CURRICULUM
VITAE
Name:
Bessie Eugenia Grekas-Spiliotis
Address:
Division of Pediatric Endocrinology and Diabetes
Department of Pediatrics
University of Patras School of Medicine
265 04 Rion
Patras, Greece TK 26504
Tel: +032613-603-741
Fax: +032610-910-869
E mail: besspil@endo.gr
I. EDUCATION :
1976
M.D. Degree
University of Athens School of Medicine, Athens, Greece
1975-1976
Rotating Internship
University of Athens Medical School Hospitals, Athens,
Greece
1987
MSc Degree
University of Patras School of Medicine, Patras Greece
II. POST-GRADUATE TRAINING :
1977-1978
First and Second Year Resident in Family Practice
Swedish Covenant Hospital and Push-Presbyterian-St. Lukes,
Medical Center, Rush University School of Medicine,
Chicago, Illinois, U.S.A.
1978-1980
First and Second Year Resident in Pediatrics
Children’s Hospital National Medical Center, George
Washington University School of Medicine, Washington, D.C.,
U.S.A.
1980-1981
Senior Resident in Pediatrics
Children’s Hospital National Medical Center George
Washington University School of Medicine, Washington, D.C.,
U.S.A.
1981-1984
Medical Staff Fellow in Pediatric Endocrinology National
Institute of Child Health and Development, National Institutes
of Health, Bethesda, Maryland, U.S.A
1
III. ACADEMIC
AND RESEARCH APPOINTMENTS
1973-1976
Research Assistant, Dept. of Obstetrics and Gynecology,
Univ. of Athens Medical School, Athens, Greece.
1985-1988
Instructor of Pediatrics
Dept. of Pediatrics
Johns Hopkins University School of Medicine, Baltimore,
Maryland, U.S.A.
1988-1991
Assistant Professor of Pediatric Endocrinology
Dept. of Pediatrics
University of Maryland School of Medicine, Baltimore,
Maryland, U.S.A.
1992-1995
Visiting Professor, Dept. of Pediatrics,
University of Patras School of Medicine, Patras, Greece
1995-2001
Assistant Professor of Pediatrics Endocrinology, Dept. of
Pediatrics, University Hospital of Patras, University of Patras
School of Medicine Patras, Greece
1995-present
Director of the Division of Pediatric Endocrinology and
Diabetes Mellitus Pediatric Endocrine Outpatient Clinic, Dept.
of Pediatrics, University Hospital of Patras, University of
Patras School of Medicine, Patras, Greece
1995-present
Director of the Pediatric Endocrine Outpatient Clinic, Dept. of
Pediatrics, University Hospital of Patras, University of Patras
School of Medicine, Patras, Greece
2001- Feb. 2010
Associate Professor of Pediatrics and Pediatric Endocrinology,
Dept. of Pediatrics, University Hospital of Patras University of
Patras School of Medicine Patras, Greece
2001-present
Director of the Research Laboratory of Molecular Pediatric
Endocrinology, University of Patras School of Medicine
Patras, Greece
2010 –present
Professor of Pediatrics and Pediatric Endocrinology, Dept. of
Pediatrics, University Hospital of Patras University of Patras
School of Medicine Patras, Greece
2
IV.CERTIFICATIONS :
1)
2)
3)
4)
ECFMG BOARD, U.S.A. (1976)
FLEX Board, U.S.A. (1978)
AMERICAN BOARD OF PEDIATRICS, U.S.A. (1984)
AMERICAN BOARD OF PEDIACRICS
FOR PEDIATRIC ENDOCRINOLOGY, U.S.A. (1986)
V. MEMBERSHIP IN PROFESSIONAL SOCIETES :
1)
2)
3)
4)
5)
6)
7)
Endocrine Society, U.S.A.
American Academy of Science
Lawson-Wilkins Pediatric Endocrine Society, U.S.A.
American Diabetes Association, U.S.A.
European Society of Pediatric Endocrinology (ESPE)
Hellenic Endocrine Society
Adolescent and Pediatric Endocrinology Society of Greece,
(vice-president: 2006-present)
VI. REVIEWER IN SCIENTIFIC JOURNALS
1) JOURNAL OF CLINICAL ENDOCRINOLOGY AND
METABOLISM
2) EUROPEAN JOURNAL OF ENDOCRINOLOGY
3) JOURNAL OF PEDIATRIC ENDOCRINOLOGY AND
METABOLISM
4) HORMONE RESEARCH
5) HORMONES
VII. AWARDS-GRANTS
1977:
Slawikowski Memorial Award for Outstanding House
Officer of the Year, Swedish Covenant Hospital,
Chicago, Illinois, ΗΠΑ
2002:
First prize for the best research study of the 29th
Hellenic Society Meeting: «Molecular profile of
children with bio-inactive growth hormone.»
3
2002:
“Karatheodori” Research Grant for Basic Science from
the University of Patras School of Medicine
2005
“Pythagoras ΙΙ” Research grant from the European
Community.
2009
First prize for the best research study of the 11th
Panhellenic meeting of the Hellenic Diabetes Society:
“The effect of the low-carbohydrate ketogenic diet on
oxidative stress in obese children and adolescents”.
2010
First prize for the best basic science research project
of the 8th Panhellenic Meeting of the Hellenic Obesity
Society :“The expression of the endocannabinoid
receptor, CB1, in pubertal children in relation to
insulin and adiponectin”.
4
VIII. PUBLICATIONS
Total Citations: 754
1.
Aravantinos, D., Corcondilas, E., Kelepouri, E., Grekas, B., Papadopoulos,
P., and Kaskarelis, D. Exposition experimentale des rattes gestantes aus
ultrason. J. Gyn Obst. Biol. Repr. 3:797-800, 1974.
2.
Pineda, J., Lee, BB.C., Spiliotis, B.E, Rivier, J., Brown, T., and Bercu, B.B.
Effect of a potent GnRH antagonist [AC-3Pro1, pFD Phe2, D
Trp3,6] GnRH on pulsatile secretion of gonadotropin secretion in the
castrate male primate. Journal of Clinical Endocrinology and Metabolism
56:420-422, 1983.
Citations: 17
3.
Bercu, B.B., Lee, B.C., Pineda, J.L., Spiliotis B.E., and Sach, H.J. Male
sexual development in the nonhuman primate. I. Cross-sectional analysis of
pulsatile hypothalamic – pituitary – testicular function. Journal of Clinical
Endocrinology and Metabolism 56:1214-1226, 1983.
Citations: 44
4.
Bercu, B.B., Lee, B.C., Spiliotis, B.E., Pineda, J.L., Denman, D.W.,
Hoffman, H.J., and Brown, T.J. Male sexual development in the nonhuman
primate. II. Cross-sectional analysis of pulsatile hypothalamic-pituitary
secretion in castrated males. Journal of Clinical Endocrinology and
Metabolism 56:1227-1235, 1983.
Citations: 15
5.
Lee, B.C., Pineda, J., Spiliotis, B.E., Brown, T., and Bercu, B.B. Male
sexual development in the nonhuman primate.III. Sertoli cell culture and age
related differences. Biology of Reproduction 28:1207-1215, 1983.
Citations : 10
6.
Spiliotis, B.E., August, G., Hung, W., Sonis, W., Mendelsohn, W., and
Bercu, B.B. Growth hormone neurosecretory dysfunction: a treatable cause
of short stature. Journal of the American Medical Association 251(17): 22232230, May 1984.
Citations: 419
5
7.
Spiliotis, B.E., August, G., Hung, W., Sonis, W., Mendelsohn, W., and
Bercu, B.B. Growth hormone neurosecretory dysfunction: a treatable cause
of short stature. (Japanese translation ) Japanese JAMA 21: 41-40, 1985.
8.
Bercu, B.B., Spiliotis, B.E., Lee, B.C., Brown, T.J., Vale, W., Rivier, J.,
Nixon, W., and Reid, R. Effect of a potent GnRH antagonist on pulsatile
testosterone and gonadotropin secretion in the male primate. Life Sciences
35(4):381-387, 1984.
Citations: 6
9.
Bercu, B.B., Schulman, D., Root, A.W., and Spiliotis, B.E. Growth hormone
(GH) provocative testing frequently does not reflect endogenous GH
secretion. Journal of Clinical Endocrinology and Metabolism 63:709-716,
1986.
Citations: 206
10.
Sonis, W.A., Spiliotis, B., Maymi-Gascue, M., Shuman, E., and Bercu, B.B.
Maturational Arrest :An Experiment in Nature. Journal of the American
Academy of Child and Adolescent Psychiatry 26:277-280, 1987.
Citations: 1
11.
Bercu, B.B., Spiliotis, B.E., Reed, G.F., and Lee, B.C. Male Sexual
Development in the Monkey: IV. Hypothalamic-Pituitary-Testicular Function
and Correlation with Electron and Light Microscopy of the Testis. The
Journal of Pediatric Endocrinology Vol. 2:7-22, 1987.
12.
Bercu, B.B., Root, A.W., Shulman, D.I., Spiliotis, B. Stimulated as
compared with spontaneous growth hormone levels for diagnosis of growth
hormone deficiency. N. Engl. J. Med. 319; 1730, 1988. Citations: 1
13.
Spiliotis, B.E., Albertson, B.D., Sienkiewicz, M.L., Cassorla, F.G., Cutler,
G.B., Booth, J.D., Anderson, K.D., Chandra, R.S., August, G.E., Loriaux,
D.L., Bercu, B.B. Activity of adrenal microsomal enzymes in a child with
micronodular adrenal hyperplasia. The Journal of Pediatric Endocrinology
3:243-249, 1989.
14.
Spiliotis B.E. Growth Hormone Neurosecretory Dysfunction: A Disorder or
a Name? Diagnostik des Wachstumshormon-Mangels. Editors: Ranke, M.B.
and Stolecke, H. Publishers: Verlag Dokument+Bild, pp. 99-106, 1994.
6
15.
Petrou, G., Makri, M., Armoni, A., Spiliotis, B.E., and Alexandrides, T.K. βcell glucose non-sensing in patients with thalassemia major and glucose
intolerance. Endocrine Disorders in Thalassemia. Physiological and
therapeutical Aspects. Editors: Ando, S., and Brancati, C., Publishers:
Spring-Verlag, Berlin, pp.157-160, 1995.
16.
Spiliotis, B.E., The Concept of Growth Hormone Neurosecretory
Dysfunction. Clinical Pediatric Endocrinology 4 (Suppl 6):1-7, 1995.
17.
Spiliotis, B.E. β-Thalassemia and normal growth: are they compatible?
European Journal of Endocrinology 139 (2):143-144, 1998.
18.
Spiliotis,B.E. Gonadotropin-releasing Hormone Analogues in the
management of precocious puberty. Ann NY Acad Sci 900:429-434, 2000.
Citations: 1
19.
Spiliotis, B.E. Can we predict the growth response to a replacement
therapy in children with GHD? In: Hypothalamic Releasing Hormones
Challenges and perspectives at the 2000 year mark. Editor: Duntas, L.H.
Beta Medical Publishers, Athens: pp. 111-114, 2000.
20.
Chrysis, D.C., Alexandrides, T.K., Koromantzou, E., Georgopoulos, N.,
Vassilakos, P., Kiess, W., Kratsch, I., Beratis, N.G., and Spiliotis B.E.
Novel application of IGF-I and IGFBP-3 generation tests in the diagnosis of
growth hormone axis disturbances in children with β-thalassemia. Clinical
Endocrinology, (Oxf) Feb; 54(2):253-259, 2001.
Citations: 9
21.
Spiliotis, Β.Ε. Prenatal diagnosis and Prenatal treatment of Congenital
Adrenal Hyperplasia. Consequences in adult life. Journal of Pediatric
Endocrinology and Metabolism, Guest Editors: Krassas, G.E., Laron Z,
Beck-Peccoz, Spiliotis BE, Publisher: Freund Publishing House Ltd.
14:1299-1302, 2001.
22.
Spiliotis, B.E. Growth Hormone Insufficiency and its Impact on Ovarian
Function. Ann NY Acad Sci, 997:77-84, 2003.
Citations: 9
23.
Spiliotis, B.E Thalassemia Endocrine Sequelae. In: Encycolpedia of
Endocrine Diseases. Ed. Pierre Sizonenko, Elsevier, Inc., Philadelphia,PA,
USA, Vol.4: 356-361, 2004.
7
24.
Stavropoulou A, Christopoulou GE, Anastassopoulos G, Panteliou SD,
Lyritis GP, Spiliotis BE, Karamanos NK, Panagiotopoulos E, Lambiris E.
Alteration in serum leptin correlates with alteration in serum N-telopeptide of
collagen type I and serum osteocalcin during the progression of
osteoporosis in ovariectomized rats. Clinical Chemistry and Laboratory
Medicine 43:1359-1365, 2005.
25.
Spiliotis, B.E. Growth and Long-Term Hormonal Therapy. Pediatric
Endocrinology Reviews, 3(Suppl 1). Guest Editors: Mastorakos G,
Creatsas G, Spiliotis BE, Publisher: Netanya, Israel : Y.S. Medical Media
Ltd. . Pediatric Endocrinology Reviews 3 (Suppl 1):192-194, 2006.
26.
Chrysis,D. Spiliotis, B.E., Stene M, Cacciari E, Davenport ML.
Gonadotropin Secretion in girls with Turner Syndrome measured by an
Ultrasensitive Immunochemiluminometric assay. Hormone Research
65:261-266, 2006.
Citations: 2
27.
Rojas-Gil AP, Ziros PG, Diaz L, Kletsas D, Basdra EK, Alexandrides TK,
Zadik Z, Frank SJ, Papathanassopoulou V, Beratis NG, Papavassiliou AG,
Spiliotis BE. Growth hormone/JAK-STAT axis signal-transduction defect: A
novel treatable cause of growth failure. FEBS Journal 273:3454-3466, 2006.
Citations: 4
28.
Spiliotis BE, Thyroid function in newborn and infant. In: Diseases of the
Thyroid in Children and Adolescence. Editors: Krassas, G.E., Rivkees,S.,
and Kiess, W. Publishers: Karger Publishers, Switzerland pp. 44-55, Vol.
11, 2007.
29.
Xekouki,,P., Nikolakopoulou, N., Kafiri, N.G., Maniati-Christidi, M, Zerva, A,
Papageorgiou, A., Livadas, S., Spiliotis, B.E., Dacou-Voutetakis, C.
Glucose Dysregulation in Obese Children: Predictive, Risk, and Potential
Protective Factors. Obesity 15 (4): 860-869. 2007.
Citations: 2
30.
Rojas-Gil A.P., Ziros P.G., Kanestsis E., Papthanassolpoulou V.,
Nikolakopoulou N.M. He K. Frank, S.J., Papavassiliou, A.G. Spiliotis, B.E.,
Combined effect of mutations of the GH1 gene and its proxzimal promoter
region in a child with growth hormone neurosecretory dysfunction (GHND).
Journal of Molecular Medicine, May 4: 1432-1440, 2007.
31.
Georgopoulos NA, Koika V, Galli-Tsinopoulou A, Spiliotis BE, Keramida M,
Adonakis G, Sgourou A, Koufogiannis KD, Papachtzopoulou A,
Papavassiliou A, Kourounis G, Vagenakis G. Renal agenesis indicates
KAL1 gene defects in patients with Kallmann. Fertil Steril. Nov;88(5):1311-7,
2007.
8
32.
Spiliotis, B.E. Pediatric Topic: Expanding the Spectrum of Noonan
Syndrome. Horm Res 68 (suppl 5):22-23, 2007.
33.
Spiliotis, B.E., Papadimitriou, D., Alexandridis, T.K., Beratis, N.G.,
Casaneuva, F.F. Combined GHRH and GH Releasing Peptide (GHRP) -6
Test for the Evaluation of GH Deficiency in children syndrome Horm Res
70:215-233, 2008. ,
34.
Spiliotis, B.E. Recombinant human growth hormone in the treatment of
Turner Syndrome. Therapeutics and Clinical Risk Management:4(6) 1177–
1183, 2008.
35.
Spiliotis, B.E., Alexandrides, T.K., Karistianos, C., Nikiforidis, G., Zadik, Z,
Beratis, N.G. The Insulin-like Growth Factor-I (IGF-I) Generation Test as a
Test of Growth Hormone Secretory Status. Hormones Hormones 8(2):
117-128, 2009
36.
Dettoraki, A, Rojas-Gil, AP, Spiliotis, BE. Association between serum
levels of the soluble receptor for Advanced Glycation Endproducts (AGEs)
and the protein expression of their Receptor (RAGE) in peripheral blood
mononuclear cells of children with Insulin Dependent Diabetes Mellitus. J of
Ped Endocr Metab 22 (10):895-904, 2009.
37.
Georgakopoulos, CD, Eliopoulou MI, Exarchou, AM, Jimis, V, Pharmakakis,
NM, Spiliotis, BE. Decreased contrast sensitivity in children and
adolescents with type I diabetes mellitus. J Pediatr Ophthalmol Strabismus.
Apr 30:1-6, 2010
38.
Karvela, A, Rojas-Gil,AP, Samkinidou, E, Papadaki H, Pappa, A, Varakis, J,
Georgiou, G, Spiliotis, BE. Cannabinoid receptor, CB1, expression in
Primary Adipocyte Cultures of Lean and Obese Pre-pubertal Children in
relation to Adiponectin, Insulin and Waist Circumference (in press in J Ped
Endocr Metab)
40.
Ioanna Partsalaki, Alexia Karvela, Andrea Paola Rojas Gil, Bessie E.
Spiliotis. Effects of a ketogenic diet as compared to a hypocaloric diet on
metabolic parameters and oxidative stress in obese children and adolescents
( in preparation)
41.
Katerina Avgeri, Alexia Karvela , Aliki Pappa, Andrea Paola Rojas- Gil,
Samkinidou Eustratia, George Georgiou, Bessie E. Spiliotis. Serum HMW
adiponectin, AdipoR1, the adaptor protein, APPL1 and the GTPase Rab5 in
primary adipocyte cultures of lean and obese prepubertal children in relation to
insulin sensitivity. ( in preparation)
9
43.
IX.
Andrea Paola Rojas Gil, Eirini Kostopoulou, Kostas Kamzelas, Bessie E.
Spiliotis. Inhibition of the protein expression of CIS ubiquitin ligase
overcomes the impairment in the GH signaling pathway in Growth Hormone
Transduction Defect (GHTD). ( in preparation)
ABSTRACTS
1.
Aravantinos, D., Grekas, BE., Gnafakis N., Papaharalambus, N., and
Kaskarelis D. The effects of postnatal hormonal treatment on the
reproductive system of female rats. Third Conference of the European
Teratology Society, Helsinki, Finland, 1974.
2.
Pineda, J.L., Lee, B.C., Grekas, BE., Sachs, H.C., Brown, T.J., and Bercu,
B.B. Age related alterations in testicular steroidogenesis during sexual
development in the subhuman primate. American Society of Andrology,
Hilton Head, South Carolina, 1982.
3.
Spiliotis, B.E., Lee, B.C., Pineda, J., Sach, H., Brown, T.J., ad Bercu, B.B.
Pulsatile gonadotropin secretion during sexual development in the male
subhuman primate. Society for Pediatric Research, Washington, D.C.,
U.S.A., 1982. Citations:1.
4.
Lee, B.C., Spiliotis, B.E., Pineda, J., Sachs, H.C., Brown, T.J., and Bercu,
B.B. The effects of castration on pulsatile gonadotropin secretion during
sexual development in the male subhuman primate. Society for Pediatric
Research, Washington, D.C., U.S.A., 1982.
5.
Pineda, J. Lee, B.C., Spiliotis B.E., Sachs, H.D., Brown, T.J. and Bercu,
B.B. Development changes in testicular steroidogenesis from early
postnatal through adult life in the subhuman primate. Society for Pediatric
Research, Washington, D.C., U.S.A., 1982.
6.
Pineda, J., Lee, B.C., Spiliotis, B.E., and Bercu, B.B. Primate Sertoli cell
culture. Age related differences. Endocrine Society, San Francisco,
California, U.S.A., 1982.
7.
Spiliotis, B.E., Lee, B.C., Pineda, J., Hoffman, H., and Bercu, B.B. Time
series analysis of pulsatile gonadotropin and testosterone secretion during
sexual development in the male monkey. Endocrine Society, San Francisco,
California, U.S.A., 1982.
8.
Spiliotis, B.E., Lee, B.C., Brown, T.J., Pineda, J.L., Vale, W., Rivier, J.,
Nixon, W., Reid, R., and Bercu, B.B. Effect of a potent GhRH antagonist on
pulsatile secretion in the male subhuman primate. American Society of
Andrology, Philadelphia, Pennsylvania, U.S.A., 1983. Citations: 2.
10
9.
Spiliotis, B.E., August, G., Hung, W., Sonis, W., and Bercu, B.B.
Broadening of the spectrum of growth hormone secretory abnormalities in
short children. Society of Pediatric Research, Washington, D.C., U.S.A.,
1983. Citations:1.
10.
Bercu, B.B., Spiliotis, B.E., Lee, B.C., Denman III, D.W., Hofman, H.J., and
Brown, T.J. Sexual development in the male subhuman primate: use of time
series analysis for characterization of hormonal secretion and comparison of
blood sampling at long and short intervals. Society of Pediatric Research,
Washington, D.C., U.S.A., 1983.
11.
Spiliotis, B.E., August, G., Hung, W., and Bercu, B.B. Effect of hGH
replacement therapy in children with short stature due to growth hormone
neurosecretory dysfunction. Endocrine Society, San Antonio, Texas, U.S.A.,
1983.
12.
Bercu, B.B., Spiliotis, B.E., Lee, B.C., and Brown, T.J. Longitudinal
analysis of pulsatile gonadotropin and testosterone secretion in the male
macaque. Endocrine Society, San Antonio, Texas, U.S.A., 1983.
13.
Spiliotis, B.E., August, G., Hung, W., and Bercu, B.B. Growth hormoneneurosecretory dysfunction. The Human Growth Hormone Symposium,
Baltimore, Maryland, U.S.A., 1983.
14.
Spiliotis, B.E., August, G., Hung, W., and Bercu, B.B. What constitutes GH
deficiency: Society for Pediatric Research, San Francisco, California,
U.S.A., 1984.
15.
Bercu, B.B., Hansen, J.W., Denman III, D.W., Hoffman, H.J. and Spiliotis,
B.E. Ultraseptan urinary gonadotropin rhythms in peripubertal boys. Society
for Pediatric Research, San Francisco, California, U.S.A., 1984.
16.
Spiliotis, B.E., Root, A.W., and Bercu, B.B. Does growth hormone
secretion increase during pubertal development? 7th International Congress
of Endocrinology, Quebec City, Quebec, Canada, 1984.
17.
Bercu, B.B., Friedman, D.P., Mishkin, M., and Spiliotis, B.E. Effect of
arcuate nucleus lesions on gonadotropin and growth hormone secretion in
the monkey. 7th International Congress of Endocrinology, Quebec City,
Quebec, Canada, 1984. Citations: 1.
18.
Sonis, W.A., Shumann, E., Maymi-Gascue, M., Spiliotis, B.E. and Bercu,
B.B. A case of environemental support of development arrest. American
Academy of Child Psychiatry, U.S.A., 1984.
19.
Spiliotis, B.E., Root, A.W., Hu, C.S., and Bercu, B.E. Pulsatile Growth
Hormone (GH) secretion during pubertal development in intact and castrate
monkeys. Society of Pediatric Research, Washington, D.C., U.S.A., 1985.
Citations: 2.
11
20.
Spiliotis, B.E., and Bercu, B.E. Comparison of Provocative and
Endogenous GH Secretion in intact and castrate monkeys. Endocrine
Society, U.S.A., 1985.
21.
Spiliotis, B.E., Saunders, R.C., Ndon, J.A., Hu, C.S., Phillip, M., Kempf, P.,
Kalogeras, K.T., and Mishkin, M. Non-human primate model for disorders of
growth hormone neurosecretion. Endocrine Society, Washington, D.C.,
U.S.A., 1991.
22.
Petrou, G., Makri, M., Armoni, A., Spiliotis, B.E., Alexandrides, T.K. β-cell
glucose non-sensing in patients with thalassemia major and glucose
intolerance. International Meditteranean Conference on Endocrine
Disorders in Thalassemia, Calabria, Italy, 1992.
23.
Crysis, D.C., Spiliotis, B.E., Alexandrides, T.K., Makri, M. and Beratis, N.G.
Growth Hormone and Insulin-like Growth Factor Dynamics in Thalassemia
Major. Endocrine Society, Washington, D.C., U.S.A., 1995.
24.
Spiliotis, B.E., Chrysis D.C., Alexandrides, T.K., Koromantzou, E.,
Vassilakos, P., and Beratis, N.G. IGF-I Generation Test as a Potential
Marker of Growth Hormone Neurosecretory Dynamics in β-Thalassemia
Major. 10th International Congress of Endocrinology, Washington, San
Francisco, California, U.S.A., 1996. Citations:1.
25.
Chrysis, D.C., Alexandrides, T.K., Koromantzou, E., Vassilakos, P., Beratis,
N.G., and Spiliotis B.E. Osteocalcinand Procollagen in β-Thalassemia
Major: Markers of Growth Hormone Action. 35th Annual Meeting of the
European Society for Pediatric Endocrinology, Montpellier, France, 1996.
26.
Spiliotis, B.E., Chrysis, D.C., Alexandrides, T.K., Georgopoulos, N.,
Κοromantzou, E., Vassilakos, P., and Beratis, N.G. A Novel Test of Growth
Hormone Neurosecretory Function in β-Thalassemia Major. 35th Annual
Meeting of the European Society for Pediatric Endocrinology, Montpellier,
France, 1996.
27.
Varvarigou, A., Spiliotis, B.E., Vassilakos, P. and Beratis, N.G. Growth
Hormone Dynamics in Asphyxiated Newborns. European Society for
Pediatric Research Congress, Szeged, Hungary, 1997.
28.
Spiliotis, B.E., Alexandrides, T.K., Chrysis, D.C., Kiess, W., Kratsch, J.,
Koromantzou, E., Vassilakos P., and Beratis, N.G. Growth Hormone Binding
Protein and Insulin-like Growth Factor Binding Proteins in Congress of
Endocrinology and β-Thalassemia. 9th Balkan Congress of Endocrinology
and 24th Panhellenic Congress of Endocrinology + Metabolism,
Thessaloniki, 1997.
12
29.
Spiliotis, B.E., Alexandrides, T.K., Chrysis, D.C., Koromantzou, E.,
Vassilakos, P., and Beratis, N.G. IGF-I Generation Test as a Test of Growth
Hormone Deficiency. 5th Joint Mtg. Of the European Society for Pediatric
Endocrinology and the Lawson Wilkens Pediatric Endocrine Society.
Stockholm, Sweden, 1997.
30.
Spiliotis, B.E., Saunders, R.C., Bercu, B.B., Wehrenberg, W.B., Kalogeras,
T.K., and Mishkin, M. Growth Hormone Secretory Dynamics in the Monkey
following Hypothalamic Lesions. 37th European Society for Pediatric
Endocrinology. Florence, Italy, 1998.
31.
Chrysis, D., Spiliotis, B.E., Stene, M., Davenport, M.L., Ultrasensitive
Assay for Gonadotropins: Potential Use in the Diagnosis of Turner
Syndrome. Endocrine Society Meeting, New Orleans, Louisiana, U.S.A.,
1998.
32.
Spiliotis, B.E., Zadik, Z., Alexandrides, T.K., Koromantzou, E., Drakou, A.,
Vassilakos, P., and Beratis, N.G. IGF-I Generation Test in the diagnosis of
GH abnormanilities. 81st Annual Endocrine Society Meeting. San Diego,
California, U.S.A., 1999.
33.
Rojas, P., Ziros, P., Diaz, L., Kletsas, D., Basdra, E., Alexandridis, T.,
Beratis, N., Papavassiliou, A., Spiliotis, B.E. Molecular profiles of the
GH/IGF-I axis in cultured fibroblasts of children with bioinactive GH: New
insights into the defect. European Society of Pediatric Endocrinology.
Madrid, Spain, September 25-28, 2002.
34.
Rojas-Gil, A.P., Ziros, P.G., Diaz, L., Kletsas, D., Basdra, E. K.
Alexandrides, T.K., Papathanasopoulou, V.S., Beratis, N.G., Papavasiliou,
A.G., Spiliotis, B.E. GH Signal Transduction Defect: Opening the black
box of idiopathic short stature. 85th Annual Endocrine Society Meeting,
Philadelphia, Pennsylvania, USA, June 19-22, 2003.
35.
Rojas-Gil, A.P., Ziros, P.G., Diaz, L., Kletsas, D., Basdra, E. K.
Alexandrides, T.K., Papathanasopoulou, V.S., Beratis, N.G., Papavasiliou,
A.G., Spiliotis, B.E., A Novel Mutation of the GH1 gene as a cause of
familial short stature. 42nd Annual Meeting of the European Society for
Paediatric Endocrinology, Ljubljana, Slovenia, September 18-21, 2003.
36.
Rojas Gil AP., Papathanasopoulou B, Kanetsis E., Karinos T., Ziros PG.,
Basdra EK., Alexandridis T., Beratis NG., Papavassiliou AG,. Spiliotis BE.
Novel Aberrant splicing of the GH1 gene as a cause of idiopathic short
stature. 12th Balkan Congres of Endocrinology and 30th Panhellenic
Congress of Endocrinology Thessaloniki May 21-25, 2003.
37.
Rojas Gil AP., Papathanasopoulou B, Kanetsis E., Karinos T., Ziros PG.,
Basdra EK., Alexandridis T., Beratis NG., Papavassiliou AG,. Spiliotis BE.
Novel Aberrant splicing of the GH1 gene as a cause of idiopathic short
13
stature. 12th Balkan Congres of Endocrinology and 30th Panhellenic
Congress of Endocrinology Thessaloniki May 21-25, 2003.
38.
Ziros, P.G, Nikolakopoulou, N, Rojas-Gil, A.P.,. Chatzantoni, K., Mouzaki,
A.., Eliopoulou, M., Alexandrides, T.K., Spiliotis, B.E. Novel Mutations of
the Melanocortin-4 Receptor Gene. 43rd Annual Meeting of the European
Society for Paediatric Endocrinology, Basel, Switzerland, September 13-16,
2004.
39.
Xekouki,,P., Nikolakopoulou, N., Kafiri, N.G., Maniati-Christidi, M, Zerva, A,
Papageorgiou, A., Livadas, S., Spiliotis, B.E., Dacou-Voutetakis, C.,
Prevalence of Impaired Glucose Tolerance (IGT) and Type 2 Diabetes
(DM2) in Greek Obese Children and Adolescents. Possible Risk Factors.
43rd Annual Meeting of the European Society for Paediatric Endocrinology,
Basel, Switzerland, September 13-16, 2004.
40.
Ziros, P.G, , Rojas-Gil, A.P., Kanetsis, E., Nikolakopoulou, N, Spiliotis,
B.E., Novel Mutations of the GH-1 Gene in a Child with GH Neurosecretory
Dysfunction (GHND). 44th Annual Meeting of the European Society for
Pediatric Endocrinology, Lyon, France, September 21-24, 2005.
41.
Andrea Paola Rojas Gil, Panos Ziros, Ioulia Karageorgou, Athanasios
Papavassiliou, Bessie Spiliotis. Defecto en la Transducciòn de Señales
de la Hormona de Crecimiento Como Resultado de la Regulaciòn Negativa
y Activaciòn Defectuosa del Eje GH/IGF-I . International Congress of
Genetics. Bucaramanga, Colombia, Feb. 2006
42.
Ziros Panos, Rojas-Gil Andrea Paola, Kanetsis Efthimios, Spiliotis Bessie
E. Two novel mutations in the promoter region of GH1 gene in a child with
GH Neurosecretory Dysfunction (GHND) attenuate the DNA binding activity
of Pit1 transcription factor. European Society for Pediatric Endocrinology,
45nd Annual Meeting. Rotterdam Holland, June 30- July 3, 2006.
43.
Karvela Alexia, Rojas-Gil Andrea Paola, Papadaki Helen, Avgeropoulos
Avgerinos, Varakis John, Georgiou George, Spiliotis Bessie E.The
involvement of adiponectin receptor 1 (AdipoR1) and peroxisome
proliferator-activated receptor γ (PPAR-γ) in adipocyte differentiation in
obese children. European Society for Pediatric Endocrinology 45nd Annual
Meeting. Rotterdam Holland, June 30- July 3, 2006.
44.
Rojas-Gil, Andrea Paola, Karageorgou, Ioulia, Basdra, Efthymia, Varakis,
John, Papavasiliou, Athanasios, Spiliotis, Bessie E. Enhanced inhibition of
the GH transduction pathway by CIS in patients with Growth Hormone
Transduction Defect (GHTD) is possibly overcome by Epidermal Growth
Factor (EGF) administration. European Society for Pediatric Endocrinology
43nd Annual Meeting. Rotterdam Holland. June 29- July 3, 2006.
14
45.
Eliopoulou MI, Georgakopoulos CD, Nanos P, Spiliotis BE. Impaired
contrast sensitivity in children and adolescents with type 1 (insulindependent) diabetes mellitus. European Society for Pediatric Endocrinology
45nd Annual Meeting. Rotterdam Holland, June 30- July 3, 2006.
46.
Eliopoulou Maria, Spiliotis BE, Georgakopoulos CD, Exarchou A, Lamari
FN, Kanakis J, Karamanos NK. Determination of ascorbic acid, uric acid
and malondialdehyde in reflex tears of diabetic children with capillary
elecrophoresis. European Society for Pediatric Endocrinology 45nd Annual
Meeting. Rotterdam Holland, June 30- July 3, 2006.
47.
Rojas-Gil A-P, Karageorgou, Ioulia, Ziros Panos Basdra, Efthymia, Varakis,
John, Papavasiliou, Athanasios, Spiliotis, Bessie E. Enhanced protein
degradation of the GHR/JAK2 complex through the proteasomes as a cause
of abnormal GH signaling in GH Transduction Defect (GHTD) . European
Society for Pediatric Endocrinology 44nd Annual Meeting. Helsinki, Finland.
2007
48.
Karvela Alexia, Rojas-Gil A-P, Pappa Aliki, Papadaki Helen, Samkinidou
Eustratia, Varakis John, Georgiou George, Spiliotis Bessie E. Expression
of AdipoR1, PPAR-γ and CB1 in adipocyte primary cultures and serum
Adiponectin in childhood obesity. European Society for Pediatric
Endocrinology 44nd Annual Meeting. Helsinki, Finland, 2007.
49.
Rojas-Gil, AP, Karageorgou, I1, Ziros P2 Basdra, E4, Varakis, J3,
Papavasiliou, AG2, Spiliotis, BE1. Enhanced protein degradation of the
GHR/JAK2 complex through the proteasomes as a cause of abnormal GH
signaling in GH Transduction Defect (GHTD). General Meeting of
International proteolysis society. Patras,Greece, October, 2007.
50.
Α. Karvela, Α. P. Rojas-Gil, A. Pappa, H. Papadaki, E. Samkinidou , J.
Varakis, G. Georgiou, B. E. Spiliotis. Serum adiponectin and expression of
AdipoR1, PPAR-γ and CB1 in primary adipocyte cultures from abdominal
adipose tissue of lean pre-pubertal children. Meeting of the International
Society for Pediatric and Adolescent Diabetes, Berlin, Germany, 2007.
51. Α. Karvela, Α. P. Rojas-Gil, A. Pappa, H. Papadaki, E. Samkinidou , J.
Varakis, G. Georgiou, B. E. Spiliotis. Differences in waist circumference and
expression of AdipoR1, PPAR-γ and CB1 in primary adipocyte cultures from
abdominal adipose tissue of obese and lean pre-pubertal children. . Meeting
15
of the International Society for Pediatric and Adolescent Diabetes, Berlin,
Germany, 2007.
52. Α. Karvela, Α. P. Rojas-Gil, A. Pappa, H. Papadaki, E. Samkinidou , J.
Varakis, G. Georgiou, B. E. Spiliotis. Meeting of the European Childhood
Obesity Group, Athens, Greece, 2007.
53.
Andrea Paola Rojas-Gil, Dimitris Κletsas, Kostas Kamzelas, Maria
Karageorgiou, Evthimia Basdra Athanasios G Papavasiliou , Bessie E
Spiliotis Enhanced Protein Degradation of the GHR via the proteasomes
due to over-expression of CIS Ubiquitin-Ligase as a cause of abnormal GH
signalin in GH transduction defect (GHTD). The Endocrine Society's 90th
Annual Meeting San Francisco USA, 2008.
54. Alexia Karvela, Andrea Paola Rojas Gil, Aliki Pappa, Helen Papadaki,
Eustratia Samkinidou, John Varakis, George Georgiou and Bessie E.
Spiliotis. Expression of CB1 receptor in primary adipocyte cultures and
serum adiponectin concentrations in normal lean children. The Endocrine
Society's 90th Annual Meeting San Francisco USA. 2008.
55. Alexia Karvela, Andrea Paola Rojas Gil, Aliki Pappa, Helen Papadaki,
Eustratia Samkinidou, John Varakis, George Georgiou and Bessie E.
Spiliotis. Differences in waist circumference, serum high molecular weight
(HMW) Adiponectin, serum insulin and expression of CB1 in primary
adipocyte cultures of obese and lean children. The Endocrine Society's 90th
Annual Meeting San Francisco USA, 2008.
56. Athina Dettoraki, Andrea Paola Rojas Gil, John Varakis, Bessie E. Spiliotis
Association between serum levels of soluble receptor (sRAGE) for Advanced
Glycation Endproducts (AGEs) and Receptor for AGEs (RAGE) protein
expression in peripheral blood mononuclear cells (PBMCs) in children and
adolescents with type I diabetes mellitus (IDDM) European Society for
Pediatric Endocrinology 45nd Annual Meeting. Instanbul Turkey, 2008.
57.
Andrea Paola Rojas-Gil, Dimitris Κletsas, Kostas Kamzelas, Maria
Karageorgiou, Bessie E Spiliotis. Over-expression of CIS ubiquitin (ub)Ligase and enhaced proteasome activity as a cause of abnormal GH
signaling in GH transduction defect (GHTD). European Society for Pediatric
Endocrinology 45nd Annual Meeting. Instanbul, Turkey, 2008.
16
58.
Αlexia Karvela, Αndrea Paola Rojas-Gil, Aliki Pappa, Helen Papadaki,
Efstratia Samkinidou, John Varakis, Geroge Georgiou, Bessie E. Spiliotis.
Cannabinoid receptor, CB1, expression in primary adipocyte cultures in lean
and obese pre-pubertal children, in relation to High Molecular Weight (HMW)
adiponectin, HOMA Insulin Resistance (IR) and waist circumference.
European Society for Pediatric Endocrinology 45nd Annual Meeting. Instanbul
Turkey, 2008.
59. Andrea Paola Rojas-Gil, Dimitris Κletsas, Kostas Kamzelas, Maria
Karageorgiou, Bessie E Spiliotis. Over-expression of CIS ubiquitin (ub)Ligase and enhaced proteasome activity as a possible cause of abnormal GH
signaling in a child with GH transduction defect (GHTD). FEBS congres
Athens, Greece, 2008.
60. Ioanna Partsalaki, Alexia Karvela, Andrea Paola Rojas Gil, Bessie E.
Spiliotis. Metabolic Impact of a ketogenic diet as compared to a hypocaloric
diet in obese children and adolescents. . Meeting of the International Society
for Pediatric and Adolescent Diabetes, Durban, South Africa. 2008.
61. Andrea Paola Rojas Gil, Mary Smaili, Alexia Karvela, Ioannis Kehagias,
Theodore K. Alexandrides, Dimitrios Linos, Fotis Kalfaretzos, Bessie E.
Spiliotis. RAB5, GLUT-4 and PI3 Kinase expression in preadipocytes
primary cultures of visceral, subcutaneous abdominal and gluteal tissue from
morbidly obese and lean adults in different states of insulin sensitivity.
Endocrine Society Meeting, Washington DC. June. 2009.
62.
Andrea Paola Rojas Gil, Irini Kostopoulou, Kostantinos Kamzelas, Bessie E
Spiliotis. Inhibition of the protein expression of CIS ubiquintin ligase
overcomes the impairment in the GH signalling pathway in Growth Hormone
Transduction Defect (GHTD). LWPES/ European Society for Pediatric
Endocrinology 8th Joint Meeting New York City USA. September, 2009
63. Ioanna Giannakopoulou, Andrea Paola Rojas Gil, Bessie E Spiliotis. Two
novel mutations in the promoter region of the growth hormone gene (GH1) in
familial isolated growth hormone deficiency LWPES/ European Society for
Pediatric Endocrinology 8th Joint Meeting New York City USA.
September, 2009.
17
64. Andrea Paola Rojas Gil, Mary Smaili, Alexia Karvela, Ioannis Kehagias,
Theodore K. Alexandrides, Dimitrios Linos, Fotis Kalfaretzos, Bessie E.
Spiliotis. RAB5 and GLUT-4 expression in preadipocytes primary cultures of
visceral, subcutaneous abdominal and gluteal tissue from obese children, lean
children morbidly obese and lean adults in different states of insulin sensitivity.
LWPES/ European Society for Pediatric Endocrinology 8th Joint Meeting
New York City USA. September, 2009.
65. Nikolitsa Koutroumani, Andrea Paola Rojas Gil, Athina Dettoraki, Bessie E.
Spiliotis Correlation between cyclooxygenase-2 (COX2), sRAGE and matrix
metalloproteinase 9 (MMP9) with hemoglobin A1C (HbA1c) and LDL
cholesterol and their possible role in the growth of type type 1 complications in
children . European Society for Pediatric Endocrinology 49nd Annual Meeting
Prague Czech Republic, September, 2010.
66. Aikaterini Avgeri, Alexia Karvela, Andrea Paola Rojas-Gil, Eustratia
Samkinidou, George Georgiou, Bessie E. Spiliotis. Association of the nuclear
receptor PPAR-γ and the proteins CAP and c-CBL with insulin resistance in
primary adipocyte cultures of lean and obese adolescents. European Society
for Pediatric Endocrinology 49nd Annual Meeting Prague Czech Republic,
September, 2010.
67. Aikaterini Avgeri, Alexia Karvela, Aliki Pappa, Andrea Paola Rojas-Gil,
Eustratia Samkinidou, George Georgiou, Bessie E. Spiliotis . The Expression
of AdipoR1 and APPL-1 in primary adipocyte cultures of lean and obese
children and adolescents in relation to their serum ΗΜW Adiponectin.
European Society for Pediatric Endocrinology 49nd Annual Meeting Prague
Czech Republic, September, 2010.
68. Eirini Kostopoulou, Andrea Paola Rojas-Gil, Bessie E. Spiliotis. The role of
Epidermal Growth Factor(EGF) in the treatment with human Growth Hormone
of children with Growth Hormone Transduction Defect (GHTD). European
Society for Pediatric Endocrinology 49nd Annual Meeting Prague Czech
Republic, September, 2010.
69. Andrea Paola Rojas Gil1, Emmanouil Nikolenas1, Alexia Karvela1, Ioannis
Kehagias3, Theodore K. Alexandrides2, Dimitrios Linos4, Fotis Kalfarentzos3,
Bessie E. Spiliotis. CORRELATION OF PRO-INFLAMATORY AKT-II, CD68,
MCP-1, IL6 AND IL8 WITH OBESITY AND INSULIN SENSITIVITY IN
DIABETES TYPE II (DMII). 1st Meeting of the International Diabetes and
18
Obesity Foundation , Athens, Greece Diabetes, Obesity and Metabolism 12(1)
PPO19:61-62, 2010.
70. Partsalaki I, Lamari F, Karvela A, Rojas Gil1 A P, Spiliotis B E. Effects of a
ketogenic diet as compared to a hypocaloric diet on metabolic parameter,
oxidative stress(OS), Advanced Glycation End-products (AGES) and the
soluble receptor for AGES (SRAGE) in obese children and adolescents. 1st
Meeting of the International Diabetes and Obesity Foundation , Athens,
Greece Diabetes, Obesity and Metabolism 12(1), PP052: 73 2010.
71. Alexia Karvela Aikaterini Avgeri, , Aliki Pappa, Andrea Paola Rojas-Gil,
Eustratia Samkinidou, George Georgiou, Bessie E. Spiliotis. The expression
of the endocannabinpid receptor CB1 in primary adipocyte cultures of lean and
obese prepubertal children and adolescents in relation to insulin and High
Molecular Weigh (HMW) adiponectin.1st Meeting of the International Diabetes
and Obesity Foundation , Athens, Greece. Diabetes, Obesity and Metabolism
12(1) OPO3: 38, 2010.
72. Aikaterini Avgeri, Alexia Karvela, Aliki Pappa, Andrea Paola Rojas-Gil,
Eustratia Samkinidou, George Georgiou, Bessie E. Spiliotis. The expression
of PPAR-GAMA and CAP in primary adipocyte cultures from lean and obese
prepubertal children and adolescents in relation to their serum HMW
adiponectin. 1st Meeting of the International Diabetes and Obesity Foundation
, Athens, Greece. Diabetes, Obesity and Metabolism 12(1) OPO5: 39, 2010.
19