Gynaecologic Oncology
November 2014
This bulletin covers aspects of gynaecological cancers and should be of interest to multidisciplinary
teams working in this area.
Sections can include:
 Combined Modality Therapies
 Drug Therapy
 Pathology, Staging, Polymorphisms & Biomarkers
 Prognosis, Survival & Risk Factors
 Radiotherapy & Imaging
 Supportive Care & Symptom Management
 Surgery
Many of the following articles are available online via the NHS Scotland Knowledge Network.
Please use the links where provided and your ATHENS password. A complete list of
available online journals and registration for ATHENS can be found at
www.knowledge.scot.nhs.uk/
If the article you require is not available via the NHS Scotland Knowledge Network and you
would like to request a print copy, please submit your request online at
www.quest.scot.nhs.uk
This bulletin contains a selection of material gathered from a search of the evidence base, and is
not intended to be comprehensive. Professional judgment should be exercised when appraising
the material. The Library takes no responsibility for the wording, content and accuracy of the
information supplied, which has been extracted in good faith from reputable sources. NHSGGC is
not responsible for the content of external internet sites.
Compiled by:
Kirsty Coltart
Subject Librarian
Beatson West of Scotland Cancer Centre
0141 301 7285, kirsty.coltart@ggc.scot.nhs.uk
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General
Amant, F., Floquet, A., Friedlander, M., et al. (2014). Gynecologic Cancer InterGroup (GCIG)
Consensus Review for Endometrial Stromal Sarcoma. International Journal of Gynecological
Cancer 24,9 Suppl 3:S67-72.
Berton-Rigaud, D., Devouassoux-Shisheboran, M., Ledermann, J.A., et al. (2014). Gynecologic
Cancer InterGroup (GCIG) Consensus Review for Uterine and Ovarian Carcinosarcoma.
International Journal of Gynecological Cancer 24,9 Suppl 3:S55-60.
Blake, E.A., Sheridan, T.B., Wang, K.L., et al. (2014). Clinical characteristics and outcomes
of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review
of literature. European Journal of Obstetrics, Gynecology, & Reproductive Biology 181,163170.
Brown, J., Friedlander, M., Backes, F.J., et al. (2014). Gynecologic Cancer Intergroup (GCIG)
Consensus Review for Ovarian Germ Cell Tumors. International Journal of Gynecological
Cancer 24,9 Suppl 3:S48-54.
Dizon, D.S., Mackay, H.J., Thomas, G.M., et al. (2014). State of the science in cervical
cancer: where we are today and where we need to go. Cancer 120,15:2282-2288.
Healthcare Improvement Scotland. Endometrial Cancer Quality Performance Indicators
(Oct 2014)
Healthcare Improvement Scotland. Cervical Cancer Quality Performance Indicators. (Oct 2014)
Khalique, S., Hook, J.M. and Ledermann, J.A. (2014). Maintenance therapy in ovarian
cancer. Current opinion in oncology 26,5:521-528.
Ledermann, J.A., Luvero, D., Shafer, A., et al. (2014). Gynecologic Cancer InterGroup (GCIG)
Consensus Review for Mucinous Ovarian Carcinoma. International Journal of Gynecological
Cancer 24,9 Suppl 3:S14-9.
Manders, D.B., Paulsen, A., Richardson, D.L., et al. (2014). Factors associated with clinical
trial screening failures in gynecologic oncology. Gynecologic oncology 134,3:450-454.
Okamoto, A., Glasspool, R.M., Mabuchi, S., et al. (2014). Gynecologic Cancer InterGroup
(GCIG) Consensus Review for Clear Cell Carcinoma of the Ovary. International Journal of
Gynecological Cancer 24,9 Suppl 3:S20-5.
Pautier, P., Ji Nam, E., Provencher, D.M., et al. (2014). Gynecologic Cancer InterGroup
(GCIG) Consensus Review for High-Grade Undifferentiated Sarcomas of the Uterus.
International Journal of Gynecological Cancer 24,9 Suppl 3:S73-7.
Combined Modality Therapies
Cho, H., Nam, B.H., Kim, S.M., et al. (2014). A phase 2 trial of radiation therapy with
concurrent paclitaxel chemotherapy after surgery in patients with high-risk endometrial
cancer: a Korean Gynecologic Oncologic Group study. International journal of radiation
oncology, biology, physics 90,1:140-146.
Hawkes, A.L., Quinn, M., Gebski, V., et al. (2014). Improving treatment for obese women
with early stage cancer of the uterus: rationale and design of the levonorgestrel
intrauterine device + metformin + weight loss in endometrial cancer (feMME) trial.
Contemporary Clinical Trials 39,1:14-21.
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Sehouli, J., Reinthaller, A., Marth, C., et al. (2014). Intra- and postoperative catumaxomab in
patients with epithelial ovarian cancer: safety and two-year efficacy results from a
multicentre, single-arm, phase II study. British journal of cancer 111,8:1519-1525.
Drug & Targeted Therapy
Castonguay, V., Lheureux, S., Welch, S., et al. (2014). A phase II trial of sunitinib in women
with metastatic or recurrent endometrial carcinoma: a study of the Princess Margaret,
Chicago and California Consortia. Gynecologic oncology 134,2:274-280.
du Bois, A., Floquet, A., Kim, J.W., et al. (2014). Incorporation of pazopanib in maintenance
therapy of ovarian cancer. Journal of Clinical Oncology 32,30:3374-3382.
Eisenhauer, E.L., Zanagnolo, V., Cohn, D.E., et al. (2014). A phase II study of gemcitabine,
carboplatin and bevacizumab for the treatment of platinum-sensitive recurrent ovarian
cancer. Gynecologic oncology 134,2:262-266.
Eskander, R.N. and Tewari, K.S. (2014). Targeting angiogenesis in advanced cervical
cancer. Therapeutic Advances in Medical Oncology 6,6:280-292.
Falandry, C., Krakowski, I., Cure, H., et al. (2014). Granulocyte-colony-stimulating factor in
elderly patients receiving chemotherapy for breast and gynaecological cancers: results
of a French survey. Anticancer Research 34,9:5007-5015.
Falci, C., Dieci, M.V., Guarneri, V., et al. (2014). Maintenance therapy in epithelial ovarian
cancer: from chemotherapy to targeted agents. Expert Review of Anticancer Therapy
14,9:1041-1050.
Grosso, G., Rossetti, D., Coccolini, F., et al. (2014). Intraperitoneal chemotherapy in
advanced epithelial ovarian cancer: a survey. Archives of Gynecology & Obstetrics
290,3:425-434.
Gubbi, A., Kendrick, J.E. and Finkler, N.J. (2014). The role of bevacizumab in recurrent,
platinum-sensitive ovarian cancer. Expert Review of Anticancer Therapy 14,10:1105-1113.
He, L., Wu, L., Su, G., et al. (2014). The efficacy of neoadjuvant chemotherapy in different
histological types of cervical cancer. Gynecologic oncology 134,2:419-425.
Leffers, N., Daemen, T., Helfrich, W., et al. (2014). Antigen-specific active immunotherapy
for ovarian cancer. Cochrane Database of Systematic Reviews 9,007287.
Liu, J.F., Barry, W.T., Birrer, M., et al. (2014). Combination cediranib and olaparib versus
olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised
phase 2 study. Lancet Oncology 15,11:1207-1214.
McNeish, I.A., Ledermann, J.A., Webber, L., et al. (2014). A randomised, placebo-controlled
trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian,
fallopian tube or primary peritoneal cancer+. Annals of Oncology 25,10:1988-1995.
Miller, D.S., Blessing, J.A., Ramondetta, L.M., et al. (2014). Pemetrexed and cisplatin for the
treatment of advanced, persistent, or recurrent carcinoma of the cervix: a limited access
phase II trial of the gynecologic oncology group. Journal of Clinical Oncology 32,25:27442749.
Penson, R.T., Moore, K.M., Fleming, G.F., et al. (2014). A phase II study of ramucirumab
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(IMC-1121B) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or
primary peritoneal carcinoma. Gynecologic oncology 134,3:478-485.
Powell, M.A., Sill, M.W., Goodfellow, P.J., et al. (2014). A phase II trial of brivanib in
recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology
Group Study. Gynecologic oncology 135,1:38-43.
Sato, S. and Itamochi, H. (2014). Neoadjuvant chemotherapy in advanced ovarian cancer:
latest results and place in therapy. Therapeutic Advances in Medical Oncology 6,6:293-304.
Selle, F., Sevin, E., Ray-Coquard, I., et al. (2014). A phase II study of lenalidomide in
platinum-sensitive recurrent ovarian carcinoma. Annals of Oncology 25,11:2191-2196.
van der Burg, M.E., Onstenk, W., Boere, I.A., et al. (2014). Long-term results of a
randomised phase III trial of weekly versus three-weekly paclitaxel/platinum induction
therapy followed by standard or extended three-weekly paclitaxel/platinum in European
patients with advanced epithelial ovarian cancer. European journal of cancer 50,15:25922601.
Zsiros, E., Tanyi, J., Balint, K., et al. (2014). Immunotherapy for ovarian cancer: recent
advances and perspectives. Current opinion in oncology 26,5:492-500.
Pathology, Staging, Polymorphisms & Biomarkers
Bosse, T., Nout, R.A., Stelloo, E., et al. (2014). L1 cell adhesion molecule is a strong
predictor for distant recurrence and overall survival in early stage endometrial cancer:
pooled PORTEC trial results. European journal of cancer 50,15:2602-2610.
Chao, W.R., Lee, M.Y., Lin, W.L., et al. (2014). Assessing the HER2 status in mucinous
epithelial ovarian cancer on the basis of the 2013 ASCO/CAP guideline update. American
Journal of Surgical Pathology 38,9:1227-1234.
Colon, E. and Carlson, J.W. (2014). Evaluation of the fallopian tubes after neoadjuvant
chemotherapy: persistence of serous tubal intraepithelial carcinoma. International Journal
of Gynecological Pathology 33,5:463-469.
Laskov, I., Drudi, L., Beauchamp, M.C., et al. (2014). Anti-diabetic doses of metformin
decrease proliferation markers in tumors of patients with endometrial cancer. Gynecologic
oncology 134,3:607-614.
Piovano, E., Attamante, L., Macchi, C., et al. (2014). The role of HE4 in ovarian cancer
follow-up: a review. International Journal of Gynecological Cancer 24,8:1359-1365.
Sherman, M.E., Piedmonte, M., Mai, P.L., et al. (2014). Pathologic findings at risk-reducing
salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG0199. Journal of Clinical Oncology 32,29:3275-3283.
Testa, A., Kaijser, J., Wynants, L., et al. (2014). Strategies to diagnose ovarian cancer: new
evidence from phase 3 of the multicentre international IOTA study. British journal of cancer
111,4:680-688.
Tian, C., Sargent, D.J., Krivak, T.C., et al. (2014). Evaluation of a chemoresponse assay as a
predictive marker in the treatment of recurrent ovarian cancer: further analysis of a
prospective study. British journal of cancer 111,5:843-850.
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Van Calster, B., Van Hoorde, K., Valentin, L., et al. (2014). Evaluating the risk of ovarian
cancer before surgery using the ADNEX model to differentiate between benign,
borderline, early and advanced stage invasive, and secondary metastatic tumours:
prospective multicentre diagnostic study. BMJ 349,g5920.
Wik, E., Trovik, J., Kusonmano, K., et al. (2014). Endometrial Carcinoma Recurrence Score
(ECARS) validates to identify aggressive disease and associates with markers of
epithelial-mesenchymal transition and PI3K alterations. Gynecologic oncology 134,3:599606.
Prognosis, Survival & Risk Factors
Abdel-Rahman, M.E., Butler, J., Sydes, M.R., et al. (2014). No socioeconomic inequalities in
ovarian cancer survival within two randomised clinical trials. British journal of cancer
111,3:589-597.
Cao, S., Gan, Y., Dong, X., et al. (2014). Herpes simplex virus type 2 and the risk of cervical
cancer: a meta-analysis of observational studies. Archives of Gynecology & Obstetrics
290,6:1059-1066.
Clarke, T., Galaal, K., Bryant, A., et al. (2014). Evaluation of follow-up strategies for patients
with epithelial ovarian cancer following completion of primary treatment. Cochrane
Database of Systematic Reviews 9,006119.
Hsu, K.F., Chou, H.H., Huang, C.Y., et al. (2014). Prognostic factors and treatment
outcomes for patients with surgically staged uterine clear cell carcinoma focusing on the
early stage: A Taiwanese Gynecologic Oncology Group study. Gynecologic oncology
134,3:516-522.
Lim, A.W., Ramirez, A.J., Hamilton, W., et al. (2014). Delays in diagnosis of young females
with symptomatic cervical cancer in England: an interview-based study. British Journal of
General Practice 64,627:e602-10.
Slipicevic, A., Holth, A., Hellesylt, E., et al. (2014). Wee1 is a novel independent prognostic
marker of poor survival in post-chemotherapy ovarian carcinoma effusions. Gynecologic
oncology 135,1:118-124.
Radiotherapy & Imaging
Bagshaw, H.P., Pappas, L.M., Kepka, D.L., et al. (2014). Patterns of care with brachytherapy
for cervical cancer. International Journal of Gynecological Cancer 24,9:1659-1664.
Ding, X.P., Feng, L. and Ma, L. (2014). Diagnosis of recurrent uterine cervical cancer: PET
versus PET/CT: a systematic review and meta-analysis. Archives of Gynecology &
Obstetrics 290,4:741-747.
Eldredge-Hindy, H.B., Eastwick, G., Anne, P.R., et al. (2014). Adjuvant vaginal cuff
brachytherapy for high-risk, early stage endometrial cancer. Journal of Contemporary
Brachytherapy 6,3:262-270.
Gemer, O., Eitan, R., Gdalevich, M., et al. (2014). Integration of PET/CT into the preoperative
evaluation of patients with early cervical cancer does not decrease the proportion of
patients with positive lymph nodes found after surgery. International Journal of
Gynecological Cancer 24,8:1461-1465.
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Heijkoop, S.T., Langerak, T.R., Quint, S., et al. (2014). Clinical Implementation of an Online
Adaptive Plan-of-the-Day Protocol for Nonrigid Motion Management in Locally Advanced
Cervical Cancer IMRT. International journal of radiation oncology, biology, physics 90,3:673679.
Liu, R., Wang, X., Tian, J.H., et al. (2014). High dose rate versus low dose rate intracavity
brachytherapy for locally advanced uterine cervix cancer. Cochrane Database of
Systematic Reviews 10,007563.
Lorusso, D., Sarno, I., Di Donato, V., et al. (2014). Is postoperative computed tomography
evaluation a prognostic indicator in patients with optimally debulked advanced ovarian
cancer?. Oncology 87,5:293-299.
Nunes, N., Ambler, G., Foo, X., et al. (2014). Use of IOTA simple rules for diagnosis of
ovarian cancer: meta-analysis. Ultrasound in Obstetrics & Gynecology 44,5:503-514.
Viswanathan, A.N., Erickson, B., Gaffney, D.K., et al. (2014). Comparison and Consensus
Guidelines for Delineation of Clinical Target Volume for CT- and MR-Based
Brachytherapy in Locally Advanced Cervical Cancer. International journal of radiation
oncology, biology, physics 90,2:320-328.
Supportive Care & Symptom Management
Barrett, J., Jenkins, V., Farewell, V., et al. (2014). Psychological morbidity associated with
ovarian cancer screening: results from more than 23,000 women in the randomised trial
of ovarian cancer screening (UKCTOCS). BJOG: An International Journal of Obstetrics &
Gynaecology 121,9:1071-1079.
Berek, J.S., Edwards, R.P., Parker, L.P., et al. (2014). Catumaxomab for the Treatment of
Malignant Ascites in Patients With Chemotherapy-Refractory Ovarian Cancer: A Phase II
Study. International Journal of Gynecological Cancer 24,9:1583-1589.
Goerling, U., Jaeger, C., Walz, A., et al. (2014). The efficacy of short-term psychooncological interventions for women with gynaecological cancer: a randomized study.
Oncology 87,2:114-124.
Holt, K.A., Hansen, H.P. and Mogensen, O. (2014). Supportive care needs for women with
gynecological cancer and their relatives during the prediagnostic period. Cancer nursing
37,6:457-467.
Joly F. McAlpine J. Nout R. Avall-Lundqvist E. Shash E. Friedlander M. Gynaecologic Cancer
InterGroup (GCIG). (2014). Quality of life and patient-reported outcomes in endometrial
cancer clinical trials: a call for action!. International Journal of Gynecological Cancer
24,9:1693-1699.
Mirabeau-Beale, K.L. and Viswanathan, A.N. (2014). Quality of life (QOL) in women treated
for gynecologic malignancies with radiation therapy: a literature review of patientreported outcomes. Gynecologic oncology 134,2:403-409.
Teng, F.F., Kalloger, S.E., Brotto, L., et al. (2014). Determinants of quality of life in ovarian
cancer survivors: a pilot study. Journal of Obstetrics & Gynaecology Canada: JOGC
36,8:708-715.
Ye, S., Yang, J., Cao, D., et al. (2014). A systematic review of quality of life and sexual
function of patients with cervical cancer after treatment. International Journal of
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Gynecological Cancer 24,7:1146-1157.
Surgery
Bogani, G., Cromi, A., Serati, M., et al. (2014). Laparoscopic and open abdominal staging
for early-stage ovarian cancer: our experience, systematic review, and meta-analysis of
comparative studies. International Journal of Gynecological Cancer 24,7:1241-1249.
Mitamura, T., Watari, H., Todo, Y., et al. (2014). Lymphadenectomy can be omitted for lowrisk endometrial cancer based on preoperative assessments. Journal of Gynecologic
Oncology 25,4:301-305.
Neff, R., McCann, G.A., Carpenter, K.M., et al. (2014). Is bariatric surgery an option for
women with gynecologic cancer? Examining weight loss counseling practices and
training among gynecologic oncology providers. Gynecologic oncology 134,3:540-545.
Suidan, R.S., Ramirez, P.T., Sarasohn, D.M., et al. (2014). A multicenter prospective trial
evaluating the ability of preoperative computed tomography scan and serum CA-125 to
predict suboptimal cytoreduction at primary debulking surgery for advanced ovarian,
fallopian tube, and peritoneal cancer. Gynecologic oncology 134,3:455-461.
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Sources used for this bulletin: OVID databases
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