Dr.ssa Claudia Ferrier-Guerra Pagina 1 Rev 008 12.02.2016 PERSONAL DETAILS Family Name Ferrier-Guerra Given names Claudia Paola Nationality Swiss Languages: Italian (mothertongue), English, French, German CONTACT Phone: +41 91 950 91 85 Fax: +41 91 950 91 89 E-Mail: ferrier-guerra@bluewin.ch DEGREES AND PROFESSIONAL QUALIFICATIONS Medical degree: December 16th 1981, University of Berne, Switzerland M.D. (Thesis): December 6th 1982, University of Berne, Switzerland FMH Internal Medicine: January 3rd 1989 - Title of specialist in (Swiss College Physicians) internal medicine FMH Nephrology (Specialty in nephrology): January 27th 1993 Higher degree of Doctor of Medicine March 9th 1995, University of Melbourne, Australia Present Position: Physician in charge Nephrology Clinic and Dialysis Unit, Clinica Moncucco, Lugano, Switzerland. Responsible for Quality Management System according to ISO-9001:2000 Consultant Renal Physician, Clinica Moncucco, Lugano Consultant, on request, in Obstetric Medicine at the Women’s Hospital, University of Basel, Switzerland Responsible for the continuing medical education (CME) of the Lugano District Medical Association (CML) From 2011 Master in Management and Healthcare Organisations (Net-MEGS), University of Lugano, CH PROFESSIONAL EXPERIENCE January 1982 – August 1982: University of Berne, Medizinische Poliklinik, Research fellow, Hypertension Unit October 1982 – July 1983: Clinical Fellow in Respiratory Diseases Dr.ssa Claudia Ferrier-Guerra Pagina 2 Rev 008 12.02.2016 Medizinische Klinik, University of Berne. September 1983 – September 1984: Clinical Fellow in General Internal Medicine, Ospedale Italiano, Lugano, Switzerland. (Dr.Beretta-Piccoli Carlo, Professor at the University of BerneOctober 1984 – June 1986: Registrar in Internal Medicine (incl. Nephrology) University of Berne, Medizinische Poliklinik (Prof. Reubi) July 1986 – August 1986: Visiting Medical Officer in Radiology and Infectious Diseases, St. Vincent Hospital Worchester, MA, USA. October 1986 – March 1989: Registrar in general medicine, and registrar in Nephrology. University of Berne, Medizinische Poliklinik. April 1989 – January 1991: Clinical fellow in cardiovascular diseases, hypertension, and clinical pharmacology. Baker Medical Research Institute, Melbourne, Australia. February 1991 – March 1994: Fellow in nephrology and obstetric medicine, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia (Prof. P. Kincaid-Smith & Prof. G. Becker) October 1994 – October 1995: Senior Research Fellow, University of Lausanne. November 1995- March1997 Consultant physician in Nephrology Nephrology Division, Inselspital Berne Consultant-Physician at the Women’s Hospital, University of Berne, for Renal Disease in Pregnancy. AWARDS 1988: Research Grant from the “Swiss National Science Foundation” INVITED LECTURES CNS noradrenergic function in human hypertension as assessed from internal jugular plasma noradrenaline and DHPG. National Institutes of Health, Bethesda, Maryland, USA, November 1991 COMMITEES SERVED ON Board Member of the “Swiss Italian Medical Association" (OMCT) President of Lugano District Medical Association (CML) Board Member "Ticino Sate Ethical Commision” MEMBERSHIP OF Profesional Associations 1. Swiss Society of Internal Medicine 2. Swiss Society of Nephrology 3. Italian Society of Nephrology 4. International Society of Nephrology 5. Australian & New Zealand Society of Nephrology 6. High Blood Pressure Reseasch Council of Australia Dr.ssa Claudia Ferrier-Guerra Pagina 3 Rev 008 12.02.2016 7. International Society for Study of Hypertension in Pregnancy (ISSHP) 8. Australasian Society for Study of Hypertension in Pregnancy (ASSHP) PUBLICATIONS 1. Ferrier CP, Bianchetti MG, Beretta-Piccoli CF, Link L, Bachmann C, Weidmann P. Studies on the mechanism of acute glucose-induced aldosterone suppression. Role of corticotropin. Acta Endocrinol 1983;103:391-399 2. Nuetzi D, Beretta-Piccoli CF, Ferrier CP, Link L, Weidmann P. Studies on acute glucose-induced aldosterone suppression: Role of renin-angiotensin system. Klin Wochenschr 1984;62:213-217 3. Bianchetti MG, Weidmann P, Beretta-Piccoli C, Rupp U, Boehringer K, Link L, Ferrier C. Disturbed noradrenergic blood pressure control in normotensive members of hypertensive families. Br Heart J 1984;51:306-311 4. Ferrier CP, Beretta-Piccoli CF, Weidmann P, Mordasini R. Alpha-1-adrenergic blockade and lipoprotein metabolism in essential hypertension. Clin Pharmacol Ther 1986;40:525-530 5. Beretta-Piccoli CF, Ferrier CP, Weidmann P. Alpha-1-adrenergic blockade and cardiovascular pressor responses in essential hypertension. Hypertension 1986;8:407-417 6. Bianchetti L, Ferrier, Beretta-Piccoli C, Fraser R, Morton JJ, Ziegler WH. Adrenergic activity and alosterone regulation: no evidence for alpha-1 adrenoceptor-mediated influence in normal subjects. Clinical Endrocrinol (Oxf) 1986;25:87-95 7. Bianchetti MG, Beretta-Piccoli CF, Weidmann P, Ferrier C. Blood pressure control in normotensive members of hypertensive families. Kidney Int 1986;29:882-888 8. Bianchetti MG, Weidmann P, Beretta Piccoli CF, Ferrier C. Potassium and norepinephrine- or angiotensin-mediated pressor control in pre-hypertension. Kidney Int 1987;31:956-963 9. Ferrier C, Weidmann P, Hollmann R, Dietler R, Shaw S. Impaired response of atrial natriuretic factor to high salt intake in hypertension-prone man. N Engl J Med 1988;319:1223.1224 10. Ferrier C, Kurtz A, Lehner P, Shaw S, Pusterla C, Saxenhofer H, Weidmann P. Stimulation of renin secretion by potassium-channel activation with cromakalin. Eur J Clin Pharmacol 1989;36:443-447 11. Ferrier C, Beretta-Piccoli C, Weidmann P, Gnaedinger M, Shaw S, Suchecka-Rachon K, Saxenhofer H. Hypotension and renal impairment during infusion of atrial natriuretic factor in liver cirrhosis with ascites. Am J Nephrol 1989;9:921-299 12. Suda S, Weidmann P, Saxenhofer H, Cottier C, Shaw S, Ferrier C. Atrial natriuretic factor in mild to moderate chronic renal failure. Hypertension 1988;11:483-490 13. Saxenhofer H, Angst, Weidmann P, Shaw S, Ferrier C. Corticosteroid-induced stimulation of atrial natriuretic peptide in man. Acta Endocrinol 1988;118:179-186 14. Weidmann P, Schohn D, Gnaedinger MP, Buergisser E, Ferrier C, Jahn H. Hypertensive dysregulation and its modification by calcium channel blockade in chronic non-oliguric renal failure. Am I Nephrol 1989; 9:269-278 15. Uehlinger DE, Ferrier C, Weidmann P, Matthieu R, Reuter K, Gnaedinger M, Saxenhofer H, Shaw S, Risen W. Antihypertensive contribution of sodium depletion and the sympathetic axis during chronic angiotensin II converting enzyme inhibition. J. Hypertens 1989;7:901-907 16. Ferrari P, Ferrier C, Franschini L, Saxenhofer H, Shaw S, Weidmann P. Atrial natriuretic factor and autonomic nervous system function in man. Eur J Clin Pharmacol 1990;38:25-30 Dr.ssa Claudia Ferrier-Guerra Pagina 4 Rev 008 12.02.2016 17. Ferrari P, Weidmann P, Ferrier C, Dietler R, Hollman R, Shaw S. Dysregulation of atrial natriuretic factor in hypertension-prone man. J Clin Endocrinol Metab. 1990; 71:944-951 18. Ferrier C, Ferrari P, Weidmann P, Keller U, Beretta-Piccoli C, Riesen W. Efficacy and tolerance of antihypertensive therapy with the calcium channel blocker verapamil and/or the angiotensin converting enzyme inhibitor enalapril in diabetic patients. Diabetes Care 1991;14:911-914 19. Eisenhofer G, Meredith I, Ferrier C, Cox E, Lambert G, Jennings G, Esler E. Plasma dihydroxyphenylalanine (DOPA) is dependent on sympathetic activity in humans. J Lab Clin Med 1991;117:266-273 20. Eisenhofer G, Esler M, Meredith I, Ferrier C, Lambert G, Jennings G. Neuronal re-uptake of noradrenaline by sympathetic nerves in humans. Clin Sci 1991;80:257-263. 21. Angus J, Ferrier C, Sudhir K, Jennings G. Impaired contraction and relaxation in skin resistance arteries from patients with congestive heart failure. Cardiovasc Res 1993;27:204-210 22. Saxenhofer H, Morger D, Weidmann P, Ferrier C, Shaw S. Modulation of noradrenergic but not angiotensinergic blood pressure control by beta-blockade with carteolol. J Hypertens 1991;9:1049-1056 23. Ferrier C, Esler M, Eisenhofer G, Wallin G, Horne M, Cox H, Lamberg G, Jennings G. Increased norepinephrin spillover into the jugular veins in essential hypertension. Hypertension 1992;19:62-69 24. Wallin G, Esler M, Dorward P, Eisenhofer G, Ferrier C, Westerman R, Jennings G. Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans. J Physiol 1992;453:45-58 25. Ferrier C, Cox H, Esler M. Elevated total body noradrenaline spillover in normotensive members of hypertensive families. Clin Sci 1993;84:225-230 26. Ferrier C, Jennings G, Eisenhofer G, Lambert G, Cox H, Kallf V, Kelly M, Esler M. Evidence for increased noradrenaline release from subcortical brain regions in essential hypertension. J Hypertens 1993;11:1217-1227 27. Ferrier C, North R, Becker G, Townend K, Kincaid-Smith P. Uterine Artery Waveform Indices in the second trimester: Resistance Index, Notch measurement and placental position. J Obstet & Gynaecol 1994;14:237-243 28. North R, Ferrier C, Long D, Townend Kkincaid-Smith P. Uterine artery Doppler Flow Velocity Waveform indices in the second trimester for the prediction of preeclampsia and intrauterine growth retardation. Obstet Gynaecol 1994;83:378-386 29. Ferrier C, Kincaid-Smith P et al. Doppler ultrasound of uterine arteries for prediction of superimposed pre-eclampsia in pregnant women with underlying renal disease. Clin Nephrol 1994;42:362-368 30. Ferrier C, Anapalahan M, Becker G, Kincaid-Smith P. Renal vascular changes and uterine artery resistance in pregnant women with renal disease. Nephron 1994;68:405 31. Esler M, Lambert G, Ferrier C, Kaye D, Wallin G, Kallf M, Kelly M, Jennings G. Central nervous system noradrenergic control of sympathetic outflow in normotensive and hypertensive humans. Clin Exp Hypertens 1995; 17:409-423 32. North RA, Ferrier C, Gamble G. Fairley K, Kincaid-Smith P. Prevention of preeclampsia with prophylactic heparin and anti-platelet agents in women with renal disease. Aust NZ Obstet Gynaecol 1995;35:357362 33. Depairon M, Ferrier CP, Tutta P, Descombes E, van Melle G, Wauters JP. Is ther a place for duplex screening of brachial artery in haemodialysis patients with vascular access? VASA 2001; 30: 53-58 34. Ferrier C. Ematuria: Approccio Diagnostico. Tribuna Medica Ticinese 2003; 68:5-11 Dr.ssa Claudia Ferrier-Guerra Pagina 5 Rev 008 12.02.2016 35. Barbey F, Nseir G, Ferrier C, Burnier M, Daudon M. Inhibiteurs de l'anhydrase carbonique et lithiase urinaire phosphocalcique. Nephrologie 2004; 25: 169-172 36. Casella R, Ferrier C, Giudici G, Dickenmann M, Gianini O, Hoesli I, Bachmann A, Sulser T. Surgical management of renal cell Carcinoma during the second trimester of pregnancy. Urol Int 2006; 76-180181 37. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data. Askie LM et la on behalf of the PARIS COLLABORATIVE GROUP. Lancet 2007 38. Ferrier C, Kürmann P, Antonini P, Belloni F, Vogt N. Lanzoprazole-induced acute renal failure in an older woman. A case-report, in Press 39. Ferrier-Guerra C, Solcà C. Una strana infezione urinaria. Tribuna Medica Ticinese 2011; 76: 465-467 40. Solcà C. Ferrier-Guerra C. Dialisi negli ultraottantenni? Tribuna Medica Ticinese 2011; 76:463-464 41. Giannini O, Gamondi C, Galli N, Schönholzer C, Marone C, Zwahlen U, Gabutti L, Bianchi G, Ferrier C, Neuschwander H, Cereghetti C. The DIA-PAIN STUDY: cause, severity and management of pain and other symptoms in chronic dialysis patients. Submitted REVIEWS & INVITED BOOK CHAPTERS 1. Ferrier C, Beretta-Piccoli CF, Weidmann P, Bianchetti MG. Different blood pressure responses to diuretic treatment in normotensive subjects with and without a family history of hypertension. J Hypertens 1983;1(Suppl 2):31-34 2. Bianchetti MG, Beretta-Piccoli CF, Weidmann P, Link L, Boehringer K, Ferrier C. Calcium and blood pressure regulation in normal and hypertensive subjects. Hypertension 1983;5 (Suppl 2):57-65 3. Bianchetti MG, Beretta-Piccoli CF, Weidmann P, Ferrier C, Link L, Gerber A. Correction of cardiovascular hypersensitivity to norepinephrine by potassium supplementation in normotensive members of hypertensive families and patients with essential hypertens. J Hypertens 1984;2(Suppl 3):445-448 4. Beretta-Piccoli CF, Ferrier CP, Weidmann P. Cardiovascular effects of short-term selective alpha-1adrenergic blockade with terazosin in patients with essential hypertension. J. Hypertens 1985;3(Suppl 3):S231-S234 5. Gerber A, Weidmann P, Bianchetti MG, Ferrier C, Laederach K, Mordasini R, Riesen W, Bachmann C. Serum lipoproteins during treatment with the antihypertensive agent indapamide. Hypertension 1985;7(Suppl 2):164-169 6. Weidmann P, Saxenhofer H, Ferrier C, Shaw S. Atrial natriuretic peptide in man. Am J Nephrol 1988;8:114 7. Weidmann P, Ferrier CP, Saxenhofer H, Uehlinger DE, Trost BN. Serum lipoproteins during treatment with antihypertensive drugs. Drugs 1988;35(Suppl 6):118-23 8. Esler M, Ferrier C, Lambert G, Eisenhofer G, Cox H, Jennings G. Biochemical evidence of sympathetic hyperreactivity in human hypertension. Hypertension 1991;17(Suppl III):29-35 9. Weidmann P, Ferrari P, Alleman Y, Ferrier C, Shaw S. Developing essential hypertension: A syndrome involving ANF deficiency? Can J Physiol Pharmacol 1991;69:1582-1591 10. Ferrier C, Ferrari P, Weidmann P, Keller U, Beretta-Piccoli C, Riesen WF. Swiss Hypertension Treatment Programme with Verapamil and/or Enalapril in Diabetic Patients. Drugs 1992;(Suppl 1):74-84 11. Lambert G, Ferrier C, Kaye D, Cox H, Turner A, Jennings G, Esler M. Monoaminergic neuronal activity in subcortical brain regions in essetial hypertension. Blood Pressure 1994:55-66 Dr.ssa Claudia Ferrier-Guerra Pagina 6 Rev 008 12.02.2016 12. Lambert G, Ferrier C, Jennings G, Kallf M, Kelly M, Turner A, Esler M. Central nervous system norepinephrine turnover un essential hypertension. Ann New York Ac Sci 1995; 763:679-694 13. Ferrier C. Physiopathologie de la preeclampsie: Aspets actuels. Méd Hyg 1995;53:397-400 14. Ferrier C, Wauters JP. Maladies rénales et grossese. Méd Hyg 1995;53:401-405 15. Dürig P, Ferrier C, Schneider H. Hypertensive Schwangerschaftserkrankungen. Therapeutische Umschau, 1999; 56: 561-567 16. Weidmann P, Saxenhofer H, Ferrier C. Atrial natriuretic peptide in man. In: Functional Morphology of the Endocrine Heart. Frossmann WG et al eds, Steinkopf Verlag, Darmstadt 1989 17. Saxenhofer H, Cottier C, Suda S, Shaw S, Ferrier CP, Weidmann P. Limited role of right atrial pressure in the actute control of circulating atrial natriuretic factor. In: American Society of hypertension Symposium Series, Volume 3. Advances in atrial peptide research. Brenner BM, Laragh JH eds, 1989. 18. Lambert GW, Kaye DM, Thompson JM, Turner AG, Ferrier C, Cox HS, Vaz M, Wilkinson D, Meredith IT, Jennings GL, Esler MD. Catecholamine metabolites in internal jugular plasma: A window into the human brain. In: Catecholamines: Bridging Basic Science with Clinical Medicine. Edited by D. Goldstein. Vol. 42 of Advances in Pharmacology, 1997 19. Ferrier C, Gallery E. Pregnancy and therapeutic measures in the patient with diabetic nephropathy. In: Diabetic Nephropathy. Edited by Geoffrrey Boner & Mark Cooper, 199-206: 2003 20. Roncelli N, Ferrier C, Dürig P, Köferl U, Frey F, Schneider H. Underlying maternal diseases in women who suffered fron severe preeclampsia and HELLP syndrome. N. Roncelli, MD Thesis, University of Berne, 18th December 2000 MD THESIS (PD Equivalent) Ferrier Claudia. Uterine Artery Doppler Ultrasound: Prediction of Pregnancy Outcome in Women with Renal Disease. Melbourne, 1994. ABSTRACTS ACCEPTED AND PERSONALLY PRESENTED Ferrier C, Beretta-Piccoli C, Weidmann P, Mordasini R. Alpha-1-adrenergic blockade and lipoprotein metabolism in essential hypertension. First International Symposium on Cardiovascular Pharmacotherapy, Geneva, Switzerland, April 22-26, 1985 Ferrier C, Beretta-Piccoli C, Weidmann P, Gnaedinger M, Shaw S, Suchecka-Tachon K, Saxenhofer H. Hypotension and renal impairment during infusion of atrial nariuretic factor in liver cirrhosis with ascites. Annual Meeting of the Swiss Society of Nephrology, Lausanne, Switzerland, December 2-4, 1988 Ferrier C, Hollman R, Dietler R, Shaw S, Weidmann P. Impaired response of atrial nariuretic factor to high saly intake in hypertension-prone man. 21st Meeting of the American Society of Nephrology, San Antonio, USA, December 11-14, 1988 Ferrier C, Ferrari P, Weidmann P, Keller U, Riesen W. Renal and metabolic effects of antihypertensive therapy with verapamil and/or enalapril in patients with diabetes mellitus. 20 th Meeting of the German Society of Nephrology, Berne, Switzerland, September 17-20, 1989 Dr.ssa Claudia Ferrier-Guerra Pagina 7 Rev 008 12.02.2016 Ferrier C, Jenning G, Angus J, Dart A. Impaired contraction and relaxation in resistance arteries of patients with congestive heart failure. 38t h Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Hobart, Australia, May 1990 Ferrier C, Esler M, Jennings G, Eisenhofer G, Lambert G, Cox H, Wallin G, Horne M. Catecholamine spillover methodology for studying central nervous system turnover in essential hypertension. 13 th Meeting of the International Society of Hypertension, Montreal, Canada, June 26-29, 1990 Ferrier C, Ferrari P, Weidmann P, Keller U, Riesen W. The Swiss Hypertension Treatment Program in Diabetes: Antihypertensive effects of verapamil or enalapril in diabetes associated hypertension. Annual Scientific Meeting of the Australian Diabetes Society, Perth, September 25-27, 1990 Ferrier C, Jennings G, Eisenhofer G, Lambert G, Cox H, Kallf V, Kelly M, Esler M. Evidence for increased subcortical noradrenaline release in essential hypertensive patients. 14th Meeting of the International Society of Hypertension. Madrid, Spain, June 15-19, 1992 Ferrier C, Cox H & Esler M. Elevated total body adrenaline spillover in normotensive members of hypertensive families. 14th Meeting of the International Society of Hypertension, Madrid, Spain, June 15-19, 1992 Ferrier C, North R, Fairley K, Becker G, Dong FP & Kincaid-Smith P. Doppler ultrasound of uterine arteries for prediction of pregnancy-induced hypertension in women with underlying renal disease. 8 th World Congress of International Society for the Study of Hypertension in Pregnancy, Buenos Aires, Argentina, November 8-12, 1992 Ferrier C, Anpalahan M, Becker G, Cincotta R & Kincaid-Smith P. Pre-pregnancy renal vascular changes are associated with increased uterine artery resistance and predict the development of preeclampsia. 9 th World Congress of International Society for the Study of Hypertension in Pregnancy. Sydney, Australia, March 1518, 1994 Ferrier C, Taminelli L, Wauters JP. Pregnancy in renal disease. Experience of a single Swiss Center. Annual Meeting of the Swiss Society of Nephrology, Lausanne, Switzerland, December 7-8, 1995 Ferrier C, North R, Becker G, Kincaid-Smith P. Aspirin does not prevent, but delays the onset of preeclampsia in pregnancies with increased uteroplacental resistance. 10th World Congress of International Society for the Study of Hypertension in Pregnancy, Seattle, USA, August, 1996 Ferrier C, Spichtig S, Schneider H, Frey F. Subarachnoidal hemorrhage and ventricular bleeding as first presentation of severe preeclampsia. A case-report. 10th World Congress of International Society for the Study of Hypertension in Pregnancy, Seattle, USA, August, 1996 Ferrier C, Pfister M, Montandon A, Frey F. Obstetric Outcome in women with renal transplant: A 15 years experience. 10th World Congress of International Society for the Study of Hypertension in Pregnancy, Seattle, USA, August, 1996 Dr.ssa Claudia Ferrier-Guerra Pagina 8 Rev 008 12.02.2016 Ferrier C, Durig P, Frey F, Schneider H. Severe early-onset preeclampsia and HELLP Syndrome are associated with underlying essential hypertension. XIV International Congress of Nephrology, Sydney, Australia, May 25-29 1997 Ferrier C, North R, Becker G, Fairley K, Kincaid-Smith P. Sucessfull pregnancy outcome in women with reflux nephropathy, normal renal function and uterine artery Doppler. XIV International Congress of Nephrology, Sydney, Australia, May 25-29 1997 Ferrier C, Köferl U, Dürig P, Schneider H. LMW-heparin and low-dose aspirin for prevention of preeclampsia: preliminary data of a randomized prospective study. 11th World Congress of International Society for the Study of Hypertension in Pregnancy, Kobe, Japan, October, 1998 Ferrier C, Köferl U, Dürig P, Schneider H. Effects of LMW-heparin and low-dose Aspirin on renal uric acid handling in high risk pregnancies. 12th World Congress of the International Society for Study of Hypertension in Pregnancy. Paris, France, July 2000 Ferrier C, Kürmann P, Antonini P, Belloni F, Vogt N. Acute glomerulonephritis and lanzoprazole therapy: A possible assosiation. 37th Annual Meeting Australian and New Zealand Society of Nephrology. Darwin 5-7 Sept. 2001 Ferrier C, Giudici G, Dickemann M, Gianini O, Hoesli I, Beck EA, Sulser T. Pregnancy, hypertension, suspected thrombophilia and renal mass: An unusual case-report. 39th Annual Meeting Australian and New Zealand Society of Nephrology. Perth 31.8-3 Sept. 2003 Ferrier C, Gallery E, Hösli I, Giudici G, Steiger J. The impact of interdisciplinary follow-up after preeclampsia in subsequent pregnancy. 42nd Annual Meeting Australian and New Zealand Society of Nephrology. Melbourne 14-18 August 2006 Ferrier C, Jozefowsky J, Meister G, Hösli I. Premature contractions: an unsual presentation of primary hyperparathyroidism: A sase Report. International Society of Obstetric Medicine Congress (ISOM). Melbourne 1-3 October 2010 TEACHING ACTIVITIES 1. MD Thesis Supervision 2. Clinical teaching - Medical students - Doctors in nephrology training