Вводная фраза: - 7. Rámcový program

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PROPOSAL FOR FP7 PROGRAM
Federal Research and Clinical Centre of Pediatric Hematology, Oncology and
Immunology (FRC-PHOI)
Leninsky Prospect, 117, Moscow 117513, Russia
mmaschan@yandex.ru
Calls INFRA-2007-2.2.1.15, INFRA-2007-2.2.1.16, INFRA-2007-2.2.1.18
Keynote Personnel:
Rumiantsev Alexander MD, PhD, Director of the center, professor of pediatrics,
Russian State Medical University, author of more than 300 publications in the field of
pediatrics, hematology/oncology, immunology.
Maschan Alexei MD, PhD, deputy director of the center, professor of pediatrics,
Russian State Medical University, author of more than 100 publications in the field of
pediatric hematology/oncology.
Maschan Michael, MD, head of hematology department, Russian Children’s Clinical
Hospital, assistant professor of pediatric hematology, Russian State Medical University
BACKGROUND
Federal Research and Clinical Centre of Pediatric Hematology, Oncology and
Immunology (FRC-PHOI) is the leading research and clinical facility in Russia.
Established 1991 as Research Institute of Pediatric Hematology on the base of the
largest national teaching hospital (Russian Children’s Clinical Hospital), it has grown up
into most important organization in the field of pediatric cancer in Russia. The clinical
branch of the centre incorporates 10 departments of pediatric and adolescent
hematology, oncology and immunology of 5 major hospitals of Moscow region.
In 2005 the preparatory phase for the construction of the new clinical and
laboratory complex has been started. With over 200 specialized hematology / oncology
beds and advanced laboratories equipped according to GMP standard it will become
one of the largest state-of-the-art pediatric cancer facilities worldwide. At the present
time the Centre provides comprehensive care for over 500 new patients from all over
Russia per year thus collecting unique clinical and laboratory data on vast range of
pediatric malignant and non-malignant diseases.
FRC-PHOI currently coordinates research and clinical efforts of pediatric cancer
departments in 80 regions of the country, which forms a unique base for conducting
multi-center clinical trials. Due to large referral area encompassing the whole country
our institution is able to gather information on rare cancers, inherited immune and
metabolic disorders and bone marrow failure syndromes on large groups of patients,
which is not always possible in this scale at single centers in Europe.
The clinical care and research are focused on development and implementation
of new protocols of hematopoetic stem cell transplantation, chemo- and radiation
therapy. The pediatric bone marrow transplantation program of our institution is at
present the largest in Russia, doing both related and unrelated transplants. After
bringing into the operation of the new complex hosting modern BMT units, it will be able
to make up to 300 transplants per year.
IMPACT FORESEEN

This center will build the basis for the national registry of unrelated bone marrow
donors, which would improve the quality of the European donor pool by adding
donors of different ethnic background.

Already possessing an own steadily growing bio-bank for rare diseases, FRCPHOI is going to become the foundation for the national human blood and tumor
tissue bank.

FRC-PHOI is a major platform for clinical trials, including phase III trials
obligatory for registration of new pharmaceutical compounds and diagnostic
techniques for pediatric use.
Founding on these advantages the Centre is a good platform and a promising partner
for participation in such projects of the ESFRI Roadmap as EATRIS (INFRA-20072.2.1.15), European Bio-Banking and Biomolecular Resourses (INFRA-2007-2.2.1.16)
and Infrastructures for Clinical Trials and Biotherapy (INFRA-2007-2.2.1.18).
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