Giuseppe Zamboni - Curriculum vitae
Giuseppe Zamboni, MD, is a Professor of Pathology at the Medical School of the
University of Verona since 1998 and Chief of the Pathology Department of the S. CuoreDon Calabria Hospital in Negrar, Verona, since 2000. He graduated in 1980 from the
University of Padua, discussing his thesis on “Adenomatous polyps of the colon” with Prof.
L. Fiore-Donati. He obtained his specialisation in Pathology from the University of Parma
in 1984. He spent two years as general surgical pathologist at Vicenza Hospital before
being invited to the University of Verona to focus his diagnostic activity on gastrointestinal
pathology and collaborate in scientific studies with the foundling Verona group. He is one
of the founding members of the pancreatic research team at University of Verona. His
clinically and pathologically based knowledge was instrumental in the identification of
novel pancreatic tumor types, "PEComa-Clear cell sugar tumor" and “Acinar
cystadenoma" of the pancreas and the definition of inflammatory conditions of the
pancreas such as autoimmune pancreatitis. He is a keystone in the Verona Pancreas
group, which is renowned as the most important in Italy in this field and among the first in
the world in terms of patient numbers and scientific papers, pioneering the study of
molecular anomalies associated with diverse pancreatic types. As part of this group of
collaborating clinicians and pathologists, he has provided a vast knowledge base that has
been vital in European scientific research in the field of pancreatic tumours that has led, in
the last twenty years, to the definition of clinical-pathological standards that are valid tools
for diagnosis and prognostic stratification of diverse pancreatic tumor types. In 2000 he, as
a member of the WHO international committee for the classification of the tumors of the
gastrointestinal tract, liver and pancreas, wrote the chapter on mucinous cystic neoplasms
of the pancreas. Dr. Zamboni is on the board of Virchows Archive, the official journal of the
European Society of Pathology.
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Office address
Home address
Dipartimento di Patologia
Università di Verona,
Policlinico G.B. Rossi
I – 37134 Verona
Via Torricelle, 7B
37100 Verona, Italy
tel: +39 045 916906
Anatomia Patologica
Ospedale S.Cuore-DonCalabria
Via don Sempreboni, 5
37024 Negrar-Verona-Italy
tel: +39 045 6013 415
fax: +39 045 7500 480
email giuseppe.zamboni@univr.it
giuseppe.zamboni@sacrocuore.it
PERSONAL DATA
Date of birth
Place of birth
1° November 1953
Verona, Italy
EDUCATION
1974
1980
1984
1984-85
1986-98
1998-99
2000…
High school-Degree-Scientific Lyceum, Verona.
MEDICAL DOCTOR-Degree, University of Padova (110/110 cum laude).
Board of Pathology, University of Parma (50/50 cum laude).
Assistant Pathology, Hospital of Vicenza
Assistant Pathology, University of Verona
Associate Professor of Pathology, University of Verona
Associate Professor of Pathology, University of Verona, and Chief of
Pathology, Don Calabria Hospital, Negrar, Verona
MEMBERSHIP IN PROFESSIONAL SOCIETIES
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

SOCIETA’ ITALIANA DI ANATOMIA PATOLOGICA E CITOLOGIA (SIAPEC)
EUROPEAN SOCIETY OF PATHOLOGY (ESP)
ASSOCIAZIONE ITALIANA STUDIO PANCREAS (AISP)
JOURNALS REVISER
Pathologica, Journal of Pathology, Gut, Virchows Archiv, International Journal of
Pancreatology, Pancreas, Modern Pathology.
EDITORIAL BOARD
Virchows Archiv
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PUBLICATIONS
Author of more than 100 scientific articles and 20 book chapters. In 2000, as a
member of the WHO international committee for the classification of the tumors of the
gastrointestinal tract, liver and pancreas, wrote the chapters on mucinous cystic
neoplasms of the pancreas, and rare tumors of the pancreas. His research interest is
in the area of the gastrointestinal pathology, particularly in the field of pancreatic
pathology (1-38- 39-51).
Member of WHO Classification of Tumours 2000:
Zamboni G, Klöppel G, Hruban RH, Longnecker DS, Adler G. Mucinous
cysticneoplasms of the pancreas. In: Hamilton SR, Aaltonen LA, eds. Pathology and
Genetics of Tumours of the Digestive System. WHO Classification of Tumours. Lyon:
IARC Press, 2000:234-236.
Zamboni G, Klöppel G, Hruban RH, Longnecker DS, Adler G. Rare tumors of the
pancreas. In: Hamilton SR, Aaltonen LA, eds. Pathology and Genetics of Tumours of
the Digestive System. WHO Classification of Tumours. Lyon: IARC Press, 2000:249.
Main Publications:
1.
Frazin G, Zamboni G, Scarpa A, Dina R, Iannucci A, Novelli P. Hyperplastic
(metaplastic) polyps of the colon. A histologic and histochemical study. Am J Surg Pathol.
1984;8:687-698.
2.
Zamboni G, Franzin G, Bonetti F et al. Small-cell neuroendocrine carcinoma
of the ampullary region. A clinicopathologic, immunohistochemical, and ultrastructural
study of three cases. Am J Surg Pathol. 1990;14:703-713.
3.
Bonetti F, Pea M, Martignoni G, Zamboni G, Iuzzolino P. Cellular
heterogeneity in lymphangiomyomatosis of the lung. Hum Pathol. 1991;22:727-728.
4.
Pea M, Bonetti F, Zamboni G, Martignoni G, Fiore-Donati L, Doglioni C.
Clear cell tumor and angiomyolipoma. Am J Surg Pathol. 1991;15:199-202.
5.
Pea M, Bonetti F, Zamboni G et al. Melanocyte-marker-HMB-45 is regularly
expressed in angiomyolipoma of the kidney. Pathology. 1991;23:185-188.
6.
Bonetti F, Pea M, Martignoni G, Zamboni G. PEC and sugar. Am J Surg
Pathol. 1992;16:307-308.
7.
Pelosi G, Zamboni G, Doglioni C et al. Immunodetection of proliferating cell
nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors
of the pancreas. Am J Surg Pathol. 1992;16:1215-1225.
8.
Viale G, Doglioni C, Gambacorta M, Zamboni G, Coggi G, Bordi C.
Progesterone receptor immunoreactivity in pancreatic endocrine tumors. An
immunocytochemical study of 156 neuroendocrine tumors of the pancreas, gastrointestinal
and respiratory tracts, and skin. Cancer. 1992;70:2268-2277.
9.
Scarpa A, Capelli P, Zamboni G et al. Neoplasia of the ampulla of Vater. Kiras and p53 mutations. Am J Pathol. 1993;142:1163-1172.
10.
Zamboni G, Bonetti F, Scarpa A et al. Expression of progesterone receptors
in solid-cystic tumour of the pancreas: a clinicopathological and immunohistochemical
study of ten cases. Virchows Arch A Pathol Anat Histopathol. 1993;423:425-431.
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11.
Scarpa A, Zamboni G, Achille A et al. ras-family gene mutations in neoplasia
of the ampulla of Vater. Int J Cancer. 1994;59:39-42.
12.
Sessa F, Capella C, Bonato M, Zamboni G et al. Intraductal papillarymucinous pancreatic tumors are phenotypically, genetically and behaviorally distinct
growths. An analysis of tumor cell phenotype, K-ras and p53 genes' mutations. Virchows
Archiv. 1994;425:357-367.
13.
Zamboni G, Bonetti F, Castelli P et al. Mucinous cystic tumor of the pancreas
recurring after 11 years as cystadenocarcinoma with foci of choriocarcinoma and
osteoclast-like giant cell tumor. Surgical Pathology. 1994; 5:253-262.
14.
Balercia G, Zamboni G, Bogina G, Mariuzzi GM. Solid-cystic tumor of the
pancreas. An extensive ultrastructural study of fourteen cases. J Submicrosc Cytol Pathol.
1995;27:331-340.
15.
Pelosi G, Iannucci A, Zamboni G, Bresaola E, Iacono C, Serio G. Solid and
cystic papillary neoplasm of the pancreas: a clinico- cytopathologic and
immunocytochemical study of five new cases diagnosed by fine-needle aspiration cytology
and a review of the literature. Diagn Cytopathol. 1995;13:233-246.
16.
Achille A, Biasi MO, Zamboni G et al. Chromosome 7q allelic losses in
pancreatic carcinoma. Cancer Res. 1996;56:3808-3813.
17.
Pea M, Martignoni G, Zamboni G, Bonetti F. Perivascular epithelioid cell. Am
J Surg Pathol. 1996;20:1149-1153.
18.
Pelosi G, Bresaola E, Bogina G, Zamboni G et al. Endocrine tumors of the
pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for
malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone
receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum
Pathol. 1996;27:1124-1134.
19.
Savio A, Franzin G, Wotherspoon AC, Zamboni G et al. Diagnosis and
posttreatment follow-up of Helicobacter pylori-positive gastric lymphoma of mucosaassociated lymphoid tissue: histology, polymerase chain reaction, or both? Blood.
1996;87:1255-1260.
20.
Zamboni G, Franzin G, Scarpa A et al. Carcinoma-like signet-ring cells in
gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Am J Surg Pathol.
1996;20:588-598.
21.
Zamboni G, Pea M, Martignoni G et al. Clear cell "sugar" tumor of the
pancreas. A novel member of the family of lesions characterized by the presence of
perivascular epithelioid cells. Am J Surg Pathol. 1996;20:722-730.
22.
Achille A, Biasi MO, Zamboni G et al. Cancers of the papilla of vater: mutator
phenotype is associated with good prognosis. Clin Cancer Res. 1997;3:1841-1847.
23.
Beghelli S, Pelosi G, Zamboni G et al. Pancreatic endocrine tumours:
evidence for a tumour suppressor pathogenesis and for a tumour suppressor gene on
chromosome 17p. J Pathol. 1998;186:41-50.
24.
Scarpa A, Zamboni G. Genomic anomalies in pancreatic tumors other than
common adenocarcinoma. Ann N Y Acad Sci. 1999;880:179-190.
25.
Zamboni G, Lanza G, Risio M. [Colorectal adenoma-carcinoma. Guidelines
and minimal diagnostic criteria. Italian Group for Pathology of the Digestive System].
Pathologica. 1999;91:286-294.
26.
Zamboni G, Scarpa A, Bogina G et al. Mucinous cystic tumors of the
pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic
tumors. Am J Surg Pathol. 1999;23:410-422.
27.
Bassi C, Procacci C, Zamboni G, Scarpa A, Cavallini G, Pederzoli P.
Intraductal papillary mucinous tumors of the pancreas. Verona University Pancreatic
Team. Int J Pancreatol. 2000;27:181-193.
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28.
Rigaud G, Moore PS, Zamboni G et al. Allelotype of pancreatic acinar cell
carcinoma. Int J Cancer. 2000;88:772-777.
29.
Savio A, Zamboni G, Capelli P et al. Relapse of low-grade gastric MALT
lymphoma after Helicobacter pylori eradication: true relapse or persistence? Long-term
post-treatment follow-up of a multicenter trial in the north-east of Italy and evaluation of the
diagnostic protocol's adequacy. Recent Results Cancer Res. 2000;156:116-124.
30.
Scarpa A, Di Pace C, Talamini G, Zamboni G et al. Cancer of the ampulla of
Vater: chromosome 17p allelic loss is associated with poor prognosis. Gut. 2000;46:842848.
31.
Zamboni G, Capelli P, Pesci A, Beghelli S, Luttges J, Kloppel G. Pancreatic
head mass: what can be done? Classification: the pathological point of view. Jop.
2000;1:77-84.
32.
Falconi M, Salvia R, Bassi C, Zamboni G, Talamini G, Pederzoli P.
Clinicopathological features and treatment of intraductal papillary mucinous tumour of the
pancreas. Br J Surg. 2001;88:376-381.
33.
Luttges J, Zamboni G, Longnecker D, Kloppel G. The immunohistochemical
mucin expression pattern distinguishes different types of intraductal papillary mucinous
neoplasms of the pancreas and determines their relationship to mucinous noncystic
carcinoma and ductal adenocarcinoma. Am J Surg Pathol. 2001;25:942-948.
34.
Moore PS, Zamboni G, Brighenti A et al. Molecular characterization of
pancreatic serous microcystic adenomas: evidence for a tumor suppressor gene on
chromosome 10q. Am J Pathol. 2001;158:317-321.
35.
Zamboni G, Terris B, Scarpa A et al. Acinar cell cystadenoma of the
pancreas: a new entity? Am J Surg Pathol. 2002;26:698-704.
36.
Kloppel G, Luttges J, Lohr M, Zamboni G, Longnecker D. Autoimmune
pancreatitis: pathological, clinical, and immunological features. Pancreas. 2003;27:14-19.
37.
Adsay NV, Zamboni G. Paraduodenal pancreatitis: a clinico-pathologically
distinct entity unifying "cystic dystrophy of heterotopic pancreas", "para-duodenal wall
cyst", and "groove pancreatitis". Semin Diagn Pathol. 2004;21:247-254.
38.
Barbareschi M, Roldo C, Zamboni G et al. CDX-2 homeobox gene product
expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine
tumors. Am J Surg Pathol. 2004;28:1169-1176.
39.
Zamboni G, Luttges J, Capelli P et al. Histopathological features of
diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection
specimens and 9 biopsy specimens. Virchows Arch. 2004;445:552-563.
40.
Kloppel G, Luttges J, Sipos B, Capelli P, Zamboni G. Autoimmune
pancreatitis: pathological findings. Jop. 2005;6:97-101.
41.
Longnecker DS, Adsay NV, Fernandez-del Castillo C, Zamboni G et al.
Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillarymucinous neoplasms: interobserver agreement. Pancreas. 2005;31:344-349.
42.
Sorio C, Capelli P, Lissandrini D, Zamboni G et al. Mucinous cystic
carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Virchows Arch. 2005;446:239-245.
43.
Singh R, Basturk O, Klimstra DS, Zamboni G et al. Lipid-rich variant of
pancreatic endocrine neoplasms. Am J Surg Pathol. 2006;30:194-200.
44.
Talamini G, Zamboni G, Salvia R et al. Intraductal papillary mucinous
neoplasms and chronic pancreatitis. Pancreatology. 2006;6:626-634.
45.
Basturk O, Zamboni G, Klimstra DS et al. Intraductal and papillary variants of
acinar cell carcinomas: a new addition to the challenging differential diagnosis of
intraductal neoplasms. Am J Surg Pathol. 2007;31:363-370.
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46.
Iacono C, Verlato G, Zamboni G et al. Adenocarcinoma of the ampulla of
Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are
relevant prognostic factors. J Gastrointest Surg. 2007;11:578-588.
47.
Kloppel G, Sipos B, Zamboni G, Kojima M, Morohoshi T. Autoimmune
pancreatitis: histo- and immunopathological features. J Gastroenterol. 2007;42 Suppl
18:28-31.
48.
Kojima M, Sipos B, Klapper W, Zamboni G et al. Autoimmune pancreatitis:
frequency, IgG4 expression, and clonality of T and B cells. Am J Surg Pathol.
2007;31:521-528.
49.
Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F. Perivascular
epithelioid cell tumor (PEComa) in the genitourinary tract. Adv Anat Pathol. 2007;14:36-41.
50.
Crippa S, Salvia R, Warshaw AL, Zamboni G et al. Mucinous cystic
neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients.
Ann Surg. 2008;247:571-579.
51.
Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F. PEComas: the
past, the present and the future. Virchows Arch. 2008;452:119-132.
52.
Casetti L, Bassi C, Salvia R, Butturini G, Graziani R, Falconi M, Frulloni L,
Crippa S, Zamboni G, Pederzoli, P. "Paraduodenal" Pancreatitis: Results of Surgery on
58 Consecutives Patients from a Single Institution. World J Surg. 2009.
53.
Frulloni L, Scattolini C, Falconi M, Zamboni G, Capelli P, Manfredi R,
Graziani R, D'Onofrio M, Katsotourchi AM,Amodio A, Benini L, Vantini I. Autoimmune
pancreatitis: differences between the focal and diffuse forms in 87 patients. Am J
Gastroenterol. 2009;104:2288-2294.
54.
Hruban RH, Zamboni G. Pancreatic cancer. Special issue--insights and
controversies in pancreatic pathology. Arch Pathol Lab Med. 2009;133:347-349.
55.
Zamboni G, Capelli P, Scarpa A, Bogina G, Pesci A, Brunello E, Kloppel G.
Nonneoplastic mimickers of pancreatic neoplasms. Arch Pathol Lab Med. 2009;133:439453.
56.
Basturk O, Khayyata S, Klimstra DS, Hruban RH, Zamboni G, Coban I,
Adsay NV. Preferential Expression of MUC6 in Oncocytic and Pancreatobiliary Types of
Intraductal Papillary Neoplasms Highlights a Pyloropancreatic Pathway, Distinct From the
Intestinal Pathway, in Pancreatic Carcinogenesis. Am J Surg Pathol. 2010;34:364-370.
57.
Martignoni G, Pea M, Reghellin D, Gobbo S, Zamboni G, Chilosi M, Bonetti
F. Molecular pathology of lymphangioleiomyomatosis and other perivascular epithelioid
cell tumors. Arch Pathol Lab Med. 2010;134:33-40.
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