Material Transfer Agreement This letter is an agreement between National University Corporation Kobe University at Rokkodai 1-1, Nada, Kobe, Hyogo 657-8501, Japan (“Provider”) and having its principal office at ( ”Recipient”). In response to Recipient’s request, Provider will supply WHHLMI rabbits to Recipient, provided that Recipient agrees to the following: 1. Recipient can use the WHHLMI rabbits and their progeny (hereinafter collectively referred to as “Material”) solely for research purpose (including breeding) described in the Application Format. 2. Recipient can only use the Material in its research facilities. 3. Recipient agrees to comply with all applicable laws, rules and regulations relating to the care, animal welfare, handling, breeding, storage, transfer and disposal of the Material. Relevant to the foregoing, Recipient shall submit the copy of Permit License with using Material in the Research to Provider, which was issued by Institutional Animal Care and Use Committee (IACUC) in the Recipient Institute or supervisory authority. Recipient agrees to hold harmless Provider, Provider’s employees and Provider’s agents from and against all claims, damages and liability (together with the ‘Claims’) that may be asserted by third parties arising out of Recipient’s use, care, handling, disposal, transfer, breeding and shipment of the Material in the research, except for Claims caused by the negligence or willful misconduct of Provider. 4. Recipient must not transfer the Material to any third party without the prior written consent of Provider. 5. The WHHLMI rabbits must not be bred with any rabbits other than WHHLMI rabbits without the prior written consent of Provider. 6. Recipient agrees to carry out the Studies by using provided Material on the premise of research collaboration and to publish or publicly disclose such results with co-authorship. 7. Recipient agrees to cite a paper, “Arteriosclerosis, Thrombosis and Vascular Biology 2003; 23 (7): 1239-1244”, as the reference of WHHLMI rabbits in any publications reporting on the research performed with the Material, and the Material shall be referred to as WHHLMI rabbit (Myocardial infarction-prone Watanabe heritable hyperlipidemic rabbit). 8. In case of publishing the results of the research, a copy of the publication, or the summary in case of oral presentation, shall be sent to Dr. Masashi Shiomi, 1/4 WHHLMI Rabbit Research and Bioresource Center, Kobe University Graduate School of Medicine. 9. Recipients are required to allocate a room/rooms for exclusive housing of WHHLMI rabbits. The rooms for WHHLMI rabbits have to be equipped and maintained as follows; 1) constant temperature and humidity, 2) ventilated as appropriate to keep ammonia concentration low (<20 ppm), 3) have structures that protect the rooms from invasion of other animals, birds, and insects, 4) have automatically-controlled lighting system, 5) periodical change of the cages which are cleaned, disinfected, and sterilized, 6) prepare and follow the standard operating procedure for the care of WHHLMI rabbits. 10. Recipient agrees to reimburse Provider for the animal costs (see the attached sheet, “unit price for academia in collaboration 2015”) and Recipient have to pay the all cost of animal exportation procedure, even the case may happen that WHHLMI rabbits accidentally die or debilitate. Payment is due within thirty (30) days from the date of the invoice provided by Provider. 11. The Material is experimental in nature and it is provided without any warranties, expressed or implied, including any warranty of merchantability and fitness for a particular purpose. 12. PROVIDER MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION THAT THE USE OF MATERIAL WILL NOT INFRINGE ANY THIRD PARTY PATENT, COPYRIGHT, TRADEMARK, OR OTHER RIGHTS. IN NO EVENT SHALL PROVIDER BE LIABLE TO THE RECIPIENT HERE UNDER FOR ANY CONSEQUENTIAL, INCIDENTAL OR SPECIAL DAMAGES OR EXPENSES INCLUDING WITHOUT LIMITATION LABOR, TRANSPORTATION, LOSS OF USE AND DAMAGE TO PERSONS OR PROPERTY INCURRED BY MATERIAL. 13. Recipient hereby agrees to assume any and all liability for damages arising from the use, storage or disposal of the Material by Recipient or its employees or co-workers. 14. Provider shall retain any legal titles and interests to the Material. 15. This Agreement shall be governed by and construed in accordance with the laws of Japan without application of its rules on conflicts of law. 16. This Agreement will terminate December 31st, 2015. Provided however that, Provider will defer the effective date of termination for a period of one year, upon request from the Recipient. 17. Notwithstanding foregoing Paragraph 16, Paragraphs 3, 7, 8, 12, 13, 14 and 15 shall survive termination. If Recipient agrees with the above conditions, please sign and date the two of 2/4 this letter and return one copy to Provider. Provider will then send the Material to Recipient. Provider Kobe University Kazuo Yoshii Date Executive Vice President, In Charge of Finance National Corporation Kobe University Professor Ken-ichi Hirata Date Director Graduate School of Medicine WHHLMI Rabbit Research and Bioresource Center Recipient __________________ Date (President or Director) Date (Principal Investigator) 3/4 April 1, 2015 Unit price of a WHHLMI rabbit for academic use Age of months A unit price (Yen) 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 14,100 14,720 15,340 16,840 17,460 18,080 18,700 19,320 19,940 21,440 22,060 22,680 23,300 23,920 24,540 26,040 26,660 27,280 27,900 28,520 29,140 30,640 31,260 31,880 32,500 33,120 33,740 34,360 4/4