August 2006
CURRICULUM VITAE
Paul Anthony Insel, M.D.
Departments of Pharmacology and Medicine
University of California, San Diego
9500 Gilman Drive
La Jolla, California 92093-0636
858/534-2295 (Work)  858/822-1007 (Fax)  pinsel@ucsd.edu (E-Mail)
Residence:
8660 Kilbourn Drive
La Jolla, California 92037
858/558-1816 (Phone/Fax); 858/472-1817 (Cell)
Birth date:
November 22, 1945 – New York, NY
Education:
1962-64
1964-68
George Washington University, Washington D.C.
University of Michigan, Ann Arbor, Michigan, M.D., cum laude
Military Service:
1970-74
United States Public Health Service (NIH)
Professional
Experience:
1968-69
1969-70
Honors
and
Awards
1965
1966-68
1966
1968
1976
1977-82
1981
1994
2002
2005
Rollo McCotter Award, University of Michigan
Dean's Award, University of Michigan
Alpha Omega Alpha, University of Michigan
Lange Award, University of Michigan
Katz Research Prize, American Heart Association (runner-up)
Established Investigatorship, American Heart Association
U.S.-France Cooperative Program in Cancer Research and INSERM Visiting Fellowship
UCSD School of Medicine Faculty Distinguished Lecturer
Honorary Doctorate (Doctorate Honoris Causa), University of Paris–XII
American Association for the Advancement of Science Fellow
Board
Certifications
1969
1970
1973
National Board of Medical Examiners, Diplomate
Medical License in California, Maryland
American Board of Internal Medicine, Diplomate
Professional
1969
1976
1978
1978
1979
American Association for the Advancement of Science
American Federation for Clinical Research
Western Society for Clinical Investigation
American Society for Pharmacology and Experimental Therapeutics
American Society for Cell Biology
Intern, Harvard Medical Unit, Boston City Hospital, Boston, Mass.
Asst. Resident, Harvard Medical Unit, Boston City Hospital, Boston, Massachusetts;
Clinical Fellow in Medicine, Harvard Medical School
1970-74
Clinical Associate and Medical Officer, National Institute of Child Health & Human
Development, Gerontology Research Center, NIH, Baltimore, MD
1970-72
Attending Physician, Endocrine-Metabolic Clinic, Baltimore City Hospitals, Baltimore,
Maryland
1971-74
Assistant in Medicine, Dept. of Medicine, Johns Hopkins University School of Medicine
1974-77
Research Fellow, Div. of Clinical Pharmacology, Dept. of Medicine and Cardiovascular
Research Institute, Univ. of Calif. San Francisco
1974-78
Attending Physician, Emerg. Service, San Francisco General Hospital
1977-78
Assistant Professor of Medicine-in-Residence and Associate, Cardiovascular Research
Institute, University of California, San Francisco
1978-81
Assistant Professor of Medicine, Division of Pharmacology, UCSD.
1978Member, Cancer Center, Biomedical Sciences Graduate Program, Neurosciences
Graduate Program, Molecular Pathology Graduate Program, UCSD.
1981-87
Associate Professor of Medicine, Division of Pharmacology, UCSD
1981 & 86 Visiting Scientist, INSERM Unite 99 Creteil, France
1987Professor of Pharmacology and Professor of Medicine, UCSD.
1989Director, M.D.-Ph.D. (Medical Scientist Training) Program, UCSD.
2005
Consultant/Visiting Scientist, NHLBI, NIH.
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1979
1980
1980
1980
1983
1997
Endocrine Society
American Heart Association (Basic Science & Hypertension Councils)
American Society for Clinical Investigation
American Society for Biochem. and Mol. Biol.
Council for High Blood Pressure Research
Association of American Physicians
Editorial
Boards:
1978-92
19801983-05
1988-91
1988-93
1988-94
1990-95
19901993-95
1994-00
1999-00
20002000200120022003200420052005-
Annual Review of Pharmacology and Toxicology
Journal of Receptors and Signal Transduction Res. (formerly J. Cyclic Nucleotide Res.)
Molecular Pharmacology
Endocrinology
Journal of Biological Chemistry
American Journal of Physiology (Renal Fluid and Electrolyte Physiology)
Hypertension
American Journal of Physiology (Cell Physiology)
Pharmacology and Toxicology
Journal of Molecular Medicine
Prevention Magazine (Advisory Board)
Nauyn Schmiedeberg's Archives of Pharmacology
American Journal of PharmacoGenomics
Biomed Central Pharmacology (Subject Advisor)
Pharmacogenetics
Journal of American College of Cardiology (Editorial Advisor)
Purinergic Signaling
FASEB Journal
Molecular Diagnosis & Therapy
Editorships:
1992-97
1992-93
19961998-01
1998-01
19992001-03
20002003-06
2006-
Deputy Editor, Journal of Clinical Investigation; Co-Chief Editor 1996-97
Associate Editor, Circulation
Associate Editor, American Journal of Physiology-Cell Physiology
Associate Editor, Journal of Pharmacology and Experimental Therapeutics
Associate Editor, British Journal of Pharmacology
Associate Editor, Annual Review of Pharmacology and Toxicology
Associate Editor, Molecular Pharmacology
Associate Editor, Pharmacological Reviews
Editor-in-Chief, Molecular Pharmacology
Co-Chief Editor, Faculty of 1000, Pharmacology
Visiting Professorships and Invited
Seminars
(since 1985)
National Institutes of Health, NIGMS/PRAT Program; NIA; NICHD
University of Washington, Dept. of Pharmacology
University of Iowa, Dept. of Medicine
UCLA, Dept. of Pharmacology
University of California, Davis, Dept. of Biochemistry
University of California, Riverside, Division of Biomedical Sciences
St. Louis University, Dept. of Biochemistry
University of Southern California, Dept. of Physiology
University of Southern Calif., Dept. of Biochemistry
University of Michigan, Dept. of Pharmacology
Bowman Gray School of Medicine
University of California, Irvine, Dept. of Pharmacology
Abbott Laboratories, Pfizer, Allergan, Easai Pharmaceutical Corporation, Wyeth-Ayerst, Proctor and
Gamble Research Laboratory, Genentech, Specialty Laboratories, Syntex, Bristol-Myers Squibb
Res. Institute, Lederle Laboratories, Athena Neurosciences, Small Molecule Therapeutics, Isis
Pharmaceuticals, Axiom Biotechnologies, Acadia Pharmaceuticals; Theravance
University of Leicester, Dept. of Pharmacology
Glasgow University, Dept. of Biochemistry
University of London, Dept. of Biochemical Pharmacology
Mario Negri Institute, Italy
University of North Carolina, Dept. of Biochemistry
City University of Yokohama, Dept. of Pharmacology
University of Tokyo, School of Pharmaceutical Chemistry
University of Tubingen, Institute of Pharmacology and Toxicology
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University of South Carolina, Depts of Pharmacology and Medicine
Emory University
Case Western Reserve University, Dept. of Pharmacology
Cleveland Clinic Foundation
Scripps Clinic and Research Foundation
INSERM U-99
University of Essen (Germany), Dept. of Pharmacology; Depts. of Medicine & Pediatrics
Stanford University, Howard Hughes Medical Institute
Endocrine Society, Introduction to Endocrine Research; Introduction to Molecular & Cellular Research
Washington University, Myocardial SCOR Program
Georgetown University, Dept. of Physiology and Dept. of Pharmacology
University of Western Ontario, Dept. of Pharmacology, London Cardiovascular Research Society
Brown University, Depts. of Medicine and Pharmacology
Dartmouth University, Dept. of Pharmacology
Oberlin College, Depts. of Biology and Neurosciences
University of South Alabama, Dept. of Pharmacology
Stanford University, Hopkins Marine Station
Columbia University, Dept. of Pharmacology
Thomas Jefferson University, Dept. of Physiology
SUNY Stonybrook, Undergraduate Colloquium
University of Nevada, Reno, Dept. of Pharmacology
Loma Linda University, Perinatal Biology Division
University of Texas, San Antonio, Dept. of Pharmacology
University of Pennsylvania, Dept. of Pharmacology
University of Minnesota, Dept. of Pharmacology
University of Houston School of Pharmacy
Harvard Medical School, Seminar in Medicine, Beth Israel Hospital
Harvard-University of Massachusetts Toxicology Research Roundtable
Presidential Lecturer, American College of Neuropsychopharmacology
State of the Art Lecturer, Western Clinical Research Meetings
Cornell University Medical School, Dept. of Pharmacology
University of Pittsburgh, Dept. of Pharmacology
Scripps Research Institute
University of Colorado, Dept. of Pharmacology
Hokkaido Univ., Dept. of Pathology and Cardiovascular Medicine (Japan)
Baylor Univ., Dept. of Medicine
New York Univ., Dept. of Medicine
University of Alabama, Dept. of Physiology
University of Utah, Dept. of Pharmacology
Karolinska Inst.(Sweden)
Dalhousie University, (Peter Dresel Memorial Lecturer)
University of South Alabama (Distinguished Basic Science Lecturer)
University of Virginia (Medical Student Research Symposium, Keynote Address)
Professional Service:
Consultant &
1983
1982-86
1982-87
1978-
19781987-93
1990-95
1991
1991-98
1992-94
1994-00
1997-00
1993
Member, Adv. Panel on Cell. and Molec. Neurobiology; Grant Reviewer, NIMH
Member, Pharmacology Study Section, NIH
Member, Research Allocation Committee (Chair, 1984-1985), San Diego Heart Assn.
NSF, Veterans' Administration, March of Dimes Fdn, Canadian Med. Research Council,
Australian Med. Research Council, NIH Ad Hoc reviewer, Wellcome Trust Medical
Research Council of Hong Kong; Medical Res. Council UK Ad-hoc reviewer
American Cancer Soc. and NIH (NIGMS, NHLBI, NIA, NINCDS, NCI, NINCDS, NCI,
DRG) Ad Hoc study section member
American Heart Association, California Affiliate South Peer Review Committee, Vice Chair
(1989-1991); Chair (1991-1993)
Amer. Heart Assoc., Western States Affiliate Research Committee; Vice-chair (1997-99)
Board of Science. Councilors (Ad Hoc), Natl. Inst. on Aging
Member, Pharmacology Test Cmte, Natl. Board of Medical Examiners; Chair (1994-98)
Chair, Applied Pharmacology Task Force, Natl Board of Medical Examiners
Member, National Board of Medical Examiners
Chair, Step 1 Committee, National Board of Medical Examiners
Board of Scientific Advisors, Sandoz Research Institute
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1993
19951996
1996-02
1997
1997
1997
1997,2000
1998-03
19991999-03
2000-01
2000-02
2002-03
20032002-03
2003-04
2002-06
2004
2004
2006
2006-09
Member, Medical Research Council (UK) Review of Cell Regulation
Board of Scientific Councilors (Ad Hoc), NIMH, NINDS, NICHD
NIGMS Advisory Council, Ad Hoc Member
Scientific Advisory Board, Collateral Therapeutics
IUPHAR Nomenclature Committee on P2-purinergic receptors
University of South Carolina, NSF EPSCO Advisory Committee
University of Illinois, M.D./Ph.D. Program Advisory Committee
External Advisor, Case Western Reserve University, Pharmacology Training Grant
Member, Graduate Research and Training Group, American Association of Medical
Colleges; Nominating Committee Member, Program Committee Member
American Association of Medical Colleges (AAMC), Advisory Panel on Research; Medical
School Curriculum Review Committee
Member, Interdisciplinary Committees, National Board of Medical Examiners
American Association of Medical Colleges, Basic Science Content Panel
Scientific Advisory Board, Axiom Biotechnologies
Scientific Advisory Board, Prime Biotech
Scientific Advisory Board, Sequenom
External Advisor, Cell and Molecular Biology Grad Program, Univ. Pennsylvania and
Medical Scientist Training Program, Yale University
External Examiner, PhD Theses: Karolinska Institute, Sweden; Nat. Univ Singapore; U of
Houston
Chair, Keystone Symposium on G-Protein-Coupled Receptors
Scientific Advisory Board Member, Cambridge Health Tech Institute Signal Transduction
Conference
Advisory Member, NIH Roadmap Workshop on Clinical Research Training
Ad-hoc Reviewer, Howard Hughes Medical Institute
Council Delegate, Medical Sciences, American Association for the Advancement of
Science
Manuscript Reviewer:
Science; Proceedings Natl. Acad. Science, USA; Analytical Biochemistry; Biochemistry;
(since 1985) Life Sciences; Biochemical Pharmacology; Journal of Pharmacology and
Experimental Therapeutics; FEBS Letters; Journal of Clinical Investigation; Cancer
Research; FASEB Journal/Federation Proceedings; Hypertension; Circulation Research;
American Journal of Physiology; Molecular and Cellular Endocrinology; Journal of
Gerontology; Metabolism; Journal of Allergy & Clinical Immunology; Circulation; Kidney
International; Blood; Archives Biochemistry and Biophysics; Journal of Neuroscience; New
England Journal of Medicine; Biochimica Biophysica Acta; Journal of Cell Biology; Journal
of Molecular and Cellular Cardiology; Journal of Lipid Research; Proceedings of Society
for Experimental Biology and Medicine; Association of Proceedings of American
Physicians; Regulatory Peptides; European Journal of Pharmacology; Journal of
Hypertension; Cell Regulation; Journal of Cell Physiology; Molecular Endocrinology;
Trends in Cardiovascular Sciences; Human Genetics, Pharmacogenetics; J Cardiac
Failure ; Trends in Pharmacological Sciences, Journal of American College of Cardiology
Professional
Organizations
Councilor, Western Society for Clinical Investigation
Publications Committee, Council for High Blood Pressure Research, Am. Heart Assn.
President, Pharmacology Education and Research Foundation
Program Committee, Am. Soc. Pharmacol. Exp. Therapeutics (Chair, 1996-1999)
John Abel Award Selection Committee, Am. Soc. Pharmacol. Exp. Therap, Chair (1993)
Program Theme Committee Member Experimental Biology; Chair, Signal Transduction
Theme
Nominating Committee, Am. Soc. Pharmacol. Exp. Therap.
ASPET Award Selection Committee
Program Committee, Experimental Biology: '98; Experimental Biology '99; Intl Pharmacol.
IUPHAR Meeting, 2002
President, National Association of MD-PhD Directors; 1997- Member, Executive
Committee
ASPET representative to Experimental Biology Board
Chair, Experimental Biology Board
1980-83
1988-91
19901992-99
1992-93
1994-96
1995
1995
1997
1997-00
19992000-
University Service: Univ. of Calif. Systemwide: Member, Cancer Research Coord. Committee, 1982-1985; Chair, 1984-85
Page 4
UCSD Clinical Research Center Advisory Committee (1985-1986; Chair 1987-1988); Board of
Inquiry, VA Medical Center
UCSD: Distinguished Faculty Lecture Committee (1987, 1995); American Cancer Society Award
Committee (1988); Searle Award Selection Committee (1990); Ad Hoc Promotion Committees
(1992-), Pharmacy School Dean Search Committee; Chair, 2000-2002
School of Medicine Academic Senate Research Committee (1987-1990; Chair, 1988-1990)
UCSD School of Medicine: Nominating Committee (1987-1990); Chair 1988;1994-96; Chair, 199798); Ad Hoc Member (1998-99); Recruitment and Admissions Committee (1989-1991, 1992);
Faculty Council (Vice Chair, 1990-1991; Chair, 1991-1992, Past Chair 1992-93; Member 1997);
Student Summer Research Steering Committee (1994-97); Graduation Speaker Selection
Committee (1995-99); Dean’s Self Study Review Committee (1995-96); 25th Anniversary
Outstanding Faculty (1998) Selection Committee (1997); Strategic Planning Committee (199798); Strategic Planning Transition Team Committee (1998); Graduate Program Support
Committee, Chair (2000); Graduate Program Education Committee (2001-); Self Study Review
Committee in Graduate Training (2002); Department of Pediatrics, Search Committee (2004)
UCSD Biomedical Sciences (formerly Physiology-Pharmacology) Graduate Program: Core
Committee Member; Steering Committee member; Graduate Student Advisor; Admissions
Committee member; Minor Proposition Committee member and Chair; Major Proposition
Committee member and Chair; Standing and Promotions Committee Chairman; Faculty
Membership Committee member
UCSD Neuroscience Graduate Program: Minor Proposition Committee
UCSD Biology Dept.: Graduate Thesis and Minor Prop. Comm. Member
UCSD Chemistry Dept.: Minor Proposition and Graduate Thesis Committee member
UCSD Medical Student Advisor
UCSD Dept. of Medicine: several ad hoc, review and search committees; Advisory Committee (198386); Education Committee (1984-87; 1999-); Research Committee (1986-88); Honors and
Awards Committee (1988-91)
UCSD Dept. of Pharmacology: Chair and Member, several ad/hoc review and search committees;
Joint Appointments Committee (Chair); Space Committee; Teaching Committee; Long Range
Planning Committee
UCSD School of Pharmacy Planning Committee Member (2000-2); Dean's Search Committee, Chair
(2001); Educational Policy and Academic Oversight Committee (2002-); Committee on
Academic Personnel (2004-)
Stein Research Institute Scientific Advisory Board (2004-)
Research Support: 1977-82 Established Investigator, Amer. Heart Assoc., "Adrenergic Receptors and Cyclic AMP in
Cellular Function" – $128,000
1977-78 UCSF Academic Senate Committee on Research and Research Evaluation and Allocation
Committee, "Identification and Regulation of Beta-adrenergic Receptors of Cultured S49
Cells – $5,500
1977-78 National Science Foundation, "Genetic Analysis of Hormone Action and Cell Growth" (CoP.I. with Henry Bourne) – $70,000
1978-79 NIH, "Hormonal Control of Uterine Adrenotropic Receptors" (co-invest. with Dr. James
Roberts and Alan Goldfien) – $96,000
1978-79 UCSF Committee on Research Evaluation and Allocation, "Insulin Action in Cultured S49
Cells" – $3,000
1978-80 UCSD Academic Senate Committee on Research, "Cellular Mechanism of Refractoriness
to Catecholamines" – $4,500
1979-82 National Science Foundation, "Regulation of Beta-adrenergic Receptors and Response" –
$211,000
1979-82 American Heart Association "Molecular Properties of -adrenergic Receptors" – $69,000
1979-81 California Heart Association, "Regulation of Beta-adrenoreceptors by Glucocorticoids" –
$17,477
1979-80 American Cancer Society, Institutional Research Grant "Polyamine Biosynthesis in S49
Lymphoma Cells" – $2,500
1980-82 Calif. Heart Assoc., "Adrenergic Receptors in Hypertension" – $16,209
1980-85 NIH, SCOR in Hypertension (PI, Morton Printz) Unit 4, "Adrenergic Receptors in
Hypertension" and Core, "Radioiodination and Radioligand Binding", – $86,800
1982-83 University of California Cancer Research Coordinating Committee, "Cell Cycle Analysis of
Lymphoma Cells Grown in Defined Medium" – $15,500
1982-84 American Cancer Society, "Function of Tumor Cells Grown in Defined Medium" - $121,000
Page 5
1982-85 National Science Foundation, "Regulation of -adrenergic Receptors and Response" –
$210,000
1983-85 NIH, "Cellular Metabolism of Adrenergic Receptors" – $217,000
1985-88 National Science Foundation, "Regulation of -adrenergic Receptors and Response" –
$290,000
1985-86 Elsa U. Pardee Foundation, "Catecholamine Receptors in Human Erythroleukemia Cells" –
$29,000
1986-91 NIH, "Cellular Metabolism of Adrenergic Receptors" – $562,000
1986-91 NIH, "Renal Adrenergic Receptors in Hypertension" – $542,400
1988-93 NIH, "-Adrenergic Receptors in S49 Lymphoma Cells"– $548,000
1989-90 Univ. of California, “Generation of phospholipase C variants and oligonucleotide inhibitors
of protein kinase C” - $31,000
1990-95 NIH, SCOR in Myocardial Ischemia (PI, John Ross), Unit I, “Adrenergic Receptors and
Post-Receptor Components in Myocardial Ischemia” – $117,000
1991-95 NIH, "Cellular Action of Adrenergic Receptors" – $414,000
1992-97 NIH, "Genetic and receptor mechanisms in hypertension" (PI, Morton Printz), Unit 4, Renal
adrenergic receptors in hypertension, – $540,008
1993-97 NIH, "-adrenergic receptors in S49 lymphoma cells" – $497,300
1995-00 NIH, SCOR in Heart Failure (PI, John Ross), Unit III, “Adrenergic receptor signalling in
heart failure”, $115,000
1995-99 NIH "Cellular Action of Adrenergic Receptors" – $580,000
1999-04 NIH, "Sympathetic Neuroeffector Junctions and Blood Pressure" (PI, D.T. O’Connor), Core
C, “Adrenergic Receptor and Intracellular Signalling Core” – $84,286
1999-00 Univ. of Calif. University-wide AIDS Research Program, “CXCR4 Receptor Signalling and
Desensitization” – $60,400
1999-00 Cystic Fibrosis Foundation, “Cyclic AMP Signaling in Airway Epithelial Cells” – $75,000
1999-00 Elsa U. Pardee Fndn., “Tumor-Cell Killing by Cyclic AMP” – $97,620
1999-04 NIH, "Signaling in Anion Trasport and Inflammation in Cystic Fibrosis" (PI, P. Quinton),
Project 3, "Cyclic AMP signalling in epithelial cells" – $96,120
2000-04 NIH, "Molecular Physiology of Heart Failure" (PI, K. Chien), Project 4, “Adenylate Cyclase
Regulation and Heart Failure” – $140,866
2000-04 NIH/NHLBI, "Gene Transfer of Adenylyl Cyclase to Cardiovascular Cells" – $200,000
2001-05 NIH, ”Autonomics Pharmacodynamics Pharmacogenomics – Receptors and Signal
Transduction" (PI, D. O'Connor); Core D – $168,921
2001-05 NIH, Gene Therapy: From Basic Science to Clinical Practice (PI, H.K. Hammond); Project
2, "Gene Transfer of Adenylyl Cyclase to Pulmonary Smooth Muscle Cells" – $175,997
2002-06 NIH/NIGMS, "-adrenergic Receptors of S49 Lymphoma Cells" – $225,000
2003-07 NIH/NIGMS, "Hypertonic Saline and Immune Function," (PI, W. Junger) –$200,000
2003-05 SIRA, “Cell Death in Colon Cancer Cells” (Co-PI with Lars Eckman) - $120,000
2004-08 NIH/NIGMS ”Adrenergic and Purinergic Regulation of Target Cells— $217,500
2005-08 Lymphoma and Leukemia Society SCOR, Unit 3 PI: “Targeting cyclic nucleotide
phosphodiesterase in the treatment of CLL”-$195,000.
2005-10 NIH “Sympathetic Neuroeffector Junctions and Blood Pressure - Core E, “Biochemistry and
Signal Transduction” (Co-PI with M. Ziegler): – $50,000
Student and Trainee Supervision:
UCSF (1975-78)
UCSD (1978-present)
Medical Student Research Fellows: Michael Shear, Lloyd Stoolman, Robert Goldfein, John
Peabody
Clinical Pharmacology Fellows: Michael Johnson, M.D., Michael Kennedy, M.D.
Graduate Students Supervised for Ph.D.
Marshall Snavely
(1979-84)
Lawrence Mahan
(1980-84)
Sandra Slivka
(1983-88)
Jeffrey Jasper
(1985-90)
Barbara Weiss
(1987-90)
Bonnie Firestein
(1991-95)
Sheryl Denker
(1992-97)
Alex Zambon
(1997-00)
Brian Head
(2001-05)
James Swaney
(2001-05)
David Arthur
(2001-06)
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Ross Corriden
(2002-)
Graduate Students on Rotation:
Brian Guth, Susan Brown, Paul Shapiro, Susannah Chang, Dale Schenk, Eric First, Jan
McCallister, Gary Heiserman, Teresa Donch, James Moberly, Grai Andreason, Michael Boyle,
Alan Fong, Bruce Gill, Scott Struthers, Jeff Frost, Joel Zhou, Tso-Pang Yao, Sonia Villejas,
Jody Martin, Karen Anderson, Elizabeth Peters, David Dirig, Fran Putkey, Dan Kalafus, Brian
Molles, Melissa Betts, Alex Zambon, Amy Bower, Jason Trama, Scott Burkette, Jennifer Knox,
Michael Morrisette, Helen Chen, Kevin Ring, Brett Crawford, Dan Shen, Jon Violin, Scott
Coleman, Brett Holquin, David Arthur, Matt Pecot, Brian Head, James Swaney, Chris Means,
Ryan Hibbs, Kathryn Nguyen, Ross Corriden, Mike Griffin, John Mongan, Christine Gould,
Jacob Gump, Valerie Vitkauskas, Yousuke Horikawa, Chen-Ting Ma, Rhiannon Nolin, Sean
Kandel, Cynthia Perry
Medical Students Supervised for Independent Study:
Daniel Sternfeld, Karin Klijn, *Carlos Corvera, Frank Ho, *J. Paul Jacobson, Allison Nguyen,
Matt Bengard, Jason Etzel (Duke University) (*Graduating Medical Student Research Prize)
Undergraduate Independent Research Students:
Michael Honeysett, Michael Boyle, Foster Carr, Lisa Tall, Daryn Sperling, Virginia Simnad,
Blair Conner, Brian Fong, Kirsten Lowrey, Susanne Pederson, Kevin Menkes, Carol Yeo,
Cecilia Kao, Jonathon Holt, Derek Guist, Julie Wu, Jason Hofer, Will Ferguson, Kathryn
Nguyen, Ross Corriden, Linda Pan, Jean-Paul Strong, Catherine Tzao, Hunaid Gurji, Aaron
Nagiel, Kimber Bennett, Nicole Chin, Michael Hwang, Jessica Witherspoon, Madeline
Lancaster, LeMar Slater, Darwin Castillo, Ryan Suda, Magnus Lu, Nicolas Boehling, Heidi
Petersen, Sean Georgi, Joseph Kaminsky, Tracy Yep, Daisy Chou, Steve Fuhs
Postdoctoral Fellows:
Mark Dibner, Ph.D.
Frederick Darfler, Ph.D.
Richard Hughes, Ph.D.
Harvey Motulsky, M.D.
Kathryn Meier, Ph.D.
Peter Munzel, Ph.D.
Lawrence Mahan, Ph.D.
Bruce Terman, Ph.D.
Alan Maisel, M.D.
Ruth McKernan, Ph.D.
Marthe Howard, Ph.D.
Jerene Waite, Ph.D.
Martin Michel, Ph.D.
Lennart Ransnäs, M.D., Ph.D.
Catherine Godson, Ph.D.
Denis Leiber, Ph.D.
Douglas Craig, Ph.D.
Cynthia Jackson, Ph.D.
Kazushi Urasawa, M.D., Ph.D.
Steven Post, Ph.D.
Naoki Mochizuki, M.D., Ph.D.
Daniel Kiel, Ph.D.
Maria Balboa, Ph.D.
Greg Shen, Ph.D.
Mingzhao Xing, M.D., Ph.D.
Ginell Post, M.D., Ph.D.
Rainer Büscher, M.D.
Volker Herrmann, M.D.
Michael Samardzija, Ph.D.
Kuniko Horie, M.D., Ph.D.
Rennolds Ostrom, Ph.D.
Lizhen Yan, Ph.D.
Brinda K. Rana, Ph.D.
Lingzhi Zhang, Ph.D.
Page 7
1979-80
1979-82
1979-82
1980-83
1981-84
1983-84
1984-85
1984-87
1984-86
1985-87
1985-88
1986-90
1987-89
1986-88
1988-91
1989-91
1991-92
1990-93
1990-93
1992-95
1993-95
1993-95
1993-95
1993-97
1994-97
1995-96
1996-98
1996-99
1997-98
1997-00
1998-01
1999
1999-01
2000; 2002-04
Xiaoqiu Liu, Ph.D
Richard Bundey, Ph.D.
Shelli Kirstein, Ph.D.
Chih-Min Tang, Ph.D.
Hiroshi Nishihara, M.D., Ph.D
Hemal Patel, Ph.D.
Fiona Murray, Ph.D.
Neil Siecke, M.D.
Evan Riddle, Ph.D.
Lin Wang, M.D., Ph.D.
Utako Yokoyama, M.D., Ph.D.
Visiting Scientists:
Esam Moustafa, Ph.D.
Rainer Box, Ph.D.
Adolpho Garcia-Sainz, Ph.D.
Petr Svoboda, Ph.D.
Adawia Alousi, Ph.D.
Adela Sanchez, Ph.D.
Jesus Saiz, Ph.D.
Jose Camacho, M.D.
Lars Christian Rump, M.D.
Luisa Iacovelli, M.D.
Christine Bohmann, Ph.D.
Stefania Mariggio
Darakhshanda Shehnaz, Ph.D.
Tetsuo Shiina, Ph.D.
Rainer Buscher, M.D.
Andre Hornung, M.D.
2000-03
2001-04
2002-05
2002-05
2002-04
2002-05
2003-present
2003-05
2003-05
2005-present
2005-present
1980-81
1987
1987
1986,1988
1989-92
1991-92
1991-92
1992-96
1995
1995
1996
1997
1998-99
2000-02
2004
2004
BIBLIOGRAPHY
Original Articles
1.
Wolter JR, Insel PA, Willey EN. Eye pathology following maternal rubella: A study on four children. J Ped Ophth,
3:29-35, 1966.
2.
Sherwin RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist JE, Berman M, Andres R. A model of the kinetics of insulin
in man. J Clin Invest, 53(5):1481-1492, 1974.
3.
Insel PA, Liljenquist JE, Tobin JD, Sherwin RS, Watkins P, Andres R, Berman M. Insulin control of glucose
metabolism in man: A new kinetic analysis. J Clin Invest, 55(5):1057-1066, 1975.
4.
Insel P, Balakir R, Sacktor B. The binding of cyclic AMP to renal brush border membranes. J Cyclic Nucleotide
Res, 1:107-122, 1975.
5.
Insel PA, Bourne HR, Coffino P, Tomkins GM. Cyclic AMP dependent protein kinase: Pivotal role in regulation of
enzyme induction and growth. Science, 190:896-898, 1975.
6.
Hochman J, Insel PA, Bourne HR, Coffino P, Tomkins GM. A structural gene mutation affecting the regulatory
subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Nat Acad Sci USA, 72(12):50515055, 1975.
7.
Coffino P, Bourne HR, Hochman J, Insel P, Melmon KL, Tomkins GM. Hormone mediated lymphoma cell death:
Mechanism of glucocorticoid and cyclic AMP action. J Invest Dermatol, 67(5):648-649, 1976.
Page 8
8.
Insel PA, Maguire ME, Gilman AG, Bourne HR, Coffino P, Melmon KL. Beta adrenergic receptors and adenylate
cyclase: Products of separate genes? Mol Pharmacol, 12:1062-1069, 1976.
9.
Shear M, Insel PA, Melmon KL, Coffino P. Agonist-specific refractoriness induced by isoproterenol: Studies with
mutant cells. J Biol Chem, 251(23):7572-7576, 1976.
10.
Hochman J, Bourne HR, Coffino P, Insel PA, Krasny L, Melmon KL. Subunit interaction in cyclic AMP-dependent
protein kinase of mutant lymphoma cells. Proc Nat Acad Sci USA, 74(3):1167-1171, 1977.
11.
Roberts J, Insel PA, Goldfien RD, Goldfien A. Identification of beta-adrenergic binding sites in rabbit myometrium.
Endocrinology, 101:1839-1843, 1977.
12.
Roberts JM, Insel PA, Goldfien RD, Goldfien A. -adrenoreceptors but not -adrenoreceptors increase in rabbit
uterus with oestrogen. Nature, 270:624-625, 1977.
13.
Coffino P, Bourne HR, Insel PA, Melmon KL, Johnson G, Vigne J. Studies of cyclic AMP action using mutant tissue
culture cells. In Vitro, 14(1):140-145, 1978.
14.
Insel PA, Fenno J. Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine
and S-adenosylmethionine decarboxylase activities. Proc Nat Acad Sci USA, 75(2):862-865, 1978.
15.
Insel PA, Stoolman LM. Radioligand binding to beta-adrenergic receptors of intact cultured S49 cells.
Pharmacol, 14:549-561, 1978.
16.
Insel PA, Kennedy MS. Colchicine potentiates -adrenoceptor-stimulated cyclic AMP in lymphoma cells by an
action distal to the receptor. Nature, 273(5662):471-473, 1978.
17.
Galant SP, Underwood S, Duriseti L, Insel PA. Characterization of high-affinity 2-adrenergic receptor binding of
(–)-[3H]-dihydroalprenolol to human polymorphonuclear cell particulates. J Lab Clin Med, 92(4):613-618, 1978.
18.
Insel PA, Nirenberg P, Turnbull J, Shattil SJ. Relationships between membrane cholesterol, -adrenergic
receptors, and platelet function. Biochemistry, 17:5269-5274, 1978.
19.
Kaywin P, McDonough M, Insel PA, Shattil SJ. Platelet function in essential thrombocythemia: Decreased
epinephrine responsiveness due to a deficiency of platelet -adrenergic receptors. New Engl J Med, 299:505-509,
1978.
20.
Galant SP, Duriseti L, Underwood S, Insel PA. Decreased beta-adrenergic receptors on polymorphonuclear
leukocytes after adrenergic therapy. New Engl J Med, 299:933-936, 1978.
21.
Johnson GL, Bourne HR, Gleason MK, Coffino P, Insel PA, Melmon KL. Isolation and characterization of S49
lymphoma cells deficient in beta-adrenergic receptors: Relation of receptor number to activation of adenylate
cyclase. Mol Pharmacol, 15:16-27, 1979.
22.
Roberts JM, Goldfien RD, Tsuchiya AM, Goldfien A, Insel PA. Estrogen treatment decreases -adrenergic binding
sites on rabbit platelets. Endocrinology, 104(3):722-728, 1979.
23.
Kennedy MS, Insel PA. Inhibitors of microtubule assembly enhance beta-adrenergic and prostaglandin E1stimulated cyclic AMP accumulation in S49 lymphoma cells. Mol Pharmacol, 16:215-223, 1979.
24.
Insel PA, Sanda M. Temperature-dependent changes in binding to -adrenergic receptors of intact S49 lymphoma
cells. Implications for the state of the receptor that activates adenylate cyclase under physiological conditions. J Biol
Chem, 254:6554-6559, 1979.
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Kaiser N, Bourne HR, Insel PA, Coffino P. Regulation of phosphodiesterase and ornithine decarboxylase by cAMP
is cell cycle independent. J Cell Physiol, 101(3):369-374, 1979.
26.
Galant SP, Duriseti L, Underwood S, Allred S, Insel PA. Beta-adrenergic receptors of polymorphonuclear
particulates in bronchial asthma. J Clin Invest, 65(3): 577-585, 1980.
27.
Darfler FJ, Murakami H, Insel PA. Growth of T-lymphoma cells under serum-free medium: Lack of involvement of
the cyclic AMP pathway in long-term cultures. Proc Nat Acad Sci USA, 77(10):5993-5997, 1980.
28.
Motulsky HJ, Shattil SJ, Insel PA. Characterization of 2-adrenergic receptors on human platelets using
[3H]yohimbine. Biochem Biophys Res Commun, 97(4):1562-1570, 1980.
29.
Shattil SJ, McDonough M, Turnbull J, Insel PA. Characterization of -adrenergic receptors in human platelets using
[3H]clonidine. Mol Pharmacol, 19:179-183, 1981.
30.
Insel PA, Darfler FJ, Kennedy MS. Cholera toxin can recouple hormone receptors that are uncoupled from
adenylate cyclase. FEBS Letters, 128(1):59-62, 1981.
31.
Dibner MO, Wolfe RA, Insel PA. Replacement of serum with a defined medium increases -adrenergic receptor
number in cultured glioma cells. Exp Cell Research, 131:424-427, 1981.
32.
Roberts JM, Insel PA, Goldfien A. Regulation of myometrial adrenoreceptors and adrenergic response by sex
steroids. Mol Pharmacol, 20:52-58, 1981.
33.
Dibner MD, Insel PA. Growth of C6 glioma cells in serum-containing medium decreases -adrenergic receptor
number. J Cell Physiol, 109:309-315, 1981.
34.
Darfler FJ, Hughes RJ, Insel PA. Characterization of serum-induced alterations in the cyclic AMP pathway in S49
lymphoma cells. J Biol Chem, 256(16):8422-8428, 1981.
35.
Dibner MD, Insel PA. Serum catecholamines desensitize -adrenergic receptors of cultured C6 glioma cells. J Biol
Chem, 256(14):7343-7346, 1981.
36.
Insel PA, Honeysett JM. Glucocorticoid-mediated inhibition of ornithine decarboxylase activity in S49 lymphoma
cells. Proc Nat Acad Sci USA, 78(9):5669-5672, 1981.
37.
Honeysett JM, Insel PA. Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of
S49 lymphoma cells by agents increasing cyclic AMP, J Cyclic Nucleotide Res, 7(15):321-332, 1981.
38.
Motulsky HJ, Insel PA. [3H]Dihydroergocryptine binding to alpha-adrenergic receptors of human platelets:
a reassessment using the selective radioligands [3H]prazosin, [3H]yohimbine, and [3H]rauwolscine. Biochem
Pharmacol, 31(16):2591-2597, 1982.
39.
Darfler FJ, Insel PA. Serum-free culture of resting, PHA-stimulated and transformed lymphoid cells, including
hybridomas. Exp Cell Res, 138:287-295, 1982.
40.
Karliner JS, Motulsky HJ, Insel PA. Apparent "down regulation" of human platelet alpha 2-adrenergic receptors is
due to retained agonist. Mol Pharmacol, 21:36-43, 1982.
41.
Karliner JS, Motulsky HJ, Dunlap J, Brown JH, Insel PA. Verapamil competitively inhibits 1-adrenergic and
muscarinic but not -adrenergic receptors in rat myocardium. J Cardiovas Pharmacol, 4:515-520, 1982.
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Hughes RJ, Boyle MR, Brown D, Taylor PW, Insel PA. Characterization of coexisting alpha 1- and beta2-adrenergic
receptors on a cloned smooth muscle line, BC3H-1. Mol Pharmacol, 22:258-266, 1982.
43.
Snavely MD, Insel PA. Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex: differential
regulation of alpha1- and alpha2-receptors by guanyl nucleotides and Na+. Mol Pharmacol, 22:532-546, 1982.
44.
Snavely MD, Motulsky HJ, O'Connor DT, Ziegler M, Insel PA. Adrenergic receptors in experimental and clinical
pheochromocytoma. Clin Exp Hypertens, A4 (4,5):829-848, 1982.
45.
Insel PA, Stengel D, Ferry N, Hanoune J. Regulation of adenylate cyclase of human platelet membranes by
forskolin, J Biol Chem, 257(13):7485-7490, 1982.
46.
Insel PA, Koachman AM.
Cytochalasin-B enhances hormone and cholera toxin-stimulated cyclic AMP
accumulation in S49 lymphoma cells. J Biol Chem, 257(16):9717-9723, 1982.
47.
Motulsky HJ, Hughes RJ, Brickman A, Farfel Z, Bourne HR, Insel PA. Platelets of pseudohypoparathyroidism
patients: Evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate
cyclase. Proc Natl Acad Sci USA, 79:4193-4197, 1982.
48.
Snavely MD, Motulsky HJ, Moustafa E, Mahan LC, Insel PA. -adrenergic subtypes in the rat renal cortex: selective
regulation of 1-adrenergic receptors by pheochromocytoma. Circ Res, 51(4):504-513, 1982.
49.
Darfler FJ, Mahan LC, Koachman AM, Insel PA. Stimulation by forskolin of intact S49 lymphoma cells involves the
nucleotide regulatory protein of adenylate cyclase. J Biol Chem, 257(20):11901-11907, 1982.
50.
Stengel D, Guenet L, Desmier M, Insel P, Hanoune J. Forskolin requires more than the catalytic unit to activate
adenylate cyclase. Mol and Cell Endocrinol, 28:681-690, 1982.
51.
Hughes RJ, Insel PA. Human platelets are defective in processing of cholera toxin. Biochem J, 212:669-678, 1983.
52.
Motulsky HJ, O'Connor DT, Insel PA. Platelet 2-adrenergic receptors in treated and untreated essential
hypertension. Clin Science, 64:265-272, 1983.
53.
Motulsky HJ, Snavely MD, Hughes RJ, Insel PA. Interaction of verapamil and other calcium channel blockers with
1- and 2-adrenergic receptors. Circ Res, 52(2):226-231, 1983.
54.
Motulsky HJ, Insel PA. The influence of sodium on the 2-adrenergic receptor system of human platelets: Role for
intraplatelet sodium in receptor binding. J Biol Chem, 258(6):3913-3919, 1983.
55.
Darfler FJ, Insel PA. Clonal growth of lymphoid cells in serum-free media requires elimination of H202 toxicity. J Cell
Physiol, 115:31-36, 1983.
56.
Snavely MD, Mahan LC, O'Connor DT, Insel PA. Selective down-regulation of adrenergic receptor subtypes in
tissues from rats with pheochromocytoma. Endocrinol, 113(1):354-361, 1983.
57.
Meier KE, Snavely MD, Brown SL, Brown JH, Insel PA. 1- and 2-adrenergic receptor expression in the MadinDarby canine kidney epithelial cell line. J Cell Biol, 97:405-415, 1983.
58.
Insel PA, Mahan LC, Motulsky HJ, Stoolman LM, Stoolman LM, Koachman AM. Time-dependent decreases in
binding affinity of agonists for -adrenergic receptors of intact S49 lymphoma cells:
A mechanism of
desensitization. J Biol Chem, 258(22):13597-13605, 1983.
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Motulsky HJ, Insel PA. ADP- and epinephrine-elicited release of [3H]guanylylimidodiphosphate from platelet
membranes: implications for receptor-Ni stoichiometry. FEBS Letters, 164(1):13-16, 1983.
60.
Mahan LC, Insel PA. Use of superoxide dismutase and catalase to protect catecholamines from oxidation in tissue
culture studies. Analytical Biochemistry, 136:208-216, 1984.
61.
Moustafa E, Snavely MD, Insel PA. Selective inhibition by organic mercurials of binding to the beta 1 population of
rat renal cortical beta-adrenergic receptors. Biochem Pharmacol, 33(7):1148-1151, 1984.
62.
Münzel PA, Healy DP, Insel PA. Autoradiographic localization of -adrenergic receptors in rat kidney slices using
[125I]iodocyanopindolol. Am J Physiol, 246:F240-F245, 1984.
63.
Meier KE, Sternfeld DR, Insel PA. Alpha1- and beta2-adrenergic receptors co-expressed on cloned MDCK cells are
distinct glycoproteins. Biochem Biophys Res Commun, 118(1):73-81, 1984.
64.
Darfler FJ, Mullen MD, Insel PA. Serum-stimulated cyclic-AMP production in S49 lymphoma cells grown in serumfree medium. Biochim Biophys Acta, 803:203-209, 1984.
65.
Motulsky HJ, Maisel AS, Snavely MD, Insel PA. Quinidine is a competitive antagonist at 1- and 2-adrenergic
receptors. Circ Res, 55(3):376-381, 1984.
66.
Maisel AS, Motulsky HJ, Insel PA. Hypotension after quinidine plus verapamil: Possible additive competition at
alpha-adrenergic receptors. N Engl J Med, 312:167-170, 1985.
67.
Meier KE, Sperling DN, Insel PA. Agonist-mediated regulation of alpha1- and beta2-adrenergic receptor in cloned
MDCK cells, Am J Physiol Cell Physiol, 246:C69-C77, 1985.
68.
Mahan LM, Koachman AM, Insel PA. Genetic analysis of -adrenergic receptor internalization and down regulation,
Proc Natl Acad Sci USA, 82(1):129-133, 1985.
69.
Snavely MD, Ziegler MG, Insel PA. A new approach to determine rates of receptor appearance and disappearance
in vivo: Application to agonist-mediated down-regulation of rat renal cortical 1- and  2-adrenergic receptors. Mol
Pharmacol, 27:19-26, 1985.
70.
Mahan LC, Motulsky HJ, Insel PA. Do agonists promote rapid internalization of -adrenergic receptors? Proc Natl
Acad Sci USA, 82(19):6566-6570, 1985.
71.
Healy DP, Münzel PA, Insel PA. Localization of 1- and  2-adrenergic receptors in rat kidney by autoradiography,
Circ Res, 57:278-284, 1985.
72.
Insel PA, Motulsky HJ, Mahan LC. Regulation of cyclic AMP accumulation in lymphoid cells. Proc Soc Exp Biol
Med, 179:472-478, 1985.
73.
Wheeler AH, Ziegler MG, Insel PA, Motulsky HJ. Episodic catatonia, hypertension, and tachycardia: elevated
plasma catecholamines. Neurology, 35:1053-1055, 1985.
74.
DeBlasi A, Liportiti H, Motulsky HJ, Insel PA, Fratelli W. Agonist-induced redistribution of beta-adrenergic receptors
on intact human mononuclear leukocytes: redistributed receptors are nonfunctional. J Clin Endocrinol Metab,
61:1081-1088, 1985.
75.
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Insel PA, Snavely MD, Healy DP, Münzel PA, Potenza CL, Nord EP. Radioligand binding and functional assays
demonstrate postsynaptic alpha2-receptors on proximal tubules of rat and rabbit kidney. J Cardiovasc Pharmacol,
7(suppl.8):S9-S17, 1985.
77.
Maisel AS, Motulsky HJ, Insel PA. Externalization of -adrenergic receptors promoted by myocardial ischemia.
Science, 230:183-186, 1985.
78.
Hughes RJ, Insel PA. Agonist-mediated regulation of 1- and 2- adrenergic receptor metabolism in a muscle cell
line, BC3H-1. Mol Pharmacol, 29:521-530, 1986.
79.
Motulsky HJ, Cunningham EMS, DeBlasi A, Insel PA. Desensitization and redistribution of -adrenergic receptors
on human mononuclear leukocytes. Am J Physiol, 250:E583-E590, 1986.
80.
Terman BI, Insel PA. Photoaffinity labeling of 1-adrenergic receptors of rat heart. J Biol Chem, 261(12):56035609, 1986.
81.
Motulsky HJ, Shattil SJ, Ferry N, Rozansky D, Insel PA. Desensitization of epinephrine-initiated platelet
aggregation does not alter binding to the 2-adrenergic receptor or receptor coupling to adenylate cyclase. Mol
Pharmacol, 29:1-6, 1986.
82.
Mahan LC, Insel PA. Expression of -adrenergic receptors in synchronous and asynchronous S49 lymphoma cells,
I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle, Mol
Pharmacol, 29:7-15, 1986.
83.
Mahan LC, Insel PA. Expression of -adrenergic receptors in synchronous and asynchronous S49 lymphoma cells,
I. Relationship between receptor number and response. Mol Pharmacol, 29:16-22, 1986.
84.
Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and
subsequent desensitization of human platelets by epinephrine. Blood, 68(6):1224-1231, 1986.
85.
Maisel AS, Motulsky HJ, Ziegler MG, Insel PA. Ischemia- and agonist-induced changes in - and -adrenergic
receptor traffic in guinea pig hearts. Am J Physiol, 253 (Heart CRC Physiol 22) H1159-H1166, 1987.
86.
Maisel AS, Motulsky HJ, Insel PA. Propranolol treatment externalizes -adrenergic receptors in guinea pig
myocardium and prevents further externalization by ischemia. Circ Res, 60(1):108-112, 1987.
87.
Terman BI, Slivka SR, Hughes RJ, Insel PA. 1-adrenergic receptor-linked guanine nucleotide-binding protein in
muscle and kidney epithelial cells. Mol Pharmacol, 31:12-20, 1987.
88.
Slivka SR, Insel PA. 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E 2 formation in
Madin-Darby canine kidney cells: possible parallel activation of phospholipase C and phospholipase A 2. J Biol
Chem, 262(9):4200-4207, 1987.
89.
Nord EP, Howard MJ, Hafezi A, Moradeshagi P, Vaystub S, Insel PA. Alpha 2 adrenergic agonists stimulate Na+-H+
antiport activity in the rabbit renal proximal tubule. J Clin Invest, 80(6):1755-1762, 1987.
90.
Howard MJ, Mullen MD, Insel PA. Amiloride interacts with renal - and -adrenergic receptors. Am J Physiol,
253:F21- F25, 1987.
91.
Insel PA, Howard MJ, Motulsky HJ, Hughes RJ. Amiloride: An -adrenergic antagonist in platelets, kidney, and
muscle cells. J Cardiovasc Pharmacol, 10(Supp 4):S11-S14, 1987.
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Hughes RJ, Struthers RS, Fong AM, Insel PA. Regulation of atrial natriuretic peptide receptor on a smooth muscle
cell line. Am J Physiol Cell Physiol, 253(6):C809-C816, 1987.
93.
Lotersztajn S, Pavoine C, Mallat A, Stengel D, Insel PA, Pecker F. Cholera toxin blocks glucagon-mediated
inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase. J Biol Chem, 262(7):3114-3117, 1987.
94.
Howard MJ, Hughes RJ, Motulsky HJ, Mullen M, Insel PA. Interaction of amiloride with - and -adrenergic
receptors: Amiloride reveals an allosteric site on 2-adrenergic receptors. Mol Pharmacol, 32:53-58, 1987.
95.
McKernan RM, Howard MJ, Motulsky HJ, Insel PA. Compartmentation of 2-adrenergic receptors of human
erythroleukemia (HEL) cells. Mol Pharmacol, 32:258-265, 1987.
96.
Henry DY, Gueritte-Voegelein F, Insel PA, Ferry N, Bouguet J, Potier P, Sevenet T, Hanoune J. Isolation and
characterization of 9-hydroxy-10-trans, 12-cis-octadecadienoic acid, a novel regulator of platelet adenylate cyclase
from Glechoma hederacea L. Labiatae. Eur J Biochem, 170:389-394, 1987.
97.
Hughes RJ, Struthers RS, Fong AM, Insel PA. Receptor-induced degradation of atrial natriuretic peptide receptors
in a smooth muscle cell. Mol Endocrinol, 2:117-124, 1988.
98.
Hughes RJ, Mahan LC, Insel PA. Certain ß-blockers can decrease ß-adrenergic receptor number II. Down
regulation of receptor number by alprenolol and propranolol in cultured lymphoma and muscle cells. Circ Res
63(2):279-286, 1988.
99.
Maisel AS, Ziegler MG, Carter S, Insel PA, Motulsky HJ. In vivo regulation of -adrenergic receptors on
mononuclear leukocytes and heart: Assessment of receptor compartmentation after agonist infusion and acute
aortic constriction in guinea pigs. J Clin Invest, 82(6):2038-2044, 1988.
100. Terman BI, Reece JF, Brown RD, Insel PA. The oligosaccharide component of 1-adrenergic receptors from BC3H1
and DDT1 muscle cells: studies with glycosidases and photoaffinity labelling of intact cells. Biochem J, 253:363370, 1988.
101. Slivka SR, Insel PA. Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release
and phosphoinositide hydrolysis in Madin-Darby Canine Kidney cells. J Biol Chem, 263(29):14640-14647, 1988.
102. Jasper JR, Motulsky HJ, Insel PA. Characterization of a bromoacetylated derivative of pindolol as a high affinity,
irreversible beta adrenergic antagonist in cultured cells. J Pharmacol Exp Ther, 244(3):820-824, 1988.
103. McKernan RM, Strickland WR, Insel PA. Selective blockade and recovery of cell surface 2-adrenergic receptors in
human erythroleukemia (HEL) cells. Studies with the irreversible antagonist benextramine. Mol Pharmacol, 33:5157, 1988.
104. Terman BI, Insel PA. Use of 1-deoxymannojirimycin to show that complex oligosaccharides regulate cellular
distribution of the alpha1-adrenergic receptor glycoprotein in BC3H-1 muscle cells. Mol Pharmacol, 38:8-14, 1988.
105. Slivka SR, Meier KE, Insel PA. 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1-cells:
A mechanism for rapid activation of protein kinase C. J Biol Chem, 263(25):12242-12246, 1988.
106. Ransnäs LA, Insel PA. Quantitation of the guanine nucleotide binding regulatory protein G s in S49 lymphoma cell
membranes using antipeptide antibodies to s. J Biol Chem, 263(19):9482-9485, 1988.
107. Jasper JR, Michel MC, Insel PA. The molecular mechanism of -adrenergic receptor blockers with intrinsic
sympathomimetic activity. FASEB J, 2:2891-2894, 1988.
Page 14
108. Ransnäs LA, Insel PA. Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native
membranes. J Biol Chem, 263(33):17239-17242, 1988.
109. Hammond HK, Ransnäs LA, Insel PA. Noncoordinate regulation of cardiac G s proteins and -adrenergic receptors
by a physiological stimulus, chronic dynamic exercise. J Clin Invest, 82(6):2168-2171, 1988.
110. Ransnäs LA, Insel PA. Quantitation of a guanine nucleotide binding regulatory protein by an enzyme-linked
immunosorbent competition assay. Anal Biochem, 176:185-190, 1989.
111. Weiss BA, Slivka SR, Insel PA. Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated
arachidonic acid metabolism in Madin-Darby canine kidney cells. Mol Pharm, 36:317-326, 1989.
112. Michel MC, Brodde O-E, Schnepel B, Behrendt J, Tschada R, Motulsky HJ, Insel PA. [ 3H]idazoxan and some other
2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Mol Pharmacol, 35:324-330, 1989.
113. Ransnäs LA, Svoboda P, Jasper JR, Insel PA. Stimulation of -adrenergic receptors of S49 lymphoma cells
redistributes the subunit of the stimulatory G protein between cytosol and membranes. Proc Nat Acad Sci, USA,
86:7900-7903, 1989.
114. Jasper JR, Motulsky HJ, Mahan LC, Insel PA. -Adrenoceptor metabolism in wild-type, Gs, and protein kinase
A-variant S49 cells. Am J Physiol Cell Physiol, 259(1):C41-C46, 1990.
115. Howard MJ, Insel PA. Elevated extracellular K+ enhances arachidonic acid release in MDCK-D1 cells. Am J Physiol
Cell Physiol, 259(2):C224-C231, 1990.
116. Maisel AS, Knowlton KU, Rearden A, Carter S, Ziegler MG, Insel PA, Michel MC. Adrenergic control of circulating
lymphocyte subpopulations: Effects of congestive heart failure, dynamic exercise and terbutaline treatment. J Clin
Invest, 85(2):462-467, 1990.
117. Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ. Nonadrenergic [ 3H]idazoxan sites are
physically distinct from 2-adrenergic receptors. Mol Pharmacol, 37:65-68, 1990.
118. Maisel AS, Lee P, Michel MC, Ziegler M, Insel PA. Pertussis toxin treatment of whole blood offers a novel approach
to assess G protein function in congestive heart failure. Circulation, 81:1198-1204, 1990.
119. Jasper JR, Michel MC, Insel PA. The -adrenoceptor antagonist carteolol and its metabolite 8-hydroxycarteolol
have different intrinsic sympathomimetic activities. Br J Clin Pharmacol, 30:109S-111S, 1990.
120. Slivka SR, Godson C, Insel PA. ras-transformation of MDCK cells alters responses mediated by protein kinase C
without altering responses mediated by bradykinin. J Cell Biochem 42:59-70, 1990.
121. Jasper JR, Michel MC, Insel PA. Amplification of -adrenergic receptor mediated cyclic AMP by antagonists with
intrinsic sympathomimetic activity. Mol Pharmacol, 37:44-49, 1990.
122. Waite JJ, Insel PA. G-protein-linked polyphosphoinositide phospholipase C activity in cell membranes from clonally
derived and ras-transformed Madin-Darby canine kidney cells. Biochem Cell Biol, 68:1119-1127, 1990.
123. Godson C, Weiss BA, Insel PA. Differential activation of protein kinase C  is associated with arachidonate release
in MDCK-cells. J Biol Chem, 265(25):8369-8372, 1990.
124. Alousi AA, Jasper JR, Insel PA, Motulsky HJ. Stoichiometry of receptor-Gs-adenylate cyclase interaction. FASEB J,
5:2300-2303, 1991.
Page 15
125. Weiss BA, Insel PA. Intracellular calcium and protein kinase C interact to regulate 1-adrenergic and bradykinin
receptor-stimulated phospholipase A2 activation in MDCK cells. J Biol Chem, 266(4):2126-2133, 1991.
126. Klijn K, Slivka SR, Bell K, Insel PA. Renal 1-adrenergic receptor subtypes: MDCK-D1 cells, but not rat cortical
membranes, possess a single population of receptors. Mol Pharmacol, 39:407-413, 1991.
127. Ransnäs LA, Leiber D, Insel PA. Inhibition of subunit dissociation and release of G s by somatostatin in S49
lymphoma cell membrane: Dependence on Mg++ and GTP. Biochem J, 280:303-307, 1991.
128. Hughes RJ, Howard MJ, Allen JN, Insel PA. Decreased beta2-adrenergic receptor mRNA expression in receptordeficient S49 lymphoma cells. Mol Pharmacol, 40:974-979, 1991.
129. Jasper JR, Michel MC, Insel PA. Partial agonistic activity of two irreversible inhibitors of -adrenergic receptors.
Biochem Pharmacol, 42:212-214, 1991.
130. Roth DA, Urasawa K, Leiber D, Insel PA, Hammond HK. A substantial proportion of cardiac G s is not associated
with the plasma membrane. FEBS Letters, 296:46-50, 1992.
131. Ransnäs LA, Jasper JR, Leiber D, Insel PA. -adrenergic receptor mediated dissociation and membrane release of
the Gs protein in S49 lymphoma cell membranes. Biochem J, 283:519-524, 1992.
132. Hammond HK, Roth DA, Insel PA, Ford CE, White FC, Maisel AS, Ziegler MG, Bloor CM. Myocardial -adrenergic
receptor expression and signal transduction after chronic volume overload hypertrophy and circulatory congestion.
Circulation, 85:269-280, 1992.
133. Jackson CA, Michel MC, Insel PA. Expression of renal adrenergic receptor subtypes in established hypertension. J
Cardiovasc Pharmacol, 19:857-862, 1992.
134. Michel MC, Jäger S, Casto R, Rettig R, Graf C, Printz M, Insel PA, Phillip T, Brodde O-E. On the role of renal adrenergic receptors in spontaneously hypertensive rats. Hypertension, 19:365-370, 1992.
135. Svoboda P, Krapil P, Insel PA, Ransnäs LA. Plasma-membrane-independent pool of -subunit of the stimulatory
guanine nucleotide binding regulatory protein in a low-density-membrane fraction of S49 lymphoma cells. Eur J
Biochem, 208:693-698, 1992.
136. Leiber D, Jasper JR, Alousi AA, Martin J, Bernstein D, Insel PA. Alteration in G s-mediated signal transduction in S49
lymphoma cells treated with inhibitors of microtubules. J Biol Chem, 268(6):3833-3837, 1993.
137. Michel MC, Brodde O-E, Insel PA. Are cardiac G-proteins altered in rat models of hypertension? J Hypertension,
11:355-363, 1993.
138. Godson C, Bell KS, Insel PA. Inhibition of expression of protein kinase C  by antisense cDNA inhibits phorbol
ester-mediated arachidonate release. J Biol Chem, 268(16):11946-11950, 1993.
139. Saffitz JE, Nash JA, Green KG, Luke RA, Ransnäs LA, Insel PA. Immunoelectron microscopic identification of
cytoplasmic and nuclear Gs in S49 lymphoma cells. FASEB J, 8:252-258, 1994.
140. Blue DR, Craig DA, Ransom JT, Camacho JA, Insel PA, Clarke DE. Characterization of the alpha-1 adrenoceptor
subtype mediating [3H]-arachidonic acid release and calcium mobilization in Madin-Darby canine kidney cells. J
Pharmacol Exp Ther, 268(3):1588-1596, 1994.
141. Büscher R, Insel PA, Michel M. Is SDZ NVI-085 an alpha-adrenoceptor-subtype selective agonist? Life Sci, 54:991007, 1994.
Page 16
142. Michel MC, Insel PA. Comparison of cloned and pharmacologically defined rat tissue 1-adrenoceptor subtypes.
Naunyn-Schmiedeberg's Arch of Pharmacol, 350:136-142, 1994.
143. Balboa MA, Firestein BL, Godson C, Bell KS, Insel PA. Protein kinase C mediates phospholipase D activation by
nucleotides and phorbol ester in Madin-Darby canine kidney cells. J Biol Chem, 269(14):10511-10516, 1994.
144. Jasper JR, Post SR, Desai KH, Insel PA, Bernstein D. Colchicine and cytochalasin B enhance cyclic AMP
accumulation via postreceptor actions. J Pharmacol Exp Ther, 274(2):937-942, 1995.
145. Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced -adrenergic receptor activation
decreases G-protein expression and -adrenergic receptor kinase activity in porcine heart. J Clin Invest,
95(3):1271-1280, 1995.
146. Insel PA, Urasawa K, Mochizuki N. Use of antisense cDNA to assess 1-adrenergic receptor coupling to G 
proteins. Pharmacol Commun, 6(1-3):73-77, 1995.
147. Post SR, Hilal-Dandan R, Urasawa K, Brunton LL, Insel PA. Quantification of signalling components and
amplification in the -adrenergic-receptor–adenylate cyclase pathway in isolated adult rat ventricular myocytes.
Biochem J, 311:75-80, 1995.
148. Balboa M, Balsinde J, Dennis EA, Insel PA. A phospholipase D-mediated pathway for generating diacylglycerol in
nuclei from Madin-Darby canine kidney cells. J Biol Chem, 270(20):11738-11740, 1995.
149. Mochizuki M, Urasawa K, Sanchez A, Insel PA. Developmental regulation of the  subunit of Gq/G11 as determined
by quantitative immunoblot analysis. Biochem Biophys Res Commun, 210(2):246-252, 1995.
150. Mochizuki N, Hibi M, Kanai Y, Insel PA. Interaction of the protein nucleobindin with G i2, as revealed by the yeast
two-hybrid system. FEBS Letters, 373:155-158, 1995.
151. Balboa MA, Insel PA. Nuclear phospholipase D in Madin-Darby canine kidney cells. J Biol Chem, 270(50):2984329847, 1995.
152. Godson C, Masliah E. Balboa MA, Ellisman M, Insel PA. Isoform-specific redistribution of pretein kinase C in living
cells. Biochim Biophys Acta, 1313:63-71, 1996.
153. Hughes RJ, Anderson KL, Kiel D, Insel PA. Cloning of GRK2 cDNA from S49 murine lymphoma cells. Am J Physiol:
Cell Physiol, 270(3):C885-C891, 1996.
154. Xing M, Insel PA. Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated
protein kinase by 1-adrenergic receptors in Madin-Darby canine kidney cells. J Clin Invest, 97(5):1302-1310, 1996.
155. Firestein BL, Xing M, Hughes RJ, Corvera CU, Insel PA. Heterogeneity of P2u - and P2y-purinergic receptor
regulation of phospholipases in MDCK cells. Am J Physiol, 271:F610-F618, 1996.
156. Post S, Jacobson JP, Insel PA. P2 purinergic receptor agonists enhance cAMP production in Madin-Darby canine
kidney epithelial cells via an autocrine/paracrine mechanism. J Biol Chem, 271(4):2029-2032, 1996.
157. Denker S, McCaffrey JM, Palade GE, Insel PA, Farquhar MG. Differential distribution of  subunits and  subunits
of heterotrimeric G-proteins on Golgi membranes of the exocrine pancreas. J Cell Biol, 133(5):1027-1040, 1996.
Page 17
158. Lortie M, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, Satriano J, Insel PA, Thomson SC, Blantz
RC. Agmatine, a bioactive metabolite of arginine production: degradation, and functional effects in the rat kidney. J
Clin Invest, 97(2):413-420, 1996.
159. Post SR, Aguila-Buhain O, Insel PA. A key role for protein kinase A in homologous desensitization of the 2adrenergic receptor pathway in S49 lymphoma cells. J Biol Chem, 271(2):895-900, 1996.
160. Mochizuki N, Cho G, Wen B, Insel PA. Identification and cDNA cloning of a novel human mosaic protein, LGN,
based on interaction with Gi2. Gene, 181:39-43, 1996
161. Balsinde J, Balboa MA, Insel PA, Dennis E. Differential regulation of phospholipase D and phospholipase A2 by
protein kinase C in P388D1, macrophages. Biochem J, 321:805-9, 1997.
162. Hughes RJ, Pasillas M, Saiz J, Jasper J, Insel PA. Decreased transcript expression coincident with impaired
glycosylation in the 2-adrenergic receptor gene does not result from differences in the primary sequence. Biochim
Biophys Acta, 1356:281-291, 1997.
163. Xing M, Tao L, Insel PA. Role of extracellular signal-regulated kinase and PKC in cytosolic PLA2 activation by
bradykinin in MDCK-D1 cells. Am J Physiol Cell Physiol, 272(2):C1380-C1387, 1997.
164. Xing M, Firestein BL, Shen GH, Insel PA. Dual role of protein kinase C in the regulation of cPLA 2-mediated
arachidonic acid release by P2u receptors in MDCK-D1 cells: Involvement of MAP kinase-dependent and
-independent pathways. J Clin Invest, 99(4):805-814, 1997.
165. Dao TT, Kailasom MT, Parmer RJ, Le HV, Le Verge R, Kennedy BP, Ziegler MG, Insel PA, Wright FA, O'Connor
DT. Expression of altered 2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary
(essential) hypertension. J Hypertension, 16:779-792, 1998.
166. Balboa M, Insel PA. Stimulation of phospholipase D via α 1-adrenergic receptors in MDCK cells independent of
PKC and -activation. Mol Pharmacol, 53:221-227, 1998.
167. Yang M, Büscher R, Taguchi K, Insel PA, Michel MC. Protein Kinase C Does Not Mediate Phenylephrine-Induced
Down-regulation of Madin-Darby CAnine Kidney Cell Alpha-1B Adrenoceptors. J Pharmacol Exp Ther, 286(1):3643, 1998.
168. Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI
proportionately increases -adrenergic receptor-stimulated cAMP in neonatal rat cardiac myocytes. Proc Natl Acad
Sci, 95:1038-1043, 1998.
169. Büscher R, Herrmann V, Insel PA. PCR-based method for identifying genetic variations in human 1B- and 2adrenergic receptors. Mol Genet Metab 64(4):266-270, 1998.
170. Post SR, Rump LC, Zambon A, Hughes RJ, Buda MD, Jacobson JP, Kao CC, Insel PA. ATP activates cAMP
production via multiple purinergic receptors in MDCK-D1 epithelial cells: Blockade of an autocrine/paracrine
pathway to define receptor preference of an agonist. J Biol Chem 273(36):23093-23097, 1998.
171. Xing M, Post S, Ostrom RS, Samardzija M, Insel PA. Inhibition of Phospholipase A2-mediated arachidonic acid
release by cyclic AMP defines a negative feedback loop for P 2Y receptor activation in Madin-Darby Canine Kidney
D1 cells. J Biol Chem, 274(15):10035-10038, 1999.
172. Büscher R, Herrmann V, Ring KM, Kailasam MT, O’Connor DT, Parmer RJ, Insel PA. Variability in phenylephrine
response and essential hypertension: a search for human 1B-adrenergic receptor polymorphisms. J Pharmacol
Exp Ther 291(2): 793-798, 1999.
Page 18
173. Shehnaz D, Torres B, Balboa M, Insel PA. Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a putative
P2Y1 receptor antagonist, blocks signaling at a site distal to the receptor in Madin-Darby Canine Kidney-D1 cells. J
Pharmacol Exp Ther, 292(1):346-350, 2000.
174. Ostrom RS, Violin JD, Coleman S, Insel PA. Selective enhancement of -adrenergic receptor signaling by
overexpression of adenylyl cyclase type 6: co-localization of receptor and adenylyl cyclase in caveolae of cardiac
myocytes. Mol Pharmacol, 57:1075-1079, 2000.
175. Ostrom RS, Gregorian C, Insel PA. Cellular release of and response to ATP as key determinants of the set-point of
signal transduction pathways J Biol Chem, 275(16):11735-11739, 2000.
176. Herrmann V, Büscher R, Go MM, Ring KM, Hofer JK, Kailasam MT, O’Connor DT, Parmer RJ, Insel PA. 2adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in Whites
and African Americans. Am J Hypertension, 13(9):1021-1026, 2000.
177. Horie K, Insel PA. Retrovirally-mediated transfer of a G protein-coupled receptor kinase dominant-negative mutant
enhances endogenous calcitonin receptor signaling in Chinese hamster ovary cells. J Biol Chem, 275(38):2943329440, 2000.
178. Yan L, Herrmann V, Hofer JK, Insel PA. -Adrenergic receptor/cAMP-mediated signaling and apoptosis of S49
lymphoma cells. Am J Physiol Cell Physiol, 279(5):C1665-C1674, 2000.
179. Zambon AC, Hughes RJ, Mezaros JG, Wu JJ, Torres B, Brunton LL, Insel PA. P2Y2 receptor of MDCK cells:
cloning, expression, and cell-specific signaling. Am J Physiol: Renal Physiol, 279(6):F1045-F1052, 2000
180. Brodde O-E, Büscher R, Tellkamp R, Radke J, Dhein S, Insel PA. Blunted cardiac responses to receptor activation
in subjects with Thr164Ile 2-adrenoceptors,Circulation, 103:1048-1050, 2001.
181. Büscher R, Belger H, Eilmes KJ, Tellkamp R, Radke J, Dhein S, Hoyer PF, Michel MC, Insel PA, Brodde, O -E.
In-vivo studies do not support a major functional role for the Gly 389Arg  1-adrenoceptor polymorphism in humans.
Pharmacogenetics, 11:199-205, 2001
182. Rana BK, Pan L, Insel PA. Use of an in silico approach to define the gene structure of eukaryotic adenylyl
cyclases. Biochem Biophys Res Commun, 285:152-157, 2001.
183. Zambon AC, Brunton LL, Barrett KE, Hughes RJ, Torres B, Insel PA. Cloning, expression, signaling mechanisms,
and membrane targeting of P2Y 11 receptors in Madin Darby canine kidney cells, Mol Pharmacol, 60(1):26-36,
2001.
184. Ostrom RS, Gregorian C, Drenan RM, Gabot K, Rana BK, Insel PA. Key role for constitutive cyclooxygenase-2 of
MDCK cells in basal signaling and response to released ATP, Am J Physiol: Cell Physiol, 281:C524-C531, 2001.
185. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar colocalization determine receptor coupling efficiency to adenylyl cyclase, J Biol Chem, 276(45):42063-9, 2001.
186. Zhang L and Insel PA. Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cyclic AMP
and dexamethasone. Am J Physiol: Cell Physiol, 281:C1641-1647, 2001.
187. Qi A-D, Zambon AC, Insel PA, Nicholas RA. Arginine-265 at the juxtaposition of TM 6 and the 3rd extracellular loop
contributes to the markedly different nucleotide selectivities of human and canine P2Y 11 receptors, Mol Pharmacol,
60(6):1375-1382, 2001.
188. Zheng B, Ma Y-C, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang X-Y, Farquhar MG. RGS-PX1: A gap for Gs
and a sorting nexin in vesicular trafficking, Science, 294:1939-1942, 2001.
Page 19
189. Torres B, Zambon AC, Insel PA. P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted
cAMP formation in MDCK-D1 cells: A mechanism for nucleotide-mediated autocrine-paracrine regulation, J Biol
Chem, 277(10):7761-5, 2002.
190. Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel PA, Ratjen F. β2 adrenoceptor gene
polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 12:347-53, 2002.
191. Ostrom RS, Liu X, Head B, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G
protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains.
Mol Pharmacol, 62(4):983-992, 2002.
192. Loomis WH, Namiki S, Ostrom RS, Insel PA and Junger WG. Hypertonic stress increases T cell interleukin-2
expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem,
278:4590-6, 2003.
193. Bruck H, Leineweber K, Büscher R, Ulrich A, Radke J, Insel PA and Brodde O.-E. The Gly27Glu β2-adrenoceptor
polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics, 13:5966, 2003.
194. Lee A, Rana BK, Schiffer H, Brann M, Insel PA, Weiner D. Distribution analysis of non-synonymous polymorphisms
within the G protein-coupled receptor gene family. Genomics. 81:245-8, 2003.
195. Ostrom RS, Naugle JE, Hase M, Gregorian C, Insel PA, Brunton LL, Meszaros JG. Angiotensin II enhances
adenylyl cyclase signaling via calcium-calmodulin: Gq-Gs crosstalk regulates collagen production in cardiac
fibroblasts. J Biol Chem. 278: 24461-8, 2003.
196. Hughes RJ, Torres B, Zambon A, Arthur D, Bohmann C, Rump LC, Insel PA. Expression of multiple P2Y receptors
by MDCK-D1 cells: P2Y1 receptor cloning and signaling. Drug Dev Res, 59:1-7, 2003.
197. Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L. Inhibition of apoptosis in normal and transformed intestinal
epithelial cells by cyclic AMP through induction of inhibitor apoptosis protein–2 (IAP-2). Proc Natl Acad Sci USA,
100:8921-6, 2003.
198. Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LOV, Jensen RV, Gullans SR, Insel PA,
Nithipatikom K, Gross GJ. 12-Lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass
spectrometric and pharmacological analysis. Circ Res, 92(6):676-82, 2003.
199. Bundey RA, Insel PA. Quantification of adenylyl cyclase messenger RNA by real-time polymerase chain reaction.
Anal Biochem 319:318-322, 2003.
200. Brindikova TA, Bourcier N, Torres B, Pchejetski D, Gekle M, Maximov GV, Montminy V, Insel PA, Orlov SN,
Isenring P. Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter. Am J
Physiol Cell Physiol, 285(6):C1445-53, 2003.
201. Liu X, Ostrom RS, Insel PA. Cyclic AMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. Am J Physiol – Cell Physiol, 286:C1089-99, 2004.
202. Ostrom RS, Bundey RA, Insel PA. Nitric oxide inhibition of adenylyl cyclase type-6 activity is dependent upon lipid
rafts and caveolin signaling complexes, J Biol Chem, 279:19846–53, 2004.
203. Zhang L, Insel PA. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and
glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem, 279:20858-65, 2004
Page 20
204. Nishihara H, Hwang M, Kisaka-Kondohi S, Eckmann L, Insel PA. Cyclic AMP promotes cAMP-responsive elementbinding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon
cancer cells through ERK1/2 and p38 MAPK. J Biol Chem, 279:26176-83, 2004.
205. Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar T, Ho H, Leverge R, Smith DW, Ziegler MG, Insel PA,
Schork NJ, Flockhart D, O'Connor DT. Human sympathetic activation by α 2-adrenergic blockade with yohimbine:
Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism, Clinical Pharmacology and
Therapeutics, 76:139-53, 2004.
206. Chen Y, Namiki S, Rictors J, Insel PA, Junger W. Defining a putative osmoreceptor in human neutrophils that
involves ATP release conversion to adenosine and activation of A 2 adenosine and P2 receptors. J Leukocyte Biol,
76:245-53, 2004.
207. Egan LJ, Smith JR, Truong F, Kirstein S, Sugimoto Y, Narumiya S, Varki NM, Insel PA, Kagnoff M, Eckmann L.
Thromboxane A2 and prostacyclin receptors are opposing regulators of the severity of experimental murine colitis,
manuscript submitted.
208. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein coupled receptor signaling
components localize in both sacrolemmal and intracellular caveolin-3-associated microdomains in adult cardiac
myocytes, J Biol Chem, 280 (35):31036-31044, 2005.
209. King D, Etzel JP, Chopra S, Smith J, Cadman PE, Rao F, Funk S, Rana BK, Schork NJ, Insel PA, O’Connor DT.
Human response to α2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence
of dose, age, gender, and receptor genotype, Clin Pharmacol Exptl Therap, 77:388-403, 2005.
210. Etzel JP, Rana BK, Wen G, Parmer R, Schork N, O”Connor DT, Insel PA. Genetic variation at the human α2Badrenergic receptor locus: role in blood pressure variation and yohimbine response, Hypertension, 45:1207-13,
2005.
211. Tang CM, Hoerning A, Buescher, R, O’Connor DT, Ratjen F, Grasemann H, Insel PA. Human adenosine 2B
receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis, Pharmacogenetics and
Genomics, 15:321-327, 2005.
212. Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel PA. Inhibition of cardiac myofibroblast formation
and collagen synthesis by activation and overexpression of adenylyl cyclase, Proc Natl Acad Sci USA, 102:427442, 2005.
213. Arthur DB, Akassoglou K, Insel PA. P2Y2 receptor activates NGF/TrkA receptor signaling to enhance neuronal
differentiation, Proc Natl Acad Sci USA, 102:19138-19143, 2005.
214. Zambon AC, Zhang L, Minovitsky S, Kanter J, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin B, Insel
PA. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase
A. Proc Natl Acad Sci USA, 102:8561-8566, 2005.
215. Akimova OA, Bouricer N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, and Orlov SN. Clsecretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P2Y1 receptors, phospholipase
A2 and protein kinase A. J. Physiol. 568:789-801, 2005.
216. Arthur DB, Akassoglou K, Insel PA. P2Y2 receptor activates NGF/TrkA receptor signaling to enhance neuronal
differentiation, Proc. Natl Acad. Sci. USA, 102:19138-19143, 2005.
217. Patel HH, Head BP, Petersen HN, Niesman IR, Feramisco JR, Farquhar MG, Gross GJ, Insel PA*, Roth DM*.
Protection of adult rat cardiomyocytes from ischemic cell death: role of caveolar microdomains and opioid receptors,
Am J Physiol - Heart and Cardiovascular Physiol, 291(1):H344-50, 2006 (*co-senior authors).
Page 21
218. Buescher R, Hoerning A, Patel HH, Zhang S, Arthur, DB, Grasemann H, Ratjen F, Insel PA. P2Y 2 receptor
polymorphisms and haplotypes in cystic fibrosis and their impact on Ca 2+ influx, Pharmacogenetics and Genomics
16:199-205, 2006.
219. Hoekstra HI, Hirschmann RJ, Bundey RA, Insel PA, Crossland JP. A single amino acid mutation contributes to
adaptive beach mouse color pattern, Science 7;313(5783):101-4, 2006.
220. Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O’Connor DT Insel PA. Polymorphisms and Haplotypes of the
Regulator of G Protein Signaling-2 Gene in Normotensives and Hypertensives, Hypertension 47:3-415-420, 2006.
221. Arthur DB, Georgi S, Akassoglou K, Insel PA. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for
neuronal survival, J Neuroscience, 26(14):3798 –3804, 2006.
222. Swaney JS, Patel HH, Yokoyama, U, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold
adenylyl cyclase with phosphorylated caveolin, J Biol Chem, 281:17173-79, 2006.
223. Arthur DB, Akassoglou K, Insel PA. P2Y2 and TrkA receptors interact with Src family kinase for neuronal
differentiation, Biochem Biophys Res Commun, 347(3):678-82, 2006.
224. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin
microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components, J Biol Chem. 2006
Jul 3; [Epub ahead of print].
225. Bundey RA, Insel PA. Adenylyl cyclase 6 over-expression decreases the permeability of endothelial monolayers via
preferential enhancement of prostacyclin receptor function, Mol Pharmacol. 2006 Aug 2 [Epub ahead of print].
226. Arthur DB, Taupenot L, Insel PA. Nerve growth factor-stimulated neuronal differentiation induces changes in P2
receptor expression and nucleotide-stimulated catecholamine release, J Neurochem (in revision).
227. Rana BK, Insel PA, Payne S, Abel K, Beutler E, Ziegler MG, Schork NJ, O’Connor DT. A large population-based
sample reveals the contribution of gene-gender interactions in blood pressure in Caucasian-Americans,
Hypertension (in revision).
228. Murray F, Patel HH, Suda RYS, Zhang S, Thistlethwaite PA, Yuan JX, and Insel PA. Expression and Activity of
cAMP Phosphodiesterase Isoforms in Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary
Hypertension; Role of PDE1, Am J Physiology- Lung and Resp. Physiology (in revision).
229. Akimova, OA, Grygorzcyk A, Bundey RA, Gekle M, Insel PA, Orlov SG. Transient activation and delayed inhibition
of NA, K+, Cl- cotransport in ATP-treated C11-MDCK cells: evidence of Ca2+-mediated and independent signalling
triggered by distinct P2Y receptors, J Biol Chem (in revision).
230. Patel HH, Zhang S, Murray F, Suda R, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti
S, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX and Insel PA. Increased caveolin-1 and caveolae
expression contribute to the pathophysiology of idiopathic pulmonary arterial hypertension (submitted).
231. Steagall WK, Barrow BJ, Glasgow CG, Woo J, Ethrmantraut M, Lin J, Insel PA, Moss J. β 2-adrenergic Receptor
Polymorphisms in Cystic Fibrosis, Pharmacogenet Genomics (in revision).
232. Rana BK, Shiina T, Rao F, Mauboubi V, Kirstein SL, Ziegler MG, O’Connor DT, Insel PA. A polymorphism in the 5’
untranslated region of the dopamine D1 receptor influences receptor expression (in revision).
233. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi, N, Zinkernagel, A, Nizet V, Insel, PA*, Junger WG*. Polarized
ATP release, P2Y2 receptors, and A3 adenosine receptors guide neutrophil chemotaxis, Science (in revision). (*cosenior authors)
234. Yip L, Cheung, CW, Chen Y, Hashiguchi N, Corriden R, Insel PA, Junger WG. Expression and activity of adenosine
P1 and nucleotide P2 receptors during T-cell activation (submitted).
235. Zhang S, Patel HH, Schach C, Murray F, Remillard CV, Thistlethwaite PA, Insel PA, Yuan JX-J. Pulmonary artery
smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension show
divergent cAMP-mediated effects on TRPC expression and capacitative Ca 2+ entry (submitted).
Page 22
236. Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. Hypertonic stress regulates T cell function by the
opposing actions of extracellular ATP and adenosine (submitted).
Book Chapters, Invited Publications and Review Articles
1.
Insel PA, Kramer KJ, Berman M, Sherwin RS, Liljenquist JE, Tobin JD, Andres R. Modelling the insulin glucose
system in man. Fed Proc 33:1865-1868, 1974.
2.
Bourne HR, Coffino P, Hochman J, Insel PA, Jones P, Melmon KL, Tomkins GM. Genetic and functional studies of
the cyclic AMP receptor in a cultured mammalian cell. In Proceedings of the Sixth International Congress of
Pharmacology, vol. 1, Receptors and Cellular Pharmacology (E. Klinge, ed.), Pergamon Press, New York, pp 223232, 1976.
3.
Coffino P, Bourne HR, Friedrich U, Insel PA, Lemaire I, Hochman J, Melmon KL, Tomkins GM. Somatic genetic
analysis of cyclic AMP action. Recent Prog in Hormone Res, 32:669-682, 1976.
4.
Coffino P, Gray JW, Lemaire I, Insel PA. Growth regulation by cyclic AMP in mouse lymphoma cells. In Cyclic
Nucleotides and the Regulation of Cell Growth (Morad Abou-Sabe, ed.), Dowden, Hutchison and Ross, Inc.,
Stroudsbourg, Pennsylvania, pp 276-278, 1977.
5.
Melmon KL, Insel PA. Inflamatory and immune responses: Cell individuality amidst ubiquitous hormonal signals,
Johns Hopkins Med J, 141:15-22, 1977.
6.
Melmon KL, Weinstein Y, Poon T, Bourne HR, Shearer GM, Coffino P, Insel PA. Receptors for low molecular
weight hormones in lymphocytes. In Immunopharmacology (J.W. Hadden, R.C. Coffey and F. Spreafica, eds.),
Plenum Press, New York, pp. 331-356, 1977.
7.
Insel PA. Membrane-active hormones: Receptors and receptor regulation. In International Review of
Biochemistry, series II, Biochemistry and Mode of Action of Hormones (H.V. Rickenberg, ed.) University Park Press,
pp 1-43, 1978.
8.
Miller R, Insel PA, Melmon KL. Drugs in inflammatory disease. In Clinical Pharmacology (K.L. Melmon and H.F.
Morrelli, eds.), Macmillan, pp 657-708, 1978.
9.
Insel PA, Shear M, Sanda M, Melmon KL, Peabody J, Kennedy M. Refractoriness to beta-adrenergic agonists in
S49 cells. Frontiers in Catecholamine Research, pp. 483-485, 1979.
10.
Melmon KL, Verlander M, Krasny L, Goodman M, Kaplan N, Castagaoli M, Insel PA. Chemistry and Pharmacology
of Catecholamines and other low molecular weight ligands conjugated to insoluble carriers. Frontiers in
Catecholamine Research, pp. 474-476, 1979.
11.
Roberts JM, Goldfien RD, Goldfien A, Insel PA. Regulation of alpha-adrenergic receptors and response by
estrogen. Frontiers in Catecholamine Research, pp. 441-443, 1979.
12.
Roberts JM, Goldfien RD, Insel PA. Dihydroergocryptine binding and alpha-adrenoreceptors in smooth muscle.
Nature (Matters Arising) 283:108-109, 1980.
13.
Insel PA, Snavely MD. Catecholamines and the Kidney: Receptors and renal function. Annu Rev of Physiology,
43:625-636, 1981.
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Insel PA. Use of a genetic approach to study cyclic AMP metabolism, in Cell Regulation by Intracellular Signals (S.
Swillens and J. Dumont, eds.) NATO an Advanced Study Institutes Series, Series A: Life Sciences, Vol. 44, pp.
137-145, 1982.
15.
Insel PA, Darfler FJ, Hughes RJ, Meier KE, Dibner MD, Mahan LC, Snavely MD, Boyle MR, Koachman AM. Cell
biological studies of adrenergic receptors. Hormones and Cell Regulation, (Dumont JE, Nunez J, Schultz G, eds.)
Elsevier Biomedical Press, Vol. 6, 167-178, 1982.
16.
Darfler FJ, Insel PA. Growth of hybridomas & other lymphoid cells in hormonally defined media. Cold Spring Harbor
Conference on Cell Proliferation, Growth of Cells in Defined Media, Vol. 9, pp. 717-726, 1982.
17.
Motulsky HJ, Insel PA. Adrenergic receptors in man: direct identification, physiological regulation, and clinical
alterations. N Engl J Med, 307:18-29, 1982.
18.
Insel PA, Motulsky HJ. Calcium channel blocking agents. N Engl J Med (Letter to Editor), 308:1361-2, 1983.
19.
Ferry N, Adnot S, Insel PA, Hanoune J. Le systeme adenylate cyclasique des plaquettes humaines. Nouvelle
Revue Francaise d'Hematologie 25:343-353, 1983.
20.
Motulsky HJ, Insel PA. The study of cell surface receptors with radioligand binding: Methodology, data analysis
and experimental problems. In Receptor Science in Cardiology (S.I. Haft and J.C. Karliner, eds.). pp. 1-42, 1984.
21.
Darfler FJ, Insel PA. Growth of lymphoid cells in serum-free medium. In Methods for Serum-Free Culture of
Neuronal and Lymphoid Cells, Alan R. Liss, Inc.: New York, pp. 187-196, 1984.
22.
Motulsky HJ, Insel PA. Radioligand binding to adrenergic receptors in humans, in Norepinephrine: Clinical Aspects
(M. Ziegler and R. Lake, eds.) pp. 271-306; Wiliams and Wilkins, 1984.
23.
Insel PA. Identification and regulation of adrenergic receptors in target cells. Am J Physiol Endocrinol Metab,
247-E53-E58, 1984.
24.
Insel PA, Motulsky HJ. A hypothesis linking intracellular sodium, membrane receptors, and hypertension. Life
Sciences 34:1009-1113, 1984.
25.
Meier KE, Insel PA. Hormone receptors and response in cultured renal epithelial cell lines. In Tissue Culture of
Epithelial Cells (M. Taub, ed.), Plenum Pub. Corp., pp 145-178, 1985.
26.
Insel PA. Adrenergic receptors on human blood cells, in Pharmacology of Adrenoceptors (E. Szabaodi, C.M.
Bradshaw, S. Nahorski, eds.), Macmillan Press, pp. 215-225, 1985.
27.
Insel PA, Hughes RJ, Meier KE, Mahan LC, Snavely MD. Cellular metabolism of alpha- and beta-adrenergic
receptors. Adrenergic Receptors: Molecular Properties and Therapeutic Implications (R.D. Lefkowitz, E.
Lindenbaur, eds.), F. K. Schattaner Verlag., pp. 537-548, 1985.
28.
Motulsky HJ, Mahan LC, Insel PA. Radioligands, agonists and membrane receptors on intact cells: data analysis
in a bind. Trends in Pharmacol Sci, 6(8):317-319, 1985.
29.
Insel PA. Cardiovascular alpha2 receptors (Letter to the Editor), J Mol Cell Cardiol, 18, 457-459, 1986.
30.
Insel PA, Motulsky HJ. Physiologic and pharmacologic regulation of adrenergic receptors, in Adrenergic Receptors
in Man (P.A. Insel, ed.) Marcel Dekker, pp. 201-236, 1987.
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31.
Motulsky HJ, Insel PA. In Vitro methods for studying human adrenergic receptors: Methods and applications. In
Adrenergic Receptors in Man (P.A. Insel, ed.), Marcel Dekker, pp. 139-160, 1987.
32.
Maisel AS, Motulsky HJ, Insel PA. Life cycles of cardiac 1 -and -adrenergic receptors. Biochem Pharmacol,
36(1):1-6, 1987.
33.
Mahan LC, McKernan RM, Insel PA. Metabolism of alpha- and beta-adrenergic receptors. Annu Rev Pharmacol
Toxicol, 27:215-235, 1987.
34.
Insel PA, Mahan LC, Hughes RJ, Motulsky HJ, Snavely MD. Agonist-regulated metabolism of alpha- and betaadrenergic receptors. Epinephrine in the Central Nervous System, (J. Stolk, D.C.U. Prichard and K. Fuxe, eds.) pp.
188-195, 1988.
35.
Insel PA, Motulsky HJ. Regulation of alpha-2 adrenergic receptors. In The Alpha2-Adrenergic Receptors (L.E.
Limbird, ed.), Humana Press, pp. 281-321, 1988.
36.
Insel PA, Terman BI, Slivka SR, Hughes RJ, Howard MJ. Molecular mechanisms and regulation of alpha 1adrenergic receptors. Proc. Xth Intl. Congress of Pharmacology, (M.J. Rand and C. Raper, eds.) Excerpta Media,
pp.13-16, 1988.
37.
Loterstajn S, Pavoine C, Mallat A, Stengel D, Insel P, Pecker F. Hormonal inhibition of the liver plasma membrane
(Ca++-Mg++) ATPase is mediated by a Gs-like protein. Cell Calcium Metabolism 87, (G. Fiskum, ed.) pp. 3-11, 1988.
38.
Insel PA. Phenylalkylamines are promiscuous receptor blockers. Trends in Pharmacol Sci, (Letter 9:10), 1988.
39.
Insel PA. How should we study brain adrenergic receptors in aging? Neurobiol of Aging, 9:64-66, 1988.
40.
Insel PA, Ransnäs LA. G proteins & cardiovascular disease. Circulation, 78:1511-1513, 1988.
41.
Michel MC, Insel PA, Brodde O-E. Renal -adrenergic receptor alterations: a cause of essential hypertension?
FASEB J, 3:139-144, 1989.
42.
Insel PA. Adrenergic Receptors: Evolving concepts on structures and function. Am J Hypertension, 2:112S-118S,
1989.
43.
Michel MC, Insel PA. Are there multiple imidazoline binding sites? Trends Pharmacol Sci, 10(9):342-344, 1989.
44.
Insel PA. Structure & function of alpha-adrenergic receptors. Am J Med, 87:2A-12S-18S, 1989.
45.
Insel PA, Maisel AS Alpha1- and beta-adrenergic receptors in myocardial ischemia and injury. Adrenergic System
and Ventricular Arrhythmias in Myocardial Infarction (J. Brochman and A. Schomig, eds.) Springer-Verlag, pp. 8190, 1989.
46.
Insel PA. Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of rheumatoid
arthritis and gout. In: Goodman and Gilman's Pharmacological Basis of Therapeutics, 8th edition, pp. 638-681,
1990.
47.
Michel MC, Brodde O-E, Insel PA. Peripheral adrenergic receptors in hypertension. Hypertension, 16:107-120,
1990.
48.
Taylor P, Insel PA Molecular basis of pharmacologic selectivity. In: Principles of Drug Action, 3rd ed., (W.B. Pratt
and P. Taylor, eds.), pp. 1-102, 1990.
Page 25
49.
Taylor P, Insel PA. Molecular basis of drug action. In: Principles of Drug Action, 3rd ed., (W.B. Pratt and P. Taylor,
eds.) pp. 103-200, 1990.
50.
Insel PA, Characterization and function of renal -adrenergic receptors. Excerpta Medica, Sixth Alpha-Adrenoceptor
Symposium. Tokyo, pp. 43-52, 1990.
51.
Maisel AS, Ransnäs LA, Insel PA. -adrenergic receptors and the Gs protein in myocardial ischemia and injury.
Basic Research in Cardiology, 85 (Suppl.):47-56, 1990.
52.
Insel PA, Wasserman SI. Asthma: A disease of altered adrenergic receptor sensitivity? FASEB J, 4:2732-2736,
1990.
53.
Insel PA. Characterization of 1-adrenergic receptors: structure and function. J Vasc Med Biol, 2:225-230, 1990.
54.
Insel PA. G Proteins in myocardial failure. Congestive Heart Failure Index and Reviews, 3:3, 1990.
55.
Insel PA. GTP-binding protein-coupled receptors. Introduction to Endocrine Invest.: Techniques and Concepts. pp.
85-92, 1990 and 1991.
56.
Hughes RJ, Howard MJ, Insel PA. Beta2-adrenergic receptor regulation in receptor-deficient S49 lymphoma cells.
Adrenoceptors: Structure, Mechanisms, Function (E. Szabadi and C.M. Bradshaw, eds). Birkhaüser Verlag-Basel,
pp. 347-348, 1991.
57.
Insel PA. ß-adrenergic receptors in pathophysiologic states and in clinical medicine. In: The Beta-Adrenergic
Receptors (J.P. Perkins, ed.), pp. 295-343, 1991.
58.
Insel PA, Hughes RJ, Ransnäs LA, Leiber D, Jasper JR, Motulsky HM, Alousi A. Adrenergic receptors coupled to
adenylyl cyclase. Adrenoceptors: Structure, Mechanisms, Function (E. Szabadi and C.M. Bradshaw, eds).
Birkhaüser Verlag-Basel, pp. 117-126, 1991.
59.
Urasawa K, Insel PA. GTP-binding proteins in cardiovascular disease. (Book Chapter) G Proteins: Signal
Transduction and Disease, G. Milligan and M.O. Wakelam, eds. Academic Press, pp.47-85, 1992
60.
Insel PA, Weiss BA, Slivka SR, Howard MJ, Waite JJ, Godson CA. Regulation of phospholipase A 2 by receptors in
MDCK-D1 cells. Biochem Soc Trans, 19:329-333, 1991.
61.
Jasper JR, Insel PA. Evolving concepts of partial agonism: the -adrenergic receptor as a paradigm. Biochem
Pharmacol, 43(2):119-130, 1992.
62.
Insel PA. GTP-binding proteins and post-receptor components in hypertension. Pharmacol & Toxicol, 70:528-531,
1992.
63.
Insel PA, Urasawa K, Leiber D, Roth D, Hammond HK. Regulation of the G s protein in the heart. New Aspects Of
The Treatment Of Failing Heart. Yasuda H. and Kawaguchi, eds. Springer-Verlag: Tokyo, pp. 58-61, 1992.
64.
Insel PA. Adrenergic receptors, G-proteins, and cell regulation: Implications for aging research. Experimental
Gerontology, 28:341-348, 1993.
65.
Insel PA, Hammond HK. -adrenergic receptors in heart failure. J Clin Invest, 92(6): 2564-5, 1993.
66.
Jackson CA, Insel PA. Renal -adrenergic receptors and genetic hypertension. Ped Nephrol, 7:853-858, 1993.
Page 26
67.
Insel PA. GTP-binding protein-coupled receptors. Introduction to Molecular & Cellular Res, Endocrine Soc., pp.
113-120, 1993 and 1994.
68.
Cohen JS, Insel PA. Weaning patients addicted to codeine for pain relief. Consultant, 36:196-97, 1996.
69.
Insel PA. Adrenergic receptors: evolving concepts and clinical implications. New Engl J Med, 334:580-585, 1996.
70.
Cohen JS, Insel PA. The Physician's Desk Reference: Problems and possible improvements. Arch Intern Med,
156:1375-1380,1996.
71.
Insel PA. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout in
Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., pp. 617-658, 1996.
72.
Michel M, Insel PA. Making sense out of antisense for the study of drug receptors. J Clin Invest, 98(5):1074-1075,
1996.
73.
Insel PA, Balboa MA, Mochizuki N, Post SR, Urasawa K, Xing M. Mechanisms for activation of multiple effectors by
alpha1-adrenergic receptors. Adv Pharmacol, 42: 451-453, 1997.
74.
Hammond HK, Ping P, Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor
antagonist. Adv Pharmacol, 42: 507-510, 1997.
75.
Insel PA, Firestein BL, Xing M, Post SR, Jacobson JP, Balboa, MA, Hughes RJ. P 2 purinoceptors utilize multiple
signalling pathways in MDCK D1 cells. J Autonom Pharmacol 16:311-3, 1997.
76.
Varki AP, Kagnoff MF, Insel PA. Passing the baton at high speed: time to hand over to a new editorial board. J Clin
Invest, 99(4):553-4, 1997.
77.
Insel PA. Solo dances within a monograph. a2-Adrenergic Receptors: Structure, Function and Therapeutic
Implications spotlight on alpha2-adrenergic receptors. Trends in Pharmacol Sci 19(3):116, 1997.
78.
Insel PA. Agents for the treatment of gout, Quick Look: Pharmacology, Robert B. Raff and Gerald H. Sterling, eds.
(book chapter). Fencecreek Publishing, 1997.
79.
Insel PA, Büscher R, Xing M, Balboa M, Guist D. Mechanisms of 1B-adrenergic receptor signalling. Pharmacol &
Toxicol, 83 (Suppl): 17-19, 1998.
80.
Büscher R, Herrmann V, Insel PA. Human adrenoceptor polymorphisms: Evolving recognition of clinical
importance. Trends in Pharmacol Sci, 20(3):94-99, 1999.
81.
Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospolipase A 2. Annu Rev Pharmacol
Toxicol, 39:175-189, 1999.
82.
Post SR, Hammond HK, Insel PA. -adrenergic receptors and receptor signaling in heart failure. Annu Rev
Pharmacol Toxicol, 39:343-60, 1999.
83.
Ostrom RS, Insel PA. Caveolar microdomains of the sarcolemma: Compartmentation of signaling molecules comes
of age. Circ Res, 84:1110-1112, 1999.
84.
Post SR, Ostrom RS, Insel PA. Biochemical methods for detection and measurement of cyclic AMP and adenylyl
cyclase activity, Adrenergic Receptor Protocols, Curtis A. Machida, ed. (book chapter), Humana Press, Inc., pp.
363-374, 2000. Also appeared in Methods in Molecular Biology, 126:363-74, 2000.
Page 27
85.
O’Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. Heredity and the
Autonomic Nervous System in Human Hypertension. Current Hypertension Reports, 2:16-22, 2000.
86.
Ostrom RS, Insel PA. Signal transduction pathways in caveolae. Science & Medicine, 7:44-53, 2000.
87.
Ostrom RS, Post SR and Insel PA. Stoichiometry and compartmentation in G protein-coupled receptor signaling:
implications for therapeutic interventions involving Gs. J Pharmacol Exp Ther, 294(2):407-412, 2000.
88.
Glew, RH, Insel, PA. Academic health center administrators don't perish when they don't publish, Acad Med,
75(10):996-998, 2000.
89.
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. EB Symposium
Report: Protein kinase C isozymes and the regulation of diverse cell responses. Amer J Physiol: Lung Cell Mol
Physiol, 279(3):L429-L438, 2000.
90.
Rana BK, Shiina T and Insel PA. Genetic variations and polymorphisms of G-protein coupled receptor
polymorphisms: functional and therapeutic implications. Annu Rev Pharmacol Toxicol, 42:593-624, 2001.
91.
Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL,
Xing M, Post SR. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clin Exp
Pharmacol Physiol, 28:351-354, 2001.
92.
Rana BK and Insel PA. Useful GPCR Websites. Trends Pharmacol Sci, 22(9):485-486, 2001.
93.
Insel PA, Ostrom RS, Michel MC, and Büscher R. α1-Adrenergic receptors of MDCK-D1 cells utilize multiple
signalling components. Catecholamine Research: Molecular Insights to Clinical Medicine, (T. Nagatsu, T.
Nabeshima, R. McCarthy, D.S. Goldstein, eds.) Kluwer Academic/Plenum: New York, pp 257-60, 2002.
94.
Rana BK and Insel PA. G-protein-coupled receptor websites. Trends Pharmacol Sci, 23(11):535-536, 2002.
95.
Michel MC, Jasper J, Insel PA. Adrenoceptors: a convergence of thinking. Molecular Interventions, 2:198-200,
2002.
96.
Ostrom RS, Rana BK and Insel PA. Stoichiometry of G Protein-coupled Receptor Signaling: Implications in the
Genomic Era Pharmaceutical News. 9:295-303, 2003.
97.
Insel PA and Ostrom RS. Forskolin as a tool for examining adenylyl cyclase expression, regulation and G protein
signaling. Cellular and Molecular Neurobiology. 23(3):305-314, 2003.
98.
Michel MC, Insel PA. Receptor gene polymorphisms: lessons on function relevance from the β 1-adrenoceptor. Brit
J Pharmacol, 138:279-282, 2003.
99.
Insel PA. Location, location, location. Trends Endocrinol Metab. 14(3):100-102, 2003.
100. Insel PA, Kirstein SL. Naturally occurring variants in catecholamine receptor genes. Auton Autacoid Pharmacol,
23:228-30, 2003.
101. Insel PA, Feldman R. Norepinephrine Receptors. In: Encyclopedia of Endocrine Diseases. Elsevier, 3:375-82,
2004.
102. Koopmans RP, Insel PA, Michel MC. Pharmacogenetics of hypertension treatment: a structured review,
Pharmacogenetics, 13:705-13, 2003.
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103. Kirstein SL, Insel PA. Autonomic nervous system pharmacogenomics: a progress report, Pharmacological
Reviews, 56:31-52, 2004.
104. Tang C-M, Insel PA. GPCR expression in the heart: "New" receptors in myocytes and fibroblasts. Trends
Cardiovasc Med, 14:94-9, 2004.
105. Bundey RA, Insel PA. Discrete Intracellular Signaling Domains Of Soluble Adenylyl Cyclase: Camps of cAMP?
Science STKE 231:pe19, 2004.
106. Rana BK, Insel PA. Receptor databases and computational websites for ligand binding. Receptor Binding
Techniques, (A Davenport, ed.), Humana Press, Totowa, NJ, 1-15, 2005.
107. Ostrom RS, Insel PA. The evolving role of lipid rafts in G protein-coupled receptor signaling: Implications for
molecular pharmacology. Brit J Pharmacol, 143(2):235-45, 2004.
108. Siecke N, Insel PA. Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters.
J Am. College Cardiology, 44(10):2016-18, 2004.
109. Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP,
Weiss SJ, Wilson JD. Historical highlights 1924-2004: Blasts from the past. J. Clin Invest. 114(8):1017-1033, 2004.
110. Riddle E, Schwartzman R , Bond M, Insel PA. Multi-tasking RGS Proteins in the Heart: the Next Therapeutic
Target? Circulation Research, 96:401-11, 2005.
111. Michel MC, Insel PA. Adrenergic Receptors in Clinical Medicine. In: The Adrenergic Receptors in the 21st Century
(D. Perez, ed.). Humana Press, 1-58829-423-4, 2005.
112. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang C-M, and Roth DM. Caveolae and Lipid Rafts: G
Protein–Coupled Receptor Signaling Microdomains in Cardiac Myocytes. Ann. NY Acad Sci., 1047:166-172, 2005.
113. Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors
and their signaling components in lipid rafts and caveolae Biochem Soc Transactions, 33:1131-34, 2005.
114. Tang CM, Insel PA. Genetic variation in G-protein-coupled receptors – consequences for G-protein-coupled
receptors as drug targets. Expert Opinion on Therapeutic Targets, 9:1247-65, 2005.
115. Murray F, Insel PA, Yuan JX-J. Role of O2-sensitive K+ and Ca2+ channels in the regulation of the pulmonary
circulation: Potential role of caveolae and implications for high altitude pulmonary edema. Respir Physiol Neurobiol,
151:192–208, 2006.
116. Ostrom RS, Insel PA. Methods for the study of signaling molecules in lipid rafts and caveolae. In: Transmembrane
Signaling Protocols. (H. Ali, B. Haribabu, ed.). Humana Press, 1-58829-546-X, 2006.
117. Murray F, Insel PA, Yuan JX. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary
circulation: potential role of caveolae and implications for high altitude pulmonary edema, Respir Physiol Neurobiol,
151(2-3):192-208, 2006.
118. Insel PA, The IUPS Congress and Experimental Biology: An experiment that worked! The Physiologist (in press).
119. Head BP and Insel PA. Do caveolins regulate cells by actions outside of caveolae? Trends Cell Biol (in revision).
120. Insel PA, Tang C-M, Hahntow I, Michel M. Impact of GPCRs in clinical medicine: genetic variants and drug targets,
Biochim Biophys Acta (submitted).
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