BIOL 750.03 DEVELOPMENTAL BIOLOGY: SCHEDULE OF LECTURES AND TOPICS
DATE
TOPIC
GILBERT
WEB
REFS
PART ONE: PRINCIPLES OF DEVELOPMENT
1/30
Introduction
Ch. 1-3
2/1
Genomic equivalence
Ch 4
Yes
2/6
Genes and Development
Ch 4
Yes
2/8
Differential gene expression
Ch 5
5.1, 5.3, 5.4, 5.5
2/13
NO CLASS/MONDAY SCHEDULE
2/15
Differential gene expression
Ch 5
5.8
Yes
2/20
Induction/Signaling Pathways
Ch 6
6.2, 6.3, 6.4, 6.6
Yes
2/22
Induction/Signaling Pathways
Ch 6
Yes
2/27
Model Systems: Drosophila (Guest Lec: Brennan)
Ch 9
3/1
Model Systems: Drosophila (Guest Lec: Brennan)
Ch 9
3/6
EXAM #1
PART TWO: EARLY DEVELOPMENT IN VERTEBRATES
3/8
Fertilization
Ch 7
5.9
Yes
3/13
Comparative early development
10,11
11.6, 11.7, 11.10
Yes
3/15
Comparative early development
10,11
3/20
Comparative early development
10,11
3/22
The HOX gene code
11
Yes
3/27
Neural Induction, CNS development
10,12
12.4, 12.5
Yes
3/29
Nerual Crest
13
13.1, 13.2, 13.3
Yes
4/3
Model Systems: Dictyostelium (Guest Lec: Brazill) 2
2.5
4/5
EXAM #2
PART THREE: SELECTED ORGAN SYSTEM DEVELOPMENT
4/17
Mesoderm development, Somites (Guest Lec: Atit) 14
4/19
Limb Development (Guest lecturer: Atit)
16
4/24
Blood and Vasculature development
15
Yes
4/26
Model Systems: Hematopoiesis in Zebrafish
Yes
5/1
Selected Organ Development
5/3
Selected Organ Development
5/8
Stem Cell Biology
Yes
5/10
Primary Literature
5/15
Primary Literature
LEC DATE
REFERENCE LIST (will be updated as necessary)
2/1 (Y)
Wakayama and Yanagimachi (1999) Cloning the laboratory mouse. Sem. Cell Dev. Biol. 10:253-258
2/1. 3/13 (Y)
Kikyo and Wolffe (2000) Reprogramming nuclei: Insights from Cloning. J. Cell Sci. 113:11-20
2/6
Anderson (2000) Finding the genes that direct mammalian development. Trends Genet. 16:99-102
2/6 (Y)
Rajewsky, et. al. (1996) Conditional gene targeting. J. Clin. Invest. 98:600-603
2/15 (Y)
Li and Peterson (1999) Locus Control Regions. Trends Genet. 15:403-408
2/20-2/22 (Y)
Munroe, et. al. (1999) Hedgehog signal transduction. Exp. Cell. Res. 253:25-33
2/20-2/22 (Y)
Polakis, P. (2000) Wnt signaling and cancer. Genes Dev. 14:1837-1851
2/20-2/22 (Y)
Piek, et. al. (1999) Specificity, diversity and regulation in TGFb superfamily signaling. FASEB J. 13:2105-24
3/8 (Y)
Wassarman, P. (1999) Mammalian Fertilization. Cell 96:175-183
3/13-3/20 (Y)
Beddington and Robertson (1999) Axis development and early asymmetry in mammals. Cell 96:195-209
3/22 (N)
Deschamps, et. al (1999) Initiation, establishment and maintenance of Hox gene expression patterns in the mouse.
Int. J. Dev. Biol. 43:635-650
3/27 (Y)
Harland, R. (2000) Neural induction. Curr. Opin. Genet. Dev. 10:357-362
3/29 (N)
LaBonne and Bronner-Fraser (1999) Molecular mechanisms of neural crest formation. Ann. Rev. Cell. Dev.Biol.
15:81-112
4/24 (Y)
Engel and Murre (1999) Transcription factors in hematopoiesis. Curr. Opin. Genet. Dev. 9:575-579
4/26 (Y)
Amatruda and Zon (1999) Dissecting hematopoiesis and disease using the zebrafish. Dev. Biol. 216:1-15
References that are not available as PDF files on the website (marked with "N") will be placed on reserve in the Socrates Center