CV of Hua Zhang
Curriculum Vitae of Hua Zhang
Date of Birth: 1980-12-16
Gender: Male
Marital status: Married, with 2 daughters, 4-year-old and 0-year-old.
Civil Status: Chinese citizen
Current position: Senior researcher at the Department of Chemistry and Molecular
Biology, University of Gothenburg.
Ph.D. degree: Physiology, China Agricultural University, China, December 18, 2008.
Education & Career
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June 1999—September 2003: B.Sc. student at the College of Bioscience, China
Agricultural University, China.
September 2003—December 2008: Ph.D student at the College of Bioscience, China
Agricultural University, China.
January 2009—June 2010: Research assistant at the College of Bioscience, China
Agricultural University, China.
June 2010—December 2011: Postdoctoral researcher at the Department of Medical
Biochemistry and Biophysics, Umeå University, Sweden.
December 2011-present: Senior researcher at the Department of Chemistry and
Molecular Biology, University of Gothenburg, Sweden.
Participated projects
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Chinese 863 Project, China, (2006-2011): Ovarian development and ovarian disease.
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The National Natural Science Foundation, China, (2006-2008): The role of CYP51,
the key synthase of Meiotic activated steroids (MAS), in meiotic mature of mice
oocytes.
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National Basic Research Program of China, China, (2008-2010): The regulated
mechanism of mouse folliculogenesis and oogenesis.
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Chinese 973 Project, China, (2009-2014): Oogenesis and aging.
Supported project:
Swedish Research Council (2010–2014): Studies of signaling molecules in oocytes that affect
the physiological and pathological changes of the ovary.
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CV of Hua Zhang
Conference Abstract
Speaker at the Annual Meeting of national animal physiology and chemistry academy, Shanxi,
China, July 28 - 30, 2008
Hua Zhang, Huirong Xie, Jing Wen, Ge Li, Bo Zhou, Meijia Zhang and Guoliang Xia. 2004.
th
Meiosis Activating Sterols regulates the mouse primordial folliculogenesis. 10 Annual
Meeting of National Animal physiology and chemistry academy, p139 (Beijing, China)
Lei Lei, Hua Zhang, Fengchao Wang, Shiying Jin, Maoyong Fu, Guoliang Xia, Hainbin
Wang. 2005. Stage specific acquiring the follicle forming ability of female germ cells in fetal
mouse. First Sino-Canada Bilateral Workshop on Reproductive Health Research, p51
(Beijing, China)
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CV of Hua Zhang
Publication list of Hua Zhang
1. Hua Zhang, Sanjiv Risal, Nagaraju Gorre, Kiran Busayavalasa, Xin Li, Yan Shen,
Mats Brännström, and Kui Liu. Somatic cells initiate primordial follicle activation and
govern the development of dormant oocytes in mice. Current Biology, 2014 Nov 03;
24(21):2501-8
2. Hua Zhang*, Wenjing Zheng*, Yan Shen, Deepak Adhikari, and Kui Liu.
Experimental evidence showing that no mitotically active female germline progenitors
exist in postnatal mouse ovaries. Proceedings of the National Academy of Sciences of
the United States of America, 2012 Jul 31;109(31):12580-5
3. Wenjing Zheng*, Hua Zhang*, Gorre Najaraju, Sanjiv Risal, Yan Shen, Kui Liu.
Two classes of ovarian primordial follicles exhibit distinct developmental dynamics
and physiological functions. Hum Mol Genet. 2014 Feb 15;23(4):920-8
4. Hua Zhang, Deepak Adhikari, Wenjing Zheng, and Kui Liu. Combating ovarian
aging depends on the use of existing ovarian follicles, not on putative oogonial stem
cells. Reproduction, 2013 Oct 21;146(6):R229-33. Review
5. Hua Zhang, Baoshan Xu, Huirong Xie, Bo Zhou, Hong Ouyang, Gang Ning, Ge Li,
Meijia Zhang and Guoliang Xia. Lanosterol metabolic product(s) is involved in
primordial folliculogenesis and establishment of primordial follicle pool in mouse
fetal ovary. Molecular Reproduction and Development. 2009 May;76:514-21
6. Wenjing Zheng, Hua Zhang, Kui Liu. The two classes of primordial follicles in the
mouse ovary: their development, physiological functions and implications for future
research. Mol Hum Reprod. 2014 Apr;20(4):286-92. Review
7. Ge Li*, Hua Zhang*, Yijing Wang, Jing Wen, Zhen Teng, Guoping Mao, Jianwei
Wang, Meng Guo, Xinyi Mu, Guoliang Xia. Stage-specific mice ovarian somatic cell
is involved in primordial folliculogenesis. Frontiers in Bioscience (Elite Ed). 2011
Jun 1;3:1025-33.
8. Meng Guo, Hua Zhang, Fenghua Bian, Ge Li, Xinyi Mu, Jing Wen, Guankun Mao,
Zhen Teng, Guoliang Xia, Meijia Zhang. Progesterone down-regulates the expression
of Jagged2 and Notch1, which are involved in primordial follicle formation in the
mouse ovary. Frontiers in Bioscience (Elite Ed). 2012 Jun 1;4:2731-44.
9. Jing Wen, Hua Zhang, Ge Li, Guanping Mao, Xiufen Chen, Jianwei Wang, Meng
Guo, Xinyi Mu, Hong Ouyang, Meijia Zhang, Guoliang Xia. PAR6, a potential
marker for the germ cells selected to form primordial follicles in mouse ovary. PLoS
One. 2009 Oct 7;4(10):e7372
10. Lei Lei, Hua Zhang, Shiying Jin, Fengchao Wang, Maoyong Fu, Haibin Wang,
Guoliang Xia. Stage-specific germ-somatic cell interaction directs the primordial
folliculogenesis in mouse fetal ovaries. Journal of Cellular Physiology. 2006
Sep;208(3):640-7
11. Adhikari D, Gorre N, Risal S, Zhao Z, Zhang H, Shen Y, Liu K. The safe use of a
PTEN inhibitor for the activation of dormant mouse primordial follicles and
generation of fertilizable eggs. PLoS One. 2012;7(6):e39034
12. Gang Ning, Hong Ouyang, Songbo Wang, Xiufen Chen, Baoshan Xu, Jiange Yang,
Hua Zhang, Meijia Zhang, and Guoliang Xia. 3',5'-cyclic adenosine monophosphate
response element binding protein up-regulated cytochrome P450 lanosterol 14alphademethylase expression involved in follicle-stimulating hormone-induced mouse
oocyte maturation. Molecular Endocrinology. 2008 Jul; 22(7):1682-94.
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CV of Hua Zhang
13. Songbo Wang, Gang Ning, Xiufen Chen, Jiange Yang, Hong Ouyang, Hua Zhang,
Ping Tai, Xinyi Mu, Bo Zhou, Meijia Zhang, Guoliang Xia. PDE5 modulates oocyte
spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling. Frontiers in
Bioscience. 2008 May 1; 13:7087-95.
14. Jun Yan, Bo Zhou, Jie Yang, Ping Tai, Xiufen Chen, Hua Zhang, Meijia Zhang,
Guoliang Xia. Glucose can reverse the effects of acute fasting on mouse ovulation and
oocyte maturation. Reproduction Fertility and Development. 2008;20(6):703-12.
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