP-244
Montréal, Québec, Canada, H4B 1R6
tel: (514) 848-2424 x2220
fax: (514) 848-2817
e-mail: andrew.chapman@concordia.ca
POSITIONS HELD:
2013Professor
2004-2013
Associate Professor
1999-2004
Assistant Professor
Center for Studies in Behavioral Neurobiology,
Department of Psychology, Concordia University,
Montréal, Québec.
1995-1999
Post-Doctoral research fellow
Département de Physiologie, Université de Montréal,
Montréal, Québec.
EDUCATION:
1995-1999
Post-Doctoral research (Prof. J.-C. Lacaille),
Université de Montréal, Département de Physiologie,
Montréal, Québec.
In vitro electrophysiological analysis of the role of inhibitory neurons of the rat hippocampus in the
generation of theta-frequency EEG activity, and in the control of learning-related changes in
synaptic strength.
1990-1995
Ph.D. (Prof. R.J. Racine)
McMaster University, Department of Psychology,
Hamilton, Ontario.
In vivo electrophysiological analysis of synaptic plasticity in olfactory inputs to the entorhinal
cortex and modulation of these inputs by cholinergic afferents from the medial septum.
Computational modelling and spectral analysis of sensory processing in the olfactory system.
Analysis of long-term potentiation in sensorimotor cortex in vivo.
1988
B.Sc. (Honours; Prof. J.S. Yeomans and Dr. R.B. Coambs)
Department of Psychology, University of Toronto,
Toronto, Ontario.
Behavioural analysis of neuronal pathways mediating electrically evoked behaviours including the
startle reflex and movement of the forearm in the rat.
TEACHING
Undergraduate courses:
Fundamentals of Behavioral Neurobiology.
Human Neuropsychology.
Specialization Project (Thesis class)
Graduate courses:
Statistical Analysis and Experimental Design.
Multivariate Statistics.
RESEARCH
PEER REVIEWED PUBLICATIONS:
Sparks, D., Chapman, C.A. (2014, In Press) Contribution of Ih to the relative facilitation of synaptic
responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the
parasubiculum. Neuroscience.
Frederick, A., Bourget-Murray, J., Chapman, C.A., Amir, S., Courtemanche, R. (2014, In Press)
Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum
and cerebellar cortex of the anesthetized rat. Frontiers in Systems Neuroscience
Glovaci, I., Caruana, D.A., Chapman, C.A. (2014) Dopaminergic enhancement of excitatory
synaptic transmission in layer II entorhinal neurons is dependent on D1 receptor-mediated
signaling. Neuroscience 258; 74-83.
Barrett, S., Chapman, C.A. (2013) Contribution of muscarinic M1 receptors to the cholinergic
suppression of synaptic responses in layer II of the entorhinal cortex. Neuroscience Letters;
252:266-74.
Hutter, J.A., Chapman, C.A. (2013) Exposure to cues associated with palatable food reward results
in a dopamine D2 receptor-dependent suppression of evoked synaptic responses in the
entorhinal cortex. Behavioral and Brain Functions; 9:37.
Hutter, J.A., Martel, A., Trigliani, A. Barrett, S., Chapman, C.A. (2013) Rewarding stimulation of
the lateral hypothalamus induces a dopamine-dependent suppression of synaptic responses
in the entorhinal cortex. Behavioural Brain Research; 252:266-274.
Glasgow SD, Chapman CA (2013) Muscarinic depolarization of layer II neurons of the
parasubiculum. PLoS ONE 8:e58901.
Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard
JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA,
Ruthazer ES, Kennedy TE. (2013) DCC Expression by Neurons Regulates Synaptic
Plasticity in the Adult Brain. Cell Reports; 3:1-13.
Sparks, D., and Chapman, C.A. (2012) Cholinergic receptor activation induces a relative facilitation
of synaptic responses in the entorhinal cortex during theta- and gamma-frequency
stimulation of parasubicular inputs. Neuroscience; 230:72-85.
Reed, S.J., Plourde, G., Tobin, S., Chapman, C.A. (2012) Partial antagonism of propofol anesthesia
by physostigmine in rats is associated with potentiation of fast (80-200 Hz) oscillations in
the thalamus. British Journal of Anesthesia; 12:1-8.
Horn KE, Xu B, Gobert D, Hamam BN, Thompson KM, Wu CL, Bouchard JF, Uetani N, Racine
RJ, Tremblay ML, Ruthazer ES, Chapman CA, Kennedy TE (2012) Receptor protein
tyrosine phosphatase sigma regulates synapse structure, function and plasticity. Journal of
Neurochemistry; 122:147-161.
Glasgow, S.D., Glovaci, I., Karpowicz, L.S., and Chapman, C.A. (2012) Cholinergic suppression of
excitatory synaptic transmission in layers II/III of the parasubiculum. Neuroscience; 201:111.
Pfaus, J.G., Tse, T.L.M., Werk, C.M., Chanda, M.-L., Leblonde A., Harbour, V.L., and Chapman,
C.A. (2009) Enhanced synaptic responses in the piriform cortex associated with sexual
stimulation in the male rat. Neuroscience;164:1422-1430.
Glasgow, S., and Chapman, C.A. (2008) Ionic conductances mediating theta-frequency membrane
potential oscillations in layer II parasubicular neurons. Journal of Neurophysiology;
100:2746-2756.
Chapman, C.A., Jones, R.S.G., and Jung, M. (2008) Neuronal plasticity in the entorhinal cortex.
Neural Plasticity; 2008:1-2.
Caruana, D.A., and Chapman, C.A. (2008) Dopaminergic suppression of synaptic transmission in
the lateral entorhinal cortex. Neural Plasticity; 2008:1-14.
Kourrich, S., Glasgow, S.G., Caruana, D.A., and Chapman, C.A. (2008) Postsynaptic signals
mediating induction of long-term synaptic depression in the entorhinal cortex. Neural
Plasticity; 2008:1-9.
Caruana, DA, Nesbitt, C., Mumby, D.G., & Chapman, C.A. (2008) Seizure activity in the rat
hippocampus, perirhinal and prefrontal cortex associated with transient global cerebral
ischemia. Journal of Neural Transmission; 115:401-411.
Gosselin, B., Sawan, M., Chapman, C.A. (2008) A low-power integrated bioamplifyer with a new
active DC rejection scheme. IEEE Transactions on Biomedical Circuits and Systems; 1:184192.
Caruana, D.A., Reed, S.J., Sliz, D.J., and Chapman, C.A. (2007) Inhibiting dopamine reuptake
blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex
of awake rats. Neuroscience Letters; 426:6-11.
Glasgow, S., and Chapman, C.A. (2007) Local generation of theta-frequency EEG activity in layer
II of the parasubiculum. Journal of Neurophysiology; 97: 3868-3879.
Hamam, B., Sinai, M., Poirier, G., and Chapman, C.A. (2007) Cholinergic suppression of excitatory
synaptic responses in layer II of the medial entorhinal cortex. Hippocampus; 17:103-113
Caruana, D.A., and Chapman, C.A. (2006) Dopamine has bidirectional effects on synaptic
responses to cortical inputs in layer II of the lateral entorhinal cortex. Journal of
Neurophysiology; 96:3006-3015.
Werk, C.M., Klein, H., Nesbitt, C., Chapman, C.A. (2006) Long-term depression in the
sensorimotor cortex induced by repeated delivery of 10 Hz trains in vivo. Neurosicence;
140:13-20.
Mueller D., Chapman, C.A., and Stewart J. (2006) Amphetamine induces dendritic growth in
ventral tegmental area dopaminergic neurons in vivo via basic fibroblast growth factor.
Neuroscience; 137:727-735.
Werk, C., Harbour VL and Chapman, C.A. (2005) Induction of long-term potentiation leads to
increased reliability of evoked neocortical spindles in vivo. Neuroscience; 131:793-800.
Caruana, D.A., and Chapman, C.A. (2004) Stimulation of the parasubiculum modulates entorhinal
cortex responses to piriform cortex inputs in vivo. Journal of Neurophysiology; 92:12261235.
Werk, C., and Chapman, C.A. (2003) Long-term potentiation of polysynaptic responses in layer V
of the sensorimotor cortex induced by theta-patterned tetanization in the awake rat. Cerebral
Cortex; 13:500-507.
Kourrich, S., and Chapman, C.A. (2003) NMDA receptor-dependent long-term synaptic depression
in the entorhinal cortex in vitro. Journal of Neurophysiology; 89:2112-2119.
Bouras, R., and Chapman, C.A. (2003) Long-term synaptic depression in the adult entorhinal cortex
in vivo. Hippocampus; 13:780-790.
Patenaude, C., Chapman, C.A., Bertrand, S., Congar, P., and Lacaille, J.-C. (2003) GABABR- and
mGluR-dependent cooperative long-term potentiation of hippocampal GABAA synaptic
transmission. Journal of Physiology (London); 553:155-167.
Froc D.J., Chapman, C.A., Trepel, C., Racine, R.J. (2000) Long-term depression and depotentiation
in sensorimotor cortex of the freely moving rat. Journal of Neuroscience; 20:438-445.
Chapman, C.A., and Lacaille, J.-C. (1999) Cholinergic induction of theta-frequency oscillations in
hippocampal inhibitory interneurons and pacing of pyramidal cell firing. Journal of
Neuroscience; 19:8637-8645.
Chapman, C.A., and Lacaille, J.-C. (1999) Intrinsic theta-frequency membrane potential
oscillations in hippocampal CA1 interneurons of stratum lacunosum-moleculare. Journal of
Neurophysiology; 81:1296-1307.
Perez, Y., Chapman, C.A., Woodhall, G., Robitaille, R., and Lacaille, J.-C. (1999) Differential
induction of long-lasting potentiation of inhibitory postsynaptic potentials by theta patterned
stimulation versus 100 Hz tetanization in hippocampal pyramidal cells in vitro.
Neuroscience; 90:747-757.
St-Jacques, R., Chapman, C.A., Lacaille, J.-C, Mohr, G., and Schipper, H.M. (1999) Acceleration of
ageing-related gliopathic changes and hippocampal dysfunction following
intracerebroventricular infusion of cysteamine in adult rats. Neuroscience; 90:1103-1113.
Chapman, C.A., Perez, Y., and Lacaille, J.-C. (1998) Effects of GABAA inhibition on the
expression of long-term potentiation in CA1 pyramidal cells are dependent on tetanization
parameters. Hippocampus; 8:289-298.
Chapman, C.A., Trepel, C., Ivanco, T.L., Froc, D.J., Wilson, K., and Racine, R.J. (1998) Changes
in field potentials and membrane currents in rat sensorimotor cortex following repeated
tetanization of the corpus callosum in vivo. Cerebral Cortex; 8:730-742.
Chapman, C.A., Xu, Y., Haykin, S., and Racine, R.J. (1998) Beta-frequency (15-35 Hz)
electroencephalogram activities elicited by toluene and electrical stimulation in the behaving
rat. Neuroscience; 86:1307-1319.
Chapman, C.A., and Racine, R.J. (1997) Converging inputs to the entorhinal cortex from the
piriform cortex and medial septum: Facilitation and current source density analysis. Journal
of Neurophysiology; 78:2602-2615.
Chapman, C.A., and Racine, R.J. (1997) Piriform cortex efferents to the entorhinal cortex in vivo:
Kindling-induced potentiation and the enhancement of long-term potentiation by lowfrequency piriform cortex or medial septal stimulation. Hippocampus; 7:257-270.
Allan, L.G., Siegel, S., Kulatunga-Moruzi, C., Eissenberg, T., and Chapman, C.A. (1997)
Isoluminance and contingent color aftereffects. Perception and Psychophysics; 59:13271334.
Chapman, C.A., Yeomans, J.S., Blaha, C.D., and Blackburn, J.R. (1997) Increased striatal
dopamine efflux follows scopolamine administered systemically or to the tegmental
pedunculopontine nucleus. Neuroscience; 76:177-186.
Haykin, S., Racine, R.J., Xu, Y., and Chapman, C.A. (1996) Monitoring neuronal oscillations and
signal transmission between cortical regions using time-frequency analysis of
electroencephalographic activity. Proceedings of the Institute of Electrical and Electronics
Engineers (IEEE), Special Issue on Time-Frequency Analysis; 84:1295-1301.
Racine, R.J., Chapman, C.A., Teskey, G.C. and Milgram, N.W. (1995) Post-activation potentiation
in the neocortex. III. Kindling-induced potentiation in the chronic preparation. Brain
Research; 702:77-86.
Racine, R.J., Chapman, C.A., Trepel, C.D., Teskey, G.C., and Milgram, N.W. (1995) Postactivation potentiation in the neocortex. IV. Multiple sessions required for induction of
long-term potentiation in the chronic preparation. Brain Research; 702:87-93.
Rashid, K., Van der Zee, C.E.E.M., Ross, G.M., Chapman, C.A., Stanisz, J., Riopelle, R.J., Racine,
R.J., and Fahnestock, M. (1995) An nerve growth factor peptide retards seizure
development and inhibits neuronal sprouting in a rat model of epilepsy. Proceedings of the
National Academy of Sciences; 92:9495-9499.
Chapman, C.A., and Becker, S. (1995) Model synapses with frequency potentiation characteristics
can cooperatively enhance Hebbian learning. The Neurobiology of Computation; J.M.
Bower (Ed.), Kluwer Academic Publishers, Boston, pp.197-202.
Chapman, C.A., and Yeomans, J.S. (1994) Motor cortex and pyramidal tract axons responsible for
electrically evoked forelimb flexion: refractory periods and conduction velocities.
Neuroscience; 59:699-711.
Yeomans, J.S., Hempel, C.M.E., and Chapman, C.A. (1993) Axons and synapses mediating startlelike responses evoked by electrical stimulation of the reticular formation in rats: symmetric
and asymmetric collision effects. Brain Research; 617:309-319.
Hempel, C.M.E., Si-Shun, Z., Chapman, C.A., and Yeomans, J.S. (1993) Crossed reticular
formation connections that mediate the startle reflex. Brain Research; 617:329-338.