Table of Contents INTRODUCTION AND BACKGROUND ..................................................... 1 BACKGROUND INFORMATION - DVS ...................................................... 1 Poultry Production Systems ........................................................................ 2 Situation Analysis ................................................................................... 2 PANDEMIC PREPAREDNESS .................................................................. 5 CO-ORDINATION AND RESOURCES MOBILISATION ................................. 10 EPIDEMIOLOGY AND SURVEILLANCE EMERGENCY PREPAREDNESS PLAN ... 17 EPIDEMIOLOGY AND SURVEILLANCE (DOMESTIC BIRDS) WORK PLAN ........ 20 EPIDEMIOLOGY AND SURVEILLANCE (HUMANS) WORK PLAN ................... 23 EPIDEMIOLOGY AND SURVEILLANCE (WILD BIRDS) WORK PLAN ............... 24 LABORATORY AND RESEARCH ............................................................ 29 INFECTION PREVENTION AND CONTROL ............................................. 37 CASE MANAGEMENT ........................................................................ 43 INFORMATION, EDUCATION AND COMMUNICATION ............................... 48 SUMMARY AVIAN FLU GUIDELINE ....................................................... 54 i ii Executive summary 1 ACRONYMNS AND ABBREVIATIONS WHO FAO USAID OIE AU-IBAR MOH MOLFD IEC IPC UNDP DANIDA 1 THE NATIONAL AVIAN INFLUENZA STRATEGIC EMERGENCY PREPAREDNESS AND RESPONSE PLAN INTRODUCTION AND BACKGROUND THE COUNTRY The contemporary Republic of Kenya was founded on 12th December 1963 when the country gained her independence. It lies on the eastern part of the African continent East Africa and is bisected by the Equator. It covers an area of some 582,000 Sq Km and has a human population of 32 million persons. It is classified as a developing country and is characterized by a continuing search for solutions to problems of poverty, ignorance and disease inherited from the past and exacerbated by a plethora of international and local circumstances that are sometimes beyond its capacity to resolve fully at the present time. At the international level some of the problems arise from disadvantaged historical position in trade, investment, finance, development and political economy. At the nationnal level, problems have arisen from leadership and governance systems that leave quite some room for improvement. The country has however continued to grapple with these problems and has received tremendous support from the international community while still addressing local level problems in all sectors of the economy, health included, in order to ensure a better future for its contemporary citizens and residents and visiters and for posterity. BACKGROUND INFORMATION - DVS THE DISEASE Avian influenza is a viral disease of poultry caused by RNA viruses. There are three main groups of influenza viruses: Type A, B, and C. Avian variants of influenza virus are classified as type A. These naturally occur in domestic fowls, ducks, geese, turkeys, guinea fowl, quail and pheasants. Disease outbreaks occur most frequently in domestic fowl and turkeys. Influenza B and C viruses are generally restricted to humans. Influenza A viruses are widespread in birds and mammals although most avian and other non-human variants do not infect humans. There are two known pathotypes of Avian Influenza: Highly Pathogenic Avian Influenza (HPAI) This pathotype causes severe disease with high mortality of up to 100%. To date, only (but not all) viruses of H5 or H7 subtype are in this pathotype 1 Low Pathogenic Avian Influenza (LPAI) mild respiratory disease, depression, egg production problems may exacerbate other infections/conditions Influenza A viruses infecting poultry can be divided into 2 distinct groups. The most virulent viruses cause fowl plague, now referred to as highly pathogenic avian influenza (HPAI) while other viruses cause a milder, primarily, respiratory disease designated low pathogenic avian influenza (LPAI). HPAI can cause up to 100% mortality. LPAI may under certain conditions cause a more serious disease depending on environmental conditions and other concurrent infections. Most outbreaks in domestic poultry probably start with direct or indirect contact with water birds and migratory birds in which the disease is inapparent. Many of the strains that circulate in wild birds are either non pathogenic or mildly pathogenic for poultry and may become virulent through either genetic mutation or re-assortment. 0nce AI is established in domestic poultry, it is a highly contagious disease and wild birds are no longer essential for spread. Infected birds secrete the virus in high concentration in their faeces, nasal and ocular discharges. Within a flock, the disease spreads rapidly by direct contact and airborne transmission. The virus is then spread from flock to flock by the usual methods involving the movement of infected birds, contaminated equipment, egg cartons, feed trucks, human traffic and airborne transmission for birds in close proximity. There is a possibility of vertical transmission though this has not been resolved. Clinical signs are variable and are influenced by factors such as virulence of the infecting virus, species affected, age, sex, concurrent disease and environment. In HPAI, infected birds show signs of depression, inappetence, ruffled feathers, fever, cyanotic and oedematous combs and wattles, profuse watery diarrhoea and respiratory distress. Neurological signs may also be observed. VIRULENCE OF AVIAN INFLUENZA VIRUSES • The presence of multiple basic amino acids at the HAO cleavage site means the viruses are able to spread systemically in all tissues • Without additional basic amino acids at the cleavage site the viruses are restricted to replication in the respiratory and intestinal tracts Poultry Production Systems The poultry population in Kenya is estimated at 30,000,000, 80% of which are indigenous chicken under backyard production, 19% commercially reared broilers and layers, and 1% made up of other poultry (ducks, turkeys, geese etc). Commercially poultry keeping is mainly practiced in urban and peri-urban areas of the country. On the average, every rural Kenyan household has 2-3 backyard chicken. Poultry is mainly kept for supply of domestic protein, income generation and for social purposes. Situation Analysis Avian influenza has not been diagnosed in Kenya. However, Kenya is at high risk because it lies along the migratory route of birds from Europe to Southern Africa and its water points serve as a stop-over. Virus excreted by these birds can survive in the environment for long, especially in ponds, waterways and cool damp areas. However, the low population of intensively farmed turkeys, ducks or water fowls reduces the risk of spread of the virus if introduced. In contrast, pigs and poultry are kept in close proximity and thereby pose a public health risk. 2 Retrospective analyses of avian diseases diagnosed at the Central Veterinary Laboratory, Kabete between 1935 and 2004 do not indicate the occurrence of avian influenza in poultry in the country. Studies looking for heamagglutinating viruses in wild birds, water fowls, domestic and indigenous chicken only showed presence of Avian Paramyxovirus (APMV) type 2 in migratory birds, APMV type 2,3 and 8 in ducks, APMV type 3 in chickens and APMV type 4 in flamingos (Kasiti J. L, MSc Thesis 2000). Avian influenza was declared a notifiable in Kenya, with effect from 1996 through a gazette notice. Following recent outbreaks in different parts of the world, Kenya has placed a ban on the importation of poultry and their products from South Africa , Asia, Turkey, Greece, Romania and any other country reporting avian influenza. Veterinary personnel at ports of entry have been placed on high alert over possible entry of poultry and their products. A circular on disease recognition and the need for prompt reporting of suspicious cases has been sent to all field offices. Kenya has an elaborate national epidemiological surveillance network comprising both public and private veterinary professionals (veterinarians and paravets) and other stakeholders including livestock keepers and traders. The public structures include District and Provincial offices, Abattoir inspectorate, National and Sub-national Veterinary Laboratories and a Central Epidemiology Unit. Other collaborators are Kenya Wildlife Services and Research institutions. Though the National Veterinary Laboratory has some capacity to diagnose avian influenza, it requires reagents, consumables, training and some equipment to be able to confirm avian influenza cases. The Sub-national laboratories are poorly equipped for diagnostic work. BACKGROUND INFORMATION - HEALTH Kenya faces with a burden of communicable diseases that comprise 70% of all outpatient morbidity. The country has adopted The Integrated Diseases Surveillance and Response (IDSR) Strategy for the purpose of promptly detecting priority diseases, re-emerging and emerging diseases. The country’s health system is beset with severe inherent weaknesses, among them the following: Poor disease surveillance system (in terms of timeliness, completeness, human capacity), Inadequacy of emergency stocks of vaccines, anti viral drugs and protective gear & other non-pharmaceuticals Limited laboratory capacity Inadequate funding for research Past Influenza Pandemics The following are milestones in the outbreak of influenza pandemics: •Before 1880: Influenza was thought to be‘The Influence of Stars on epidemics of Cough and Fever’ •1880-1933 : H. Influenza thought to be the causative agent for the disease •1918: Pandemic Alerts world on potentials of influenza •1933: First Isolation of influenza virus •1946: First Vaccine against influenza developed and tested in USA •1947: WHO: Establishment of first influenza Centre in London Influenza pandemics are associated with high mortality, morbidity, social & economic disruption. Deaths in pandemics are usually caused by Primary Viral Pneumonia and Pneumonia caused by secondary Bacterial Infections. Three pandemics were reported in the 20th C at intervals of 103 50 years. The 1918 pandemic is regarded as the most deadly event in human history. It is reported to have killed more than 40 million people in one year compared to total military deaths of 8.3 million over 4 yrsof the First World war Most pandemics have originated from Asia where humans live close to pigs and ducks. The main challenge is provision of adequate hospital and medical facilities due to a surge in medical care needsThe capacity of the virus to cause severe disease in ‘non traditional age groups’ e.g. young adults determines overall impact. Milder pandemics cause excess mortality in the very young and old and in those with underlying chronic conditions (at risk groups for seasonal epidemics). Countries with good vaccination programs expect better outcome due to experience in logistics of vaccine delivery and conversely. Influenza Surveillance Influenza trend in Kenya Monitored by Surveillance Network in Nairobi Nairobi 2001 - 03 flu +ve 25 20 15 flu +ve 10 5 N ov .0 1 F eb M ay A ug N F ov eb .0 3 M ay A ug N ov 0 Type ‘B’ constitute 94% of all detected cases while type ‘A’ 6% Avian Influenza Risk Information The main sources of avian Flu risk arises from importation of wild birds, poultry and their products from affected countries, migratory birds flying from affected countries an international tourism as Nairobi is a hub for international travel. This may be exacerbated by risk behaviour inherent in local cultural practices such as consumption of inadequately cooked poultry and their products, consumption of birds when signs of illness appear and living in the same dwellings with poultry. These practices may expose our population to H5N1 virus infection. Kenya lies along the migratory birds route from Europe to Southern Africa and is a stop over point for many species thereof. Birds start to arrive in mid September and peak in mid November. Migratory birds stop at water points and mix freely with local water birds. Water birds mix freely with domestic poultry. It is estimated that some 270 species of birds migrate into Kenya. Kenya’s poultry population is estimate at 30 million of which indigenous birds account for 70%, commercial birds 28% and others such as (geese, turkeys, ducks etc.) 2% of the total bird population. The figure below shows the migratory bird routes. H5N1Outbreaks in 2004 have become a major global concern since January 2004 when Thailand and Vietnam reported their first case of human infection with avian Influenza previously reported in chicken . These cases are directly linked to outbreaks of highly pathogenic H5NI 4 avian Flu reported in 2003. The fear is that the virus may improve transmissibility in humans and therefore represents a serious pandemic in waiting. H5N1 is mainly feraed for its documented ability to pass from birds to humans. It also has the ability to cause severe disease conditions with high mortality (42/55 have reportedly died, and only 13 recovered). It ha the undoubted potential to ignitea pandemic. Available vidence indicates that H5N1 is now endemic in parts of Asia and the risk fis that the virus may expand its range of mammalian hosts. For example the Oct 2004 outbreak in captive tigers and domestic cats in Thailandin which some 147 tigers were affected. H5N1 is also being excreted by asymptomatic ducks in highly pathogenic form maintaining silent transmission. Studies in the outbreak for the first time show H5N1 strain can infect humans directly who serve as the mixing vessel for exchange of virus genes. The first probable case of human to human transmission was reported from in Thailand in December 2004. Migratory Bird Flyways Main issues facing Kenya’s Response system The Kenyan response system is characterised by Weak surveillance system Inadequate support to laboratory Inadequate human resources inadequate research funding Inadequacy of supplies of Anti-viral drugs Vaccines Protective material PANDEMIC PREPAREDNESS Main objectives of the WHO global agenda for FLU are:•To strengthen the WHO Global influenza Surveillance Network •To assess the burden of influenza and benefits of prevention and control •To generate Global and National influenza pandemic preparedness 5 •To develop policies for influenza vaccine and antiviral usage during influenza pandemics and epidemics •To increase influenza vaccine usage and support acceleration of vaccine development WHO urges all countries to develop/update their Influenza pandemic preparedness plans. It is recognised that global spread is impossible to stop but preparedness will undoubtedly reduce impact the final death toll. Planning should include estimates of the nunber of people to be affected and likely deaths. Estimates of deaths are expected to range from 2-50 million based on extrapolations from past pandemics. National preparedness National preparedness for the pandemic is being addressed from the vantage point of this strategic preparedness plan which aims to facilitate mobilisation of resources needed to mount an efficient and effective response. The plan has been developed by an ad hoc multi-sectoral task force which has been set up to respond to the impending threat of the Avian Influenza outbreak. The task force has followed WHO guidelines in developing the National emergency preparedness and response plan The plan focuses on the following issues: 1. Co-ordination, Resource Mobilisation and Human Resource Management 2. Epidemiologial Surveillance 3. Laboratory and Research 4. Case Management 5. Infection Prevention and Control 6. Information, Education, Communication and Social Mobilisation The purpose of this plan is to mobilise resources and crystallise action to facilitate effective surveillance, research, coordination, diagnosis, infection control, case management and information dissemination and hence handling of the problem. Main Assistance needed from the International Community Response activities are coordinated by the multi-sectoral task force through its 6 technical working groups. International community are partners in the National Avian Influenza MultiSectoral Task Force. The main forms of assistance expected from the international community include : Technical assistance and information Mobilisation of resources and funding International liaison & coordination Harmonisation of monitoring and evaluation indicators Strengthen at least one of the existing laboratories to the level of a regional Influenza reference facility ACTION TAKEN OR COMPLETED BY STAKEHOLDERS Various stakeholders from the privare, pubic, civil society and development partner sectors have taken, planned and/or contemplated some activities geared towards addressing the Avian Flu problem among them the following:i) Ministry of Health Multisectoral Taskforce in place, formed during the first avian influenza WHO alert in 2004. Integrated disease surveillance being implemented by the in all districts and will be strengthened for influenza surveillance. 6 ii) MOH in collaboration with KEMRI is currently undertaking the Flu surveillance through a Flu surveillance network of private medical practitioners. This surveillance is limited in Nairobi & will be expanded through additional sentinile sites. Diagnostic laboratory capacity to identify the virus is available in the country at KEMRI. Additional facilities will however be required. An alert issued to all health facilities with instructions to start preparing isolation units should need arise. Treatment: There is currently no vaccine available for H5N1 virus strin. The drug for treatment is Tamiflu but is not available in the country and supply not adequate. Discussed with WHO to assist in availing it to the country Infection Prevention and Control: Protective gear ordered in advance, but there is need to establish requirements for the current response & gaps. Some materials available for normal preparedness. The workload in health facilities is anticipated to be very high. The health facilities should be stocked with all necessities for response. All ports of entry have been alerted. Wild birds would still migrate into the country with or without immigration controls. Winter is approaching in Europe and birds are expected to fly into the country. Importation of poultry and poultry products will be contained through the ports. KEMRI - the personnel is available, but need upgrading of the lab to protect staff. Ministry of Livestock and Fisheries Development Addressed a press conference on 18th October 2005 stating government position. Mobilised all veterinary officials for a technical briefing on Avian Flu and actions required of them. Established a hotline for the public to ask questions on Avian Flu manned by technical staff at Kabete. The Numbers are 020-631639 and 0722-726682 Prepared IEC materials for electronic and print media, for use in public education. Assessed the laboratories at the headquarters and regionally to see whether they meet surveillance requirements with requirements & costs. Assessed the available veterinary expertise and found adequate Assessed required funds and set priorities thus:. 1. Materials for professionals, media & public sensitisation; 2. protective clothing for professionals safety and 3. laboratory reagents that may cost Ksh 1 million A Veterinary preparedness task force of 7 is meeting at Kabete and a vehicle has been made available to it. An AU-IBAR ymposium was held in Sept to inform stakeholders on the threat from Avian flu and adopt a strategy to enable the region to cope. Country delegates were asked for proposals on disease control and review of epidemiology. During the neeting it was reported that: Africa is estimated to have 1.1billion chicken population and 2% may get affected and require to be culled. An animal vaccine produced in China is available at the cost US$ 0.1 per bird. Africa has had previous Avian Flu outbreaks; 8 outbreaks were recorded in South Africa in 2004. Other countries include Egypt and Morocco. University of Nairobi There exists capacity for training at the University of Nairobi Faculty of Veterinary Medicine and laboratory facility that may need some refurbishment and be available to flu surveillance. 7 ILRI ILRI that has global operations is headquartered in Nairobi. ILRI has also set up a taskforce and is currently compiling a synthesis of information from experiences in Asia that will be available for information and knowledge in various websites. On research, ILRI has capacity that could benefit Avian flu surveillance. GIS services could be made available to map out areas where migratory birds land. International Emerging Infections Programme (IEIP) The US Embassy has set up a taskforce to check out what help could be made available. The area of surveillance on humans and birds will be strengthened in early 2006. Some sites will be in Nairobi, Mombassa, Western and Northern regions. Surveillance on migratory birds is expected to start in November. A recommended primary strategy is to avoid contact of migratory birds with flocks of domestic birds. There should also be surveillance on birds deaths, an early warning sign. The importance of strengthening communication cannot afford to be underexpressed. It is essential to know about the work of neighbouring countries. CDC communicating with their counterparts in neighbouring countries .Communication to health care workers on how to suspect suspicious respiratory symptoms. Kenya Red Cross Society (KRCS) KRCS is a grass root organisation with 57 branches and 69,000 volunteers. It has strengths in mobilisation and awareness creation and shall make available this social resource at the disposal of the Avian Flu preparedness taskforce. WHO WHO is closely working with MoH. The DPC stressed that WHO is keen to collaborate with MoH on strengthening surveillance for early detection of cases and the virus. WHO will support in development of surveillance tools for avian influenza. This is a good opportunity for strengthening integrated disease surveillance & response in the country. As we are in the pre-pandemic phase, the influenza pandemic virus is still unknown and main intervention strategy remainsto be rapid virus identification and stoppage of transmission. WHO providing technical guidelines & provision of technical support from the Global alert network On stock pilling of anti–viral drugs, WHO is building strategic stocks, one million doses of Tamiflu by end of 2005 and three million doses by end of March 2006 for use once an outbreak diagnosed Countries with resources can stockpile some, problem being low production. FAO FAO sent apologies through Mr. Langat. The organisation indicated support to the taskforce and requested to be updated with all developments. National Museums of Kenya – Ornithology Dept NMK called for urgent measures to initiate monitoring the distribution of waterbuck & where they at different times. However, resources minimal at the institution to undertake this exercise. The migratory birds flying into the country arrive from September peaking in November. Some flocks from European countries that could have been infected could start arriving in mid November. Sanofi Pasteur The company has been supporting the Influenza Flu network for the last 5 years based on sentinel sites of private medical practitioners. It has been established that Flu epidemic seasons in 8 Kenya are mainly from March to July and again in a less scale in November. Dr. Mwangi underscored the need and urgency to scale up the surveillance network. The company has in stock the inter-pandemic vaccine in the country. 9 CO-ORDINATION AND RESOURCES MOBILISATION VISION An adequately and effectively coordinated emergency preparedness and response to avian influenza and pandemic flu. MISSION To ensure an effective emergency preparedness and response system is in place. OBJECTIVES 1. To set up and strengthen the National Secretariat for Avian Influenza. 2. To oversee and coordinate the activities of the sub-committees of the National Avian Influenza Task Force. 3. To mobilize required resources locally, regionally and internationally. 4. To coordinate international communication and dissemination of vital information and give periodical updates on Avian Influenza in Kenya. 5. To ensure that a country emergency preparedness and response plan is in place and implemented. 6. To monitor and evaluate the implementation of the country preparedness plan. SITUATIONAL ANALYSIS A multi-sectoral Task Force was set up encompassing all the major stakeholders. The membership of this Task force is as follows: 1. Ministry of Health 2. Ministry of Livestock and Fisheries 3. Ministry of Special Programmes- Office of the President. 4. WHO 5. African Union-International Bureau of Animal Resources (IBAR) 6. Ministry of Finance 7. UNDP 8. Centre for Disease Control 9. USAID/Kenya 10. Walter Reed Project 11. Faculty of Veterinary Medicine-UoN 12. Ministry of Tourism and Wildlife 13. Disaster Management Unit-MOH 14. International Livestock Research Institute 15. National Museums of Kenya 16. Sanofi Pasteur 17. KEMRI 18. Centre for Virus research- Flu surveillance Network 19. UoN-Department of Community Health 20. Department of Immigration 21. Kenya Wildlife Services 22. UNICEF 23. Kenya Red-Cross Society The task force has established 6 subcommittees. These are: 1. Epidemiological Surveillance Committee To screen birds and humans to determine whether the disease is present in the country or not. Its activities include the following:10 Carry out targeted surveillance in domestic birds and animals. Carry out targeted surveillance in wild birds (migratory & resident) Strengthen active surveillance. Carry out prompt outbreak reporting and investigations Focus surveillance on high-risk groups. Train health workers on disease surveillance especially Avian Influenza. 2. Information, Education, Communication and Social Mobilization committee It ensures that timely and useful information on avian flu is disseminated to the public and all the stakeholders in health. Currently it is working with districts so as to get the information to grassroots levels. 3. Case Management Committee It has the responsibility of setting up clear guidelines on the treatment of sick people in case the pandemic occurs. It should also strengthen hospitals (especially referral ones) to improve their capacity to meet the challenge. Its greatest task is to procure anti-viral drugs (Tamiflu) in readiness for any outbreak in humans. Bird handlers and health workers are especially at high risk of infection. Its immediate activities include: Purchase of Antiviral drugs (Tamiflu) for at least 2000 people. Purchase of protective clothing for the high risk groups. Purchase non-pharmaceutical commodities (e.g. gloves, cotton wool, needles, syringes) 4. Laboratory and Research Committee It has the responsibility of collecting and testing specimens from birds and humans for avian influenza infection. This will help in diagnosis of the disease and further research. Its immediate activities include the following: Upgrade KEMRI human influenza laboratory and Central Veterinary Laboratories to BL3 level. Buy reagents for both laboratories. 5. Infection Prevention and Control Committee Its responsibility is to prevent entry of the virus into the country and respond appropriately should entry occur. The immediate activities include the following: Establish quarantine facilities for birds and humans at the ports of entry. Procurement of protective gear (for both health workers at institutions & veterinary workers) Purchase of disinfectant for use in contaminated areas. Culling of birds once infection is detected to prevent spread. Work with the office of the Attorney General on the review of laws on compensation after the culling of birds. Purchase of the seasonal flu vaccine. Control of movement of poultry 6. Co-ordination and Resource Mobilization Committee It coordinates all the other committees. It also has the responsibility of mobilizing resources (Both financial and human). It also supports the secretariat of the task force. Its immediate activities include the following:- 11 Establish logistics for proper communication of the task force- purchase stationery, computers, printers, scanners e.t.c and cater for the upkeep of the secretariat. Coordinate transport for the task force- procure 2 vehicles especially for disease surveillance, fuel and drivers’ upkeep. A secretariat of the National task force is in place. Both the ministry of health and the ministry of livestock and fisheries development have teams in place dealing with the specific coordination of AI activities in their respective departments. These ministries also have technical capacity to handle Avian Influenza activities. However this technical capacity needs strengthening. There is infrastructure in place. This includes hospitals, labs, research institutes, abattoirs, and institutions of higher learning. These are spread out between the govt and the private sector, including regional and international institutions. Currently the on going activities include surveillance in both birds and humans, laboratory diagnosis, enforcement of bans on importation of poultry and its products from affected countries, and awareness creation. The available financial resources are inadequate. The on going activities have so far been funded by through the recurrent govt allocations from parent ministries and departments. The existing legal framework includes the Public Health Act and the Animal Diseases Act. They need to be reviewed to cater for: Notification of HPAI Compensation issues during the culling of birds in case of an outbreak. This will put the put the legal framework in line with the provisions of the international regulations. Communication networks exist for the Secretariat that is currently housed in the Ministry of Health. These include telephone, fax and e-mail services. These facilities are inadequate due to competing tasks with other ministry departments. The services are not networked with the districts hence the channelling of surveillance data and general communication with the field is not efficient. Institutional vehicles are currently being used for transport. Most of the time the vehicles are in use by the respective departments thus not readily available. Some of them are old and unreliable. Therefore two 4WD vehicles are needed specifically for the AI secretariat to be used for monitoring and evaluation of the sub-committee activities. There is political goodwill from the government. The office of the president-special programmes is a member of the multi-sectoral task force. It has been very supportive in the generation of an emergency preparedness plan. JUSTIFICATION Communication For effective coordination of the activities on avian influenza, this team needs to hold weekly meetings, to communicate with other stakeholders locally and internationally. .Stationery to generate minutes and reports, computers and their accessories for the generation and storage of data are required. Airtime and telephone services are needed due to the constant communication with the sub-committees. 12 The Task Force has diverse membership. It has been meeting weekly with most of these meetings taking most of the day. The Secretariat will be expected to work daily from Monday to Friday. These teams need allowances to cater for their upkeep including transport costs. Transport The task force has no specific vehicles for its work. Currently it has been relying on vehicles from govt departments. These vehicles are inadequate due to competing tasks. Some of them are very old and unreliable. The team therefore needs at least two 4WD vehicles for its work. Human Resources Mobilization The staff two ministries require to respond to outbreaks of avian flu is a lot more than those in place. The ministries will need to involve the private sector who will have to be paid. The budget for this has been included. Monitoring and Evaluation The subcommittee will be monitoring all the activities of the other subcommittees to ensure that they are on schedule and are carrying out activities as per the set budgetary limits. Preparation of Sessional Papers and Legal Review A policy on the modalities of how all the stakeholders will work together should be put in place to ensure effective and efficient running of the programme. Issues of compensation and prosecution charges in the present Acts (Animal diseases Act and Public health Act) are very outdated. These Acts have to be reviewed so as to address the relevant legal issues. The process of preparing the sessional paper and review the Acts will require holding several retreats where stakeholders will be represented. 13 COORDINATION AND RESOURCE MOBILISATION WORKPLANS 1 2 Activity Sub-activity Convening of National Task Force meetings Purchase of stationery Facilitation of the coordination & resource mobilisation subcommittee 3 Monitoring and Evaluation 4 Preparation of sessional paper Responsibility (Who?) DMS DVS By When Purchase of airtime Telephone expenses DMS DVS Mid-Dec DMS DVS Mid Dec Internet services DMS DVS Mid-Dec Purchase of computers and accessories DMS DVS Mid-Dec Secretariat allowances Entertainment allowances Purchase of 2 4WD vehicles Fuel for vehicles DMS DVS Mid-Dec DMS DVS Mid-Dec DMS DVS DMS DVS March 2006 Mid-Dec Vehicle maintenance Supervision DMS DVS Mid-Dec DMS DVS On- going Hold planning retreats DMS DVS Jun 2006 Mid-Dec Expected output Stationery purchased Airtime purchased Official telephone calls made Official internet communicati on made Computers and accessories purchased Allowances paid Allowances paid Vehicles purchased Fuel procured Vehicles serviced Supervision of subcommittees done Sessional paper on coordination of Avian Influenza in place Indicator Verification Assumptions Amount of stationery purchased Value of airtime cards purchased Value of calls made Recipts/LPOs Funds will be available by Mid Dec 2005 Receipts Funds will be available by Mid Dec 2005 Telephone bills/Records Funds will be available by Mid Dec 2005 Amount of communication done Internet bills Funds will be available by Mid Dec 2005 No. of computers and accessories purchased Receipts/LPOs Funds will be available by Mid Dec 2005 No. of members paid No of members paid No. of 4WD vehicles purchased Amount of fuel procured No. of service sessions No. of supervisory visits Records Funds will be available by Mid Dec 2005 Records Funds will be available by Mid Dec 2005 Log books/records Funds will be available by March 2006 Fuel ledgers/records Log books/Records Funds will be available by Mid Dec 2005 Records Extra funds will be available by Mid Dec 2005 No. of retreats undertaken Sessional paper 14 Funds will be available by Mid Dec 2005 5 6 Activity Sub-activity Review of legal statutes Collaboration and liasing with international communities Hold planning workshops Attendance of international and regional meetings and conferences Responsibility (Who?) DMS DVS By When DMS 0-5 years DVS Jun 2005 Expected output Amended Acts in place Good international collaboration Indicator Verification No. of workshops undertaken No. of meetings and conferences attended Amended Acts Assumptions Meetings and conference proceedings BUDGET REQUIREMENTS 1 Activity Convening of National Task Force meetings Sub-activity Purchase of Stationery Provision of phone services Details As in annex Prepaid Airtime for sub-committee members Post-paid Airtime for DMS and DVS Prepaid Calling Cards (Telecom) Provision of Internet Services Connection to DMS Connection to DVS 2 Facilitation of the coordination & resource mobilisation Procurement of ICT Equipment and accessories Allowances As in annex Allowances for Secretariat members Quantity See Annex 25 25 25 2 2 2 25 25 25 1 1 1 1 1 1 See Annex Cost (KShs) See Annex 5,000 5,000 5,000 7,500 7,500 7,500 5,000 5,000 5,000 30,000 30,000 30,000 30,000 30,000 30,000 590,000 Immediate Budget KShs 768,080 750,000 25 25 25 2,500 2,500 2,500 5,625,000 15 Medium Term Budget KShs 2,038,400 Long Term Budget KShs 4,527,975 2,250,000 4,500,000 90,000 270,000 540,000 125,000 2,250,000 4,500,000 180,000 540,000 1,080,000 180,000 540,000 1,440,000 360,000 1,080,000 100,000 16,875,000 33,750,000 Action by DMS DVS Activity subcommittee Sub-activity Office entertainment Lunch allowance Vehicles Other sub-committees Fuel for vehicles Maintenance 3 4 5 6 Human Resource Mobilisation Implementation and Monitoring Preparation of sessional paper Review of legal statutes 7 Collaboration and liasing with international communities TOTAL Hiring of staff Supervision of Subcommittees Hold planning retreats Hold planning workshops Attendance of international and regional meetings and conferences Details Allowances for drivers Beverages Allowance for Secretariat members 4WD Double cabin Petrol for two vehicles Servicing of motor vehicles. One service monthly for two vehicles Cost (KShs) Quantity 2 2 2 500 500 500 assorted 10 10 10 2 500 500 500 2,500,000 30 30 30 12 18 78 80 85 5,000 5,000 36 7,500 1,200 25,000 Supervisory visits to the field for 3 teams 3 104,000 Five retreats 5 Three retreats A total of eleven meetings Immediate Budget KShs 120,000 Medium Term Budget KShs Long Term Budget KShs 360,000 120,000 450,000 360,000 720,000 720,000 1,350,000 2,700,000 5,000,000 561,600 1,728,000 3,672,000 60,000 90,000 270,000 540,000,000 1,080,000,000 624,000 1,572,000 4,192,000 649,700 649,700 2,598,800 3 649,700 649,700 1,949,100 1 300,000 600,000 12,993,080 2,400,000 582,531,300 16 Action by 3,600,000 1,145,951,975 1,741,476,355 EPIDEMIOLOGY AND SURVEILLANCE EMERGENCY PREPAREDNESS PLAN STATEMENT OF FUNCTION, PURPOSE AND MANDATE It has long been known that wild birds represent a resoervor of avian influenza virus worldwide. This is a concern because many of these birds are migratory and travel long distances across international borders. Currently there is pandemic of the avian flu in the palearctic region and some of the bird species that are reservoir for this virus are migrating into Kenya. The arrival of these birds started in september this year and is expected to peak in December. Return journey starts from March to April next year. Although HPAI has not been diagnosed in Kenya either in wild birds or domestic birds, there is a great risk of the virus being introduced into the country particularly because of its ability to survive in envirronment for long periods especially in ponds, waterways and cool damp areas. These are the same areas where our domestic birds go for watering. There is therefore a critical and urgent need to detect the virus in the wildbirds and domestic birds basically to answer the question as to whether or not we have HPAI in Kenya. SITUATION ANALYSIS Of the approximatelly 25 million poultry in Kenya, 81% are indiginieous birds which are reared under back yard production. These are the birds that at risk since they roam freely and can easily come in contact with wild bids or their secretions. Retrospective surveys of avian diseases diagnosed at Central Veterinary Laboratory, Kabete between 1935 and 2004 mention no avian influenza in the Kenyan poultry. However, no active for avian influenza has been carried out so far. In spite of that, Kenya has regarded avian influenza as a high risk disease and in fact declared it to be a notifiable disease through a gazette notice in 1996. Subsequent to the reported outbreaks in South East Asia, Kenya imposed a ban, through another legal notice in 1998, on importation of poultry or poultry products from Asia and any other country reporting HPAI. STATEMENT OF STRATEGY Kenya is on the migratory route of wild birds. It is therefore necessary to establish mechanisms and systems to detect cases of HPAI in domestic and wild birds, as well as other domestic animals such as pigs and also in humans. Adequate resources need to be set aside to reduce close contacts between humans and domestic poultry, and wild birds through scientific approaches. This makes it necessary to carry out surveillance in domestic birds, wild migratory birds and humans. VISION To be the leading African country in HPAI infection detection and early response. MISION To have a functional and efficient epidemiosurveillance system for HPAI. GOALS AND OBJECTIVES Goal To detect promptly outbreak of H5N1 in migratory, domestic and wild birds and humans and provide information on H5N1 pandemic. Objective To strengthen the existing surveillance structures To ensure that all the reported case are thoroughly investigated 17 Train human and animal health workers on disease surveillance and response with special focus on HPAI Collect, analyze interpret data and disseminate the information for appropriate action SWOT ANALYSIS Strengths An Epidemiosurveillance system (ESS) is in place for humans, domestic and wild birds Linkages with other organization in place For humans, there is an operational IDSR system in place and an available HMIS Trained technical staff in the fields Weakness Health workers poorly understand Avian flu Logistical support not adequate Inadequate resources Opportunities Global interest in the HPAI The threat of the pandemic Threat Sustainability Insecurity in the field Mutating nature of the virus involved PROGRAMME DEVELOPMENT TERMS OF REFERENCE In the light of the background information on HPAI given, the members developed the following TORs: 1. Define practical approaches to determine whether HPAI (H5N1) is present in the country or not. 2. Define steps that are needed for early and rapid detection of HPAI in birds and other animals 3. Create a plan of action for surveillance of HPAI (H5N1) in humans 4. Determine means for early and rapid detection of person to person HPAI (H5N1) transmission 5. Develop mechanisms for data storage and analysis and rapid communication of information with other national sub-committees on HPAI 6. Develop mechanisms for coordination and harmonisation of activities related to foregoing TOR. 1. Define practical approaches to determine whether HPAI (H5N1) is in the country Domestic Birds Carry out targeted surveillance Map high-risk areas based on agreed criteria Carry out targeted surveillance in identified high-risk areas o Clinical on species exhibiting signs (chicken) o Serological and viral for all species Carry out random surveys- appropriate accuracy 18 Develop sampling frame, else opt for random coordinates o Clinical on species exhibiting signs (chicken) o Serological and viral for all species Wild birds Carry out targeted surveillance Migratory – focus on water birds (ducks and geese) Resident birds- focus on water birds: before and after migration 2. Define steps that are needed to identify HPAI in birds and other animals Domestic Birds Carry out passive surveillance in individual flocks, bird markets, borders Case definition: Increased mortality, reduced feed and water consumption, presence of signs of respiratory disease or a drop in egg production Awareness creation among AHSPs, poultry keepers & breeders, traders, butchers, slaughter-house operators and the general public Maintenance of rumour registers + verification of reports Prompt reporting (telephone, email, SMS, VHF radio) of suspicious cases with follow-up investigations leading to a logical conclusion (In the absence of suspicious cases, zero report and at what frequency?) Wild Birds Carry out passive surveillance in individual flocks, bird markets, borders Tentative case definition: Increased mortality Determine HPAI status in wild migratory birds Create awareness among rural population, hunters, rangers, and general public Prompt reporting 3. Surveillance of HPAI (H5N1) in humans Case definition: Focus on ports of entry and persons/ institutions in high-risk areas identified for passive and targeted surveillance in birds Continuously educate health workers about HPAI Provide health workers with fact sheets about HPAI 4. Determine means for early and rapid detection of person to person HPAI (H5N1) transmission Follow up all in-contacts with index cases Persons once infected should be isolated Scale-up the integrated disease surveillance and control to include influenza 5. Develop mechanisms for data storage and analysis and rapid communication of information with other national sub-committees on HPAI Share information with other national HPAI sub-committees 6. Develop mechanisms for coordination and harmonisation of activities related to foregoing TOR DVS to coordinate activities related to foregoing TORs 19 EPIDEMIOLOGY AND SURVEILLANCE (DOMESTIC BIRDS) WORK PLAN No Activity Sub-activity Action By DVS By when Dec-Jan Mar-Apr Expected output Indicators 1 Carry out targeted surveillance in domestic poultry and other domestic animals. To clinically inspect up to 400 poultry flocks/ markets and collect sera and virological material from up to 10,800 poultry, plus sera from up to 3600 pigs per field mission DSA for field mission- 14 teams each composed of 2 vets, 1 technician, and 1 driver- 19 days inclusive if travel Number of –ve & +ve cases of HPAI diagnosed 10,800 poultry samples and 3,600 pig samples collected and analysed Vehicle servicing, maintenance, fuel and lubricants for 14 vehicles DVS Dec-Jan Serviceable vehicle Operational vehicle Tires and batteries DVS Jun 2006 Tires and batteries No. purchased Field sampling kit for 14 teams DVS Dec 2005 Sampling kits No. Purchased Briefing & debriefing of 14 teams (DSA, transport refunds, stationery) DVS Dec 2005 Officers briefed/trained Short-term training (local) DVS Dec 2006 Trained officers Imprest warrant forms; work tickets; bus fare tickets; reords of the meeting Efficiency in carrying out duties Short-term training (external) DVS Dec 2006 Trained officers Purchase of motorized cool boxes for field work DVS Motorised boxes Purchase of portable computers DVS Dec 2005 and Dec 2007 Jun 2006 Assumptions Log book entries Payments for services Stores records S3 cards and S11 Stores records S3 cards and S11 Report generated Adequate and timely release of funds HPAI Continues to be a threat Cert of attendance MTC minutes Cert of attendance MTC minutes Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat No. purchased Stores ledger S3 cards and S11 Adequate and timely release of funds HPAI Continues to be a threat No. purchased Stores ledger S3 cards and Adequate and timely release of funds Efficiency in carrying out duties cool Portable computers 20 Means of Verification Reports Field visits made Adequate & timely funding from GoK and partners Cooperation from poultry and domestic animal owners Functional laboratory facilities HPAI Continues to be a threat Adequate and timely release of funds. HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat No 2 3 Activity Carry out random surveys in poultry and other domestic animals. To clinically inspect at least 600 poultry flocks/ markets and collect sera and virological material from at least 20,000 poultry, plus sera from at least 5,000 pigs per field mission To Strengthen passive surveillance in both poultry and wild birds. Sub-activity Action By By when Expected output Indicators Means of Verification S11 Assumptions Stores ledger S3 cards and S11 Stores ledger S3 cards and S11 Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat HPAI Continues to be a threat Purchase of GPS DVS Dec 2007 GPS No. purchased Purchase of 4 WD vehicles DVS 4 WD vehicles No. purchased DSA for field mission- 20 teams each composed of 2 vets, I technician, and I driver- 25 days inclusive if travel DVS Dec 2006 and Dec 2007 Jun 2006 each year Number of –ve & +ve cases of HPAI diagnosed 20,000 poultry samples and 5,000 pig samples collected Reports Rumour registors Adequate & timely funding from GoK and partners Cooperation from poultry and domestic animal owners Functional laboratory facilities HPAI Continues to be a threat Vehicle servicing, maintenance, fuel and lubricants for 20 vehicles DVS Dec-Jan Serviceable vehicle Operational vehicle Adequate and timely release of funds HPAI Continues to be a threat Field sampling kit for 20 teams DVS Sampling kits No. Purchased Briefing & debriefing of 14 teams (DSA, transport refunds, stationery) DVS Dec 2005 and Jun 2007 Dec 2005 Log book entries Payments for services Stores records S3 cards and S11 Officers briefed/trained Report generated Adequate and timely release of funds HPAI Continues to be a threat Lunches and DSA for district and provincial offices respectively while carrying out market inspection. 115 districts/provinces Vehicle servicing, maintenance, fuel and lubricants for 20 vehicles DVS Jul 2006 Number of –ve & +ve cases of HPAI diagnosed Imprest warrant forms; work tickets; bus fare tickets; reords of the meeting 20,000 poultry samples and 5,000 pig samples collected and analysed Reports Field visits made DVS Dec-Jan Serviceable vehicle Operational vehicle Log book entries Payments for services Adequate & timely funding from GoK and partners Cooperation from poultry and domestic animal owners Functional laboratory facilities HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat 21 Adequate and timely release of funds HPAI Continues to be a threat No Activity Sub-activity 4 Carry out prompt disease reporting and investigation Running costs for toll free number 5 Develop and run database for avian influenza for DVS Action By DVS By when Dec 2005 Expected output Indicators Toll-free number The number exists and operational Field investigations - DSA DVS Dec 2005 Number of –ve & +ve cases of HPAI diagnosed Field investigations— vehicle maintenance, servicing, fuels & lubricants Purchase of field sampling kits for 20 districts DVS Dec 2005 Serviceable vehicle 20,000 poultry samples and 5,000 pig samples collected and analysed Operational vehicle DVS Sampling kits No. Purchased Purchase server DVS Dec 2005 and Jun 2007 Jul 2006 Server No. purchased Purchase PCs (with printer and UPS) for high risk districts and provinces Purchase/develop software DVS Jul 2006 and Dec 2007 Computers No. purchased DVS Jul 2006 Software No. purchased or developed Collate and analyze avian influenza data, including GIS mapping – 5 personnel DVS Dec 2006 Collated analysed data and Share and disseminate information (email and internet running costs)DVS Hold national workshops on topical subjects related to epidemio-surveillance DVS Dec 2006 e-mails downloaded information and DVS Jan 2006 Harmonised and updated information on HPAI 22 Raw data to be collated and analysed in form of questionnaires and checklists ISP charges; Telephone charges No. of workshops Means of Verification Bills; list of calls made Reports Field visits made Assumptions Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat Log book entries Payments for services Stores records S3 cards and S11 Adequate and timely release of funds HPAI Continues to be a threat Stores ledger S3 cards and S11 Stores ledger S3 cards and S11 Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat Stores ledger S3 cards and S11 Reports Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat Copies of emails and disseminated information Workshop proceedings reports Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat Adequate and timely release of funds HPAI Continues to be a threat EPIDEMIOLOGY AND SURVEILLANCE (HUMANS) WORK PLAN Activity Sub Activity Surveillance Active surveillance on avian influenza and monitor pneumonia trends in hospitals Responsibility (Who?) National, Provincial and Districts surveillance teams Time frame (By when?) Dec 2005 – May 2006 Expected outputs Means of Verifications Surveillance Reports Assumption No. of Surveillance reports from teams Surveillance Reports Availability of funds. HPAI remains a threat Surveillance data tools printed and distribute No. of disease surveillance tools printed and distributed Distribution report Availability of funds. Jan 2008 Dec 2005 – Dec 2010 Sentinel sites established No. of functional sentinel sites Availability of funds. Functional emergency response teams in place Number of cases investigated Influenza laboratory data from the sentinel sites Surveillance reports Early detection suspected cases Indicators of Pneumonia trends monitored in hospitals Early detection of suspected cases No. of Surveillance reports from teams Availability of funds. HPAI remains a threat Surveillance Focused surveillance in 20 high risk districts based on migratory birds pattern National, Provincial and Districts surveillance teams 2006 Dec 2005 – May Strengthening data collection and reporting Develop, print & disseminate Surveillance data tools DOMU Jan 2006 Sentinel surveillance Scale up Sentinel surveillance in 10 identified hospitals KEMRI Targeted surveillance Targeted surveillance in 8 ports of entry – Emergency response teams Carry out targeted surveillance for poultry and poultry products -Food quality control Train Health Workers on Integrated disease surveillance with special focus on Avian Influenza Data management and dissemination DOMU Dec 2010 Chief Public Health officer Dec Dec2010 2005- Poultry and poultry products surveillance carried out Number of poultry and poultry products inspected Inspection reports Availability of funds DOMU Dec-2005 2006 May Strengthened district capacity in IDSR and avian influenza Training reports Availability of funds DOMU Dec- 2005 May 2006 Computers and accessories procured and distributed No.0f DHMTs trained, No of facilities H/workers trained No. of computers and accessories procured and distributed Distribution schedule Availability of funds Surveillance on poultry and poultry products Training Data management Jan 2007 2005-Dec 23 Availability of funds. HPAI remains a threat Data management Strengthen logistical support for surveillance Strengthen logistical support for surveillance Strengthening Communication capacity Coordinate and harmonize all sub-committee activities Develop and install a data base for HPAI & human influenza at National, provincial and district levels Transport operations and maintenance DOMU Dec20052006 May IDSR soft ware installed and functional DOMU PHMTs DHMTs Permanent Secretary Health Dec Dec2010 2005- Vehicles serviced and used for surveillance activities Dec 2005 –May 2006 Vehicles procured distributed Communication costs at all levels DOMU PDSCs DDSCs Dec 2005 –Dec 2010 Effective and Efficient reporting of cases Entertainments DOMU Dec 2005 –Dec 2010 Subcommittees done Strengthen disease surveillance in all level and meetings No. of programmes, provinces and districts with IDSR data base Inspection reports Availability of funds Availability of funds No. of vehicles procured and distributed No. of reports received through Fax, emails and SMS No. of Sub committees meetings held Procurement reports Availability of funds Availability of funds Sub committees minutes Availability of funds EPIDEMIOLOGY AND SURVEILLANCE (WILD BIRDS) WORK PLAN Activity Sub-activity By Who By when time frame Expected output Indicators Immediate targeted surveillance Carry out targeted surveillance focusing mainly on migratory bird species in the 7 critical zones NMK-Ornithology Dept. Dec.2005 to May 2006 Specimens samples for HPAI screening At least 4000 birds specimens from all the seven critical zones KWS-Vet.+ Research Depts. MOV Assumptions Lab reports Funds available Data base HPAI threats persists Specimens Funds available Build Capacity Developing the existing human Train bird ringers/trapper on methodologies of collecting the specimens Train ornithological tour guides to collect NMK-Ornithology Dept. KWS-Vet.+ Research Depts. NMK-Ornithology Dept. 3rd quarter of year one Trained ringers/trappers for 3 zones At least 20 ringers/trappers trained Progress report At least 20 ringers/trapper trained Workshop report three Trained ringers/trappers for 4 zones in 23rd quarter of first year Trained ornithological tour At least one key ornithological tour Workshop report HPAI reporting 1st quarter of year 24 HPAI threats persists Training manuals Ornithological tour companies provide Activity Sub-activity capacity and convey information related to HPAI to NMKOrnithology Dept. and KWS-Vet. + Research Depts. for quick response Carry out surveillance in the seven zones targeting mainly the resident bird Carry out targeted surveillance By Who By when time frame KWS-Vet.+ Research Depts. NMK-Ornithology Dept. May-September 1st to 5th year KWS-Vet.+ Research Depts. Expected output Indicators MOV Assumptions guides able to provide accurate information on HPAI in wild birds within operational circuits guide in each of the seven key zones trained guideline manual for Tour guides key persons for training Resident birds’ specimen collected from all the seven critical zones At least 800 resident bird specimens collected in each of the seven HPAI critical zones Workshop report Annual report Carry out targeted surveillance Review and harmonize the methods used to collect specimens Create information exchange and databases wild bird surveillances Carry out surveillance in the seven HPAI critical zones targeting mainly the migratory water bird Theoretical and practical orientation of the wild birds surveillance team to reviewed methods Establish databases for information on the ringed sampled birds and internet with web page for exchange of such information Carry out passive surveillance NMK-Ornithology Dept.KWS-Vet.+ Research Depts. NMK-Ornithology Dept.-. KWS-Vet.+ Research Depts. NMK-Ornithology Dept. KWS-Vet.+ Research Depts. NMK-Ornithology Dept.KWS-Vet.+ Research Depts. September –April 1st to 5th year Migratory birds’ specimen collected from all the seven critical zones 3rd quarter of year one 1st quarter of year three Wildlife surveillance team members trained on the reviewed methods At least 1000 migratory bird specimens collected in each of the seven HPAI critical zones At least one workshop held At least one workshop held 3rd quarter of year one Database and internet web page functioning at NMKOrnithology Dept. and KWS-Vet.+ Research Depts. Two Computers with sampled birds information databases and internet web pages functioning Information on HPAI status in all parts of the country for rapid response Quarterly Passive surveillance reports from all the seven critical HPAI Zones plus the rest of the country Lab reports Data base Water birds will be available in the all the zones Specimens Lab reports Data base Specimens Workshop report Migratory Water birds will be available and equally dispersed in the all the zones Funds will be available Training manual Receipts Funds are available Equipment themselves HPAI and other wild bird diseases threat persists Funds are available 2nd quarter Of first year continuous to year five Ornithological tour guides 25 Quarterly reports Rumor reports HPAI and other wild bird diseases threat persists EPIDEMIOLOGY AND SURVEILLANCE BUDGET SUMMARY Activity Sub-activity Carry out targeted surveillance in domestic poultry and other domestic animals. To clinically inspect up to 400 poultry flocks/ markets and collect sera and virological material from up to 10,800 poultry, plus sera from up to 3600 pigs per field mission DSA for field mission- 14 teams each composed of 2 vets, 1 technician, and 1 driver- 19 days inclusive if travel Vehicle servicing, maintenance, fuel and lubricants for 14 vehicles Tyres and batteries Field sampling kit for 14 teams Briefing & debriefing of 14 teams (DSA, transport refunds, stationery) Short-term training (10 personnel) Immediate Medium Term Long Term 2,500,000 10,000,000 15,000,000 616,000 1,848,000 3,696,000 1,148,000 2,296,000 916,700 2,750,100 5,500,200 1,000,000 3,000,000 6,000,000 2,500,000 5,000,000 5,000,000 10,000,000 Short-term training (5 personnel) Purchase of motorized cool boxes for field work 4,000,000 Purchase of portable computers 2,000,000 2,000,000 Purchase of GPS Carry out random surveys in poultry and other domestic animals. To clinically inspect at least 600 poultry flocks/ markets and collect sera and virological material from at least 20,000 poultry, plus sera from at least 5,000 pigs per field mission 2,000,000 Purchase of 4 WD vehicles 25,000,000 12,500,000 DSA for field mission- 20 teams each composed of 2 vets, I technician, and I driver- 25 days inclusive if travel Vehicle servicing, maintenance, fuel and lubricants for 20 vehicles at KShs 55/km Field sampling kit for 20 teams 15,000,000 75,000,000 6,050,000 12,110,000 2,620,000 3,930,000 2,000,000 5,000,000 Briefing and debriefing of teams (DSA, transport refunds, stationery) Purchase of palm tops Targeted surveillance of migratory and resident birds Surveillance during the months of Palearctic migration total of 105 days Surveillance during the months of Palearctic migration total of 384 days (24days/month for 16 months) 26 200,000 3,045,000 11,136,000 Activity To Strengthen passive surveillance in both poultry and wild birds. Carry out prompt disease reporting and investigation Sub-activity Immediate Surveillance during no Palearctic migration period total of 96 days (12 days per month for 8 months) Surveillance during no (144 days) and when there is (576 days) palearctic migration total 720 days) in three years Lunches and DSA for district and provincial offices respectively while carrying out market inspection. 115 districts/provinces Vehicle servicing, maintenances, fuel and lubricants 115 districts and provinces at ksh 55/km Running costs for toll - free number at Ksh 60,000 per month Medium Term Long Term 2,784,000 20,880,000 36,000,000 90,000,000 6,050,000 69,575,000 34,500,000 360,000 1,440,000 3,600,000 Field investigations - DSA at 80,000 per month 480,000 1,920,000 4,800,000 Field investigations - vehicle maintenance, servicing, fuels & lubricants at KShs 55/km Purchase of field sampling kits for 20 districts 300,000 900,000 2,700,00 1,310,000 3,930,000 7,860,000 750,000 750,000 Purchase server Active surveillance on avian influenza and monitor pneumonia trends in hospitals Focused surveillance in 20 high risk districts based on migratory birds pattern Strengthening data collection and reporting Support the National, province and district for surveillance activities Rapid response teams by the national, provincial and district 3,800,000 30,000,000 60,000,000 3,000,000 9,000,000 18,000,000 Develop, print & disseminate Surveillance data tools 1,500,000 4,500,000 9,000,000 Sentinel surveillance Scale up Sentinel surveillance in 10 identified hospitals. Nyeri PGH, Eldoret Moi refferal, KNH, Mbagathi, Kisumu, Coast PGH, Rift Valley PGH, Embu PGH, Garissa PGH and Machakos. Targeted surveillance in 8 ports of entry – Emergency response teams Carry out targeted surveillance for poultry and poultry products -Food quality control. Public health inspections and food sampling in 8 ports of entry , 20 high risk districts and 2 for central level (30 sites) Train Health Workers on Integrated disease surveillance with special focus on Avian Influenza Strengthen data collection, reporting, analysis and dissemination 2,522,000 9,000,000 25,280,000 2,480,000 5,940,000 11,880,000 4,480,000 10,170,000 20,340,000 5,000,000 25,000,000 2,000,000 3,000,000 2,500,000 Targeted surveillance Training of Health workers Data management 27 Activity Sub-activity Strengthen logistical support for surveillance Develop and install a data base for HPAI & human influenza at National, provincial and district levels Transport operations and maintenance Strengthen logistical support for surveillance Purchase 85 surveillance double cabin vehicles Strengthening Communication capacity Communication costs at all levels Develop and run database for avian influenza for DVS Purchase PCs (with printer and UPS) for high risk districts and provinces Purchase/ develop software Coordination and secretariat Sampling Kit Capacity building Collate and analyze avian influenza data, including GIS mapping – 5 personnel Share and disseminate information (email and internet running costs)- DVS Hold national workshops on topical subjects related to epidemio-surveillance Purchase of sampling Kit Immediate Medium Term Long Term 1,500,000 1,800,000 1,800,000 5,610,000 16,830,000 33,660,000 12,500,000 200,000,000 2,232,000 4,464,000 5,600,000 2,000,000 744,000 1,000,000 375,000 1,125,000 2,250,000 180,000 540,000 1,080,000 360,000 1,080,000 2,160,000 1,959,000 5,887,000 11,754,000 3,130,000 4,560,000 735,480 2,206,440 4,412,880 53,590 160,770 321,540 Communication Training of human resource on sampling protocols all over the country Telephone and administration Stationery Purchase of various stationery Transport Purchase of vehicles 3,504,045 Passive Surveillance Transportation to, within and from the field using two land rovers boats Carry out passive surveillance Equipment Purchase of various equipment 1,762,000 8,773,000 58,380,815 308,373,310 5,000,000 TOTALS 28 14,016,180 35,040,450 1,520,000 1,520,000 581,220,620 LABORATORY AND RESEARCH INTRODUCTION Avian influenza is an infectious disease caused by avian influenza viruses. It is highly contagious among birds and has the potential to cause high mortality. It does not usually infect humans. However, some 122 people have so far been reported to have been infected by H5N1 subtype with a 50% mortality rate. Pandemics may be induced when influenza viruses from birds, humans and pigs grow together. The H5N1 subtype currently infecting chickens in the Far East has directly infected humans from birds thus sending danger signals for a global pandemic should it develop capacity for human to human transmission. There is therefore an urgent need for Kenya, like all other countries worldwide, to develop preparedness plans covering birds, humans and other at risk animals which should incorporate research to improve understanding of avian influenza, as well as plans to enhance capacity for laboratory diagnosis of the disease. Laboratory Diagnosis of Influenza Viruses Infection During epidemics, a presumptive diagnosis can be made on the basis of the clinical symptoms. However, influenza A and B can co-circulate, and mixed infections of influenza and other viruses have been reported. Isolated cases of suspected influenza should be investigated for these may represent the first cases of an impending epidemic. Virus Isolation - Throat swabs, NPA and nasal washings may be used for virus isolation. It is reported that nasal washings are the best specimens for virus isolation. The specimen may be inoculated in embryonated eggs or tissue culture. 10-12 day embryonated eggs are used for virus isolation. The specimen is inoculated into the amniotic cavity. The virus replicates in the cells of the amniotic membrane and large quantities are released back into the amniotic fluid. After 2-3 days incubation, virus in the amniotic fluid can be detected by adding aliquots of harvested amniotic fluid to chick, guinea pig, or human erythrocytes. Pathological specimens can be inoculated on to tissue cultures of kidney, chicks or a variety of other species. Rhesus monkey cells are the most sensitive. Although no CPE is produced, newly produced virus can be recognized by haemadsorption using the cells in the tissue culture, and haemagglutination using the culture medium which contains free virus particles. Influenza B virus and occasionally influenza A will produce a CPE in MDCK cells. Influenza viruses isolated from embryonated eggs or tissue culture can be identified by serological or molecular methods. Influenza viruses can be recognized as A, B, or C types by the use of complement fixation tests against the soluble antigen. (A soluble antigen is found for all influenza A, B or C type virus but antibody against one type does not cross react with the soluble antigen of the other. The further classification of influenza isolates into subtypes and strains is a highly specialized responsibility of the WHO reference laboratories. The HA type is identified by HAI tests, the NA type is also identified. Rapid Diagnosis by Immuno-fluorescence - cells from pathological specimens may be examined for the presence of influenza A and B antigens by indirect immuno-fluorescence. Although many workers are convinced of the value of this technique, others have been disappointed with the specificity of the antisera and the level of background fluorescence that makes the test difficult to interpret. EIA tests for the detection of influenza A viral antigens are available that are easier to interpret than immuno-fluorescence. PCR assays for the detection of influenza RNA have also been developed but there usefulness in a clinical setting is highly questionable. Serology - Virus cannot be isolated from all cases of suspected infection. More commonly, the diagnosis is made retrospectively by the demonstration of a rise in serum antibody to the 29 infecting virus. CFT is the most common method used using the type specific soluble antigen. However, the CF test is thought to have a low specificity. A more specific test is the HAI test. Infection by influenza viruses results in a rise in serum antibody titre, but the requirement for a 4fold or greater rise in titre of HI of CF antibody reflects the inaccuracy of these tests for detecting smaller increases in antibody. A more precise method for measuring antibody is by SRH. SRH is more sensitive than CF or HAI tests and has a greater degree of precision. A 50% increase in zone area represents a rise in antibody and is evidence of recent infection. Sera do not have to be pretreated to remove non-specific inhibitors which plaque the HAI test. SRH may well replace CF and HAI tests in diagnostic laboratory in future. VISION Kenya attains best practice status in the establishment and operation of centers of excellence for research, detection and diagnosis for Highly Pathogenic Avian Influenza (HPAI). MISSION To provide timely, accurate and reproducible research, detection and diagnosis systems and mechanisms for HPAI in a safe environment. GOALS Build capacity to carry out safe HPAI screening for all suspect cases of avian, human and other animal sources. The HPA1 status of the KEMRI, CVL, UON labs are authenticated to conform to BL3 status to ensure that HPAI is safely handled To promote research to improve understanding of the disease OBJECTIVES To develop pertinent research to further understand and control avian influenza in Kenya To develop sensitive and specific molecular diagnostic techniques for diagnosis AI To provide adequate bio-safety mechanisms for laboratory and field workers To demonstrate circulating strain of avian flu viruses including genetic information To engage properly trained laboratory and field personnel to handle HPAI specimens To harmonize handling and processing procedures for detection of HPAI To ensure that all the logistical materials are in place including reagents STRENGTHS Well trained and competent personnel in place Already existing laboratory network Surveillance teams (both animal and human) already exist in the districts A measure of cooperation from between public and private sector stakeholders on avian influenza control Multidisciplinary approach by various stakeholders in the sector The ability to detect presence of HPAI WEAKNESSES Insufficient staff Inadequate laboratories supplies and equipment Inadequate logistical support such as transport Inadequate bio-safety and bio-security preparedness 30 OPPORTUNITIES Willing development partners Collaboration with international laboratories e.g. ILRI, CDC Training of personnel on emergency preparedness THREATS Kenya being on migratory path of migratory birds suspected to carry HPA1 virus Many species of migratory birds pass through Kenya Rearing of poultry in close proximity to humans The HPAI may be introduced before the laboratories have been updated Use of slow diagnostic procedures Lack of bio-safety level 3 laboratories Inadequate capacity of the laboratories to handle a large number of specimens SITUATION ANALYSIS HPAI Diagnostic Ability It is projected that approximately 30,000 specimens from among migratory birds, 23,000 from domestic poultry, 4000 specimens from pigs, and 5000 human specimens annually. There are five laboratories in Kenya that can handled avian influenza specimens, namely; KEMRI, Central Veterinary laboratory (CVL), Centers for Disease Control-International Emerging Infections Program (CDC/IEIP), University of Nairobi-Faculty of Veterinary Medicine (UON-FVM), and International Livestock Research Institute (ILRI). The KEMRI, CVL, and UON-FVM laboratories handle influenza-suspect human or animal cases at the present. Indeed, the KEMRI laboratory has processed specimens and isolated Influenza type A strains (low pathogenic) annually, whereas CVL and UON – FVM have processed all animal (primarily avian) suspect cases of avian influenza using egg inoculation followed by hemagglutination inhibition (HI) methodologies. The CDC/IEIP laboratory is a newly built biosafety level-3 facility with technical capability for performing conventional and real-time PCR for both human and animal specimens. Presently, this US-funded laboratory provides molecular diagnostic services. The ILRI laboratory is technically capable of performing molecular diagnosis but it is not a BL-3 facility, thereby making safety a serious concern. The ILRI is in the process of upgrading the laboratory, which will, however, take some time to complete. Experts recommend that human and animal specimens be processed in different laboratories to minimize cross-contamination. Measures to revamp and upgrade the diagnostic capacity for HPAI and to ensure that diagnosis is carried out safely are therefore quite urgent. Recommended Specimen Flow 1. KEMRI laboratory will handle all human AI specimens in Kenya. 2. CVL laboratory will handle all migratory birds, pigs, and some domestic bird specimens. 3. The UON-FVM laboratory will handle the rest of domestic poultry specimens. 4. CDC/IEIP laboratory will perform RT-PCR testing for all human and animal specimens in the interim. 5. ILRI laboratory will later (by June 2006) handle RT-PCR testing for avian samples in order to keep human and animal tissues separate. 31 COLLECTION, HANDLING, AND TRANSPORTATION OF AI SUSPECT SPECIMENS Materials destined for the laboratories will be treated as follows: Dead domestic and wild birds will be picked with hands surrounded by plastic paper and enclosed in the plastic. If possible, a second layer of plastic paper will be used. The birds will then be sent to local VIL or VO. Farmers around Nairobi can also send samples to UONFVM as they have done in the past. The first responders (VIL/VO) will perform the post-mortem on dead birds as usual using standard PPE. Collect spleen, trachea, intestines, and long bone and send these to Central Veterinary Laboratory (CVL) in transport media. Any persons coming into contact with sick wild or domestic birds should call the veterinary officer immediately In respect of HPAI suspect patients at a local clinic or hospital, clinician/nurses will collect throat or nasopharyngeal swabs (under routine PPE) and send them to the KEMRI Influenza Laboratory through the normal transportation channels. TRAINING NEEDS In each provincial and district hospital, laboratory and clinic staff will be trained on collection, packaging, and transportation of suspect influenza virus specimens. The DVS laboratory and field staff will be trained on safe handling of suspect AI specimens. BIO-SAFETY ISSUES All laboratory personnel shall be vaccinated against seasonal influenza (this is not HPAI) in order to protect them against existing influenza subtypes and to raise the alarm in case they show avian influenza-like symptoms. All laboratories shall endeavour to stock reasonable amounts of TamifluR stock to be able to treat laboratory personnel (TamifluR for approx 500 lab/hospital personnel is required). Each provincial hospital will have PPE for approx 20 people, and each district hospital a PPE for 10 people Each district veterinary office shall have at least 5 sets of PPE. IMMEDIATE RESEARCH OBJECTIVES The KEMRI laboratory will be funded to expand it’s surveillance activity to Nyanza, Rift Valley, Coast, and Western provinces. Currently, the laboratory carries out surveillance in the Nairobi area only. This would include doubling the personnel in the laboratory, and upgrading the laboratory to BL-3. Established routine AI surveillance programs at UON, DVS, and ILRI will be carried out to cover both wild and domestic birds. This surveillance will particularly focus on the areas with high density of ducks. All HPAI surveillance and monitoring in the country will be coordinated through the National Task Force (via the Laboratory and Research Ccommittee). No materials will be exported without permission of the National Task Force to ensure proper documentation of AI prevalence in the country. LABORATORY UPGRADE 1. The KEMRI Human Influenza Laboratory will be upgraded to BL-3 immediately 2. Two Avian Influenza laboratories will be upgraded to BL-3, in the listed order of priority 32 (i) CVL - Kabete (ii) UON-FVM - Kabete BUDGET The expected work load from which budgetary estimates are derived are as follows A. Specimens from routine outbreak public health response Wild and domestic birds specimens – Immediate 10,000, thereafter 20,000 per year Human -Immediate 5000, and an equal number per year B. Specimens from targeted HPAI surveillance (Surveillance subcommittee) Migratory birds – Immediate 7,000, Medium 30,000 (total), Long-term 45,000 (total) Domestic poultry – Immediate 11,000, Medium 20,000/yr, Long-term 20,000/yr Pigs - Immediate 3600, Medium 5,000/yr, Long-term 5000/yr Definition: Immediate = 0-6 months, Medium = 7 month – 2 yrs (1.5 yrs), Long-term 3-5 yrs (3 yrs) The samples to be processed sum up to 36,600 in the immediate period; 80,000 in the medium period, and 195,000 in the long-term period; for a grand total of 301,600 specimens over the next 5 years. 33 BUDGET SUMMARY FOR THE LABORATORY PROGRAMME Item (KShs for 1.5yrs) 50,000,000 50,000,000 50,000,000 150000000 12018000 3833775 6000000 Long-term (KSh/yr) 10000000 10000000 10000000 30000000 2,003,000 2,555,850 4,000,000 (KSh for 3 yrs) 30,000,000 30,000,000 30,000,000 90000000 6,009,000 7,667,550 12,000,000 Total (KSh for 5 yrs) 90,000,000 90,000,000 90,000,000 270,000,000 36,054,000.00 14,057,175 25,925,575 2,000,000 16,567,850 500,000 3000000 24,851,775.00 750000 2,000,000 10,558,850 500,000 6,000,000 44,576,211 1,500,000 13,875,000 102,811,411 2,750,000 3,000,000 3,500,000 2,710,455 1,313,984 1,313,984 5,338,423 4,000,000 500,000 1,000,000 1,224,029 1,313,984 1,313,984 3,851,997 2,000,000 750000 1,500,000 1836043.5 1970976 1970976 5,777,995.50 3000000 500,000 1,000,000 1,224,029 1,313,984 1,313,984 3,851,997 2,000,000 1,500,000 3,000,000 3,672,087 3,941,952 3,941,952 11,555,991 6,000,000 5,250,000 8,000,000 8,218,585.50 7,226,912 7,226,912 22,672,410 13,000,000 Sub total 9,000,000 13,000,000 2,000,000 4,000,000 3000000 6,000,000 2,000,000 4,000,000 6,000,000 12,000,000 18,000,000 31,000,000 TOTAL 85,221,848 125,419,847 188,129,771 49,410,847 161,132,202 434,483,821 Laboratory upgrade Sub total Procurement (Laboratory reagents and consumables) Sub total Capacity (Training safety) building on bio- Lab. Action by Immediate ksh CVL KEMRI UON DVS DMS Dean-FVM CVL KEMRI ILRI DVS DMS DVS UON Dean-FVM CVL DVS KEMRI DMS CVL KEMRI UON DVS DMS Dean-FVM CVL DVS KEMRI DMS Sub total Laboratory safety Sub total Logistical (transport) support 10,000,000 10,000,000 10,000,000 30,000,000 18,027,000 2,555,850 7,925,575 Medium (KSh/yr) 33333333.33 33333333.33 33333333.33 100000000 8,012,000 2,555,850 4,000,000 4,875,000 33,383,425 500,000 *Itemized budgets from each laboratory are provided as Appendix 1, 2, 3, 4 and 5 34 BUDGET JUSTIFICATION Upgrading the CVL, KEMRI, and UON-FVM laboratories to BL-3 with capability to handle HPAI is a critical and immediate need. The CVL laboratory has facilities for HI and IFA and virus culture for avian diseases, but currenly operates at BL-2 level. There are therefore, major bio-safety issues relating tothe handling of HPAI strains (H5N1). As a first line of defense the National Taskforce requires this facility be upgraded to a BL-3. There is also a need for diagnostic reagents for H5N1 and training for the staff. The KEMRI laboratory is a BL-2 facility but performs cell culture, HI, and IFA for human influenza viruses. Presently, the laboratory can routinely detect A and B subtypes, and H1N1 and H3N1. Like CVL, KEMRI has no HI or IFA reagents for detecting H5N1. The requested 20 million shillings for upgrading the two laboratories is based on the cost of upgrading the CDC/IEIP laboratory. This includes installation of class II biosafety cabinet, vented outside with Hepafilter system, non-slippery floors, hand-free sinks, double doors and shower-in shower-out systems. In addition, the laboratories would be installed with negative airflow in the isolation laboratory with Hepafilter system and decontamination units for annual cleaning and re-certifications. Upgrading the UON-FVM laboratory (Kshs 10 million), which handles a significant number of domestic poultry, would be advantageous for two reasons. First, being a University laboratory, the UON-FVM laboratory is likely to attract private funding to sustain itself longer. Second, the anticipated number of animal specimens (migratory birds, domestic birds, and pig) is large and it makes sense to have two laboratories commissioned to undertake primary diagnosis for animal influenza, with ILRI laboratory providing molecular diagnosis back up. Reagents and consumables for the 4 laboratories (Kshs 103 million over 5 years) are requested to ensure sustained AI detection system for the next 5 years. The CDC/IEIP laboratory will work with the CVL laboratory to improve the sensitivity of their egg inoculation and HI detection system by providing additional PCR screening for all their samples for the next 6 months. In addition, CDC/IEIP laboratory will transfer PCR (conventional and real-time) activities for animal specimens to ILRI laboratory. This activity transfer will ensure sustained diagnostic capacity for a long time to come. Similar assistance will be provided to UON-FVM laboratory. The biosafety requirements (Kshs 22.6 million over 5 yrs) and training requirements (Kshs 8 million over 5 yrs) are essential for protecting the first responders in rural areas of Kenya (veterinarians, clinicians, nurses). Logistical support (Kshs 31 mill over 5 years) involves purchasing two vehicles, one for DVS and another for DMS dedicated to AI in order to ensure fast and timely response to die-off collections and collection of specimens (human, animal) from hard-to reach areas of the country. 35 LABORATORY PROGRAMME WORK PLAN ACTIVITY SUB-ACTIVITY BY WHOM? BY WHEN EXPECTED OUTPUT PERFORMANCE MOV ASSUMPTIONS Expertise exist in each lab Timely procurement INDICATORS Capacity building Personnel safety Harmonize SOPs between labs Acquire reagents and consumables Training on biosafety Laboratory directors DVS and DMS Laboratory directors Jan 30 ‘06 Vaccination Provision of PPE Laboratory and environmental safety Laboratory upgrade to BL-3 (CVL,KEMRI, UON) Advanced GLP training Improved waste management Expert consultation Drawing of plans Pre-construction preparations Laboratory-based HPAI prevalence determination Data analysis IQA and EQA New questions Laboratory upgrade to BL-3 (CVL,KEMRI, UON) research Constructions SOPs available with laboratory directors Materials in place SOPs Jan 30 ‘06 Laboratory SOPs harmonized Required material acquired Staff trained in Observance of safety procedures Trainers are available DVS and DMS DVS and DMS Laboratory directors DVS and DMS DVS and DMS Experts and MOW Experts, DVS, DMS Immediate Staff immunized Immediate Staff protected Personnel don’t come down with disease PPE in use Training progress report Safety procedure Manuals Immunisation records PPE records Timely procurement Jan 30 ‘06 Staff trained on GLPs Jan 30th ‘06 Waste management system in place Experts consulted Training progress report Inventory reports Trainers are available Immediate Good safety procedures in place Incinerators and biopits functional Experts report Experts report Expertise available April 30th ‘06 Blueprints Blueprints in place Blueprints Expertise available April 30th ‘06 Timely process Continuous - Tender report Construction materials in place Laboratory reports/manuscript Laboratory reports/manuscripts Inventory reports Laboratory directors Laboratory directors and collaborators Laboratory directors/epid emiologist Experts, DVS, DMS - Tendering done Construction materials in place Data analyzed Laboratory reports and records Laboratory reports and records Expertise available New proposals funding Challenges requiring research will emerge Feb 28th ‘06 IQA-continuous EQA-annually Reproducible results Continuous New research areas Proposals in place Dec 31st ‘07 BL-3 laboratories at KEMRI, CVL, UON BL-3 laboratories at KEMRI, CVL, UON Inventory reports for Actual Structures Construction reports Vaccine available Timely installation tendering Expertise available Expertise & materials available 36 INFECTION PREVENTION AND CONTROL INTRODUCTION Infection prevention and control (IPC) services provide the means to break the chain of infection and limit spread of an infectious disease. This is a key strategy in control of communicable diseases. IPC involves the observance of standard transmission precautions in addition to efforts to eliminate infective agents. Avian Influenza is a viral infectious disease. As a viral disease, there is no effective anti-viral drug so far developed. Currently a vaccine against the culprit Highly Pathogenic Avian Influenza (HPAI) virus responsible for the new epidemic has not been developed. Therefore, IPC remain a central strategy to the control efforts of the epidemic. VISION To ensure that Kenya remains HPAI free MISSION To put in place mechanisms to prevent introduction of HPAI and in case of occurrence; control transmission at source including stamping out GOALS 1. To prevent introduction of HPAI into the country, that would affect wild and domestic birds and human beings. 2. To develop strategies for control of HPAI in the event of an outbreak OBJECTIVES To put in place quarantine and isolation facilities To establish a vaccination programme for both birds and humans To provide sanitary regulations and guidelines to all farmers To establish an effective culling and compensation system To train technical (animal and human health) workers on IPC To put in place strategic stocks of protective gear & disinfectants SWOT ANALYSIS Strengths A National Avian Influenza Task force in place Qualified technical man power in place A clear quarantine policy for sick animals Epidemio-surveillance system in place both with the DVS and IDSR WHO has issued guidelines on EPP for HPAI OIE has issued guidelines on regulation of trade in Livestock and their products Training mechanisms are in place Weakness Insufficient technical staff in some areas Weak quarantine policy for humans Infection Prevention and Control committees in most hospitals not activated 37 Lack of isolation units in hospitals Lack of quarantine facilities in some ports of entry Inadequate financial allocation Inadequate legal provisions in the current laws Opportunities High level of awareness in the community Experiences with preparedness in the face of previous global threats e.g. Ebola and SARS Interest from the international community Threat Migratory birds whose movement cannot be controlled Lack of sustainability of preparedness and response programme Assumptions Continued goodwill from the government Continued goodwill from development partners That neighbouring countries will equally apply preparedness and response measures That neighbouring countries cooperate share experiences An effective vaccine against H5N1 will be available soon Adequate stock of Tamiflu anti-viral drug will available Constraint Protective material and gear are very expensive 38 INFECTION PREVENTION AND CONTROL WORK PLAN 1. Activity Sub activity Item Prevent introduction of HPAI virus into the country Ban imports from infected country Demand risks assessment from exporting country Establish quarantine stations at ports of entry Domestic & wild birds & their products Risk assessment report Strengthen the inspection of imports at ports of entry Protect personnel investigating HPAI Prevent transmission of HPAI from contaminated surfaaes and materials Ensure no HPAI introduced through Swill Ensure no HPAI introduced through Fomites Ensure no HPAI introduced through animal By Who DVS By When Expected Output Indicators immediate No imports from infected countries ,, immediate immediate Imported Avian products KAA, KPA & DVS KAA,K PA & ,DMS KRA & DVS Issue protective gear DVS / DMS Decontaminate areas suspected of contamination DVS Decontaminte swill from aircrfts and ships Animal quarantine Human quarantine Safely dispose off swill Public education on fomites that may carry HPAI Demand sanitary certificate from exporting countries Assumptions No. DVS import licences Means of Verification Inspection records at ports of entry Awareness on risk status of exporting countries Quarantine facilities in place No of reports received Physical inspection of reports at DVS No of facilities put in place Establishment reports Exporting will cooperate and be transparent Funds will be available immediate Inspections strengthened No. of inspection reports Physical inspection of reports No illegal imports into the country immediate Personnel are protected No of gear issued Stores records Gear available DMS DVS, KAA, KPA DMS immediate Aircrafts and ships are not HPAI contaminated Disinfection schedules Disinfection certification reports Appropriate authorities in place to certify disinfection immediate All swill safely disposed off Quantities disposed Disposal schedules All swill is declared DMS & DVS immediate DVS immediate only safe animal feeds premixes imported No of sanitary certificates presented KRA & DVS records No illegal imports into the country No illegal imports into the country immediate 39 Activity Sub activity Item By Who By When Expected Output Indicators Means of Verification Assumptions Feed premixes International travel 2 3 4 Prevent infection of domestic birds and other susceptible animals Prevent HPAI to humans HPAI outbreak response DMS, DVS, KAA, KPA DVS Create awareness and encourage confinement of domestic bird Procure doses of seasonal vaccine to vaccinate people at risk Stop inerraction between HPAI infected and the non-infected Provide for compensation of culled birds during outbreak response Disposal of culled/dead birds Engage extra staff to cope with increased workload Limit transmission of disease through poultry movement Stop consumption of Order human influenza vaccine DMS immediate People at risk vaccinated No of people vaccinated DMS reports Vaccine supplies and funds available Issue quarantine advisories DMS when necessary Infected individuals observing travel restrictions No of people on travel restrictions DMS reports Field staff to supervise quarantine Review animal diseases act cap 364 DVS immediate Compensation catered for in cap 364 Legal ammendment available Gazette Notice Political support available Inceneration or burial & decontamination of the area Hire extra Vet& Health Personnel DVS when necessary No nuisance of carcasses of birds No of disposed birds Disposal reports Wild scavengers will not eat the dead birds DVS & DMS when necessary Extra staff hired No hired Employment records Resources available and staff will agree to set terms Enforce poultry movement control DVS when necessary Poultry movement controlled No of movement permits issued DVS Reports Compliance from the general public Enforce poultry inspection DVS when necessary Safe poultry consumed in the No of poultry inspections DVS Reports Compliance from the general public 40 Activity 5 6 7 8 Sub activity HPAI infected poultry Protect birds from HPAI Limit transmission of disease to humans Protect personnel in contact with HPAI from infection Prevent hospital acquired infection with HPAI Item By Who By When Expected Output Indicators Means of Verification Assumptions No of birds vaccinated No of people vaccinated DVS Reports Compliance from the general public Epidemic vaccine avalaible country when necessary when necessary Vaccinated birds DMS/ DVS when necessary Personnel are protected No of gear issued Stores records Issued to the right personnel 2 national referred hospital 8 provincial hospital 6 district hospitals DMS immediatel y Medium term Long term Isolation units established No of units established DMS Reports Funds are available Equip and furnish the isolation units See list of items DMS when necessary Isolational units operational No of isolation units DMS Reports Funds available Provide logistical support to IPC sub committee Provide transport facilitation immediatel y Medium term immediatel y Amount allocated Financial records Funds available Additional vehicles purchased Awareness amongst stakeholders created No procured DMS & DVS Reports Funds available Create general awareness among stakeholders Train the technical personnel DVS & DMS DVS & DMS DVS & DMS Transport available Build human capacityto cope with HPAI Cater for transport costs Proccure additional vehicles Hold sensitisation forums No sensitised DMS & DVS Reports Cooperation by stakeholders Hold staff update & consultative meetings DVS & DMS immediatel y Technical staff competent to deal with HPAI No updated Training reports Funds available Put up isolation units for Avian Influenza Operationalise the isolation units Vaccinate birds at risks Vaccinate 10% of human population at risk DVS Provide protective gear DMS DMS DMS People at risk vaccinated DMS reports DMS 41 INFECTION PREVENTION AND CONTROL BUDGET SUMMARY Activity Immediate Budget (Kshs) Medium Term Budget (Kshs) Long Term Budget (Kshs) 7,600,000 19,200,000 9,100,000 0 0 0 6,200,000 11,600,000 8,800,000 1 Prevent introduction of HPAI into the country 2 Prevent infection of domestic birds and other susceptible animals (*) 3 Prevent HPAI to humans 4 Respond to an HPAI outbreak 15,000,000 1,072,400,000 725,110,000 5 Put up isolation units for Avian Influenza 13,500,000 36,000,000 12,500,000 6 Strengthen National IPC secretariat 0 11,470,000 0 7 Operationalise the isolation units 0 0 0 8 Provide logistical support to IPC sub committee (*) 0 0 0 9 Build human capacityto cope with HPAI (*) 0 0 0 42,300,000 1,150,670,000 755,510,000 TOTAL 42 CASE MANAGEMENT INTRODUCTION Case management is care and treatment of a patient admitted with HPA1 virus infection. It includes: Clinical diagnosis Specimen collection for laboratory confirmation of the clinical diagnosis Admission procedures and referral where necessary Drug treatment whether in-patient or out patient Care while in hospital that includes preventive precautions to prevent spread of infection Referrals and transfers where necessary Discharge protocols and procedures VISION All or almost all people who contract the HPA1 virus infection survive through intensive case management in selected health facilities MISSION Establish and sustain capacity for effective case management of HPA1 virus infection in health facilities in Kenya PROBLEM STATEMENT 1. There is an impending threat of HPAI virus infection in Kenya, which is likely to turn into an epidemic or a pandemic. 2. There is inadequate capacity to handle such a situation GOAL To achieve a (hundred percent) 100% survival rate OBJECTIVES 1. Develop case management guidelines 2. Improve infection prevention and control standards in health facilities 3. Well equipped isolation wards established 4. Develop referral standards and guidelines SITUATION ANALYSIS The country is divided into seven HPA1 virus high risk zones based on migratory patterns of birds form Europe and Asia These are: 1. North Western migratory route covering Turkana and Marsabit districts 2. Nyanza and western migratory routes around L. Victoria and Ahero 3. Central Rift Valley covering lakes Baringo, Bogoria, Elementaita, Nakuru, Naivasha and Magadi 4. Amboseli region covering the national park and its surrounding area. 5. Nairobi and central highlands covering south Kinangop and surrounding wet lands 6. Tsavo covering lakes Jipe, Ngulia, other pools and wet lands 7. Coast region covering Watamu. Mombasa, Malindi and Kilifi 43 Health facilities in these seven zones lack adequate isolation facilities to facilitate ideal case management of HPA1 virus infection. In these seven areas, the following eight (8) hospitals have been identified. North Western Zone – 2 hospitals have been identified due to large geographical bio diversity. They are: 1. Lokichoggio ICRC hospital 2. Marsabit District hospital 3. New Nyanza General Hospital 4. Nakuru Provincial General Hospital 5. Narok District Hospital 6. Kenyatta National Hospital 7. Voi District Hospital 8. Port Reitz District hospital HPA1 virus is highly contagious and the eight identified hospitals in the seven zones will be used to provide care and treatment for these patients. This is necessary because such patients require isolation from the rest of the public until they recover fully to prevent spread of the infection. These hospitals therefore require well equipped isolation wards and currently only KNH has one which is ill equipped. These hospitals have all cadres of health personnel but they have not been trained on identification and management of HPA1 virus infection which is a new disease in Kenya. There is need to develop guidelines on case management, referral and drug management. Each of the high risk regions covers large geographical areas with high population and several health facilities which could diagnose a suspected case. This therefore calls for a stand by ambulance within the zonal hospital specifically meant for quick transfer of such patients. The same facilities identified also need to be provided with full communication equipment to link them with the rest of the facilities in their zones. 44 CASE MANAGEMENT WORK PLAN Objectives Activities Develop case management guidelines Set up a task force to develop the guideline Improve infection Prevention in the health facilities Develop training curriculum Provide update trainings for healthcare providers Purchase specially designed ambulances Well equipped isolation wards established Set up isolation wards Sub-objectives By who By When Output Hold 8 meetings DMS Task force in place Three Workshop DMS Last week of October 2005 Nov 2005 to Feb 2006 Printing and publishing of guidelines Set up task force to develop the curriculum DMS April 2006 Guidelines published DMS/CNO February 2006 to March 2006 Task force in place Workshops conducted Number of meetings held Print and publish curriculum DMS/CNO April 2006 Curriculum available Conduct Training of Trainers (ToT) Conduct training for healthcare providers Develop ambulance design/specificatio n Procure and supply specially designed ambulances Develop design of the isolation wards DMS/CNO March 2006 ToTs trained DMS/CNO Healthcare providers trained DMS From April 2006 to Dec. 2006 January 2006 DMS August 2006 DMS/MoP W February 2006 Number of ambulances purchased Design developed Put up the buildings Purchase and supply equipment Purchase and supply infection DMS/MoP W DMS August 2006 Wards completed September 2006 Wards equipped Design developed Performance Indicators Number of meetings held MoV Assumptions Minutes of meetings Funds will be available in time Number of workshops conducted Guidelines available in clinical areas Draft guidelines developed “ Observable “ Number of meetings held Minutes of meetings held “ Curriculum developed Number of copies of curriculum distributed Number of ToTs trained Number of healthcare providers trained Copy of design available Curriculum in place Copy of design of ambulance The design will be available Specially designed ambulances purchased Design of the isolation ward, developed Wards incomplete Log books of purchased ambulances Copies of the designs Funds will be availed Number of wards put up List of equipments purchased Wards will be put up as per design Funds will be available Equipment purchased Register of number of curriculum copies distributed Training reports Training reports Training curriculum developed in time - Designs will be made Ass planned in the Infection prevention 45 Objectives Activities Sub-objectives prevention requirements Purchase and supply nopharmaceuticals items Purchase and supply drugs Develop referral standards and g uidelines Set up a technical task force for patients referral guidelines Hold 8 meetings Printing and publishing of the referral manual By who By When Output Performance Indicators MoV Assumptions Items available Items purchased List of items purchased Funds will be available Items available Drugs are bought Lists of drugs bought - Drugs will be available and control plan DMS DMS DMS DMS Emergency con. Jan 2006. The rest – August 2006 Emergency con. Jan 2006. The rest – August 2006 End of December 2005 to end of February 2005 April 2006 - Funds will be available Task force in place Guidelines developed Guidelines published Number of meetings held Guidelines developed Minutes of meetings held Copies of guidelines developed Referral manual published Number of copies of referral Funds will be available 46 CASE MANAGEMENT BUDGET SUMMARY Immediate Budget (KShs) 24,000 Medium Term Budget (KShs) 0 Long Term Budget (KShs) 0 159,000 3,000,000 0 1,800 0 0 0 3,840,000 0 0 8,000,000 8,000,000 2.1 Buying drugs 37,500,000 592,500,000 592,500,000 2.2 Supportive drugs 44,368,740 0 0 0 1,404,230,000 2,808,460,000 2.3 Buy non-pharmaceuticals 7,500,000 0 0 3.1 Setting up isolation wards 75,000 26,000,000 54,000,000 0 0 48,000,000 3.2 Buy Equipments for the isolation wards 4.1 Setting up Technical Task force on Referral guidelines 4.2 Purchase of 8 Special Ambulances 0 20,708,680 0 24,000 3,000,000 0 40,000 12,000,000 12,000,000 GRAND TOTAL 89,712,540 2,073,278,680 3,522,960,000 Activity Setting up a technical taskforce 1.2 Developing Curriculum 20,000 1.3 Training of Health Workers 47 INFORMATION, EDUCATION AND COMMUNICATION SITUATION ANALYSIS There have been outbreaks of Avian Flu in several countries, especially in Asia, where some of the cases resulted in fatalities. In view of this, governments worldwide have been putting systems and controls in place in order to mitigate its expected effects. STATEMENT OF FUNCTION The Information, Education and Communication (IEC) Sub Committee was constituted alongside five other sub committees of the National Preparedness Task Force to create awareness, sensitisation and education to the Kenyan public on the Highly Pathogenic Avian Influenza (HPAI). These awareness functions are to be executed in close coordination with other sub committees. STATEMENT OF PURPOSE AND MANDATE On 26th October 2005, the Government of Kenya established a National Preparedness Task Force co-chaired by the Ministries of Livestock and Fisheries Development and Health. This National Task Force was mandated to carry out activities such as surveillance and epidemiology (Avian and human), prevention and control, case management, laboratory, research, IEC and Resource Mobilisation functions. The IEC Sub Committee is mandated; 1. 2. 3. 4. To develop a risk communication strategy that addressed different target groups. To establish and manage an official HPAI Website. To undertake media monitoring and develop appropriate media briefings. To establish a partnership with both local and international media houses to disseminate information on HPAI. 5. To coordinate the development of appropriate IEC materials. 6. To facilitate preparation of media briefs and press statements by the official spokespersons. 7. To facilitate media coverage of activities being undertaken by the various subcommittees. STATEMENT OF STRATEGY The statement of strategy involves the following action points: a. Establishment and manning of a Media Centre b. Conducting Research Analysis and Media Monitoring c. Carrying out Social Mobilisation d. Mass Media campaigns e. Production and distribution of IEC materials f. Establishment and maintenance of an HPAI Website VISION Proper management of information on HPAI so that Kenya’s economy is not affected in any way by panic arising from false information or rumours and that all Kenyans become active participants in the country’s rapid response plan to tackle the HPAI threat MISSION To respond countrywide through effective, efficient and appropriate public sensitisation and awareness tools. 48 GOAL Kenyans are adequately and correctly sensitized and informed about Highly Pathogenic Avian Influenza (HPAI). OBJECTIVES 1. To develop the Media Centre 2. To educate and disseminate accurate information timely to the general public and other stakeholders about HPAI 3. To prepare education materials for the public 4. To build capacity of all persons who will be involved in the Information dissemination and social mobilization programs 5. To collect and collate information on HPAI 6. To maintain a data bank of HPAI related issues 7. To ensure stakeholders are interlinked for information exchange 8. To communicate to the public through any appropriate languages 9. To communicate to the public simplified messages 10. To correct any misconceptions on bird flu 11. To use all available media SWOT ANALYSIS Strengths a. Availability of highly trained personnel to man the Media Centre b. Availability of materials on HPAI c. Kenya is covered by vast mass media, d. Already existing IT structures Weaknesses a. b. c. d. e. Lack of resources Untimely release of funding Illiteracy of the populace Media politics and priorities No media center Opportunities a. Willingness of media houses to disseminate information to the general populace b. Partners willing to support the HPAI budget c. Widespread civil society network in Kenya d. Donor funding e. Government goodwill f. Public expectant of information g. Immense global information on HPAI Threats a. Incorrect HPAI messages in media and within the population b. Minimal awareness of bird species both local and migratory c. Lack of funds BUDGET JUSTIFICATION Media Centre 49 The Media Centre shall be developed and maintained by the members of the IEC sub committee in collaboration with relevant members of the National Task Force. It will serve as a nerve centre from which information will be managed and flow systematically to the general public. This information flow will include press statements and interviews, production of IEC materials and any other media related issues. This will ensure that information is properly managed. The centre shall ensure that the Website is updated with the latest information, which shall be accessed by both local and international media, as well as the general public. It is expected that the Media Centre will be fully equipped to ensure that the work is implemented effectively and efficiently. Research The Media Centre shall collect, collate and utilise information for the purposes of designing a risk communication strategy. This initial material will also be used to develop useful tools for dissemination activities. This research stage will include media monitoring and analysis on the ongoing HPAI interest issues, which would be essential for gauging the information disseminated to the Kenyan public. Social Mobilisation Noting that social mobilisation is a necessary tool in such a campaign, therefore stakeholders, partners, policy makers and all other relevant groups will be actively involved. Communities living along the migratory route of the birds will be targeted as a priority. The committee will also be targeting communities, in both rural and urban areas, where there is close interaction between humans and poultry. 20 districts have been identified and will be targeted for initial awareness campaigns. These numbers of districts can either increase or decrease depending on the HPAI situation in the country. Other players in the NGO sector shall also be actively involved in the implementation on the ground of the social mobilisation activities. Mass Media The mass media is a vehicle for sensitising small and large numbers of people spread across the country. These media include; Radios, TVs and Newspapers. Noting that language is of critical importance in this campaign, these media shall be used to reach the rural communities with structured messages in the local dialects. Newspaper supplements and advertisements are crucial to maintaining a concerted approach to enlightening the public. It is important that these campaign tools are done in the initial stages of the campaign. Free interviews are expected to be conducted through the goodwill of the mass media, including radio, television and newspapers. At the same, the Media Centre, through the National Task Force, shall seek and gain mutual support from other government institutions, the corporate sector and the media to ensure success of the activities. 50 IEC COMMITTEE WORK PLAN 1 Activity Sub-activity Detail Research (a) Formative 1. Focussed Group Discussion (FGD) Action by Time frame Media Dec 05Centre Jan 06 2. Questionnaires (b) Media monitoring 2 Mass media (Radio) (a) Radio interviews Mass media (TV) Interviews in radio shows Media Centre (b) Radio programmes Radio presentations by experts (c) Radio spots Short, 1-minute adverts (d) Production Independent Production of radio programmes (a) TV Spots Short, 1-minute Media adverts Centre (b) TV Documentary (c) TV interviews Print media Content analysis in all mass media (a) Supplements Indicators (targets) Means of verification Research carried out to 10 FGDs conducted 10 FGDs reports help design risk strategy, as prepared well as assess the situation obtaining regarding HPAI. Questionnaires Reports on prepared and distri administration of buted Questionnaires received Short, Clips assist in analysing Clips from all media Clips collected and Medium, information flow, and houses collected and archived Long term desiging of risk collated. communication strategy Dec 05To sensitise and inform the Approx. 10 radio Radio shows and May 06 public on HPAI. The shows spots are Aired, (Through public is also sensitised in recorded and out the English, Kiswahili and any archived campaign) other relevant language. Approx. 15 radio programmes 100 spots gone on air 100 productions Radio shows and conducted spots produced Assumptions (risks) Funds Dec 05May 06 (Through out the campaign) TV shows, documentaries and spots are produced, aired, recorded and archived Media goodwill Supplements published and archived Media goodwill Independent Production of radio programmes Interviews on TV with experts Supplement in all the daily newspapers Media Centre Dec 05May 06 (Through out the Expected output To sensitise and inform the 12 spots aired in 4 public on HPAI. The TV stations public is also sensitised in English and Kiswahili languages. 3 TV productions done 3 interviews held in 4 stations, and aired in English and Kiswahili To sensitise and inform the Supplements in 4 public on HPAI. The dailies and one public is also sensitised in Kiswahili English and Kiswahili Media goodwill 51 campaign) languages. (b) Advertisement 3 IEC materials 4 Media Centre 5 Social Mobilisation (a) Developing of IECs (b) Printing and distribution of IEC materials Establishing and Equipping Media Centre Website Media Centre and members of other subcommittee s Dec 05May 06 (Through out the campaign) To facilitate the effective and efficient execution of media and awareness campaigns. printed IEC materials One million IEC materials printed and distributed Media Centre Media Centre established and established, equipped equipped and functional Media Centre Community mobilisation in 20 districts Conduct public Barazas, meetings and FGD, in churches, institutions, organised groups MoH, MoLFD, CBOs, NGOs, Advocacy meetings Conduct advocacy among media, partners, policymakers, poultry industry stakeholders, and other key groups Conduct meetings for experts in the poultry industry and medical fields, both animal and human. Developing, Software and Hardware, maintaining Media Centre Dec 05May 06 (Through out the campaign) Media Centre Medium term To keep abreast with the 10 meetings held developments in the HPAI threat. Meetings held and cooperation of information updated partners successfully. Media Centre Medium term To facilitate the effective and efficient publicity campaigns, as well as used as an educational tool for the Kenyan public. Website established, Setting up of the updated and media centre and maintaned. coordination with other committees Establishing and Maintenances Dec 05May 06 (Through out the campaign) Dec 05May 06 (Through out the campaign) To sensitise and inform the IEC materials public on HPAI. The developed public is also sensitised in English and Kiswahili languages and any other relevant language. Computers, communication and stationery. Experts meetings 6 Adverts in all the daily newspapers Posters, fliers, brochures, fact sheets, pamphlets, banners, Tshirts, caps, label stickers, quarantine stickers, quarantine ribbons, guideline manuals, To mobilise and sensitise the public on HPAI. The public is also sensitised in English and Kiswahili languages. 20 districts mobilised Mobilisation for activities successful, people participate actively and information about HPAI adopted in the communities. To advocate on the 10 meetings held Meetings held and immediate concerns of the advocacy HPAI threat. successfully conducted. Website set up and utilised Funds Funds Community cooperation cooperation of partners 52 IEC MATERIALS IEC materials shall be developed, printed and distributed through the Media Centre. These materials include; Posters, fliers, brochures, fact sheets, pamphlets, banners, T-shirts, caps, label stickers, quarantine stickers and ribbons. All IEC materials required by National Task Force will be prepared with the consultation of the IEC Sub Committee. This will ensure accurate information that is well edited and designed for the targeted audience. BUDGET DEVELOPMENT No Activities Short term Medium term Long term 1 Research 2,000,000 1,000,000 1000,000 2 a. Mass Media (Radio) 4,000,000 9,000,000 3,100,000 b. Mass Media (TV) 2,160,000 34,500,000 16,500,000 0 5,000,000 3,000,000 c. Mass Media (Print) 3 IEC Materials 1,020,000 22,000,000 1,000,000 4 Media Centre 580,000 350,000 200,000 5 Social Mobilisation 9,360,000 24,000,000 22,000,000 6 Website 680,000 1,000,000 200,000 20,000,000 96,850,000 47,750,000 TOTAL Collaboration and Coordination The Media Centre will not work in isolation, but rather in consultation with the National Task Force and its sub committees. Gaps and Constraints The Media Centre is working with the assumption that funding will be made available to effectively and efficiently execute the work plan. Programme Implementation and Monitoring It is envisaged that this programme will be implemented in the short term (0-6 months), medium term (6 months-2 years) and long term (2-5 years). The members of the Media Centre shall be mandated to conduct implementation and monitoring activities. Way forward The members of the Media Centre will be part of the concerted countrywide effort to tackle the HPAI in the short, medium and long-term basis. No Approved Budgets for Sub Committees for the immediate term Amount in Kshs 1 Infection Control 28,000,000 2 Epidemiology and Surveillance 61,120,000 3 Laboratory 43,240,000 4 IEC Materials 20,000,000 5 Case Management 92,500,000 6 Coordination 4,892,500 Total 249,752,500 53 SUMMARY AVIAN FLU GUIDELINE What is Flu? Influenza flu is a contagious respiratory illness caused by the influenza viruses. Some people, such as older people, young children, and people with certain health conditions, are at high risk for serious flu complications. About the Influenza Flu Viruses Influenza A and B are the two types of influenza viruses that cause epidemic human disease. Influenza B viruses are not categorized into subtypes. Since 1977, influenza A (H1N1) viruses, influenza A (H3N2) viruses, and influenza B viruses have been in global circulation. New influenza virus variants result from frequent antigenic change (i.e., antigenic drift) resulting from point mutations that occur during viral replication. Influenza B viruses undergo antigenic drift less rapidly than influenza A viruses. Antibody against one influenza virus type or subtype confers limited or no protection against another type or subtype of influenza. Symptoms of Flu fever (usually high) headache dry cough Case Definitions of Flu Cough Fever Influenza in close contacts World Health Organization Case Definitions for Influenza Suspected: a case that meets the clinical case definition Flu Transmission A combination of infection control strategies is recommended to decrease transmission of influenza in health-care settings. These include placing influenza patients in private rooms when possible and having health-care personnel wear masks for close patient contact (i.e., within 3 feet) and gowns and gloves if contact with respiratory secretions is likely. The use of surgical or procedure masks by infectious patients may help contain their respiratory secretions and limit exposure to others. Likewise, when a patient is not wearing a mask, as when in an isolation room, having health-care personnel mask for close contact with the patient may prevent nose and mouth contact with respiratory droplets. However, no studies have definitively shown that mask use by either infectious patients or health-care personnel prevents influenza transmission. Flu viruses spread in respiratory droplets caused by coughing and sneezing. Flu in Kenya Influenza Flu outbreaks recorded in Kenya October 2003 Kijabe Hospital March 2004 Kambaa Girl’s High School Vaccination 54 Influenza “B” isolated Influenza “B” isolated The single best way to prevent the flu is to get a flu vaccination each fall. The "flu shot" -- an inactivated vaccine (containing killed virus) that is given with a needle. The flu shot is approved for use in people older than 6 months, including healthy people and people with chronic medical conditions. All health care workers Clinical Management of Influenza Clinical Presentation in Babies and children Primary influenza pneumonitis can be a presenting diagnosis. Complications of influenza Respiratory: respiratory failure, bacterial superinfection, viral pneumonia Differential diagnosis of influenza Triaging at the influenza assessment/admission area Designate a separate assessment/admission clinic for patients with suspected influenza. Patients referred with “flu” should proceed directly to this area, and those with symptoms of influenza should be rapidly diverted here to minimise transmission to others in the waiting room. Divert patients requiring resuscitation to the usual emergency department area. Admission pro-forma A risk assessment classifying patients accordingly Essential epidemiology (including vaccination history– pneumococcal, influenza) Blood culture Electrocardiograph in patients with ischaemic heart disease, or older, or sicker. Fluid intake Ensure increased fluid intake. All confirmed and suspected cases of influenza or All confirmed and suspected cases of influenza in the following groups: All essential workers (including health care workers). The symptoms of uncomplicated influenza – fever, mild dyspnoea, pleuritic pain, blood tinged sputum, scattered lung crackles – all suggest possible bacterial lung involvement. 65 Available as 100mg capsules Dosage: Treatment 100mg 12hrly for 5-7 days 100mg 24hrly in renal impairment, 10-15 years or over 65 years 2-4mg/kg in children 1-9 years (syrup), maximum 100mg daily Prophylaxis 100mg 12hrly for period of time during which protection is required, or 10 days after vaccination Available as 100mg tablets and syrup 50mg/5mL Dosage: Treatment 100mg 12hrly for 5 days Available as a metered dose diskhaler, 10mg per dose Dosage: Treatment 10mg bid by diskhaler 5 days Antiviral Drugs - Dosage Regimens Available as 100mg capsules Dosage: Treatment 100mg 12-hrly for 5-7 days 55 2-4mg/kg in children 1-9 years (syrup), maximum 100mg daily Prophylaxis: 100mg 12-hrly for period of time during which protection is required, or 10 days after vaccination Available as 100mg tablets and a syrup 50mg/5mL Prophylaxis: 100mg 12-hrly for period of time during which protection is required, or 10 days after vaccination Available as a metered dose diskhaler, 10mg per dose Data for treatment in children, pregnancy, underlying diseases etc. not yet available. Infection Prevention and Control and Nursing Care for Flu Patients Ministry of Health advises strict adherence to barrier nursing practice when handling patients with Flu. Suspect cases should wear surgical masks until Flu is excluded. Wherever possible, patients under investigation for Flu should be separated from those diagnosed with the syndrome. Use disposable medical equipment wherever possible in care of patients with Flu. Surfaces soiled with spills from Flu patients should be decontaminated with an effective disinfectant e.g. 2% chlorine solution before cleaning. Health workers must observe standard, respiratory and contact precautions. Advice to Health care workers on protective apparel when handling flu patients Wear gloves and mask at all times with a suspected or confirmed case of Flu. Wear protective eye goggles, mask, gown, waterproof aprons, and head covers during procedures and patient activities that are likely to generate splashes or sprays of respiratory secretions, blood or other body secretions or fluids. Advice to Health care workers on Hand washing Wash hands before and after significant contact with any patient, after activities likely to cause contamination and after removing gloves. Hand Advice to Health care workers on protective apparel when handling wastes from patients with Flu Apply standard precautions when handling any clinical wastes. Restrict visitors but where absolutely necessary the visitors should face masks, goggles, gown and head covers when in close contact with Flu patients. Handling a case of Flu II. Infection Control Where possible, place a surgical mask on the patient. All health-care personnel should wear N-95 respirators while taking care of patients with suspected Flu. If a suspect Flu patient is admitted to the hospital, infection control personnel should be notified immediately. Infection control measures for inpatients should include: Standard precautions (e.g., hand hygiene); in addition to routine standard precautions, health-care personnel should wear eye protection for all patient contact. Contact precautions (e.g., use of gown and gloves for contact with the patient or their environment) Droplet Precautions (e.g., used when a patient is known or suspected to be infected with microorganisms transmitted by droplets (large-particle droplets {larger than 5 um in size}, generated by coughing, sneezing or talking). If airborne precautions cannot be fully implemented, patients should be placed in a private room, and all persons entering the room should wear N-95 respirators. III. Standard Precautions Use Standard Precautions for the care of all patients. 56 Handwashing Wash hands after touching blood, body fluids, secretions, excretions, and contaminated items, whether or not gloves are worn. Wash hands immediately after gloves are removed, between patient contacts, and when otherwise indicated to avoid transfer of microorganisms to other patients or environments. Gloves Wear gloves (clean, non-sterile gloves are adequate) when touching blood, body fluids, secretions, excretions, and contaminated items. Remove gloves promptly after use, before touching noncontaminated items and environmental surfaces, and before going to another patient, and wash hands immediately to avoid transfer of microorganisms to other patients or environments. Gown Wear a gown (a clean, nonsterile gown is adequate) to protect skin and to prevent soiling of clothing during procedures and patient-care activities that are likely to generate splashes or sprays of blood, body fluids, secretions, or excretions. Patient-Care Equipment Handle used patient-care equipment soiled with blood, body fluids, secretions, and excretions in a manner that prevents skin and mucous membrane exposures, contamination of clothing, and transfer of microorganisms to other patients and environments. If a private room is not available, consult with infection control professionals regarding patient placement or other alternatives. IV. Droplet Precautions Patient Placement Place the patient in a private room. When a private room is not available, place the patient in a room with a patient(s) who has active infection with the same microorganism but with no other infection (cohorting). Mask In addition to standard precautions, wear a mask when working within 3 ft of the patient. Patient Transport Limit the movement and transport of the patient from the room to essential purposes only. If transport or movement is necessary, minimize patient dispersal of droplets by masking the patient, if possible. V. Contact Precautions In addition to Standard Precautions, use Contact Precautions, or the equivalent, for specified patients known or suspected to be infected or colonized with epidemiologically important microorganisms that can be transmitted by direct contact with the patient (hand or skin-to-skin contact that occurs when performing patient-care activities that require touching the patient's dry skin) or indirect contact (touching) with environmental surfaces or patient-care items in the patient's environment. Patient Placement Place the patient in a private room. When a private room is not available, place the patient in a room with a patient(s) who has active infection with the same microorganism but with no other infection (cohorting). Consultation with infection control professionals is advised before patient placement. Gloves and Handwashing In addition to wearing gloves as outlined under Standard Precautions, wear gloves (clean, nonsterile gloves are adequate) when entering the room. Remove gloves before leaving the patient's environment and wash hands immediately with an antimicrobial agent or a waterless antiseptic agent. After glove removal and handwashing, ensure that hands do not touch potentially contaminated environmental surfaces or items in the patient's room to avoid transfer of microorganisms to other patients or environments. Remove the gown before leaving the patient's environment. After gown removal, ensure that clothing does not contact potentially contaminated environmental surfaces to avoid transfer of microorganisms to other patients or environments. 57 Patient Transport Limit the movement and transport of the patient from the room to essential purposes only. If the patient is transported out of the room, ensure that precautions are maintained to minimize the risk of transmission of microorganisms to other patients and contamination of environmental surfaces or equipment. 1. Patient-Care Equipment When possible, dedicate the use of non-critical patient-care equipment to a single patient (or cohort of patients infected or colonized with the pathogen requiring precautions) to avoid sharing between patients. Influenza Surveillance and Epidemiological Preparedness Scale –up influenza surveillance. Widen the present coverage of the current Influenza Flu Network covering only Nairobi. Strengthen all Infectious diseases surveillance Train surveillance staff on influenza Surveillance A timely, representative and efficient surveillance system is the cornerstone of influenza control. International and regional surveillance Kenya hosts one of the may WHO Collaborating National Influenza Centres for surveillance on Influenza, and this laboratory participates in diagnosis and typing of influenza viruses. has the expertise for rapid definitive identification of influenza viruses, including new pandemic subtypes; handles reagents for influenza diagnosis and identification, maintains up-to-date national information on influenza epidemiology; Requirements for a national surveillance system detect increased influenza activity, either epidemic or pandemic. This includes detection of “flulike” illnesses in the community, and the use of laboratory confirmation of influenza infection to estimate the proportion of these cases that are due to influenza. rapidly disseminate surveillance results 58