简历
（中文）王卫
姓
名
（英文）WANG WEI
性
别
现任职务
男
民族（宗教）
汉族
华东理工大学药学院肿瘤药
专业方向
物研究所所长
有机化学、药物化学与化
学生物学
电
weiwangsimm@gmail.com
话
021-6425-3739
E_mail
联系方式
通讯地址
上海市梅陇路130号268信箱，邮编200237
教育和主要工作经历
教育经历
1984.9~1988.7
南京师范大学化学系，化学专业
学士学位
1990.9~1993.7
上海药物研究所，有机化学专业
硕士学位
1996.8~2000.2
North Carolina State University,
博士学位
USA，有机化学专业
主要工作经历
1993.7-1994.9
1994.10-1996.7
2000.1-2001.12
2001.12-2003.8
2003.8-2008.7
2008.7-2012.6
2012.7-至今
2012.8-至今
华东理工大学康拜化学研究所
助理研究员
College of Pharmacy, University of Oklahoma,
USA
Department of Chemistry, University of
Arizona, USA
Genomics Institute of the Novartis Research
Foundation, San Diego, California, USA
Department of Chemistry & Chemical Biology
and College of Pharmacy, University of New
Mexico, USA
Department of Chemistry & Chemical
Biology，University of New Mexico, USA
Department of Chemistry & Chemical
Biology，University of New Mexico, USA
助理研究员
华东理工大学，肿瘤药物研究所所长
博士后
研究员 (PI)
助理教授
终身副教授
(tenured)
终身正教授
(tenured)
“国家千人
计划”教授
社会兼职
1. President, The Chinese-American Chemistry & Chemical Biology Professors
Association, June 2010 to May 2012 (中美化学与化学生物学教授协会主席)
2. Director, The Chinese-American Chemistry & Chemical Biology Professors
Association June 2008 to May 2010 (中美化学与化学生物学教授协会主任)
3. 荣誉编委（Honorary Editorial Board）Journal of China Pharmaceutical University,
December 2010 to present
4. 编委（Board member）Current Organic Synthesis, September 2009 to present
5. 荣誉编委（Honorary Editorial Board）Organic Chemistry Insights, August 2007 to
present
6. 编委（Board member）Letters in Organic Chemistry, August 2007 to present.
获奖及荣誉称号
1. The Creative Award, University of New Mexico, 2012
2. Guest Editor, Science China: Chemistry, 2011, 53(1): Special Issue on “The Frontiers
of Chemical Biology and Synthesis”
3. Scientific Advisory Board, the Open Pharma Source <<Yao Yuan>>, June 2011 to
present
4. Top 5% Most Cited Author in the Field of Chemistry
5. Tetrahedron Letters Most Cited Paper 2006-2009 Award
6. The Chinese-American Chemistry & Chemical Biology Professors Association
(CAPA) Distinguished Junior Faculty Award 2008.
7. Tetrahedron Letters Most Cited Paper 2004-2007 Award
8. Nominated for the 2006-2007 Outstanding Teacher of the Year Award, University of
New Mexico.
9. The Bruce W. Erickson Young Investigator Award, the American Peptide Society
(APS) 2001.
10. The Outstanding Research Award, the First Annual North Carolina State University
International Research Exposition, North Carolina State University, April 16, 1999,
USA.
11. Glaxo Graduate Fellowship, Department of Chemistry, North Carolina State
University, 1998-1999, USA.
研究兴趣、方向
Organic Synthesis
• Development of new synthetic methodology, particularly in the area of organocatalysis
and photocatalysis with an emphasis on atom-economical, environmentally friendly,
sustainable synthesis and catalysis in the preparation of biologically interesting molecules
and fine chemicals
Medicinal Chemistry and Chemical Biology
• Drug discovery: Design, synthesis, and evaluation of small molecules as therapeutic
agents with focus on anti-cancer, neurodegenerative diseases and anti-bacterial.
• Molecular imaging: Development of fluorescent and multi-modular probes for the
detection of reactive oxygen species, thiols, seleno-proteins, arsenic, Zn(II), sugars,
tumor cells and toxic heavy metals and other chemicals.
• Pharmaceutical chemistry: Development of novel intelligent drug delivery systems for
improving the properties and drug efficacy of medicinal agents.
发表的文章 (H index: 42):
After joining UNM (independent research work, 8/2003-present, 113 total, *as
corresponding author):
Song, A.-G.; Chen, X.-B.; Song, S.-S.; Zhang, X.-S.; Zhang, S.-L.; Wang, W.* “Synthesis
of Benzoxazoles via an Amine-Catalyzed [4 + 1] Annulation” Org. Lett., 2013, in press.
2) Zhang, Y.-Q.; Wang, S.-Z.; Wu, S.-C.; Zhu, S.-P.; Dong, G. Q.; Miao, Z.-Y.; Yao, J.-Z.;
Zhang, W-N.;* Sheng, C.-Q.;* Wang, W.* “Facile Construction of Structurally Diverse
Thiazolidinedione-derived Compounds via Divergent Stereoselective Cascade
Organocatalysis and Their Biological Exploratory Studies” ACS Comb. Sci., 2013, in press.
3) Li, T.-F.; Zhu, J.; Wu, D.-Y.; Li, X.-M.; Wang, S.-N.; Li, H.; Li, J.;* Wang, W.* “A
Strategy Enabling Enantioselective Direct Conjugate Addition of Inert Aryl Methane
Nucleophiles to Enals with a Chiral Amine Catalyst under Mild Conditions” Chem. Eur. J.,
2013, in press.
4) Huang, J.-P.; Wang, W.;* Li, H.-X.* “Water-Medium Organic Reactions Catalyzed by
Active and Reusable Pd/Y Heterobimetal-Organic Framework” ACS Catal. 2013, in press.
5) Xie, H.-X.; Song, A.-G.; Zhang, X.-S.; Chen, X.-B.; Li, H.; Sheng, C.-Q.;* Wang, W.*
“Quinine-thiourea Catalyzed Enantioselective Hydrophosphonylation of Trifluoromethyl
2(1H)-Quinazolinones” Chem. Commun., 2013, 49, 928-930.
6) Xie, H.-X.; Song, A.-G.; Song, X.-X.; Zhang, X.-S.; Wang, W.* “Organocatalytic
Enantioselective Strecker Reaction of Cyclic Trifluoromethyl-ketoimines” Tetrahedron
Lett., 2013, 54, 1409-1411.
7) Jiang, J.-A.; Huang, W.-B.; Zhai, J.-J.; Liu, H.-W.; Cai, Q.; Xu, L.-X.; Wang,W.* Ji, Y.-F.*
““One-pot” Synthesis of 4-Substituted 1,5-Diaryl-1H-pyrazole-3-carboxylates via a
Lithium tert-Butoxide-mediated Sterically Hindered Claisen Condensation-Knorr Reaction
Sequence” Tetrahedron, 2013, 69, 627-735.
8) Xia, D.-Q.; Cheng, T.-Y.; Xiao, W.; Liu, K.-T.; Wang, Z.-L.; Liu, G.-H.* Li, H.-X. Wang,
W.* “Imidazolium-Based Organic-Inorganic Hybrid Silica as A Functional Platform
Dramatically Boosts Chiral Organometallics Performance in Asymmetric Catalysis”
ChemCatChem, 2013, in press.
9) Xuan, W.; Pan, R.; Cao, Y.; Liu, K.-J.; Wang, W.* “A Fluorescent Probe Capable of
Detection of H2S at a Submicromolar Range and in Cellular Imaging” Chem. Commun.,
2012, 48, 10669-10671.
10) Zhang, X.-S.; Song, X.-X.; Li, H.; Zhang, S.-L.; Chen, X.-B.; Yu, X.-H.; Wang, W.* “An
Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1,41)
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23)
Dihydroquinolines–Unanticipated Effect of N-Protecting Groups” Angew. Chem. Int. Ed.,
2012, 51, 7282-7286.
Song, X.-X.; Zhang, X.-S.; Zhang, S.-L.; Li, H.;* Wang, W.* “Direct Transformation of
Simple Enals to 3,4-Disubstituted Benzaldehydes under Mild Reaction Conditions via an
Organocatalytic Regio- and Chemo-selective Dimerization Cascade” Chem. Eur. J., 2012,
18, 9770-9774.
Xuan, W.; Chen, C.; Cao, Y.; He, W.; Jiang, W.; Liu, K.-J.;* Wang, W.* “Rational Design
of a Ratiometric Fluorescent Probe with a Large Emission Shift for the Facile Detection of
Hg2+” Chem. Commun., 2012, 48, 7292-7294.
Wang, H.; Yang, W.; Liu, H.; Wang, W.;* Li, H.* “FeCl3 Promoted Highly Regioselective
[3+2] Cycloaddition of Dimethyl 2-Vinyl and Aryl Cyclopropane-1,1-dicarboxylates with
Aryl Isothiocyanates” Org. Biomol. Chem., 2012, 10, 5032-5035.
Xuan, W.-M. Sheng, C.-Q.;* Cao, Y.-T.; He, W.-H.; Wang, W.* “Emerging Fluorescent
Probes for the Detection of Hydrogen Sulfide in Biological Systems” Angew. Chem. Int.
Ed., 2012, 51, 2282-2284 (Highlights).
Liu, L.; Wu, D.; Li, X.; Wang, S.; Li, H.; Li,* J.; Wang, W.* “Organocatalytic
Enantioselective Conjugate Addition of Ketones to Isatylidine Malononitriles” Chem.
Commun., 2012, 48, 1692-1694.
Zhu, J.; Yu,* S.; Lu, W.-C..; Deng, J.; Li, J.; Wang, W.* “Direct Oxidative Conversion of
3-Aryl Propionaldehydes to 3-Aryl Acroleins Promoted by SOMO Catalysis” Tetrahedron
Lett., 2012, 53, 1207-1209.
Deng, J.; Wang, F.; Yan, W.-Z.; Zhu, J.; Jiang, H.-L.; Wang, W.;* Li, J.* “Synthesis of 3Substituted 1,5-Aldehyde Esters via an Organocatalytic Highly Enantioselective Conjugate
Addition of New Carbonylmethyl 2-Pyridinylsulfone to Enals” Chem. Commun., 2012, 48,
148-150. Invited for “the joint ChemComm–Organic & Biomolecular Chemistry
‘Organocatalysis’ web themed issue.”
Xie, H.-X.; Zhang, S.-L.; Li, H.; Zhao, S.-H.; Xu, Z.-A.; Song, X.-X.; Yu, X.-H.;* Wang,
W.* “Total Synthesis of Polyene Natural Product Dihydroxerulin by Mild Organocatalyzed
Dehydrogenation of Alcohols” Chem. Eur. J. 2012, 18, 2230-2234.
Zou, Z.-Q.; Deng, Z.-J.; Yu, X.-H.;* Zhang, M.-M.; Zhao, S.-H.; Lou, T.; Yin, X. Xu, H.;
Wang, W.* “A New Facile Approach to N-Alkylpyrroles from Direct Redox Reaction of 4Hydroxy-L-proline with Aldehydes” Science China – Chemistry, 2012, 55, 43-49 (invited
paper).
Liu, L.; Wu, D.; Zheng, S.; Li, T.; Li, X.; Wang, S.; Li, J.; Li, H.;* Wang, W.* “Synthesis
of Highly Functionalized Chiral 3, 3’-Disubstituted Oxindoles via an Organocatalytic
Enantioselective Michael Addition of Nitroalkanes to Indolylidene-cyanoacetates” Org.
Lett., 2012, 14, 134-137.
Du, Z.-Y.; Zhou, C.-G.; Gao, Y.-J.; Ren, Q.; Zhang, K.; Cheng, H.-S.; Wang, W.*; Wang,
J.* “Expeditious Diastereoselective Construction of a Thiochroman Skeleton via a Cinchona
Alkaloid–derived Catalyst” Org. Biomol. Chem., 2012, 10, 36-39.
Zhang, F.; Yang, X.-S.; Zhu, F.-X.; Huang, J.-L.; He, W.-H.; Wang, W.*; Li, H.-X.*
“Highly Active and Reusable Organometallic Catalysts Covalently Bonded to an Ordered
Mesoporous Polymer” Chem. Sci., 2012, 3, 476-484.
Song, X.-X.; Song, A.-G.; Zhang, F.; Li, H.-X.;* Wang, W.* “Direct Stereoselective Arylation of Unmodified Enals Using an Organocatalytic Cross-coupling-like Reaction”
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Nature Commun., 2011, 2, 524, doi:10.1038/ncomms1541. This work has been
highlighted in Synfacts.
Xie, H.-X.; Zhang, Y.-N.; Zhang, S.-L.; Chen, X.-B.; Wang, W.* “Bifunctional Cinchona
Alkaloid-thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry of Cyclic
Trifluoromethyl-Ketimines and Application in Synthesis of Anti-HIV Drug DPC 083”
Angew. Chem. Int. Ed., 2011, 50, 11773-11776. This work has been highlighted in
Synfacts.
Zhang, S.-L.; Xie, H.-X.; Song, A.-G.; Wu, D.-Y.; Zhu, J.; Zhao, S.-H.; Li, J.;*, Yu, X.-H.;*
Wang, W.* “Efficient Preparation of trans-α, β-Unsaturated Aldehydes from Saturated
Aldehydes by Oxidative Enamine Catalysis” Science China – Chemistry, 2011, 54, 19321936 (invited for special issue of International Year of Chemistry).
Zhang, S.-L.; Xie, H.-X.; Zhu, J.; Li, H.; Zhang, X.-S.; Li, J.;* Wang, W.*
“Organocatalytic Enantioselective -Functionalization of Aldehydes via Oxidation of
Enamines and Their Application in Cascade Reactions” Nature Commun., 2011, 2, 211,
DOI: 10.1038/ncomms1214. This work has been highlighted in C&EN News (March 7,
2011 issue on page 9) as “News of the Week” and Synfacts.
Zhu, F.-X., Wang, W.;* Li, H.-X.* “Water-Medium and Solvent Free Organic Reactions
over a Bifunctional Catalyst with Au Nanoparticles Covalently Bonded to HS/SO3H
Functionalized PMO” J. Am. Chem. Soc. 2011, 133, 11632-11640.
Liu, L.; Zhang, S.-L.; Xue, F.; Lou, G.-S.; Zhang, H.-Y.; Ma, S.-C.; Duan, W.-H.; Wang,
W.* “Catalytic Enantioselective Henry Reactions of Isatins. Application in Concise
Synthesis of (S)-(-)-Spirobrassinin”, Chem. Eur. J. 2011, 17, 7791-7795. This work has
been highlighted in Synfacts.
Chigaev, A.; Smagley, Y.; Zhang,Y.; Waller, A.; Haynes, M. K.; Amit, O.; Wang, W.;
Larson, R. S.; Sklar, L. A. “Real-Time Analysis of the Inside-Out Regulation of
Lymphocyte Function-Associated Antigen-1 Reveled Similarities and Differences with
Very Late Antigen-4” J. Bio. Chem. 2011, 286, 20375-20386. This work has been featured
online on the site "Global Medical Discovery" (http://globalmedicaldiscovery.com).
Liu, G.-X.; Zhang, S.-L.; Zhang, T.-Z.; Wang, W.* “Organocatalytic Enantioselective
Friedel-Crafts Reactions of 1-Naphthols with Aldimines” Org. Lett., 2011, 13, 828-831.
Wang, J.; Zhang, M.-M.; Xu, Z.-A.; Li, H.; Yu, X.-H.; Wang, W.* “Chiral Pyrrolidine
Sulfonamide Catalyzed Enantioselective Michael Addition of Cyclic Ketones to
Maleimides” Synlett, 2011, 473-476, invited for cluster topic: “Proline and Proline-Based
Organocatalyst.”
Yu, C.-G.; Zhang, S.-L.; Li, H.; Wang. W.* “Cu(II) Catalyzed Oxidation-[3+2]
Cycloaddition-Aromatization Cascade: Efficient Synthesis of Pyrrolo [2, 1-a]
Isoquinolines” Chem. Commun., 2011, 47, 2036-1038.
Yu, C.-G.; Zhang, Y.-N.; Song, A.-G.; Ji, Y.-F.;* Wang, W.* “Interplay of Direct Stereocontrol and Dynamic Kinetic Resolution in a Bifunctional Amine Thiourea Catalyzed
Highly Enantioselective Cascade Michael-Michael Reaction” Chem. Eur. J., 2011, 17, 770774.
Liu, C-L.; Zhang, X.-S.; Wang, R.;* Wang, W.* ““One-pot” Access to 4H-Chromenes with
Formation of a Chiral Quaternary Stereogenic Center by a Highly Enantioselective
Iminium-allenamine Involved Oxa-Michael-Aldol Cascade” Org. Lett., 2010, 12, 49484951.
35) Gao, Z.; Zhang, T.; Wu, M.; Xiong, Q.; Sun, H.; Zhang, Y.; Zu, L.; Wang, W.;* Li, M.*
“Isoform-specific Prolongation of KCNQ (Kv7) Potassium Channels Opening Mediated by
New Molecular Determinants for Drug-Channel Interactions” J. Bio. Chem. 2010, 285,
28322-28332.
36) Zhang, X.-S.; Zhang, S.-L.; Wang, W.* “Iminium Allenamine Cascade Catalysis: “Onepot” Access to Chiral 4H-Chromenes by a Highly Enantioselective Michael-Michael
Sequence” Angew. Chem. Int. Ed., 2010, 49, 1481-1484. This work has been highlighted
in Synfacts.
37) Xue, F.; Liu, L.; Zhang, S.; Duan, W.-H.; Wang, W.* “A Simple Primary Amine-Thiourea
Catalyzed Highly Enantioselective Conjugate Addition of  -Disubstituted Aldehydes to
Maleimides” Chem. Eur. J., 2010, 16, 7979-7982. This work has been highlighted in
Synfacts.
38) Zhang, N.; Agbor, L. N.; Scott, J. A.; Zalobowski, T.; Elased, K. M.; Trujillo, A.; Duke, M.
S.; Wolf, V.; Walsh, M. T.; Born, J. L.; Felton, L. A.; Wang, J.; Wang, W.; Kanagy, N. L.;
Walker, M. K. “An Activated Renin-angiotensin System Maintains Normotension in Aryl
Hydrocarbon Receptor Heterozygous Mice but not Null Mice” Biochem. Pharmacol., 2010,
80, 197-204.
39) Zhang, Y.-N.; Yu, C.-G.; Ji, Y.-F.;* Wang, W.* “Diastereo- and Enantioselective
Organocatalytic Direct Conjugate Addition of -Butenolide to Chalcones” Chem. Asian. J.,
2010, 5, 1303-1306.
40) Jiang, W.; Cao, Y.-T.; Liu, Y.; Wang, W.* “Rational Design of a Highly Selective and
Sensitive Fluorescent PET Probe for Discrimination of Thiophenols and Aliphatic Thiols”
Chem. Commun., 2010, 46, 1944-1966.
41) Huang, J.-L.; Zhu, F.-X.; He, W.-H.; Zhang, F.; Wang, W.* Li, H.-X.* “Periodic
Mesoporous Organometalsilicas with Unary or Binary Organometals Inside the Channel
Walls as Active and Reusable Catalysts in Aqueous Organic Reactions” J. Am. Chem. Soc.,
2010, 132, 1492-1493.
42) Yu, C.-G.; Zhang, Y.-N.; Zhang, S.-L.; He, J.;* Wang, W.* “Highly Enantioselective
Michael-cyclization Cascade Promoted by Synergistic Asymmetric Aminocatalysis and
Lewis Acid Catalysis” Tetrahedron Lett., 2010, 51, 1742-1744.
43) Deng, J.; Zhang, S.-L.; Ding, P.; Jiang, H.-L.; Wang, W.* and Li, J.* “Facile Creation of
Privileged 3-Indolyl-3-hydroxy-2-oxindoles by an Organocatalytic Enantioselective
Friedel-Crafts Reaction of Indoles with Isatins” Adv. Synth. Catal., 2010, 352, 833-838.
44) Zhang, S.-L.; Li, J.;* Zhao, S.-H.; Wang, W.* “1,3-Benzodithiole-1,1,3,3-tetraoxide (BDT)
as a Versatile Methylation Reagent in Catalytic Enantioselective Michael Addition Reaction
with Enals” Tetrahedron Lett., 2010, 51, 1766-1769.
45) Liu, J.; Zhu, J.; Jiang, H.-L.; Wang, W.;* Li, J.* “Pd-Catalyzed Cascade Heck-Saegusa:
Direct Synthesis of Enals from Aryl Iodides and Allyl Alcohol” Chem. Commun., 2010, 46,
415-417.
46) Zhang, H.-Y.; Zhang, S.-L.; Liu, L.; Lou, G.-S.; Duan, W.-H.; Wang, W.* “Synthesis of
Chiral 3-Substituted Phthalides by a Sequential Organocatalytic Enantioselective Aldollactonization Reaction. Three-step Synthesis of (S)-(-)-3-Butylphthalide” J. Org. Chem.,
2010, 75, 368-374.
47) Li, H.; Ji, Y.-F.; Li, J.; Zhang, S.-L.; Yu, C.-G.; Wang, W.* “Organocatalytic
Enantioselective Michael Addition Reactions of Fluoromalonates with -Unsaturated
Aldehydes” Science China – Chemistry, 2010, 53, 135-139.
48) Zu, L.-S.; Zhang, S.-L.; Xie, H.-X.; Wang, W.* “Catalytic Asymmetric oxa-MichaelMichael Cascade for Facile Construction of Chiral Chromans via an Aminal Intermediate”
Org. Lett., 2009, 11, 1627-1630. This work has been highlighted in Org. Chem.
Highlights.
49) Masood, A.; Huang, Y.; Hajjhussein, H.; Xiao, L.; Li, H.; Wang, W.; Hamza, A.; Zhan, C.G.; O'Donnell, J. M. “Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with
Increased cGMP Signaling” J. Pharmacol. Exp. Ther. 2009, 331, 690-699.
50) Njus, B. H.; Chigaev, A.; Waller, A.; Wlodek, D.; Ostopovici-Halip, L.; Ursu, O.; Wang,
W.; Oprea, T. I.; Bologa, C. G.; Sklar, L. A. “Conformational mAb as a Tool for Integrin
Ligand Discovery” ASSAY Drug Dev. Tech., 2009, 7, 507-515.
51) Mei, K.; Jin, M.; Zhang, S.-L.; Li, P.; Liu, W.-J.; Chen. X.-B.; Xue, F.; Duan, W.-H.; Wang,
W.* “Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly
Enantioselective Conjugate Addition of Nitroalkanes to Enones” Org. Lett., 2009, 11, 28642867.
52) Liu, J.; Zhu, J.; Jiang, H.-L.; Wang, W.;* Li, J.* “Direct Oxidation of -Aryl Substituted
Aldehydes to , -Unsaturated Aldehydes Promoted by a o-Anisidine-Pd(OAc)2 Cocatalyst” Chem. Asian. J., 2009, 4, 1712-1716.
53) Xue, F.; Zhang, S.-L.; Liu, L.; Duan, W.-H.; Wang, W.* “Organocatalytic Enantioselective
Cross-Aldol Reactions of Aldehydes with Isatins: Formation of Two Contiguous
Quaternary Centered 3-Substituted 3-hydroxyindol-2-ones” Chem. Asian. J., 2009, 4, 16641667.
54) Zhang, S.-L.; Zhang, Y.-N. Ji, Y.-F. Li, H.; Wang, W.* “Catalytic Enantioselective
Conjugate Addition of Fluorobis(phenylsulfonyl)methane to Enals: Synthesis of Chiral
Monofluoromethyl Compounds” Chem. Commun., 2009, 4886-4888.
55) Jiang, W.; Wang, W.* “A Selective and Sensitive “Turn-on” Fluorescent Chemodosimeter
for Hg2+ in Aqueous Media via Hg2+ Promoted Facile Desulfurization-lactonization
Reaction” Chem. Commun., 2009, 3913-3915.
56) Luo, G.; Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Enantioselective Organocatalytic
Synthesis of Highly Functionalized Tetrahydrothiophenes by a Michael-aldol Cascade
Reaction” Tetrahedron Lett., 2009, 50, 2946-2948.
57) Zhu, J.; Liu, J.; Ma, R.; Xie, H. Li, J.;* Jiang, H.-L.; Wang, W.* “A Direct AminePd(OAc)2 Co-catalyzed Saegusa Oxidation Reaction of Unmodified Aldehydes to alpha,
beta-Unsaturated Aldehydes” Adv. Synth. Catal., 2009, 351, 1229-1232.
58) Li, H.; Zhang, S.-L.; Yu, C. G.; Song, X.-X.; Wang, W.* “Synthesis of Chiral Fluorinated
Quaternary Carbon Containing -Ketoesters” Chem. Commun., 2009, 2136-2138.
59) Gan, X.-W.; Jiang, W.; Wang, W.;* Hu, L.-H.* “An Approach to 3,6-Disubstituted 2,5Dioxybenzoquinones via Two Sequential Suzuki Couplings. Three-step Synthesis of
Leucomelone” Org. Lett., 2009, 11, 598-592.
60) Li, H.; Zu, L.; Xie, H.; Wang, W.* “Organocatalytic Enantioselective Conjugate Addition
of 2-Fluoromalonate to Nitroolefins: Direct Synthesis of Chiral Fluorinated-Nitro
Carboxylic Acid Derivatives” Synthesis, 2009, 1525-1530, invited Special Topics.
61) Luo, G.; Zhang, S.; Duan, W.;* Wang, W.* “Chiral Primary Amine Catalyzed
Enantioselective Conjugate Addition of N-Heterocycles to -Unsaturated Ketones”
Synthesis, 2009, 1564-1572, invited Special Topics.
62) Ma, S.; Zhang, S.; Duan, W.;* Wang, W.* “An Efficient Enantioselective Synthesis of (+)(S)-[n]-Gingerol via the L-Proline-catalyzed Aldol Reaction” Bioorg. Med. Chem. Lett.,
2009, 19, 3909-3911. (Invited Special Issue)
63) Song, L; Chen, X.; Zhang, S.-L.;* Zhang, H.; Li, P.; Luo, G.; Liu, W.; Duan, W.-H.;* Wang,
W.* “An Organocatalytic Approach to the Construction of Chiral Oxazolidinone Rings and
Application in the Synthesis of Antibiotic Linezolid and Its Analogues” Org. Lett., 2008, 10,
5489-5492.
64) Li, H.; Zu, L.-S.; Xie, H.-X.; Wang, J.; Wang, W.* “Highly Enantio- and
Diastereoselective Organocatalytic Cascade aza-Michael-Michael Reactions: A Direct
Method for the Synthesis of Trisubstituted Chiral Pyrrolidines” Chem. Commun., 2008,
5636-5638. This work has been highlighted in Org. Chem. Highlights as “New
methods for C-N ring construction.” by Organic Chemistry Portal: http://www.organicchemistry.org/Highlights/2009/27April.shtm.
65) Fu, Z.; Malureanu, L.; Huang, J.; Wang, W.; Li, H.; van Deursen, J. M.; Tindall, D. J.;*
Chen, J.* “Plk1-dependent Phosphorylation of FoxM1 Regulates a Transcriptional Program
Required for Mitotic Progression” Nature Cell Biol., 2008, 10, 1076-1082.
66) Xue, F.; Zhang, S.-L.;* Duan, W.-H.;* Wang, W.* “A Novel Bifunctional Sulfonamide
Primary Amine-Catalyzed Enantioselective Conjugate Addition of Ketones to Nitroolefins”
Adv. Synth. Catal., 2008, 350, 2194-2198.
67) Zhang,Y.-N.; Zhang, S.-L. Ma, L.; Zhang, Y.; Shen, X.;* Wang, W.;* Hu, L.-H.* “Total
Synthesis of (+)-Rutamarin” Adv. Synth. Catal., 2008, 350, 2373-2379.
68) Wang, J.; Xie, H.-X.; Li, H.; Zu, L.-S.; Wang, W.* “A Highly Stereoselective Hydrogenbond Mediated Cascade Michael-Michael Process through Dynamic Kinetic Resolution”
Angew. Chem. Int. Ed., 2008, 47, 4177-4179. This work has been selected as “hot”
paper by Angew. Chem. Editors.
69) Zu, L.-S.; Xie, H.-X.; Li, H.; Wang, J.; Yu, X.-H.; Wang, W.* “Chiral Amine Catalyzed
Enantioselective Cascade Aza-ene-type Cyclization Reactions” Eur. Chem. J., 2008, 14,
6333-6335.
70) Zhou, L.; Wang, W.-J.; Zuo, L.;* Yao, S.-Y.; Wang, W.;* Duan, W.* “Selective
Debenzylation of Aromatic Benzyl Ethers by Silica-Supported Sodium Hydrogen Sulfate”
Tetrahedron Lett., 2008, 49, 4876-4878. This work has been highlighted in Synfacts.
71) Liu, G.-X.; Wang, W.* “An Update: Diisopropyl 2-Allyl-1,3,2-dioxaborolane-4,5dicarboxylate” Encyclopedia of Reagents for Organic Synthesis [EROS], 2008, invited
book chapter.
72) Zuo, L.; Yao, S.-Y.; Wang, W.*; Duan, W.* “An Efficient Method for Demethylation of
Aryl Methyl Ethers” Tetrahedron Lett., 2008, 49, 4054-4056. This work has been
selected as “Best Synthetic Methods: Functional Group Protection” by Organic
Chemistry Portal: http://www.organic-chemistry.org/Highlights/2008/10November.shtm.
73) Xu, H.; Yu, X.-H.* Sun, L.; Liu, J.; Fan, W.; Shen, Y.;* Wang, W.* “Microwave-Assisted
Three Component Knoevenagel-nucleophilic Aromatic Substitution Reactions”
Tetrahedron Lett., 2008, 49, 4687-4689.
74) Xie, H.-X.; Zu, L.-S.; Oueis, H. R.; Li, H.; Wang, J.; Wang, W.* “Proline Catalyzed Direct
Inverse Electron Demand Diels-Alder Reactions of Ketones with 1,2,4,5-Tetrazines” Org.
Lett., 2008, 10, 1923-1926.
75) Zu, L.-S.; Xie, H.-X.; Li, H.; Wang, J.; Wang, W.* “Highly Enantioselective Aldol
Reactions Catalyzed by a Recyclable Fluorous (S) Pyrrolidine Sulfonamide on Water” Org.
Lett., 2008, 10, 1211-1214.
76) Mei, K.; Zhang, S.;* He, S.; Li, P.; Jin, M.; Xue, F.; Luo, G.; Zhang, H.; Song.; L.; Duan,
W.;* Wang, W.* “(S) Pyrrolidine Sulfonamide Catalyzed Asymmetric Direct Aldol
Reactions of Aryl Methyl Ketones with Aryl Aldehydes” Tetrahedron Lett., 2008, 49, 26812684.
77) Yu, X.; Wang, W.* “Hydrogen-Bond Mediated Asymmetric Catalysis” Chem. Asian J.,
2008, 3, 516-532 (invited review).
78) Jiang, W.; Fu, Q.-Q.; Fan, H.Y.; Wang, W.* “An NBD Fluorophore-Based Sensitive and
Selective Fluorescent Probes for Zinc Ion” Chem. Commun., 2008, 259-261.
79) Zhang, S.; Chen, X.; Zhang, J.; Wang, W.;* Duan, W.* “An Enantioselective Formal
Synthesis of (R)-(+)--Lipoic Acid by L-Proline-catalyzed Aldol Reaction” Synthesis, 2008,
383-386.
80) Yu, X.; Wang, W.* “Organocatalysis: Chiral Secondary Amine Catalyzed Asymmetric
Cascade Reactions” Org. Biomol. Chem., 2008, 6, 2037-2046. The paper is featured as
the cover of Org. Biomol. Chem.
81) Xiong, Q.-J.; Gao, Z.-B.; Wang, W.; Li, M.* “Activation of Voltage-Activated Potassium
Channels by Chemical Ligands” Trends Pharmacol. Sci., 2008, 29, 99-107.
82) Jiang, W.; Fu, Q.-Q.; Fan, H.-Y.; Ho, J.; Wang, W.* “A Highly Selective Fluorescent Probe
for Facile Detection of Thiophenols” Angew. Chem. Int. Ed., 2007, 46, 8445-8448.
83) Zu, L.-S.; Xie, H.-X.; Li, H.; Wang, J.; Wang, W.* “Three Step Synthesis of Chrial
Baclofen via a Highly Enantioselective Organocatalytic Conjugate Addition of
Nitromethane to -Unsaturated Aldehydes” Adv. Synth. Catal., 2007, 349, 2660-2664.
84) Wang, J.; Li, H.; Xie, H.-X.; Zu, L.-S.; Shen, X.; Wang, W.* “Organocatalytic
Enantioselective Cascade Michael-Aldol-Dehydration Reactions: Efficient Assembly of
Densely Functionalized Chiral Cyclopentenes” Angew. Chem. Int. Ed., 2007, 46, 90509053. This article has been selected as a “Hot paper” by ACIE.
85) Xie, H.-X.; Zu, L.-S.; Li, H.; Wang, J.; Wang, W.* “Organocatalytic Enantioselective
Cascade Michael-Alkylation Reactions. Synthesis of Chiral Cyclopropanes and
Investigation of Unexpected Organocatalyzed Stereoselective Ring Opening of
Cyclopropanes” J. Am. Chem. Soc., 2007, 129, 10886-10894. This work was
highlighted in Synfacts.
86) Zu, L.-S.; Xie, H.-X.; Li, H.; Wang, J.; Jiang, W.; Wang, W.* “A Chiral Amine Thiourea
Promoted Enantioselective Domino Michael-Aldol Reactions between 2-MercaptoBenzaldehydes and Maleimides” Adv. Synth. Catal., 2007, 349, 1882-1886.
87) Zu, L.-S.; Wang, J.; Li, H.; Xie, H.-X.; Jiang, W.; Wang, W.* “Cascade Michael-aldol
Reactions Promoted by Hydrogen-Bonding Mediated Catalysis” J. Am. Chem. Soc., 2007,
129, 1036-1037. This work was recognized as the “Most-cited” and a “Hot” paper of
JACS.
88) Wang, W.* Book Review: “Analogue-Based Drug Discovery” Drug Dev. Ind. Pharm.,
2007, 33, 803.
89) Zu, L.-S.; Li, H.; Xie, H.-X.; Wang, J.; Jiang, W.; Tang, T.; Wang, W.* “Synthesis of
Highly Functionalized Chiral Cyclopentanes by Catalytic Enantio- and Diastereoselective
Double Michael Addition Reactions” Angew Chem. Int. Ed., 2007, 46, 3732-3734. This
work was highlighted in Synfacts.
90) Li, H.; Zu, L.-S.; Xie, H.-X.; Wang, J.; Jiang, W.; Wang, W.* “Enantioselective
Organocatalytic Double Michael Addition Reactions” Org. Lett., 2007, 9, 1833-1835. This
work was highlighted in Synfacts and Org. Chem. Highlights (http://www.organicchemistry.org/ Highlights/2008/10March.shtm).
91) Wang, J.; Heikkinen, L. D.; Li, H.; Zu, L.-S.; Jiang, W.; Wang, W.* “Quinine-Catalyzed
Enantioselective Michael Addition of Diphenyl Phosphite to Nitroolefins: Synthesis of
Chiral Precursors of -Substituted -Amino Phosphonates” Adv. Synth. Catal., 2007, 349,
1052-1056. This work was recognized as one of the most accessed articles in 05/2007
of Adv. Synth. Catal. and highlighted in Synfacts.
92) Li, H.; Wang, J.; Xie, H.-X.; Zu, L.-S.; Jiang, W.; Duesler, E. N.; Wang, W.*
“Enantioselective Organocatalytic Cascade Reactions: Facile Synthesis of Chiral 1,2Dihydroquinolines” Org. Lett., 2007, 9, 965-968. This work was recognized as the
“Most-cited” and “Hot” paper of OL.
93) Li, H.; Wang, J.; E-Nunu, T.; Zu, L.-S.; Jiang, W.; Wei, S.-H.; Wang, W.* “One-Pot
Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino OxaMichael-Aldol Reaction” Chem. Commun., 2007, 507-509. This work was recognized in
the top 5 (number 2) of the “Most cited” papers published on Chem. Commun. since
2007.
94) Wang, J.; Zu, L.-S.; Li, H.; Xie, H.-X.; Jiang, W. Wang, W.* “Enantioselective Michael
Addition of N-Heterocycles to Enones Catalyzed by a Bifunctional Cinchona Alkaloid
Thiourea” invited to contribute to Special Topics Thiourea in Synthesis, 2007, 2576-2580.
95) Wang, J.; Li, H.; Zu, L.-S.; Jiang, W.; Xie, H.-X.; Duan, W.-H.; Wang, W.*
“Enantioselective Organocatalytic Conjugate Additions to Enones” J. Am. Chem. Soc.,
2006, 128, 12652-12653. This work was recognized as the “Most-cited” and a “Hot”
Paper of J. Am. Chem. Soc..
96) Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “A Recyclable Fluorous (S)-Pyrrolidine
Sulfonamide Promoted Direct, Highly Enantioselective Michael Addition of Ketones and
Aldehydes to Nitroolefins in Water” Org. Lett., 2006, 8, 3077-3079. This work was
recognized as a “Hot Paper” in March 2007 and one of the most cited articles (top 6)
in 2006 on Org. Lett.
It was also highlighted in http://www.organicchemistry.org/abstracts/lit1/320.shtm.
97) Liu, S.-Y.; Fan, Y.-P.; Peng, X.-X.; Wang, W.;* Hua, W.-Y.; Akber, H.; Liao, L.-X.* “A
Concise and Enantioselective Approach to the Total Synthesis of (-)-Lasubine I”
Tetrahedron Lett., 2006, 47, 7681-7684.
98) Wang, W.;* Li, H.; Wang, J.; Zu, L.-S.; “Enantioselective Organocatalytic Tandem
Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes” J. Am. Chem. Soc.,
2006, 128, 10354-10355. This work was recognized as the “Most-cited” and a “Hot”
Paper of J. Am. Chem. Soc. and highlighted in Synfacts.
99) Wang, J.; Li, H.; Zu, L.; Jiang, W.; Wang, W.* “Organocatalytic, Enantioselective
Conjugate Addition of Nitroalkanes to Nitroolefins” Adv. Synth. Catal., 2006, 348, 20472050. This work was recognized as one of the Most Accessed Articles from 6/2006 to
5/2007 of Adv. Synth. Catal. and highlighted in Synfacts.
100) Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Enantioselective Organocatalytic Michael
Addition Reactions between N-Heterocycles and Nitroolefins” Org. Lett., 2006, 8, 13911394. This work was highlighted in Synfacts.
101) Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Highly Enantioselective Organocatalytic Michael
Addition Reactions of Ketones with Chalcones” Adv. Synth. Catal., 2006, 348, 425-428.
This work was recognized as one of the Most Accessed Articles in the year of 2006 on
Adv. Synth. Catal..
102) Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “Highly Enantioselective AldehydeNitroolefin Michael Addition Reactions Catalyzed by Recyclable Fluorous (S)
Diphenylpyrrolinol Silyl Ether” Tetrahedron Lett., 2006, 47, 5131-5134.
103) Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Efficient, Enantioselective Organocatalytic
Synthesis of Trichostatin A” Adv. Synth. Catal., 2006, 348, 1228-1234.
104) Li, H.; Wang, J.; Zu, L.-S.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition
of Thioacetic Acid to -Nitrostyrenes” Tetrahedron Lett., 2006, 47, 2585-2589.
105) Li, H.; Zu, L.-S.; Wang, J.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition
of Thioacetic Acid to Enones” Tetrahedron Lett., 2006, 47, 3145-3148.
106) Mei, Y.; Bentley, P. A.; Wang, W. “A Selective and Sensitive Chemosensor for Cu2+ Based
on 8-Hydroxyquinoline” Tetrahedron Lett., 2006, 47, 2447-2449.
107) Wang, J.; Li, H.; Lou, B.; Zu, L.-S.; Guo, H.; Wang, W.* “Enantio- and Diastereoselective
Michael Addition Reactions of Unmodified Aldehydes and Ketones with Nitroolefins
Catalyzed by a Pyrrolidine Sulfonamide” Eur. Chem. J., 2006, 12, 4321-4332.
108) Wang, J.; Li, H.; Yu, X.-H.; Zu, L-S.; Wang, W.* “Chiral Binaphthyl-Derived AmineThiourea Organocatalyst Promoted Asymmetric Morita-Baylis-Hillman Reaction” Org.
Lett., 2005, 7, 4293-4296. This work was recognized as a Org. Lett. Hot Paper and the
most cited paper published on Org. Lett. in 2005, 2006 and 2007.
109) Wang, J.; Li, H.; Duan, W.-H.; Zu, L-S.; Wang, W.* “Organocatalytic Asymmetric Michael
Addition of 2,4-Pentandione to Nitroolefins” Org. Lett., 2005, 7, 4713-4716. This work
has been recognized as a Org. Lett. Hot Paper and one of the most cited papers
published in Org. Lett. in 2005.
110) Wang, J.; Li, H.; Mei, Y.; Lou, B.; Xu, D.; Xie, D.; Guo, H.; and Wang, W.* “Direct, Facile
Aldehyde and Ketone -Selenenylation Reactions Promoted by L-Prolinamide and
Pyrrolidine Sulfonamide Organocatalysts” J. Org. Chem. 2005, 70, 5678-5687.
111) Wang, W.;* Li, H.; Wang, J. “Pyrrolidine Sulfonamide Promoted Direct, Enantioselective
Aldol Reactions of -Dialkyl Aldehydes: Synthesis of Quaternary Carbon-Containing Hydroxy Carbonyl Compounds” Tetrahedron Lett., 2005, 46, 5077-5079.
112) Wang, W.;* Li, H.; Wang, J. “Enantioselective, Organocatalytic Mukaiyama-Michael
Addition of Silyl Ethers to Unsaturated Aldehydes” Org. Lett., 2005, 7, 1637-1639.
113) Wang, W.;* Mei, J.; Li, H.; Wang, J. “A Novel Pyrrolidine Imide Catalyzed Direct
Formation of Unsaturated Ketones from Unmodified Ketones and Aldehydes” Org.
Lett., 2005, 7, 601-604. This paper is one of the Most Accessed Articles of Org. Lett. in
the year of 2005.
114) Wang, W.;* Wang, J.; and Li, H. “Direct, Highly Enantioselective Pyrrolidine Sulfonamide
Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes” Angew. Chem. Int.
Ed., 2005, 44, 1369-1371. This work was recognized as the most cited paper of Angew.
Chem. Int. Ed. in 2005/2006 and was highlighted in Org. Chem. Highlights 2006,
January
30.
URL:
http://www.organicchemistry.org/Highlights/2006/30JanuaryB.shtm.
115) Wang, W.;* Wang, J.; Li, H. “A Simple and Efficient L-Prolinamide-Catalyzed Selenenylation Reactions of Aldehydes,” Org. Lett., 2004, 6, 2817-2820.
116) Wang, W.;* Li, H. “An Efficient Synthesis of the Intrinsic Fluorescent Peptide Labels, (S)
and (R) (6,7-Dimethoxyl-4-coumaryl)alanines via Asymmetric Hydrogenations”
Tetrahedron Lett., 2004, 45, 8479-8481.
117) Wang, W.;* Li, H.; Wang, J., Liao, L.-X. “Direct, Organocatalytic alpha-Sulfenylation of
Aldehydes and Ketones” Tetrahedron Lett., 2004, 45, 8229-8231.
118) Wang, W.;* Wang, J.; Li, H., Liao, L.-X. “A Novel Amine Sulfonamide Organocatalyst for
Promoting Direct Highly Enantioselective -Aminoxylation Reactions of Aldehydes and
Ketones”, Tetrahedron Lett., 2004, 45, 7235-7238. "Top-50 most cited articles"
published in Tetrahedron Lett. In 2004-2007.
119) Wang, W.;* Wang, J.; Li, H. “Catalysis of Highly Stereoselective Mannich-Type Reactions
of Ketones with -Imino Esters by a Pyrrolidine Sulfonamide. Synthesis of Unnatural Amino Acids,” Tetrahedron Lett., 2004, 45, 7243-7246. "Top-50 most cited articles"
published in Tetrahedron Lett. 2004-2007.
Before joining UNM (post-doc and graduate work):
120) Zhang, J.; Wang, W.;* Xiong, C.; and Hruby, V.J.* “Efficient and Stereoselective
Synthesis of cis-4-Substittued Proline Analogues” Tetrahedron Lett., 2003, 44, 1413-1415.
121) Xiong, C.; Zhang, J.; Davis, P.; Wang, W.; Ying, J.; Porreca, F.; and Hruby, V.J.
“Stereoselective Synthesis of Individual Isomers of Leu-Enkephalin Analogues Containing
Substituted -Turn Bicyclic Dipeptide Mimetics” Chem. Commun., 2003, 1598-1599.
122) Zhang, J.; Xiong, C.; Ying, J.; Wang, W.; Hruby, V.J. “Stereoselective Synthesis of
Dipeptide -Turn Mimeitcs Targeting Melanocortin Receptors: 4,8-Disubstituted
Azabicyclo[4.3.0]nonane Amino Acid Esters” Org. Lett., 2003, 5, 3115-3118.
123) Wang, W.; Yang, J.; Ying, J.; Xiong, C.; Zhang, J.; Cai, C.; Hruby, V.J. “Stereoselective
Synthesis of Dipeptide -Turn Mimetics: 7-Benzyl and 8-Phenyl Substituted Azabicyclo[4.3.0]
Amino Acids” J. Org. Chem., 2002, 67, 6353-6360.
124) Wang, W.; Cai, M., Xiong, C.; Zhang, J.; Tevil, D.; Hruby, V.J. “Design and Synthesis of
Novel 2-Constrained Phenylalanine, Naphthylalanine, and Tryptophan Analogues and
their Use in Biologically Active Melanotropin Peptides” Tetrahedron, 2002, 58, 7365-7374.
125) Zhang, J.; Xiong, C.; Wang, W.; Ying, J.; Hruby, V.J. “Stereoselective Bromination-Suzuki
Cross-Coupling of Dehydroamino Acids to Form Novel Reverse-Turn Peptidomimetics:
Substituted Unsaturated and Saturated Indolizidinone Amino Acids” Org. Lett., 2002, 4,
4029-4032.
126) Wang, W.; Gao, X.; Wang, B. “Boronic Acid-Based Sensors for Carbohydrates” Curr. Org.
Chem, 2002, 6, 1285-1317.
127) Xiong, C.; Wang, W.; Hruby, V.J. “A General Asymmetric Synthesis of syn and anti-Substituted Cysteine and Serine Derivatives” J. Org. Chem., 2002, 67, 3514-3517.
128) Wang, W.; Zhang, J.; Xiong, C.; Hruby, V.J. “Design and Synthesis of Hydrophobic, Bulky
2-Constrained Phenylalanine and Naphthylalanine Derivatives” Tetrahedron Lett., 2002, 43,
2137-2140.
129) Xiong, C.; Wang, W.; Hruby, V.J. “Regioselective and Stereoselective Nucleophilic Ring
Opening Reactions of a Phenyl Substituted Aziridine: Enantioselective Synthesis of Substituted Tryptophan, Cysteine, and Serine Derivatives” J. Org. Chem., 2002, 67, 13391402.
130) Wang, W.; Xiong, C.; Zhang, J.; Hruby, V.J. “Practical, Asymmetric Synthesis of
Aromatic-Substituted Bulky and Hydrophobic Tryptophan and Phenylalanine Derivatives”
Tetrahedron, 2002, 58, 3101-3110.
131) Wang, W.; Xiong, C.; Hruby, V.J. “An Efficient Synthesis of (2S, 6S) and meso-(2S, 6R)Diaminopimelic Acids via Asymmetric Hydrogenation” Synthesis, 2002, 94-98.
132) Wang, W.; Xiong, C.; Hruby, V.J. “An Efficient Approach to Asymmetric Synthesis of
Dipeptide -Turn Mimetics: Indolizidinone Amino Acids” Tetrahedron Lett., 2001, 42, 31593161.
133) Wang, W.; Xiong, C.; Yang, J.; Hruby, V.J. “Practical, Asymmetric Synthesis of Aromaticsubstituted Bulky and Hydrophobic Tryptophan Derivatives” Tetrahedron Lett., 2001, 42,
7717-7719.
134) Springsteen, G., Ballard, C.E., Gao, S.; Wang, W.; Wang, B. "The Developemnt of
Photometric Sensors for Boronic Acids" Bioorg. Chem., 2001, 29, 259-270.
135) Gao, S.; Wang, W.; Wang, B. "Building Fluorescent Sensors for Carbohydrates Using
Templated-directed Polymerizations" Bioorg. Chem., 2001, 29, 308-320.
136) Gao, S.; Wang, W.; Wang, B. “A Novel OsO4-Catalyzed Carbon-Carbon Bond Cleavage
Reaction to Give Anthraquinone” Chemistry Lett., 2001, 48-49.
137) Jiang, J.; Wang, W.; Sane, D.C.; Wang, B. “Synthesis of RGD Analogs as Potential Vectors
for Targeted Drug Delivery” Bioorg. Chem., 2001, 29, 357-379.
138) Wang, W.; Borchardt, R.T.; Wang, B. “Orally Active Peptidomimetic RGD Analogs that
are Glycoprotein IIb/IIIa Antagonists” Curr. Med. Chem., 2000, 7, 437-453.
139) Wang, W.; Springsteen, G.; Gao, S.; Wang, B. "The First Fluorescent Sensor for Boronic
and Boric Acids with Sensitivity at Sub-micromolar Concentrations" Chem. Comm. 2000,
1283-1284.
140) Wang, W.; Camenisch, G.; Sane, D.C.; Zhang, H.; Hugger, E.; Wheeler, G.L.; Borchardt,
R.T.; Wang, B."The Use of Prodrug Strategy to Optimize the Oral Absorption of RGD
Peptidomimetics” J. Controlled Release, 2000, 65, 245-251.
141) Shan, D.; Zheng, A.; Ballard, C.E.; Wang, W.; Borchardt, R.T.; Wang, B. "A Facilitated
Cyclic Ether Formationand its Potential Application in Solid-phase Peptide and Organic
Synthesis" Chem. Pharm. Bull. 2000, 48, 238-244.
142) Wang, W.; Gao, S.; Wang, B. "Building Fluorescent Sensors by Template Polymerization:
The Preparation of a Fluorescent Sensor for D-Fructose" Org. Lett., 1999, 1, 1209-1212.
143) Wang, W.; Jiang, J.; Ballard, C.E.; Wang, B. "Prodrug Approaches to the Improved
Delivery of Peptide Drugs" Curr. Pharm. Design, 1999, 5, 265-287.
144) Liao, Y.; Wang, W.; Wang, B. "Building Fluorescent Sensors by Template Polymerization:
The Preparation of a Fluorescent Sensor for L-Tryptophan" Bioorg. Chem., 1999, 27, 463476.
145) Wang, B.; Nimkar, K.; Wang, W.; Zhang, H.; Shan, D.; Gudmundsson, O.S.; Gangwar, S.;
Siahaan, T.; Borchardt, R.T. "Synthesis and Evaluation of the Physicochemical Properties
of Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides Using Coumarinic Acid and
Phenylpropionic Acid Linkers" J. Peptide Res. 1999, 53, 370-382.
146) Borchardt, R.T.; Camenisch, G.; Hugger, E.; Wang, W.; Sane, D.C.; Wheeler, G.L.; Cheng,
C.-P.; Wang, B. " Prodrug Strategies to Improve the Oral Absorption of Peptide Mimetics"
Polymer Preprints, 1999, 40(1), 257-258.
147) Zheng, A.; Wang, W.; Zhang, H.; Wang, B. "Two New Improved Approaches to the
Synthesis of Coumarin-Based Prodrugs" Tetrahedron 1999, 55, 4237-4254.
148) Gudmundsson, O.S.; Pauletti, G.M.; Wang, W.; Shan, D.; Zhang, H.; Wang, B.; Borchardt
R.T. "Coumarin-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability
to Peptidases and Excellent Cellular Permeability" Pharm. Res. 1999, 16, 7-15.
149) Wang, B.; Wang, W.; Camenisch, G.P.; Elmo, J.; Zhang, H.; Borchardt, R.T. "Synthesis and
Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of
Peptidomimetic RGD Analogs with Improved Membrane Permeability" Chem. Pharm. Bull.
1999, 47, 90-95.
150) Liao, Y.; Wang, W.; Wang, B. "Enantioselective Polymeric Transporters of D-Tryptophan
Prepared Using Molecular Imprinting Techniques" Bioorg. Chem. 1998, 26, 309-322.
151) Camenisch, G.P.; Wang, W.; Wang, B.; Borchardt, R.T. "A Comparison of the
Bioconversion Rates and the Caco-2 Cell Permeation Characteristics of Coumarin-Based
Cyclic Prodrugs and Methylester-Baesd Linear Prodrugs of RGD Peptidomimetics" Pharm.
Res. 1998, 15, 1174-1181.
152) Wang, B.; Zhang, H.; Zheng, A.; Wang, W. "Coumarin-Based Prodrugs. Part 3: Structural
Effects on the Release Kinetics of Esterase-sensitive Prodrugs of Amines" Bioorg. Med.
Chem. 1998, 6, 417-426.
153) Benbrook, D.M.; Madler, M.M.; Spruce, L.W.; Birckbichler, P.J.; Nelson, E.C.;
Subramanian, S.; Weerasekare, G.M.; Gale, J.B.; Patterson, M.K.Jr.; Wang, B.; Wang, W.;
Lu, S.; Rowland, T.C.; DiSivestio, P.; Berlin, K.D. "Biologically Active Heteroarotinoids
Exhibiting Anticancer Activity and Decrease Toxicity" J. Med. Chem. 1997, 40, 3567-3583.
154) Wang, B.; Wang, W.; Zhang, H.; Shan, D.; Smith, T.D. "Coumarin-Based Prodrugs 2.
Synthesis and Bioreversibility Studies of an Esterase-sensitive Cyclic Prodrug of DADLE,
an Opioid Peptide" Bioorg. Med. Chem. Lett. 1996, 6, 2823-2826.
155) Wang, B.; Zhang, H.; Wang, W. "Chemical Feasibility Studies of a Potential CoumarinBased Prodrug System" Bioorg. Med. Chem. Lett. 1996, 6, 945-950.
Articles Appearing in Chapters in Edited Volumes:
1)
2)
3)
4)
5)
6)
7)
Xu, P.-F.; Wang, W. (Eds.) “Catalytic Cascade Reactions,” Wiley-VCH: New York, 2012.
Song, A.-G.; Wang, W.* “α,α-Diphenyl-2-pyrrolidinemethanol” in “Electronic
Encyclopedia of Reagents for Organic Synthesis,” 2011, in press.
Zhang, S.-L.; Wang, W.* “Proline Derivatives” in “Privileged Chiral Ligands” Ed. by
Zhou, Q.-L. Wiley-VCH: New York, Chapter 11, pp 409-445, 2011.
Zhang, S.-X.; Wang, W.* “Organocatalytic -Sulfenylation and -Selenenylation” in
“Comprehensive Chirality” ed. by Yamamoto, H.; Carreira, E. Elsevier: Oxford, UK, 2011,
in press.
Zhang, S.-L.; Wang, W.* “Organocatalytic Enantioselective Conjugate Additions of
Heteroatoms to -Unsaturated Carbonyl Compounds” in “Catalytic Asymmetric
Conjugate Reactions” ed. by Cordova, A. Wiley-VCH: New York, pp 295-319, 2010.
Wang, W.; Zheng, A.; Liu, S.; Wang, B.* “Solid Supports, Linkers and Solid-Phase
Supported Reagents in Chemical Library Synthesis” in Combinatorial Approaches to Drug
Lead Discovery, Liu, G.; Xiao, X.; Wang, J. Eds. page 88~122, Science Press, China, 2003.
Gao, S.; Wang, W.; Wang, B.* “Molecularly Imprinted Polymers as Recognition Elements
in Optical Sensors” in Optical Sensors, Yan, M.; Ramström, O. Eds., Marcel Dekker, Inc.,
2002, invited book chapter.
8)
9)
10)
11)
12)
13)
14)
Wang, W.; Xiong, C.; Hruby, V.J.* “Two Novel and Efficient Approaches to Synthesis of
Enantiopure Dipeptide -Turn Mimetics: Indolizidinone Amino Acids” In Peptides: The
Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International
Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 30-31.
Cai, C.; Wang, W.; Xiong, C.; Soloshonok, V.A.; Cai, M.; Hruby, V.J.* “Synthesis of
Novel  and -Substituted Prolines for Conformation-Activity Relationship Studies of the
-MSH Analogues MT-II” In Peptides: The Wave of the Future: Proceeding of the 16th
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