CENTRE FOR INNOVATIONS IN
BIOMEDICAL, HEALTH AND
BEHAVIOURAL SCIENCES
Newsletter 1
OCTOBER 2006
News:
Dr Mark Slevin has received £4,000 from
Pat Soc GB for visiting Fellowship to ICCC,
Barcelona.
Professor Bill Gilmore took up his position
as Head of School in Biology, Chemistry
and Health Sciences. Bill has come from a
5* rated Biomedical Science Research
Centre in Ulster and brings with him
expertise in nutrition and haematological
research.
Funded projects
Dr Valerie Edwards-Jones was awarded
£16,500 by Smith and Nephew Healthcare
for a part-time studentship investigating
‘the
antimicrobial
effects
of
silver
dressings’.
Professor Andrew Fox from the Health
Protection
Agency
was
awarded
a
fractional position (0.2WTE) as Professor
of Biomedical Science
Submitted bids awaiting decision
In July 2005, Dr Keith Tolfrey was
successful with his application for a
Readership in Paediatric Physiology and Dr
Mark Slevin gained a Senior Research
Fellowship.
Dr V Edwards-Jones and Professor Andrew
Fox are collaborators on a £1m bid driven
by Dr Sarah O’Brien (University of
Manchester) and all Greater Manchester
Trusts to investigate the beneficial effects
of probiotics against Clostridium difficile.
Dr Pat Kumar has been invited to speak
on PAX3 and Cancer at the Indian Cancer
Association International Conference in
Bubaneswar, India, Jan 2007 and in the
5th International Congress for Molecular
Medicine, Istanbul, Turkey, April 2007.
Dr Valerie Edwards-Jones is a collaborator
on a diabetic UK bid (£98,000) to
determine the best method of eradicating
MRSA from diabetic foot ulcers.
Dr Valerie Edwards-Jones has submitted a
£6000 bid to the Royal Society to help
strengthen links with the Agricultural
Department, University of Uzbekistan.
This follows the visit of a research fellow
from that department on a £5000
From September 2006, Dr Paul Holmes
will be representing RIHSC at MMU
Cheshire. Paul will be based at both
Alsager and Crewe sites in ESS and IDS
respectively
1
overseas fellowship awarded by The
Society for Applied Microbiology to Dr
Edwards-Jones.
of patella position 10th International
Meeting of
the Patellofemoral Study Group, Boston,
May
The Psychology and Stroke Research
Group (PSRG) at MMU Cheshire are
continuing to develop their bid for funding
to
explore
valid
neuropsychological
approaches to rehabilitation. Recent
collaborations with colleagues at Keele
University should strengthen their work.
Herrington, L., McEwan, I., Thom, J.
(2006). The quantification of patella
position by Ultrasound scanning and its
criterion validity 10th International
Meeting of the Patellofemoral Study
Group, Boston, May
Herrington, L., McEwan, I., Thom J.
(2005). The reliability and validity of a
clinical measure of medial/lateral position
of the patella 3rd International Conference
on Biomechanics of the lower limb in
Health Disease and Rehabilitation, Salford,
September
Dr Mark Slevin has submitted an
application to Wellcome Trust project
grant £250,000, about the role of Cdk5
and stroke.
Dr Mark Slevin has applied for a BBVA
Chair
in
Biomedicine
12
month
appointment (Madrid, Spain)
Finn, J., Hayman, R., & Holmes, P.
(2006). Cardiorespiratory functional
equivalence during execusion and
observation of running: An exploratory
investigation. BASES Annual Conference,
September.
Drs Tolfrey, Smith and Holmes have
submitted a bid for a Research Assistant
to support their planned work in paediatric
health.
Hackney, M., & Sherlock, P. (2006).
Digging their way out of a black
hole:women's accounts of postnatal
depression Marce Biennial Scientific
International Conference Keele UK, 12-15
September.
Conferences/invited talks
(2005-2006)
The MMU Cheshire Psychology Group had a
strong presence at the BPS Annual
Conference in Cardiff. Nick’s poster with
Mark Wilson was awarded the BPS Best
Poster Award:
Sherlock, P. & Hackney, M. (2006).
Casting a different shadow: telling the
story of productive depression Mixed
Methods Conference Cambridge, 9-11
July.
Wilson, M & Smith, N C (2006). Are codrivers a help or a hindrance? The influence
of co-driver information on performance and
mental effort during simulated rally driving.
Abstracts of the British Psychological
Society’s Annual Conference 2006, 93.
Edwards-Jones V (Jan 2006) The use of
MALDI-TOF-MS as a rapid identification
tool, Berlin, Germany
Smith, N C & Howard, C L (2006). Coping
behaviour during pre-parachute selection.
Abstracts of the British Psychological
Society’s Annual Conference 2006, 94.
Edwards-Jones V ( 2006)The
antimicrobial effect of silver , Wound
Infection Summer School, Oxford
Edwards-Jones V (2006) Alternative
Antimicrobial Therapies, Institute of
Biomedical Sciences Discussion forum,
Sheffield
Smith, N C, Gregg, V & Barber, P (2006).
The attentional characteristics of Type A and
Type B individuals. Abstracts of the British
Psychological Society’s Annual Conference
2006, 41.
Edwards-Jones V (2006) Wound
Management Microbe 2006, Sheffield
Herrington, L., McEwan, I. Thom, J.
(2006). The validity of a clinical measure
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Doran A, Nelson, G, Harrison, I and
Edwards-Jones V 2006 The antimicrobial
effects of encapsulated essential oils
incorporated into plastics, Biosciences,
London
P and Slevin M (2006) A potential role
for Cdk5 in apoptotic events following
acute ischaemic stroke in man.
International Symposium on
Neurodegeneration and neuroprotection,
Munster, Germany meeting.
Doran A, Nelson, G, Harrison, I and
Edwards-Jones V 2006 The antimicrobial
effects of encapsulated essential oils
incorporated into plastics, SFAM,
Edinburgh
Mitsios N, Mitsios N, Pennucci R, Krupinski
J, Sanfeliu C, Gaffney J, Kumar S,
Kumar P and Slevin M (2006).
Expression of Cdk5 mRNA and protein in
the human brain following acute ischaemic
stroke. 10th Congress of the European
Federation of Neurological Societies,
Glasgow,UK.
Doran A, Nelson, G, Harrison, I and
Edwards-Jones V 2006 The antimicrobial
effects of encapsulated essential oils
incorporated into plastics, proceedings of
the Hospital Infection Society, Amsterdam
Mitsios N, Pennucci R, Krupinski J,
Sanfeliu C, Gaffney J, Kumar S, Kumar
P and Slevin M (2006) A potential role for
Cdk5 in apoptotic events following acute
ischaemic stroke in man. 14th
Euroconference on Apoptosis, Chia,
Sardinia,Italy.
Fox A; Lau S; Armstrong M; Bolton F;
Chessbrough J; Reddy S; Smith G;
Thornhill C; Livermore D; Woodford N;
Upton M (2006) The Molecular
Epidemiology of Multi-Resistant
Uropathogenic Escherichia coli I in
NorthWest England 11-13th September
University of Warwick, Health Protection
Slevin M, Gaffney J, Kumar P and
Kumar S (2005) Comparison of changes in
gene and protein regulation between
human and rat models of stroke:
Identification of novel 'human associated'
markers of inflammation and apoptosis.
Exp. Biol. ASBMB/FASEB
2005,(SanDiego,USA).
Fox A (2006) “Sequence typing for Real
Time Epidemiology”
Association of Clinical MicrobiologistsSleuthing in the 21st Century. Post
Graduate Centre, Manchester Royal
Infirmary
Mitsios N, Gaffney J, Krupinski J, Kumar
P, Kumar S and Slevin M (2005) Gene
and protein regulation after acute
ischaemic stroke in man. European Stroke
Association,(Bologna,Italy).
Wang Q, Fang C, Lillycrop KA, Kumar S,
Kumar P.Detecting Changes in Gene
Expression of a Neuroblastoma Cell Line
with PAX3 RNAi Transfection poster at UK
Molecular Biology of Cancer Network
meeting, Warwick University, Dec 2006.
Kumar P, Mitsios N, Gaffney J, Krupinski
J, Kumar S and Slevin M (2005) A
microarray study of gene expression in
human brain after ischaemic stroke.
Biritsh Neuropath Soc meeting, 2005,
(London,UK).(+poster).
Kumar P Poster at UK Molecular Biology
of Cancer Network meeting, Warwick
University, Dec 2006.
Kumar S, Kumar P and Slevin M (2005)
Angiogenesis,anti-angiogenesis.
International Congress of Molecular
Medicine 2005, (Istanbul, Turkey).
Slevin M (2006) Controlling the
angiogenic switch. Identification of key
pro and anti-angiogenic components
associated with disease development.
ICCC Centre D'Investigacio Cardiovascular
CSIS-ICCC, Barcelona,Spain.-Invited
Goff M, Slevin M and Bishop P (2005)
Opticin is an inhibitor of VEGF-A and FGF2-activated angiogenesis. British Microcirculation Society, Sheffield, UK.
Mitsios N, Pennucci R, Krupinski J,
Sanfeliu C, Gaffney J, Kumar S, Kumar
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case clusters. J Clin Microbiol. 43; 600714.
RIHSC conference
MMU Cheshire BHBS members contributed
to a very successful Annual RIHSC
conference held on 3 July 2006.
Davies S, Edwards-Jones V and Dowsett
D 2005 Management of wound infections J
Community Nursing
Paul Holmes and Louise Ewan presented
papers on behalf of the PSRG that
discussed the findings from work in stroke
rehabilitation.
Edwards-Jones V (2006) The
antimicrobial and barrier effects of silver
dressings against MRSA J Wound Care
15: 285-290
The PSRG will be submitting their findings
from a recent case study to the 2007
conference. Louise Ewan
(RIHSC/Physiotherapy funded PhD student)
will also present her data from the first
study of her PhD.
Edwards-Jones V Antimicrobial and
barrier effects of silver against methicillinresistant Staphylococcus aureus.J Wound
Care. 2006 Oct ; 15 (9); 418-420
Khojashteh, V., Foster, H.A., Childs C &
Edwards-Jones, V Epidemiological study
of S. aureus in a burns unit Burns 2006
(in press)
Chen M, Kumar S, Slevin M, Kumar P
Regulation of Desmosomes in EpithelialMesenchymal Transition. Oral presentation
at RIHSC conference in July 2006.
Edwards-Jones, V (2006) Toxic Shock
Syndrome: causes in burns wounds
Wounds UK (in press)
Taha, Muhammed-Kheir; Fox, Andrew
(2006)Quality assessed non-culture
techniques for detection and typing of
meningococci FEMS Microbiology
Reviews (In Press)
Published & in press articles,
books & chapters (2005- 2006)
Ahmed N (2005) Advanced glycation
endproducts--role in pathology of diabetic
complications Diabetes Res Clin Pract 67;
3-21
Fox, Andrew; Taha, Muhammed-Kheir;
Vogel, Ulrich (2006) Standardized nonculture techniques recommended for
European reference laboratories
FEMS Microbiology Reviews (in press)
Ahmad MS and Ahmed N (2006)
Antiglycation properties of aged garlic
extract: possible role in prevention of
diabetic complications J Nutr 136(3
):796S-799S
Best E; Fox AJ; Owen R; Cheesbrough;
Bolton FJ. (2006). Specific detection of
Campylobacter jejuni from faeces using
single nucleotide polymorphisms.
Epidemiol Infect. (In Press)
Jackson KA, Edwards-Jones V, Sutton
CW, Fox AJ. . 2005 Optimisation of intact
cell MALDI method for fingerprinting of
methicillin-resistant Staphylococcus
aureus. J Microbiol Methods; 62; :27384.
Jury F; Al-Mahrous M; Apostolou M;
Sandiford S; Fox A; Ollier W; Upton M.
(2006) Rapid cost-effective subtyping of
meticillin-resistant Staphylococcus aureus
by denaturing HPLC. J Med Microbiol.
55;1053-60
Birtles A, Hardy K, Gray SJ, Handford S,
Kaczmarski EB, Edwards-Jones V, Fox
AJ. 2005 Multilocus sequence typing of
Neisseria meningitidis directly from clinical
samples and application of the method to
the investigation of meningococcal disease
Sopwith W; Birtles A; Matthews M; Fox A;
Gee S; Regan M; Syed Q; Bolton E.2006.
Campylobacter jejuni Multilocus Sequence
Types in Humans, Northwest England,
4
2003-2004. Emerg Infect Dis. 12:10October
stroke in man. Brain.129, 2158-2176.
AlQteishat A, Gaffney J, West DA,
Krupinski J and Slevin M (2006)
Hyaluronan expression and metabolism
following middle cerebral artery occlusion
in the rat. Neuroreport. 17, 1111-1114
Krupinski J, Catena E, Miguel M,
Domenech P, Vila R, Morchon S, Rubio F,
Cairols M, Slevin M, and Badimon L
(2006) D-dimer expression is increased in
unstable atherosclerotic plaques from
patients with symptomatic carotid artery
disease: Clinical-pathological correlations.
Int. J. Cardiol. In Press.
Mitsios N, Gaffney J, Krupinski J, Kumar
S, Kumar P and Slevin M (2006) Novel
protein expression after ischaemic stroke:
Identification of new therapeutic
treatments. Pathobiology. In press
Slevin M, Elasabi A, Miguel-Turu M,
Krupinski J, Badimon L and Gaffney J
(2006) Identification of differential protein
expression associated with development
of unstable human carotid plaques. Am. J.
Pathol. 168: 1004-1021.
Wang QY, Kumar S, Slevin M and Kumar
P (2006) Functional Analysis of
Alternative Isoforms of the Transcription
Factor PAX3 in Melanocytes in vitro.
Cancer Res. 66, 8574-8580..
Mitsios N, Gaffney J, Kumar P, Kumar S
and Slevin M (2006) Apoptotic pathways
after ischaemic stroke. Cell Biochem.
Biophys. In press.
Slevin M, Matou S, Krupinski J, Savani
RC, Delisser HM, Gaffney J and Kumar S
(2006) Hyaluronan-mediated angiogenesis
in vascular disease: Uncovering RHAMM
and CD44 receptor signalling pathways.
Matrix Biol. In Press.
Krupinski J, Turu MM, Martinez-Gonzalez
J, Carvajal A, Juan-Babot JO, Iborra E,
Slevin M, Rubio F, Badimon L. (2006)
Endogenous Expression of C-Reactive
Protein Is Increased in Active (Ulcerated
Noncomplicated) Human Carotid Artery
Plaques. Stroke. 37, 1200-1204.
Mitsios N, Pennucci R, Sanfeliu C,
Krupinski J, Gaffney J, Kumar P, Kumar
S and Slevin M (2006) Over-expression
and activation of cyclin-dependent kinase5 following acute ischaemic stroke in man.
Brain. Pathol. In press.
Duraisamy Y, Slevin M, Gaffney J, Smith
C and Ahmed N (2006) Comparison of
aspirin, D-penicillamine and vitamin E to
protect against high glucose and advanced
glycation end product mediated toxicity in
cultured endothelial cells. Biochem.
Biophys. Acta. 1762, 551-557.
Mitsios N, Krupinski J, Miguel-Turu M,
Kumar P, Gaffney J, Kumar S and
Slevin M. Cellular prion protein is overexpressed after ischaemic stroke. J.
Neurol. Sci.. In press.
Wang QY, Mitsios N, Slevin M, Kumar S
and Kumar P (2006) Altered gene
expression in PAX-3 transfected mouse
myoblasts identified using gene
microarrays. Int. J. Cancer. In press.
Picihard V, Berthois Y, Roccabianca M,
Prevot C, Sarrazin M, Portugal H, Kumar
S, Kumar P, Rognoni JB.Concomitant cell
growth and differentiation are dependent
on erbB1 and integrin activation in an
autonomously surviving colon
adenocarcinoma: involvement of autocrine
amphiregulin secretion. Anticancer Res,
2006, 26, 2769-2783.
Slevin M, Kumar P, Gaffney J, Kumar S
and Krupinski J (2006) Can angiogenesis
be exploited to improve stroke outcome?
Mechanisms and therapeutic potential
Clin. Sci. 111, 171-183.
Mitsios N, Gaffney J, Krupinski J,
Matthias R, Heywood S, Rubio F, Kumar
P, Kumar S, Slevin M. (2006) Expression
of apoptotic proteins in human ischaemic
AlQteishat A, Gaffney J, Krupinski J, West
DA, Kumar P, Kumar S and Slevin M
(2006) Changes in hyaluronan production
and metabolism following ischaemic
5
stroke tissue. Cell Biochem Biophys,
(accepted for publication).
science. The Sport and Exercise Scientist,
3, 28-29.
Calmels, C, Holmes, P, Lopez, E, &
Naman, V. (2006). A Chronometric
Comparison of Actual and Imaged
Complex Movement Patterns: The
Influence of Imagery Perspective. Journal
of Motor Behavior, 38, 339-348.
Wilson, M., & Smith, N. C. (In Press). A
test of the predictions of processing
efficiency theory during elite team
competition using the Thought Occurrence
Questionnaire for Sport. International
Journal of Sport Psychology.
Calmels, C., Holmes, P. S., Jarry, G.,
Leveque, J-M, & Stam, C. J. (In press)
Cortical activity prior to, and during,
observation and execution of sequential
finger movements. Brain Topography.
Wilson, M., Smith, N. C., & Holmes, P.
S. (In Press). The role of effort in
influencing the effect of anxiety on
performance: Testing the conflicting
predictions of processing efficiency theory
and the conscious processing hypothesis.
British Journal of Psychology,98.
Calmels, C., Holmes, P., Jarry, G., Hars,
M., Lopez, E., Paillard, A., & Stam, C.J.
(2006). Variability of EEG synchronization
prior to, and during, observation and
execution of a sequential finger
movement. Human Brain Mapping, 27,
251-266.
Wilson, M., Smith, N. C., Chattington, M.,
Ford, M. & Marple-Horvat, D. E. (In
Press). The role of effort in moderating
the anxiety performance relationship :
Testing the predictions of processing
efficiency theory in simulated rally driving.
Journal of Sports Sciences, 24.
Holmes, P.S. (2005). The
psychophysiology of imagery in sport. In
E. Acevedo & P. Ekkekakis (Eds.), The
Psychobiology of physical activity (pp.
251-263). Champaign IL: Human Kinetics.
Hardaker, N.J., Moss, A.D., Richards, J.,
Jarvis, S., McEwan, I. & Selfe, J. (In
press) The relationship between skin
surface temperature measured via noncontact Thermal Imaging and intramuscular temperature of the Rectus
Femoris muscle. Thermology
International.
Holmes, P. S. (2006).Theoretical and
methodological problem for imagery in
stroke rehabilitation: An observation
solution. Rehabilitation Psychology, 58,
November 2006.
Visits
Holmes, P. S., Collins, D. J., & Calmels,
C. (2006). Electroencephalographic
functional equivalence during observation
of action. Journal of Sports Sciences, 24,
605-616.
Dr Claire Calmels visited the Department
of Exercise and Sport Science to continue
her work with Paul Holmes and the PSRG.
She also worked with Paul and Louise
Ewan developing a questionnaire to assess
motor observation ability.
Martin, J., Tolfrey, K., Smith, N. C. &
Jones, A. M. (2005). Heart rate response
of rugby union referees in the English
Premiership. Journal of Human Movement
Studies, 48, 211-225.
DR Dilfuza Egamberdivya from University
of Uzbekistan visited Valerie EdwardsJones to gain experience in testing the
antimicrobial effects of natural products.
McEwan, I., Herrington, L., & Thom, J.
(In press). The validity of a clinical
measure of patella position. Manual
Therapy
Successful MSc / PhD completions
/Student achievements
Congratulations to:
Smith, N. C. & Moore, P. (2005, March).
Evaluating practice in sport and exercise
6
Dr Andrew Birtles (PhD student of Dr
Val Edwards-Jones and Professor Andrew
Fox obtained his PhD entitled ‘non-culture
typing of N. meningitidis and S.
pneumoniae using MLST’
Mr Minche Chen won 3rd prize for his oral
presentation at the John Dalton Faculty
Postgraduate Students Conference in July
2006.
New Student enrolment:
Mr Sami-Al-Baba (supervisors V
Edwards-Jones, Andrew Fox and Alison
Cottell)
MPhil/PhD entitled molecular typng of P.
aeruginosa
Mr Steve Davies (supervisors V
Edwards-Jones, Andrew Fox and Emma
Woodmansey) MPhil/PhD entitled
antimicrobial effect of sliver dressings.
Mr Minche Chen transferred from
Manchester university in Sept 2005. PhD
FT
Mr C Fang commenced Oct 2005. PhD FT
Contacts:
MMU All Saints
Dr Nessar Ahmed n.ahmed@mmu.ac.uk
Professor Andrew Fox andrew.fox@hpa.org.uk
Dr Maureen Dawson m.m.dawson@mmu.ac.uk
Dr Val Edwards-Jones v.e.jones@mmu.ac.uk
Dr John Gaffney j.gaffney@mmu.ac.uk
Professor Bill Gilmore b.gilmore@mmu.ac.uk
Dr Pat Kumar p.kumar@mmu.ac.uk
Dr Mark Slevin m.a.slevin@mmuac.uk
Dr John Stirling j.stirling@mmu.ac.uk
MMU Cheshire
Dr Paul Holmes: p.s.holmes@mmu.ac.uk
Dr Nick Smith: n.c.smith@mmu.ac.uk
Dr Keith Tolfrey: k.tolfrey@mmu.ac.uk
Ms Islay McEwan: i.mcewan@mmu.ac.uk
Louise Ewan: l.m.ewan@mmu.ac.uk
Ms Marilyn Hackney: m.hackney@mmu.ac.uk
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