2011 International Conference on Molecular Neurodegeneration
September 22-24, 2011 - Shanghai, China
Organizing Committee:
Guojun Bu (Organizer), Mayo Clinic and Xiamen University
Lan Ma (Organizer), Fudan University, Institute of Brain Science
Huaxi Xu (Organizer), Sanford-Burnham Institute and Xiamen University
Ping Zheng (Organizer), Fudan University, State Key Laboratory of Medical Neurobiology
Robert Vassar, Northwestern University
Yunwu Zhang, Xiamen University
Hui Zheng, Baylor College of Medicine
Chunjiu Zhong (Local Organizer and Secretary), Fudan University
Scientific Program Committee:
Lan Ma (Co-chair), Fudan University
Robert Vassar (Co-Chair), Northwestern University
Xiongli Yang(Co-Chair), Fudan University (Member of Chinese Academy of Science, China)
Hui Zheng (Co-Chair), Baylor College of Medicine
Guojun Bu, Mayo Clinic and Xiamen University
Huaxi Xu, Sanford-Burnham Institute and Xiamen University
Objectives:
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Promote cutting-edge neurodegeneration research.
Facilitate the exchange of information relevant to neurodegenerative research.
Provide education opportunity for students, postdocs, physicians.
Provide a platform for investigators at different career levels to interact and network, and
to foster collaborations at the international levels.
Scientific Program and Schedule
September 21
10:00 am - 9:00 pm
Arrival and Registration
6:00 pm
Welcome Reception and dinner
September 22
8:00 am - 8:10 am
Welcome Remarks by the Organizers
8:10 am - 8:20 am
Welcome Remarks by the Local Officials
Morning Session - Chairs: Guojun Bu and Xiongli Yang
8:20 am - 9:00 am
Special Lecture: Ferid Murad, George Washington University,
Nobel Laurent: Discovery of nitric oxide and cyclic GMP in cell
signaling and their role in drug development
9:00 am – 9:40 am
Keynote Address: John Hardy, University College London: What
has genetic analysis taught us about Alzheimer’s disease?
9:40 am – 9:55 am
Coffee and Tea break
9:55 am – 11:35 am
Session I: APP, BACE and gamma-secretase
9:55 am - 10:20 am
Gopal Thinakaran, University of Chicago: Endosomal trafficking
and axonal transport of Alzheimer’s disease beta-secretase
10:20 am – 10:45 am
Robert Vassar, Northwestern University: BACE1, the Alzheimer's
beta-secretase enzyme, in health and disease
10:45 am - 11:10 am
Yueming Li, Memorial Sloan Kettering Cancer Center: gammasecretase: from pathogenesis to therapeutics
11:10 am – 11:35 am
Takeshi Iwatsubo/ Taisuke Tomita, University of Tokyo: Structurefunction relationship of gamma-secretase
11:40 am - 1:00 pm
Lunch
Afternoon Session Chairs: Huaxi Xu and Lan Ma
1:00 pm - 2:40 pm
Session II: Cellular and in vivo Studies of AD Pathogenesis
1:00 pm - 1:25 pm
Wim Annert, Centre for Human Genetics, KULeuven: Sorting out
the cell biology of Alzheimer’s disease
1:25 pm - 1:50 pm
Hui Zheng, Baylor College of Medicine: Physiological functions of
the amyloid precursor protein
1:50 pm - 2:15 pm
Jie Shen, Brigham & Women’s Hospital, Harvard Medical School:
Presenilins in neurodegenerative dementia
2:15 pm – 2:40 pm
Luciano D’Adamio, Albert Einstein College of Medicine: No
plaques, No tangles. Yet, no memory -- A genetically congruous
mouse model of dementia questions the "Amyloid cascade
hypothesis" of Alzheimer's Disease
2:40 pm - 2:55 pm
Coffee and Tea break
2:55 pm - 4:25 pm
Short Talk Session I:
Six short talks of 15 min each will be selected from submitted
abstracts
4:30 pm - 6:00 pm
Poster Session I
6:00 pm - 8:00 pm
Buffet Reception
8:00 pm - 9:30 pm
Panel Discussion: Neurodegeneration Research in China:
Current State and Challenges (Modulators: )
September 23
Morning Session Chairs: Bob Vassar and Ping Zheng
8:00 am - 8:40 am
Keynote Addresses: Steve Heinemann, Salk Institute: Synaptic
dysfunction and Alzheimer’s disease
8:40 am - 9:55 am
Session III: ApoE
8:40 am - 9:05 am
Guojun Bu, Mayo Clinic Jacksonville: ApoE and apoE receptors in
brain lipid metabolism and AD
9:05 am - 9:30 am
Maria Paz Marzolo, Pontificia Universidad Católica de Chile: ApoE
receptor trafficking and metabolism
9:30 am - 9:55 am
Steve Estus, University of Kentucky: Genetics of ApoE Receptors
and Cholesterol in Alzheimer’s Disease Risk
9:55 am - 10:10 am
Coffee and Tea break
10:10 am - 11:50 am
Session IV: Parkinson’s Disease
10:10 am - 10:35 am
Ming Guo, UCLA: Molecular Pathways to Parkinson's disease
10:35 am - 11:00 am
Zhuohua Zhang, Central South University, China: Genetic and
Epigenetic Insights of Parkinson Disease
11:00 am - 11:25 am
Karen O’Malley, Washington University, St. Louis: Does
axonopathy play a role in Parkinson's disease?
11:25 am - 11:50 am
Local speaker
11:50 am - 1:00 pm
Lunch
Afternoon Session Chairs: Huaxi Xu and Lan Ma
1:00 pm - 2:15 pm
Session V: Huntington’s Disease and TDP-43 Proteinopathies
1:00 pm - 1:25 pm
Xiao-Jiang Li, Emory University: Polyglutamine expansionmediated neurodegeneration
1:25 pm - 1:50 pm
William Yang, UCLA: Novel Circuitry and Molecular Pathogenic
Mechanisms in Huntington's Disease
1:50 pm - 2:15 pm
Leonard Petrucelli, Mayo Clinic Jacksonville: Mechanisms and
Models of TDP-43 Proteinopathies
2:15 pm - 2:30 pm
Break
2:30 pm - 4:00 pm
Short Talk Session II:
Six short talks of 15 min each will be selected from submitted
abstracts
4:00 pm - 6:00 pm
Poster Session II Wine and Cheese Reception
6:00 pm - 8:00 pm
Banquet
9:00pm - 10:00pm
Huangpu River night tour (optional)
September 24
Morning Session Chairs: Hui Zheng and Chunjiu Zhong
8:00 am - 8:40 am
Keynote Address: Xiaodong Wang, National Institute of
Biological Sciences, China: Targeting neuronal necrosis as a
therapy for neurodegenerative diseases
8:40 am – 11:50 am
Session VI: Novel Targets of Neurodegenerative Diseases
8:40 am – 9:05 am
George Martin, University of Washington: Classes of gene action
with the potential to modulate aging and neurodegenerative
disorders
9:05 am – 9:30 am
Bruce Lamb, Cleveland Clinic: The role of fractalkine signaling in
neurodegenerative disease
9:30 am – 9:55 am
Huaxi Xu/Yunwu Zhang, Sanford-Burnham Institute and Xiamen
University: Identifying an APP-binding protein in neuronal cell
death
9: 55 am – 10:10 am
Coffee and Tea break
10:10 am - 10:35 am
Riqiang Yan, Cleveland Clinic: “RTN3 in cognitive dysfunction”
10:35 am - 11:00 am
Yong Shen: Trophic factors and Alzheimer's disease
11:00 am - 11:25 am
Local speaker
11:25 am – 11:50 am
Local speaker
11:50 am - 1:30 pm
Lunch
Hangzhou Day Tour (optional), Shanghai Day Tour (including Expo 2010, optional) and
Departure