David J. Burchfield, MD
Professor of Pediatrics and Physiology
Chief, Division of Neonatology
Phone: (352) 392-4195
Office: ARB RG 130
E-mail: burchdj@peds.ufl.edu
Publications: Search PubMed
Education and Training
INSTITUTION AND LOCATION
University of Florida
University of South Florida
DEGREE
B.S.
M.D.
YEAR(s)
1977
1981
FIELD OF STUDY
Chemistry
Medicine
Dr. Burchfield has been funded to study drugs of abuse in pregnancy and in the pharmacology of
resuscitation medications. Over the last 4 years, his interests have moved to clinical trials, where in
the neonatal intensive care unit, Dr. Burchfield and his team have participated in 8 different clinical
trials.
Selected peer-reviewed publications from a total of 49 (in chronological order).
1.
McTiernan MJ, Burchfield DJ, Abrams RM, Cassin S: Carboxy- and oxyhemoglobin in
pregnant ewe and fetus after inhalation of marijuana, marijuana placebo, and tobacco cigarette
smoke. Life Sci 43:2043-2047, 1988.
2.
Abrams RM, Post JC, Burchfield DJ, Gomez KJ, Hutchison AA, Conlon M: Local cerebral
blood flow increased in rapid eye movement sleep in fetal sheep. Am J Obstet Gynecol
162(1):278-281, 1990.
3.
Burchfield DJ, Abrams RM, Hutchison AA: Local cerebral glucose utilization in normoxemic
and hypoxemic newborn lambs. Dev Brain Res 55:249-253, 1990.
4.
Burchfield DJ, Graham EM, Abrams RM, Gerhardt KJ: Cocaine alters behavioral states in fetal
sheep. Dev Brain Res 56:41-45, 1990.
5.
Abrams RM, Gerhardt KJ, Burchfield DJ: Behavioral state transition and local cerebral blood
flow in fetal sheep. J Develop Physiol 15:283-288, 1991.
6.
Graham EM, Peters AJM, Abrams RM, Gerhardt KJ, Burchfield DJ: Intra-abdominal sound
levels during vibroacoustic stimulation. Am J Obstet Gynecol 164:1140-1144, 1991.
7.
DeVane CL, Burchfield DJ, Abrams RM, Miller RL: Disposition of cocaine in pregnant sheep.
I. Pharmacokinetics. Dev Pharmacol Ther 16:123-129, 1991.
8.
Burchfield DJ, Abrams RM, Miller R, DeVane CL: Disposition of cocaine in pregnant sheep. II.
Physiological Responses. Dev Pharmacol Ther 16:130-138, 1991.
9.
Burchfield DJ, Lucas VW, Abrams RM, Miller RL, DeVane CL:
Disposition and
pharmacodynamics of methamphetamine in pregnant sheep. JAMA 265(15):1968-1973, 1991.
10.
Burchfield DJ, Abrams RM, Miller RL, DeVane CL: Inhalational administration of cocaine in
sheep. Life Sciences 48(22):2129-2136, 1991.
11.
Peters AJM, Abrams RM, Gerhardt KJ, Burchfield DJ, Wasserman DE: Resonance of the
pregnant sheep uterus. J Low Freq Noise Vibr 11:1-6, 1992.
12.
Peters AJM, Abrams RM, Gerhardt KJ, Burchfield DJ: Vibration of the abdomen in nonpregnant sheep: Effect of dynamic force and surface area of vibrator. J Low Freq Noise Vibr
10(3):92-99, 1991.
13.
Gerhardt KJ, Otto R, Abrams RM, Colle J, Burchfield DJ: Cochlear microphonics recorded
from fetal and newborn sheep. Am J Otolayngol 13(4):226-233, 1992.
14.
Peters AJM, Abrams RM, Burchfield DJ, Gilmore R: Electrocorticographic seizures in fetal
lamb following cocaine exposures: a case report. Epilepsia 33:1001-1004, 1992.
15.
Burchfield DJ, Berkowitz ID, Berg RA, Goldberg RN: Neonatal advanced life support:
Medications in neonatal resuscitation. Ann Emerg Med 22(2):435-439, 1993.
16.
Abrams RM, Burchfield DJ, Gerhardt KJ, Peters AJM: Effects of cocaine on electrocortical
activity in fetal sheep. Develop Brain Res 70:97-102, 1992.
17.
Burchfield DJ, Abrams RM: Cocaine depresses cerebral glucose utilization in fetal sheep.
Develop Brain Res 73:283-288, 1993.
18.
Burchfield DJ, Preziosi MP, Lucas VW, Fan J: Hemodynamic effects of graded doses of
epinephrine in asphyxiated newborn lambs. Resuscitation 25:235-244, 1993.
19.
Preziosi MP, Roig JC, Hargrove N, Burchfield DJ: Metabolic acidemia with hypoxia attenuates
the hemodynamic responses to epinephrine during resuscitation in lambs. Crit Care Med
21:1901-1907, 1993.
20.
Meetze WH, Palazzolo V, Bowling D, Behnke M, Burchfield DJ, Neu J: Meconium passage in
the micropremie: Effect of hypocaloric enteral priming. JPEN 17:537-540, 1993.
21.
Abrams RM, Gerhardt KJ, Burchfield DJ: Cerebral glucose utilization and behavioral state in
fetal sheep during vibroacoustic stimulation. J Dev Physiol 19:171-177, 1993.
22.
Lucas VW, Preziosi MP, Burchfield DJ: Epinephrine absorption following endotracheal
administration: Effects of hypoxia-induced low pulmonary blood flow. Resuscitation 27:31-34,
1994.
23.
Sandler DL, Burchfield DJ, McCarthy JA, Rojiani AM, Drummond WH: Early-onset respiratory
failure due to severe congenital neuromuscular disease: A problem for pre-ECMO diagnosis.
J
Pediatr 124:636-638, 1994.
24.
Burchfield DJ, Peters AJM, Abrams RM, Phillips D: Fetal behavioral state patterns during and
following prolonged exposure to cocaine in sheep. Am J Obstet Gynecol 172(4):1223-1228,
1995.
25.
Burchfield DJ, Peña AE, Peters AJM, Abrams RM, Phillips D: Cocaine does not compromise
fetal cerebral or myocardial oxygen delivery in fetal sheep. Reprod Fertil Dev 8:383-389,
1996.
26.
Peña AE, Burchfield DJ, Abrams RM: Myocardial and cerebral oxygen delivery are not
adversely affected by cocaine administration to early gestation fetal sheep. Am J Obstet
Gynecol
174:1028-1032, 1996.
27.
Abrams RM, Burchfield DJ, Sun Y, Smith CB: Rates of cerebral protein synthesis in fetal and
neonatal sheep. Am J Physiol 272 (Regulatory Integrative Comp. Physiol. 41):R1235-R1244,
1997.
28.
Anderson KJ, Mason KL, McGraw TS, Theophilopoulos DT, Sapper MS, Burchfield DJ: The
ontogeny of glutamate receptors and d-aspartate binding sites in the ovine CNS. Dev Brain
Res
118:69-77, 1999
29.
Burchfield DJ: Newborn Resuscitation, Clin Pediatr Emerg Med 2: 119-123, 2001
30.
Skimming JW, Banner MJ, Spalding K, Jaeger MJ, Burchfield DJ, Davenport PW: Nitric oxide
inhalation increases alveolar gas exchange by decreasing deadspace volume. Crit Care Med
29:1195-1200, 2001
31.
Burchfield DJ, Hargrove NL, Anderson KJ: Absence of Physiological Tolerance to Cocaine in
Pregnant Sheep, J Matern Fetal Med 10:341-349, 2001
32.
Burchfield DJ, Tebbett IR, Anderson KJ: Elimination of Cocaine by Pregnant Sheep following
Single or Multiple Exposures, Toxicol Sci 63(2):157-9, 2001
33.
Hutchison AA, Burchfield DJ, Wozniak JA, Mohrman SJ: Largngeal muscle activities with
cerebral hypoxia-ischemia in Newborn lambs. Am J Respir Crit Care Med. 1;166(1):85-91,
2002.
34.
Weiss MD, Burchfield DJ: Adjunct Therapies to Bacterial Sepsis NAINR 2004: 46-50
Research Support
Burchfield, DJ (PI)
7/01/2004-current
Inhibitex Inc
Title: A Phase III, randomized, double-blind, multi-center trial comparing the safety and efficacy of
Veronate® versus placebo for the prevention of nosocomial staphylococcal sepsis in premature
infants (birth weight 500-1250 g)
Description: This study is a randomized multicenter trial of using a specific IVIG product to reduce
hospital-acquired infections in preterm infants.
Burchfield, DJ (PI)
11/01/2004-current
Medimmune, Inc
Title: A Pivotal Phase 3 Study of MEDI-524 (NumaxTM), an Enhanced Potency Humanized
Respiratory Syncycial Virus (RSV) Monoclonal Antibody, for the Prophylaxis of Serious RSV Disease
in High-Risk Children
Description: This is a multicenter clinical trial comparing two monoclonal antibody agents for
prevention of RSV in preterm infants
Burchfield, DJ (PI)
11/01/2004-current
Medimmune, Inc
Title: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of MEDI524, a Humanized Enhanced Potency Monoclonal Antibody Against Respiratory Syncytial Virus
(RSV), in Children with Hemodynamically Significant Congenital Heart Disease (David J. Burchfield,
MD, site PI)