Stephen Byers August 2012
STEPHEN BYERS BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Stephen W. Byers
Professor
eRA COMMONS USER NAME
sbyers
EDUCATION/TRAINING
INSTITUTION AND LOCATION
Liverpool University, UK
University of Queensland, Australia
Georgetown University, Washington, D.C.
DEGREE
(if applicable)
YEAR(s)
B.Sc(hon)
Ph.D.
Postdoc
1975
1981
1984
FIELD OF STUDY
Chemistry/Biochemistry
Endocrinology
Cell Biology
Biographical Material:
Stephen Byers was educated in the UK and Australia. He was a Ford Foundation Scholar and came to the US
in 1982 as a Rockefeller Foundation Fellow. He has authored more than 140 papers and patents in the areas
of, cell adhesion, chemoprevention and the development of anti-cancer drugs. In 2003 with Dr. Aydin Tozeren,
he published “New Biology for Engineers and Computer Scientists”. This book was amongst the first to
recognize that Systems Biology/Medicine would require the efforts of individuals with strong quantitative skills
who need to be educated in the fundamentals of “New Biology”. His laboratory has three major interests. The
first relates to the role of the cadherin/catenin system in carcinogenesis, the second to studies of the anti
cancer actions of vitamins A and D and cancer drug development and the third to interactions among NFb,
TGF, wnt and vitamin D pathways. In the early-mid 1980s as a junior faculty member, with Martin Dym he
discovered the role of Matrigel in promoting differentiation and developed the first examples of commercial dual
environment culture chambers. He went on the demonstrate the role of E-cadherin and -catenin in promoting
epithelial-mesenchymal transitions in breast cancer and discovered the role of cadherin-11 in this process. In
the mid-late 1990s his group demonstrated that phosphorylation of key residues in -catenin promoted its
degradation and ubiquitination and resulted in oncogenic transformation. Together with Dr. Shah his laboratory
was the first to show the interaction of the vitamin A and D pathways in the regulation of -catenin signaling
and showed that partial vitamin D antagonists could act as specific anti-cancer agents in cells that express
activated -catenin. In 2011 his laboratory discovered the long sought after tubulin tyrosine carboxypeptidase
and he has resurrected his training in chemistry to become more focused on the development of anticancer
drugs, the computational repositioning of existing FDA-approved drugs for alternative targets with Dr.
Dakshanamurthy, and metabolomic profiling of serum and urine as a means of predicting cancer patient
outcome. Dr. Byers is a Professor and an Associate Director at the Lombardi Comprehensive Cancer Center,
Georgetown University with appointments in the Departments of Oncology and Biochemistry, Molecular and
Cellular Biology. Currently he is Director of the Lombardi Shared Resources, Director of the Translational
Technologies Component of the Georgetown-Howard Universities Clinical and Translational Science Award
(CTSA), a member of the Tumor Biology and Biochemistry, Molecular and Cellular Biology Programs and is on
the boards of Adherex Technologies, Sarfez Pharmaceuticals, Adheron Therapuetics and ScienceExchange.
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Stephen Byers August 2012
Selected Publications (from 140+ and nine patents; 54 cites/item; h index 51):
New Biology for Engineers and Computer Scientists. A. Tozeren and S. Byers. Prentice-Hall 2003.
Dakshanamurthy S, Issa NT, Assefnia S, Seshasayee A, Peters OT, Shah R, Madhavan S, Uren A, Brown ML
and Byers SW. Predicting new indications for approved drugs using a proteochemometric method. J Med
Chem (2012) 55:6832-48.
Byers SW, Rowlands T, Beildeck M and Bong YS. Mechanism of action of vitamin D and the vitamin D
receptor in GI cancer prevention and treatment. Reviews in Endocrine and Metabolic Disorders (2012)
13:31-8.
Sahab ZJ, Hall M, Sung, Y-M, Dakshanamurthy, S, Ji, Y, Kumar D and Byers SW. Tumor suppressor
RARRES1 regulates -tubulin tyrosination by interaction with AGBL2 a novel cytosolic carboxypeptidase.
(2011) Cancer Research 71: 1219-1228 (Priority Report)
Shah S, Naimul Islam M, Sivanesan, D, Rivzi I, Herrell, R, Aranda, A, Moras D, Welsh J and Byers S. The
Molecular Basis of Vitamin D Receptor and -Catenin Cross Regulation (2006). Mol. Cell 21: 799-809
Easwaran,V, Pishvaian, M., Salimuddin, and Byers, S. (1999) Cross regulation of -catenin-LEF/TCF and
retinoid signaling pathways. Current Biology 9: 1415-1418
Orford, K., Orford, C. and Byers, S. (1999) -catenin regulates contact inhibition, anchorage-independent
growth, anoikis and radiation-induced cell cycle arrest. J Cell Biol 146: 855-867
Orford, K., Crockett, C., Weissman, A. and Byers, S.W. 1997. Serine phosphorylation-regulated ubiquitination
and proteosomal degradation of -catenin. J Biol Chem. 272: 24735-38
Major funding FY 2014 (not including fellowships or grants for which there is no funded % effort).
Complete funding information is provided at the end of this document:
NIH R01CA129813 (Stephen Byers PI) -catenin-specific regulation of the vitamin D pathway in colon cancer.
(15% effort)
NIH P30 CA51008-16 Weiner PI) Cancer Center Support Grant. Role: Director of Shared Resources (25%
effort)
NIH Clinical and Translational Science Award (CTSA) (Verbalis and Mellman PIs). Co-director (with John
Massari, Howard University) of the Translational Technologies Resource Component. (20% effort)
DOD Synergistic IDEA award (Byers and Kumar PIs) Role of Tazarotene Induced Gene-1 (TIG1) in Prostate
Cancer. (10% effort)
NIH R01 CA170653 Response to Provocative Question RFA. Cadherin-11 in poor prognosis cancers and
rheumatoid arthritis-common target common therapies? (Byers PI, subcontracts to Drs Shapiro
(crystallography) and Brenner (arthritis) at Columbia and Harvard respectively) (15% effort)
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Stephen Byers August 2012
Positions and Honors:
Professional Experience:
Ford Foundation Research Scholar - 1976-1980, University of Queensland
Lecturer in Biochemistry - 1977-1979, Queensland Institute of Technology
Teaching Fellow in Life Science - 1980-1981, Griffith University, Queensland
Rockefeller Foundation Fellow - 1981-1984, Department of Anatomy and Cell Biology, Georgetown University
Assistant Professor - 1984-1991, Department of Anatomy and Cell Biology, Georgetown University
Associate Professor - 1991-1997 Department of Cell Biology, Georgetown University
Professor-1997 and presently Department of Biochemistry, Molecular and Cellular Biology
Professor-1999 and presently Department of Oncology, Lombardi Comprehensive Cancer Center
Sabbatical leave-1993-1994 Laboratory of Chemoprevention, NCI, NIH
Director MDPhD Program-1999-2011 Georgetown University
Director Shared Resources-2005 and presently Lombardi Comprehensive Cancer Center
Associate Director-2005 and presently Lombardi Comprehensive Cancer Center
Director GUMC Research Resources
Director of the Translational Technologies and Resources Component of the Georgetown Howard Universities
Center for Clinical and Translational Science GHUCCTS (CTSA)
Honors and Awards:
Ford Foundation Scholarship
Daniel Walker McCloud Prize, University of Queensland 1978
Rockefeller Foundation Fellowship
Spinks Research Award, National Kidney Foundation
Komen Foundation Award
Study Section Service:
Served on over 30 NIH, DOD, NSF, Komen and other Foundation study sections. Leader of Komen
Foundation Tumor Biology Study Section and member of the Komen Foundation National Grants Program
Task Force 1999-2003. Member of site visit team for Program Project “Cellular Pathways in Oncogenesis” Eric
Weischaus PI, Princeton University, September 2000. Member of site visit team for Program Project
“Transgenic animals models of breast cancer” Richard Pestell, PI, Albert Einstein University, February 2002.
Member of site visit team for Program Project “H. Pylori and gastric cancer” Richard Peek, PI, Vanderbilt
University, May 2005. Ad hoc ember NCI T32/K99 study section 2007-present. Ad hoc member CDP study
section 2008-present. Ad hoc member TCB study section 2011. Reviewer for North Carolina Biotechnology
Center, Raine Medical Research Foundations 2008. Member of P01 review panel for 2010/10 ZCA1 RPRB-0
(O1) Molecular Oncology-Basic, Translational and Clinical Studies, May 2010, January 2011, May 2011.
Member University of Kansas Cancer Center External Advisory Board (2010-present); Ad hoc reviewer R15
AREA grants April 2012, October 2012.
Boards and Consultancies:
Consultant in cell biology for the Millipore Corporation, 1987-89.
Scientific Advisory Board Adherex Technologies 1998 and presently
Scientific Advisory Board Sarfez Pharmaceuticals 2006 and presently
Scientific Advisory Board ScienceExchange 2011 and presently
Scientific Advisory Board Adheron Therapuetics 2013 and presently
Manuscript review:
Endocrine Reviews, PNAS, PLoS One, Molecular and Cellular Biology, EMBO J, FASEB J. Journal of Clinical
Investigation, Journal of Cell Biology, Journal of the National Cancer Institute, Cancer Research, Hepatology,
Journal of Clinical Endocrinology and Metabolism, Oncogene, Journal of Biological Chemistry, Carcinogenesis,
Circulation Research, Journal of Cell Science, BMC-Cell Biology, Biology of Reproduction, American Journal of
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Stephen Byers August 2012
Anatomy, Endocrinology, Developmental Biology, American Journal of Physiology, Journal of Reproduction
and Fertility, Journal of Andrology, International Journal of Andrology, Molecular Reproduction and
Development, British Journal of Cancer, Cancer Communications, Journal of Cellular Physiology, Breast
Cancer Research and Treatment, Biochemistry, Tissue and Cell, Gastroenterology, Cancer, American Journal
of Pathology, Experimental Cell Research, Biochem and Biophys Acta, Journal of Investigative Dermatology,
Clinical Cancer Research, Human Frontiers of Science,
Book review:
"The epididymis, sperm maturation and fertilization" by TG. Cooper. Reviewed for Acta Endoc. 1987.
National Geographic GeoKit Cells and Microorganisms-1998. Teaching guide for grades 5-9.
School and College Student Mentorship:
Summers of 1991-1998-mentor for minority high school students
1996-present mentor in the Thomas Jefferson High School for Science and Technology Mentorship Program
1997-present, judge for Junior Science and Humanities Symposium
1997-present, mentor for Howard Hughes students
1992-2005, regular guest teacher in DC public elementary, middle and high schools
1999-presenter at Deal Middle School Career Day
Academic Planning and Governance:
Departmental Faculty Search committee (1985-1997)
Departmental Teaching and Research Responsibility committee (1989-93)
Director of the Confocal Microscope Facility (1990-1993)
Departmental Radiation Safety Officer (1982-1993)
Initiated and organized for the first two years the Departmental Cell Biology Journal Club
Director of the Departmental Seminar Series (1987-1988)
Committee for the design and implementation of a Medical Center Graduate Program in Molecular and Cellular
Biology (1992)
Medical Center Curriculum Committee (1994-2000)
Director of the Interdisciplinary Program in Molecular Cell Biology (1994-1995)
Chairman of the Cell Biology Graduate Advisory Committee (1993-1997)
Chairman of the MD/PhD Admissions and Mentorship Committee (1997-2000)
Medical Center Graduate Advisory Committee (1996 and presently)
Cell Biology Graduate Advisory Committee (1993-1999)
Tumor Biology Graduate Advisory Committee (1998 and presently)
Committee for Restructuring the Deans Office and Library (1997)
Associate Director of the MD/PhD Program (1998-1999)
Member, MD/PhD Program Advisory Committee (1998-2002)
Chairman, Search Committee for the Chair of Physiology (1999)
Director of the MD/PhD Program (1999-2010)
Search Committee for Cancer Center Director (2001)
Radiation Safety Committee (2001-2005)
Search Committee for Biochemistry Chair (2002)
LCME Accreditation Committee (2002)
Member, Scientific Advisory Committee of the GUMC Office of Enterprise Development-2007 and presently
Member, Committee for the design and implementation of a GU Computational and Systems Biology Program
2007
Member, Committee for the design and implementation of a Systems Medicine Curriculum at GUMC-2007 and
presently
Chair of the Systems Medicine and Translational Research Steering Committee-2008
Member GUMC Strategic Planning Committee-2008 and presently
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Stephen Byers August 2012
Member GUMC Financial Operations and Facilities Implementation Design Team-2009 Member GUMC
Systems Medicine Implementation Design Team-2009
Member GU Grievance Committee 2010-present
Teaching Activities:
Queensland Institute of Technology, Australia 1977-1979. Lecturer and Instructor in a team-taught Physical
Biochemistry course
Griffith University, Australia 1980-1981. Lecturer and Instructor in team-taught courses in Advanced Animal
Physiology, Plant Physiology, Virology and Biochemistry
Georgetown University, Departments of Anatomy, Biochemistry Molecular and Cellular Biology and Oncology
Medical Gross Anatomy
Major Lecture and Laboratory teaching commitment in Medical Gross Anatomy. From 1984-1997 I carried a
heavy teaching load in Medical Gross Anatomy. This included lectures on all anatomical regions, lecture
review and pre-laboratory sessions and 80-120 hours of laboratory instruction. Teaching evaluations were
outstanding throughout this period with several nominations for the Golden Apple award.
Molecular Cell Biology: In 1988 I developed a new 4 credit graduate level Molecular Cell Biology course. Until
1998 I directed this course which was required of all students in the Interdisciplinary Graduate Programs
(Tumor Biology, Neuroscience, MD/PhD and Biomedical Scholars) and is taken by most students in the
Departmental Programs. Each year I gave between 18 and 30 lectures covering all aspects of the subject area
ranging from transcriptional regulation to mathematical models of genetic and signaling circuits. In addition, I
organized, proctored and graded two three hour examinations and the papers submitted by the students at the
end of the course, as well as arrange for lecturers from other departments and from outside the University.
Teaching evaluations were outstanding throughout this period.
Problem Based Learning: In 1994 Georgetown University Medical Center expanded its teaching program to
include a PBL component. I was actively involved in PBL since its inception until 2002, generally running two
or three cases each semester (6 hours of contact/case), including Anatomy and Genetics cases.
1998-Design and implementation of the Core Curriculum in Biochemical and Cellular Sciences, a 12 credit
modular course designed to provide a flexible treatment of broad and in depth aspects of modern and
experimental aspects of Cell and Molecular Biology. This replaces the Molecular Cell Biology Course (see
above), Graduate Biochemistry, and Molecular Biology and fulfills the Medical Biochemistry and Microscopic
Anatomy requirements for MD/PhD students.
Other Teaching: I give occasional lectures in several other courses including Medical Microscopic Anatomy,
Embryology, Tumor Biology, Tumor Endocrinology and Survival Skills and Ethics, Life-styles and Cancer
prevention. I was co-director of a two credit seminar course, Current Topics in Cancer Research 2002-2003.
Graduate students: Advisor for Dr. Qing-Xiang Sang (Ph.D 1990), Steve Seslar (MD/Ph.D. 1993), Connie
Sommers (Ph.D. 1993) Vijay Easwaran (PhD. 1999), Keith Orford (MD/PhD, 2001), Mike Pishvaian
(MD/PhD2001), Christie Jarrett (PhD 2001), Carolyn Feltes (MD/PhD 2002) Marissa Teo (PhD 2003) Rod
Herrell (PhD 2005), Anne Kawczezsky-Farina (2008) Jaime Guidry (PhD 2009), Michael Hall (PhD 2009),
Priya Prahalad (MDPhD 2010), Marcy Beildeck (PhD 2009). Co-advisor for Mark Hadley (Ph.D 1986), John
Ojeifo (Ph.D. 1990) and Stacey Da Costa (PhD 2001),
Member of the Dissertation committees of the following students: Nancy Parenteau (Ph.D. 1983), Mark Hadley
(Ph.D. 1986), Brian Lacy (Ph.D. 1987), Shawn Green (Ph.D. 1988) Hwai Shi Wang (Ph.D. 1990), John Ojeifo
(Ph.D. 1990), Hala Azzam (Ph.D 1993), Wayne Monsky (Ph.D 1995), B. Radhakrishnan (Ph.D 1994), Prasit
Pavasant (Ph.D 1995), Chen Yong Lin (Ph.D 1994), Isabel Lacaci (Ph.D 1995), Jennifer Low (Ph.D 1996),
Sharyl Nass (Ph.D. 1996), Ted Teng (PhD 1999), Ming Yu (PhD 1997), Alex Adducci (Pathology), Rita Ward
(Biology, Ph.D 1993), Steve Weeks (Microbiology, Ph.D 1998), Mark Mense (Pathology, Ph.D 1995), Colin
McCalman (McGill University, Ph.D 1994), Matt Symonds (McGill University, MS (1999), Christelle Benaud
(PhD 2000), Joon-Ho Sheen (PhD 2001), Ranjan Ray (PhD 2002), Gary Disbrow (PhD 2003), Puneet Jolly
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Stephen Byers August 2012
(MDPhD 2006), Kimberley Batty (PhD 2007), Robert Newman (PhD 2005), Jeffrey Allen (PhD 2005), Aparna
Mani (MDPhD 2008), Carolyn Greene, Annabelle Oh (PhD 2006), Ruichi Nehra, I-Chu Tseng, Sonia Di Assis
(PhD 2006), Kelly Boeneman (PhD 2007), Mark Markowski (MDPhD 2009), Ion Cotarla (PhD 2006), Riddish
Shah (PhD 2006), Christopher Vandenbusche (MDPhD 2008), Matt Anderson (PhD 2008), Brian Yokely (PhD
2010), Christopher Chien (PhD 2011), Priyankar Anand, Valerie Trabosh (PhD 2009), Geoffrey Storcham,
Gabe Benton (PhD 2010), August Stuart (MS 2008), Shalija Divekar (PhD 2009), Elspeth Beauchamp (PhD
2010), Will Frazier, Tiernan Mulrooney (PhD 2012), Sawali Sudarshan (MDPhD 2012), Jose Angel Montero
Santamaria, Ping-Ching (PhD 2012), Kyle DeVito, Raid Sahim, Paul Sirajjudin
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Stephen Byers August 2012
Publications:
Book
New Biology for Engineers and Computer Scientists. A. Tozeren and S. Byers. Prentice-Hall. 2003.
Patents:
Title: Compounds and methods for inhibiting cancer metastasis
Inventors: Orest W. Blaschuk, Symonds; James Matthew, Stephen Byers and Barbara J. Gour
United States Patent Number: 6,433,149
Date of Patent: August 13, 2002
Title: Methods for treating cancer by modulating beta-catenin mediated gene expression
Inventors: Orest W. Blaschuk, Stephen Byers and Barbara J. Gour
United States Patent Number: 6,677,116
Date of Patent: January 13, 2004
Title: Methods for diagnosing and evaluating cancer
Inventors: Orest W. Blaschuk, James Matthew Symonds, Stephen Byers and Barbara J. Gour
United States Patent Number: 6,680,175
Date of Patent: January 20, 2004
Title: Methods for diagnosing and evaluating cancer
Inventors: Orest W. Blaschuk, James Matthew Symonds, Stephen Byers and Barbara J. Gour
United States Patent Number: 6,682,901
Date of Patent: January 27, 2004
Title: Compounds and methods for stimulating beta-catenin mediated gene expression and differentiation
Inventors: Orest W. Blaschuk, Stephen Byers and Barbara J. Gour
United States Patent Number: 6,706,685
Date of Patent: March 16, 2004
Title: Compounds and methods for modulating OB-cadherin-mediated function
Inventors: Orest W. Blaschuk, Barbara J. Gour, James Matthew Symonds and Stephen Byers
United States Patent Number: 7,481,999
Date of Patent: January 27, 2009
Title: Cadherin-11 Inhibitors and Methods of Use Thereof
Inventors: Stephen Byers, Milton Brown, Jaime Guidry and Sivanesan Dakshanamurthy
United States Serial Number: 13/148,579
Patent Filed: September 3, 2009
Title: Small Molecule Inhibitors of AGBL2
Inventors: Stephen Byers, Sivanesan Dakshanamurthy and Ziad Sahab
United States Serial Number: 61/443,069
Patent Filed: February 15, 2011
Title: Method for Predicting Drug-Target Interactions and Uses for Drug Repositioning
Inventors: Stephen Byers, Sivanesan Dakshanamurthy
United States Serial Number: 61/662,696
Patent Filed: June 21st, 2012
Papers in preparation:
Teo, M, Attiga, F. Jarrett, C, Zipper, L, Waldman, T, Gaynor, R, Pestell, R. and Byers, SW. The role of the IKK
complex in cytokine regulation of -catenin signaling.
Dakshanamurthy S, Kim, M, Brown ML and Byers SW. New Computer Aided Approach for drug discovery:
Application to the identification of angiogenesis inhibitors.
Dakshanamurthy S, Thembani, ED, Divekar S, Brown, ML Byers SW and Martin MB. Structure based
identification of a novel dual inhibitor of VEGFR2 and the estrogen receptor.
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Stephen Byers August 2012
Dakshanamurthy S, Brown, ML and Byers SW. An electrostatic potential based approach for protein-ligand
recognition and discrimination.
Dakshanamurthy S, Paige, M, Kim, M, Hansen, T, Suy, S, Shah. S, Byers, SW and Brown ML. Identification of
multi-kinase Inhibitors using a multi-step computer aided approach.
McCleskey, S. Hoxter, B, Geiger, B., Erez, N, Gour, B. Blaschuk, O and Byers, SW. Novel cyclic peptide
antagonists of classical cadherin function disrupt endothelial cell adhesion and inhibit breast tumor growth
in mice.
Zipper, L. Wellstein A, Riegel, A. and Byers, SW. Regulation of FGF-BP1 expression by -catenin and
cytokines.
Farina, A, Lechleider R and Byers SW. TGFregulation of cadherin-11 expression.
Herrell. R, Shah, S and Byers, SW. The -catenin N-terminal differentially regulates nuclear receptor and TCF
pathways.
Lee M-H, Assefnia S, Bong Yonset cholangiocarcinoma and foregut abnormalities in smad4 heterozygous mice.
rapid
Publications (from 140+; 54 cites/item; h index 51)
Bong YS, Assefnia S and Byers SW. Loss of the vitamin D receptor increases large intestinal cancer in
APC1638N mice and models the Gardners Syndrome subtype of FAP. Submitted
Bong YS, Assefnia S and Byers SW. Loss of the vitamin D receptor causes squamous cell carcinoma of the
anus and increases colorectal cancer multiplicity in azoxymethane treated mice. Submitted
Knabb JK*, Beildeck ME*, Islam MD, Byers SW (*co-first author). Regulation of epigenetic changes by the
vitamin D receptor during tumorigenesis. Submitted
Sung YM, Sahab Z, Hall M, Muthra, S, Knabb J, Glasgow E, Kumar D and Byers SW. AGBL2/CCP2 is a
tubulin tyrosine carboxypeptidase that regulates cell survival through modulation of 6-integrin. Submitted
Hall MD, Sung, Y-M, Ji Y, Madanikia S, Maxfield KE, Glasgow E, Sahab ZJ, Kumar D and Byers SW. Vitamins
A and D commonly regulate tumor suppressor RARRES1 to influence cell division and embryonic
development in zebrafish. Submitted
Clark PM, Reynolds J, Dampier W, Fatatis A, Byers SW, Pestell RG and Tozeren A. Microarray meta-analysis
reveals conserved pathways, transcription factors and regulatory crosstalk between inflammatory bowel
disease and colorectal cancer phenotypes. Submitted
Gusev Y, Natarajan T, Song L, Ms. Bhuvaneshwar K, Gauba R, Pandey A, Haddad B, Goerlitz D, Cheema C,
Juhl H, Kallakury B, Marshall J, Byers S, Weiner L. Multi-omics profiling of colorectal cancer identifies
immune determinants associated with relapse. Submitted
Assefnia, S, Auvil J, Dakshanamurthy S, Hampel C, Brown MB, Uren A, Anastasiadis, P, Brenner, MB and
Byers SW. Cadherin-11 regulates tumor growth and progression in poor prognosis cancers. In 2nd revision
(for Cancer Discovery)
Boyechko T, Adu A, Abdel-Latif A, Rangnekar V, Byers SW and Mao, CD. TCF7L2 alternative exon profiles
distinguish breast cancer cell lines with mammary epithelial lineage commitments. (2013) PLoS One In
Press
Issa NT, Byers SW and Dakshanamurthy S. Drug repurposing: From computer to bedside. (2013) Critical
Topics in Medicinal Chemistry. In Press
Issa NT, Krugar J, Byers SW, Dakshanamurthy S At the Interface of Cancer Metabolomics and Therapeutics:
A Drug Repurposing Opportunity. Metabolomics (2013) S1: e002. doi:10.4172/2153-0769.S1-e002
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Stephen Byers August 2012
Brouxhon SM, Kyrkanides S, Teng X, O’Banion MK, Clarke R, Byers SW and Ma L. Soluble-E-cadherin
activates HER and IAP family members in HER2+ and TNBC human breast cancers. (2013) Mol
Carcinogenesis Jun 18. doi: 10.1002/mc.22048.
Brouxhon SM, Kyrkanides S, Teng X, O’Banion MK, Clarke R, Byers SW, Silberfeld A, Tornos C and Ma L.
Targeting shed E-cadherin inhibits breast carcinogenesis by down-regulating key resistance pathways in
humans and mice. (2013) Clin Cancer Research 19:3234-46.
Issa NT, Krugar J, Byers SW and Dakshanamurthy S. Drug repurposing a reality: A computational systems
perspective. Expert Reviews in Clinical Pharmacology. (2013) 6: 95-97
Rodriguez OC, Kolukula VK, Tomita Y, Preet A, Zhang L, Creswell K, Palmieri F, Wellstein A, Byers SW, Giacci
AJ, Glasgow E, Albanese C and Avantaggiati ML The mitochondrial citrate transporter, CIC, maintains
mitochondrial homeostasis and promotes tumorigenesis. (2012) OncoTarget ePub October 18, 1012
Sahab ZJ, Sudarshan SR, Kirilyuk A, Suprynowicz, F, Simic V, Dai Y, Byers SW, Schlegel R and Liu X. The
HPV-16 E5 protein is expressed in two prototype cervical cancer cell lines. (2012) J Virol 86:9465-73
Dakshanamurthy S, Issa NT, Assefnia S, Seshasayee A, Peters OT, Shah R, Madhavan S, Uren A, Brown ML
and Byers SW. Predicting new indications for approved drugs using a proteochemometric method. J Med
Chem (2012) 55:6832-48.
Clark PM, Dawany N, Dampier WN, Papazoglou E, Byers SW, Pestell RG, Tozeren A. Bioinformatics analysis
reveals transcriptome and microRNA signatures, and drug repositioning targets for IBD and other
autoimmune diseases. (2012) Inflammatory Bowel Diseases 18:2315-33
Adhikari S, Karmahapatra SK, Karve TM, Bandyopadhyay S, Woodrick J, Manthena PV, Glasgow E, Byers
SW, Saha T and Uren A. Characterization of magnesium requirement of human 5'-Tyrosyl DNA
Phosphodiesterase mediated reaction. (2012) BMC Res Notes. 9;5:134
Sahab ZJ, Kirilyuk A, Sung Y-M, Zhang L and Byers S. Analysis of α-tubulin C-Terminal Tail Modifications by
Nano-UPLC-Q-TOF Following Sequential Trypsin and Proteinase K Digestion (2012) J. Proteome Res.
11:1913-23.
Byers SW, Rowlands T, Beildeck M and Bong YS. Mechanism of action of vitamin D and the vitamin D
receptor in GI cancer prevention and treatment. Reviews in Endocrine and Metabolic Disorders (2012)
13:31-8.
Sang QA, Man YG, Sung, YM, Khamis, ZL, Zhang L, Lee, M-H, Byers SW and Sahab ZJ. TYK2 deficiency in
estrogen receptor -negative in vivo human breast cancer. (2011) Clin Exp Met 29:143-53
Mao CD and Byers SW. Cell-context dependent TCF/LEF expression and function: Alternative tales of
repression, de-repression and activation potentials. Critical Reviews in Eukaryotic Gene Expression
(2011) 21:207-36.
Madhavan, S, Gusev, Y, Harris M, Tanenbaum DM, Gauba R, Bhuvaneshwar, K, Shinohara A, Rosso K,
Carabet LA, Song L, Riggins RB, Dakshanamurthy S, Wang Y, Byers SW, Clarke R, Weiner L. G-DOC: A
Systems Medicine Platform for Personalized Oncology. (2011) Neoplasia 9:771-83
Chang S, Wang R-H, Akagi K, Kim KA, Martin BK, Cavallone L, Haines DC, Basik M, Mai P, Poggi E, Isaacs
C, Looi LM, Mun KS, Greene MH, Byers SW, Teo S-H, Deng C-X and Sharan SK. Tumor Suppressor
BRCA1 epigenetically controls oncogenic miRNA-155 (2011) Nature Medicine 17:1275-82
Khamis ZI, Sahab ZJ, Byers SW and Sang QA. Stromal biomarkers define estrogen receptor status of human
breast cancer. (2011) J Biomed Biotechnol. 723650. Epub 2011 Oct 3.
Sahab ZJ, Byers SW and Sang QA Biomarkers of estrogen receptor negative breast cancer. (2011) Int J Mol
Sci 12: 4504-4521
Adhikari S, Karmahapatra SK, Elias H, Dhopeshwarkar P, Williams RS, Byers SW, Uren A and Roy R.
Development of a novel assay for human tyrosyl DNA phosphodiesterase 2 (2011) Anal Biochem
416:112-6.
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Stephen Byers August 2012
Sheikh K, Khanna S, Byers SW, Fornace AJ and Cheema AK. Small molecule metabolite extraction strategy
for improving LC/MS detection of the cancer cell metabolome. (2011) J Biomol Tech 22: 1-4
Sahab ZJ, Hall M, Sung, Y-M, Dakshanamurthy, S, Ji, Y, Kumar D and Byers SW. Tumor suppressor
RARRES1 regulates -tubulin tyrosination by interaction with AGBL2 a novel cytosolic carboxypeptidase.
(2011) Cancer Research 71: 1219-1228 (Priority Report)
Struewing I, Boyechko T, Barnett C, Beildeck M, Byers SW, and Mao CD. The balance of TCF7L2 isoforms
with differential activities in Wnt-signaling is regulated by lithium in a GSK3-independent manner. (2010)
BBRC 399: 245-50.
Sahab, Z, Man, Y-G, Semaan, S, Byers, SW, Sang, Q-X. Alteration in protein expression in estrogen receptor
alpha negative breast cancer tissues indicates a malignant and metastatic phenotype. (2010) Clin Exp
Metas 7:493-5003
Sahab, ZJ, Hall MD, Zhang L, Cheema AK, Byers SW Tumor Suppressor RARRES1 Regulates DLG2, PP2A,
VCP, EB1, and Ankrd26 (2010) J Cancer 1:14-22
Prahalad P and Byers SW. COUP-TFII and TGF-receptor activity mediate retinoic acid-induction of VEcadherin and network formation in breast cancer cells (2010) PLoS One Apr 6;5(4):e10023.
Beildeck, ME, Gelmann EP and Byers SW. Cross regulation of wnt/-catenin and nuclear receptor pathways
(2010) Exp Cell Res. 2010 316:1763-72.
Yasuhara R, Yuasa T, Byers SW, Shah S, Pacifici, M, Iwamoto M and Enomoto-Iwamoto M. Wnt 
and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix
turnover. (2010) J Biol Chem 285:317-27.
Beildeck ME, Islam MN, Shah S and Byers SW. Control of TCF4 by vitamin D and the vitamin D receptor in
mammary gland and colon cancer cells (2009) PLoS One Nov 17;4(11):e7872
Alper O, Stetler-Stevenson WG, Harris LN, Leitner WW, Ozdemirli M, Hartmann D, Raffeld M, Abu-Asab M,
Byers S, Zhuang Z, Oldfield EH, Tong Y, Bergmann-Leitner E, Criss WE, Nagasaki K, Mok SC, Cramer
DW, Karaveli FS, Goldbach-Mansky R, Leo P, Stromberg K, Weil RJ. Novel anti-filamin-A antibody
detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade
astrocytoma. (2009) Cancer Sci. 100:1748-56.
Beildeck, ME and Byers SW. Vitamin D analogs in colon cancer prevention and care. (2009) Current
Colorectal Cancer Reports. 5: 185-196
Kim D, Alaoui A, Levine E, Leonaridis L, Shields P, Byers S and Cleary, K. System architecture and
information model for integrated access to distributed biomedical information (2009) SPIE Proceedings
Vol. 7264 Medical Imaging 2009: Advanced PACS-based Imaging Informatics and Therapeutic
Applications, Khan M. Siddiqui M.D.; Brent J. Liu, Editors, 72640G 13 March 2009
Alaoui A, Kim D, Levine E, Leondaridis L, Shields P, Byers S and Cleary K. A Hybrid System Design
Approach to Enable Translational Research (2009) AMIA Summit on Translational Bioinformatics
Byers SW, Pishvaian MJ, Mishra L and Glazer RI. TGF, Notch and Wnt in Normal and Malignant Stem Cells:
Differentiating agents and Epigenetic Modulation. (2009) In: Stem Cells and Cancer (Farrar WJ Editor)
Cambridge University Press.
Mishra L, Banker T, Murray J, Byers SW, Thenappan T, He A, Shetty K, Johnson L and Reddy EP Liver Stem
Cells and Hepatocellular Carcinoma. (2009) Hepatology 49:318-29.
Farina A, Bong Y-S, Feltes C and Byers SW. Post-transciptional regulation of cadherin-11 by GSK3 and catenin in prostate and breast cancer cells. (2009) PLoS One 4:e4797.
Endo Y, Deonauth D, Prahalad P, Hoxter D, Zhu J, and Byers SW. Retinoic Acid Mediates Endothelial Transdifferentiation of Breast Cancer Cells: Role of Sox-9, ER81 and VE-cadherin. (2008) PLoS One
16;3:e2714.
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Stephen Byers August 2012
Ji Y, Shah S, Soanes K, Md Naimul Islam M, Hoxter DR, Biffo S, Heslip T and Byers SW. Eukaryotic initiation
factor 6 regulates Wnt signaling and -catenin protein translation. (2008) Oncogene 27: 755-62
Byers SW and Shah S. Vitamin D regulation of wnt/-catenin signaling and innate immunity in colorectal
cancer. (2007) Nutrition Reviews 65: S118-S120
Pishvaian M and Byers SW, Biomarkers of wnt signaling in cancer and stem cells. (2007) Cancer Biomarkers.
3(4-5):263-74.
Dakshanamurthy S, Kim M, Brown M and Byers SW. In-silico fragment-based identification of novel
angiogenesis inhibitors (2007) Bioorganic and Medical Chemistry Letters. 17:4451-6
Avvisato CL, Yang X, Shah S, Hoxter D, Li W, Gaynor R, Pestell RG, Tozeren A, and Byers SW. Mechanical
Force Modulates Global Gene Expression and -Catenin Signaling In Colon Cancer Cells. (2007) J Cell
Science 120: 2672-82.
Ertel A, Verghese A, Byers SW, Ochs M and Tozeren A. Pathway Specific Differences Between Tumor Cell
Lines and Normal and Tumor Tissue Cells. (2006) BMC Molecular Cancer 5: 55
Sakamaki T, Albanese C, Katiyar S, Wang X, Zhang X, Shah S, Byers SW, Yang JG, Nicholson R, Link T,
Shemluck M. and Pestell RG. A role for cyclin D1 in mitochondrial metabolism and lipogenesis in vivo.
(2006) Mol Cell Biol. 14:5449-69
Shah S, Naimul Islam M, Sivanesan, D, Rivzi I, Herrell, R, Aranda, A, Moras D, Welsh J and Byers S. The
Molecular Basis of Vitamin D Receptor and -Catenin Cross Regulation (2006). Mol. Cell 21: 799-809
Mishra, L, Shetty, K., Stuart, A. and Byers, SW (2005) The role of TGF-beta and wnt in gastrointestinal stem
cells and carcinogenesis. Oncogene 24:5775-89.
Allen, J, Khwaja F, Byers SW, Djakiew D. (2005) The p75NTR mediates a bifurcated signal transduction
cascade through the NFkappaB and JNK pathways to inhibit cell survival. Exp. Cell Res. 304:69-80
Hulit, J, Wang, C, Li, Z, Albanese, C, Rao, M, Di Vizio, D, Shah, S, Byers, SW, Mahmood R, Augenlicht, LH,
Russell, R and Pestell, RG. 2004 Cyclin D1 genetic heterozygosity regulates colonic epithelial cell
differentiation and tumor number in ApcMin Mice. Mol Cell Biol. 17:7598-611.
Ray, R, Cabal-Manzano, R, Zipper, L., Moser, AR, Waldman, T, Byers, SW, Riegel, AT, Wellstein, A. The
secreted fibroblast growth factor-binding protein, a modulator of angiogenesis, is a target gene of catenin. (2003) Cancer Research. 63:8085-9.
Shah, S, Hecht, A, Pestell R. and Byers. SW. Trans-repression of -catenin activity by nuclear receptors.
(2003) J Biol Chem. 278:48137-45
Albanese R., Jarrett, C. Joyce, D. Hughes, J. Wu, K. D’Amico, M. Fu, M. Backer, JD. Ben Ze’ev, A. Downward,
J. Lamberti, C. Lin. K-M. Gaynor, RB. Byers, S. and Pestell, R. IKK regulation of cyclin D1 is mediated by
changes in -catenin signaling. (2003) Mol Biol Cell. 14: 585-599
Song, L-N, Herrell, R, Shah, S, Byers, S, Wilson, EM, Gelmann, EP. -catenin binds to the activation function2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on liganddependent transcription. (2003) Mol Cell Biol 25: 1674-1687
Feltes, C, Kudo, A. Blaschuk, O. and Byers, S. An alternatively spliced cadherin-11 regulates human breast
cancer cell invasion. (2002) Cancer Res 62:6688-6697
Shah, S, Pishvaian, M., Easwaran, V. Brown, P.and Byers, S. The role of cadherin, -catenin and c-jun in
retinoid-regulated differentiation and TCF/LEF signaling (2002). J Biol Chem 277: 25313-25322
Jarrett, C.R., Blancato, J., Cao, T., Young, P., King, C.R. and Byers, S. Human APC2 localization and allelic
imbalance (2001) Cancer Res. 61:7978-7984
Lamberti, C., Lin, K-M., Yamamoto, Y., Verma, IM, Byers, S. and Gaynor, R. Cross-talk between NF-kappa B
and -catenin pathways. (2001) J Biol Chem. 276:42276-42286.
Truica, CI, Byers, S. and Gelmann, EP. (2000) -catenin enhances androgen receptor signaling. Cancer Res.
60: 4761-4769
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Stephen Byers August 2012
Easwaran,V, Pishvaian, M., Salimuddin, and Byers, S. (1999) Cross regulation of -catenin-LEF/TCF and
retinoid signaling pathways. Current Biology 9: 1415-1418
Orford, K., Orford, C. and Byers, S. (1999) -catenin regulates contact inhibition, anchorage-independent
growth, anoikis and radiation-induced cell cycle arrest. J.Cell Biol. 146: 855-867
Easwaran,V. Song, V., Polakis, P. and Byers, S. (1999) The ubiquitin-proteosome pathway and serine kinase
activity regulate APC modulation of -catenin/LEF signaling. J. Biol Chem 274: 16641-16645.
Pishvaian, M., Feltes, C., Thompson, P. and Byers, S. (1999) Expression of the mesenchymal cell-adhesion
molecule cadherin 11 associated with invasive breast cancer. Cancer Research, 59; 947-952
Wu, S., Hoxter, E., Byers, S.W. and Tozeren, A. 1998. Role of cytoskeleton and deformability on lamininmediated cell rolling. (1998) BioRheology 35: 37-51
Orford, K., Crockett, C., Weissman, A. and Byers, S.W. 1997. Serine phosphorylation-regulated ubiquitination
and proteosomal degradation of -catenin. J. Biol. Chem. 272: 24735-38
Byers, S.W., M. Pishvaian, C. Crockett, C. Peer, A. Tozeren, M. Sporn, M. Anzano. and R. Lechleider 1996. 9cis-retinoic acid increases cell-cell adhesion strength -catenin protein stability and localization to the cell
membrane in a breast cancer cell line: A role for serine kinase activity. Endocrinology 137: 3265-3273
Byers, S.W., C. L. Sommers, E. Hoxter, A. M. Mercurio, and A. Tozeren. 1995. The role of E-cadherin in the
response of tumor cell aggregates to lymphatic, venous and arterial flow: Measurement of cell-cell
adhesion strength. J. Cell Sci. 108: 2053-2064
Tozeren, A., S. Wu, D. Morales, H. K. Kleinman, A.M. Mercurio, and S. W. Byers. 1995. E-selectin mediates
dynamic adhesion of breast and colon carcinoma cells to activated endothelium. Int.J. Cancer 60: 426-431
Buras, R.R., Shabahang, M., Davoodi, F., Schumacher, L.M., Cullen, K.J., Byers, S.W., Nauta, R.J. and
Evans, S.J. 1995. The effect of extracellular calcium on colonocytes: evidence for differential
responsiveness based upon degree of differentiation. Cell Prolif. 28: 245-262.
Seslar, S.P., T. Nakamura, and S. W. Byers. 1995. Tumor-stroma interactions and stromal cell density regulate
hepatocyte growth factor expression: A role for transforming growth factor activation. Endocrinology 136:
1945-1953
Anzano, M.A., S. W. Byers, J. M. Smith, C. W. Peer, L. T. Mullen, C. C. Brown, A. B. Roberts, and M. B.
Sporn. 1994. Prevention of breast cancer in the rat with 9-cis retinoic acid as a single agent and in
combination with tamoxifen. Cancer Res. 54:4614-4617
Sommers, C.L., E. P. Gelmann, R. Kemler, P. Cowin, and S. W. Byers. 1994. Alterations in plakoglobin
expression and beta-catenin phosphorylation in human breast cancer cell lines. Cancer Res. 54:35443552.
Tozeren, A., S. Wu, H. K. Kleinman, A. M. Mercurio, and S. W. Byers. 1994. Alpha-6 beta-4 integrin mediates
dynamic interactions of breast and colon carcinoma cells on laminin. J. Cell Sci. 107: 3153-3163
Byers, S.W., S. Sujarit, B. Jegou, K. Herrenknecht, S. Butz, C. McCalman, and O. Blaschuk. 1994. Cadherins
and cadherin-associated molecules in the developing and maturing rat testis. Endocrinology 134:630-639.
Byers, S.W., M. Park, C. L. Sommers, and S. P. Seslar. 1994. Breast carcinoma: A collective disorder. Breast
Cancer Res.Treatment 31: 203-215
Sommers, C.L., S. W. Byers, E. W. Thompson, J. A. Torri, and E. P. Gelmann. 1994. Differentiation-state and
invasiveness of human breast cancer cell lines. Breast Cancer Res.Treatment 31: 325-335
Staebler, A., C. L. Sommers, S. Mueller, S. Byers, E. W. Thompson, and R. Lupu. 1994. Modulation of breast
cancer progression and differentiation by the erbB-2 ligand. Breast Cancer Res.Treatment 31: 175-182
Sunitha, I., D. Meighen, D. P. Hartman, E. W. Thompson, S. W. Byers, and M. I. Avigan. 1994. Hepatocyte
growth factor stimulates invasion across reconstituted basement membrane by a new human intestinal cell
line. Clin. Exp. Metas 12:145-154.
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Stephen Byers August 2012
Thompson, E.W., J. Torri, M. Sabol, C. Sommers, S. Byers, S. Paik, G. R. Martin, M. E. Lippman, M. R.
Stampfer, and R. B. Dickson. 1994. Oncogene cooperation for induction of basement membrane
invasiveness in human mammary epithelial cells. Clin. Exp. Metas 12:181-194.
McCalman, C.D., D. A. O'Brien, S. W. Byers, and O. W. Blaschuk. 1993. N-cadherin expression in the
seminiferous epithelium of the mouse testis. Endoc. J. 1:519-525.
Seslar, S., T. Nakamura, and S. W. Byers. 1993. Regulation of fibroblast hepatocyte growth factor/scatter
factor expression by human breast carcinoma cells and peptide growth factors. Cancer Res. 53:12331238.
Suarez-Quian, C.A. and S. W. Byers. 1993. Redistribution of the epidermal growth factor receptor as a function
of cell density, calcium and cell-cell adhesion in an epidermoid carcinoma cell line. Tiss. Cell 25:1-17.
Byers SW, Pelletier R-M, Suarez-Quian CA, Sertoli cell tight junctions and the seminiferous epithelium barrier.
In: Russell LR, Griswold MD (eds.), The Sertoli Cell. Cache River Press FL; 1993 (58)
Byers SW, Jegou B, McCalman C, Blaschuk OW, Sertoli cell adhesion molecules and the collective
organization of the testis. In: Russell LD, Griswold MD (eds.), The Sertoli Cell. Cache River Press FL;
1993 (45)
Byers, SW. and Blaschuk, O. (1993) Epithelial barriers, mucosal immunity and cell-cell adhesion in the male
reproductive tract. In "The Scientific Basis of Fertility Regulation" (Griffin PD and Johnson PM Eds.)
Oxford University Press UK pp 147-159
Jegou B, Syed V, Sourdaine P, Byers S, Gerard N, Velez de la Calle J, Pineau C, Garnier DH, Bauche F, The
dialogue between late spermatids and Sertoli cells in vertebrates: A century of research. In: Proceedings
of the Third International Testis Workshop. 1992
Byers, S., E. Amaya, S. Munro, and O. Blaschuk. 1992. Fibroblast growth factor receptors contain a conserved
HAV region common to cadherins and influenza strain A hemagglutinins. A role in protein-protein
interactions? Dev. Biol. 152:411-414.
Sommers C, Heckford SE, Skerker JM, Worland P, Thompson EW, Byers SW, Gelman EP. Loss of epithelial
markers and acquisition of vimentin expression in adriamycin-resistant MCF-7 cells. Cancer Res 1992;
52:5190-5197
Suarez-Quian CA, Jelesoff N, Byers SW. Lysosomal integral membrane proteins exhibit region and cell type
specific distribution in the epididymis of the adult rat. Anat Rec 1992; 232:85-96.
Pelletier R-M, Byers SW. The blood-testis barrier and Sertoli cell junctions: Structural considerations. Micros
Res Tech 1992; 20:3-33. (89)
Byers SW, Pelletier R-M, Sertoli cell tight junctions and the blood-testis barrier. In: Cerejido M (ed.), Tight
Junctions. Boca Raton,FL: CRC Press; 1992: 279-304. (7)
Byers SW, Citi S, Anderson JM, Hoxter B. Polarized functions and permeability properties of rat epididymal
epithelial cells in vitro. J Reprod Fertil 1992; 95:385-396
Sommers, C.L., E. W. Thompson, J. A. Torri, R. Kemler, E. P. Gelmann, and S. W. Byers. 1991. Cell adhesion
molecule uvomorulin expression in human breast cancer cell lines: Relationship to morphology and
invasive capacities. Cell Growth Diffn. 2:365-372.
Byers, SW., Graham, R., Dai, H-N. and Hoxter, B (1991) Development of junctional specializations and the
distribution of the tight junction associated protein ZO-1 in the mouse testis. Am. J. Anat. 191: 35-47
Sang Q-X, Thompson EW, Grant D, Stetler-Stevenson WG, Byers SW. Soluble laminin and RGD-containing
peptides differentially regulate type IV collagenase mRNA, activation and localization in testicular cell
culture. Biol Reprod 1991; 45:387-394.
Sommers CL, Thompson EW, Torri JA, Kemler R, Gelmann EP, Byers SW. Cell adhesion molecule uvomorulin
expression in human breast cancer cell lines: Relationship to morphology and invasive capacities. Cell
Growth Diffn 1991; 2:365-372.
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Stephen Byers August 2012
Sang Q-X, Dym M, Byers SW. (1991) Proteases in seminiferous epithelium remodeling. Matrix. (suppl. 1) 404405
Byers, SW., Graham, R., Dai, H-N. and Hoxter, B (1991) Development of junctional specializations and the
distribution of the tight junction associated protein ZO-1 in the mouse testis. Am. J. Anat. 191: 35-47
Sang Q-X, Thompson EW, Grant D, Stetler-Stevenson WG, Byers SW. Soluble laminin and RGD-containing
peptides differentially regulate type IV collagenase mRNA, activation and localization in testicular cell
culture. Biol Reprod 1991; 45:387-394.
Byers, SW and Graham, R. (1990) Distribution of sodium-potassium ATPase in the rat testis and epididymis.
Am. J. Anat. 188, 31-43
Sang, Q.-X., Dym, M. and Byers SW. (1990) Secreted metalloproteinases in testicular cell culture. Biol.
Reprod. 43, 946-955.
Sang, Q.-X., Stetler-Stevenson, W., Liotta, LA and Byers SW. (1990) Identification of type IV collagenase in rat
testicular cell culture: Influence of peritubular-Sertoli cell Interactions. Biol. Reprod. 43, 956-964.
Ojeifo, J., Byers, SW, Papadopoulos, V and Dym, M. (1990) Sertoli cell secreted proteins stimulate the growth
of highly purified rat Leydig cells. J. Reprod. Fertil. 90, 93-108
Byers, SW., Sang, Q-X., Dai, H-N., Beaudry, J and Hoxter, B. (1989) The Sertoli cell plasma membrane and
plasminogen independent proteases in seminiferous epithelium remodeling. Proceedings of the IVth
International Congress of Andrology.
Byers, S.W., Richardson, L. and Parker, C.P. (1988) Isolation and characterization of epididymal epithelial
cell plasma membranes. Biol. Reprod. 38, 201-209
Hadley, M., Byers, S.W., Djakiew, D. Suarez-Quian, C.A. and Dym, M. (1988) In vitro models of differentiated
Sertoli cell structure and function. In Vitro 24, 550-557
Byers, SW. (1988) Epithelial barriers in the testis and epididymis: A re-examination. Adv. Con. Del. Sys. 4,
369-408.
Dym, M., Hadley, M.A., Djakiew, D. and S.W. Byers. (1988) The blood-testis barrier in vitro. Serono Symposia
Review 3, 113-126
Hadley, M.A., Djakiew, D., Byers, S.W. and M. Dym. (1988) Factors involved in the maintenance of
differentiated Sertoli cell structure and function in culture. In: Advances in Andrology. (Eds. Holstein, AF,
Leidenberger, F, Holzer, KH, Bettendorf, G.) Deisbach Berlag, Berlin, 59-66.
Parker, C.P. and Byers, S.W. (1987) Transferrin-ricin A chain conjugate inhibits protein synthesis by cultured
rat Sertoli cells. Ann. N.Y. Acad. Sci. 513, 434-436
Dym, M., Hadley, M., Djakiew, D. and Byers, S.W. (1987) The blood-testis barrier in culture. Ann. N.Y. Acad.
Sci. 513, 405-408
Hadley, M.A., Djakiew, D., Byers, S.W. and M.Dym (1987) Polarized secretion of androgen binding protein
(ABP) and transferrin (Tf) by Sertoli cells grown in bicameral cell culture chambers. Endocrinology 120:
1097-1103.
Dym, M., Hadley, M., Djakiew, D. and Byers, S.W. (1987) Differentiated and polarized functions of Sertoli cells
in vitro. Adv. Exp. Med. Biol. 219, 515-533.
Byers, S.W., Hadley, M.A., Djakiew, D. and Dym, M. (1986). Growth and characterization of polarized
monolayers of epididymal epithelial cells and Sertoli cells in dual environment culture chambers. J.
Androl. 7:59-68.
Djakiew, D., Hadley, M.A., Byers, S.W. and M. Dym. (1986). Transferrin mediated transcellular transport of
iron across confluent epithelial sheets of Sertoli cells grown in bicameral cell culture chambers. J. Androl.
7: 355-366.
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Stephen Byers August 2012
Paulson, H.L., Byers, S.W. and Dym, M. (1985). A morphometric analysis of coated pits and vesicles in the
proximal and distal caput epididymis. Biol. Reprod. 32: 191-202.
Djakiew, D., Byers, S.W. and Dym, M. (1985) Receptor mediated endocytosis of alpha2-macroglobulin by
principal cells in the proximal caput epididymis in vivo. J. Androl. 6:190-196.
Byers, S.W., Djakiew, D., and Dym, M. (1985) Structural characteristics of epididymal epithelial cells in vitro. J.
Reprod. Fertil. 75:401-411.
Hadley, M.A., Byers, S.W. Suarez-Quian, C.A., Kleinman, H.K. and Dym, M. (1985). Extracellular matrix
regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro. J. Cell
Biol. 101: 1511-1522.
Byers, S.W., Musto, N.A. and Dym, M. (1985) Culture of ciliated and non-ciliated cells from rat ductuli
efferentes. J. Androl. 6: 271-278.
Byers, S.W. and Glover, T.D. (1984). The effect of scrotal insulation on the pituitary-testicular axis of the ram.
J. Reprod. Fertil. 71:23-31.
Byers, S.W. (1984) The effect of scrotal insulation on the production of testosterone from ram testis tissue in
vitro. J. Reprod. Fertil, 71:17-21.
Byers, S.W., Qasba, P.K., Paulson, H.L. and Dym, M. (1984) Immunocytochemical localization of alpha
lactabumin in the rat testis and epididymis. Biol. Reprod. 30: 171-178.
Djakiew, D., Byers, S.W. and Dym, M. (1984). Receptor mediated endocytosis of transferrin and alpha 2macroglobulin by cultured rat caput epididymidal epithelial cells. Biol. Reprod. 31:1073-1085.
Byers, S.W., Hewlett, I.K., Qasba, P.D. and Dym, M. (1984). Alpha lactalbumin-like proteins in the male
reproductive tract. Ann. N.Y. Acad. Sci. 438:8-17.
Byers, S.W. and Glover, T.D. (1983) The effect of scrotal insulation on seminal fructose, peripheral plasma
prolactin, and circulating steroids in rams. Animal Reprod. Sci. 5: 295-301.
Byers, S.W., Dowsett, K.F. and Glover, T.D. (1983) Seasonal and circadian changes of testosterone levels in
stallions and their relationship to semen quality. J. Endocrinol. 99:141-150.
Qasba, P.K., Hewlett, I.K. and Byers, S.W. (1983). The presence of the milk protein alpha lactalbumin and its
mRNA in the rat epididymis. Biochem. Biophys. Res. Commun. 117:306-312.
Byers, S.W. (1979) The search for the male pill. Semper Floreat. University of Queensland Press.
Invited Presentations:
Cadherin-11 in poor prognosis cancers and rheumatoid arthritis-common target common therapies?
Department of Medicine, OSU December 2012
The RARRES1 tumor suppressor regulates tyrosination of -tubulin to influence apoptosis and tumorigenesis.
University of West Virginia, October 2012
Vitamin D and Vitamin D Receptor in colorectal cancer. Grand Rounds, Department of Endocrinology. Yale
University. March 2012
Cadherin-11 as a therapeutic target in poor prognosis breast cancer. Invited Symposium Speaker Era of Hope
Meeting, Orlando, August 2011
The RARRES1 tumor suppressor regulates tyrosination of -tubulin and EB1 to influence mitosis, neural
development and somitogenesis. Department of Physiology University of Kentucky, December 2009
The RARRES1 tumor suppressor regulates tyrosination of -tubulin and EB1 to influence mitosis, neural
development and somitogenesis. Oncology Grand Rounds Thomas Jefferson University, October 2009
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Stephen Byers August 2012
Cadherin-11 regulates tumor growth and progression in poor prognosis cancers. Mount Sinai Medical Center,
May 2009
Gene environment interactions and cancer stem cells. Greenbaum Cancer Center, University of Maryland.
November 2008
Vitamin D and wnt signaling in colorectal cancer. Invited Symposium Speaker. AICR, Washington DC
November 2008
Gene environment interactions and cancer stem cells. National Cancer Center of Singapore. October 2008
Gene environment interactions and cancer stem cells. Department of Physiology and Biophysics, Georgetown
University. October 2008
Small molecule inhibitors of cadherin-11. Invited Symposium Speaker Era of Hope Meeting, Baltimore, June
2008.
-catenin and nuclear receptor interactions. New Jersey Medical School, June 2008
-catenin and nuclear receptor interactions. University of Kentucky, January 2008
-catenin and nuclear receptor interactions. NCI, Frederick, October 2007
Cell-adhesion and signaling, cancer and sunlight. Department of Biochemistry, FSU, Tallahassee FL,
September 2007
The cell as a complex adaptive sytem. The duality of network and machine theories of organization
Department of Chemistry, FSU, Tallahassee FL, September 2007
“Vitamin D and Health in the 21st Century” Invited Discussant for the Office of Dietary Supplements at the
National Institutes of Health, NIH September 5-6, 2007
What is the molecular basis of vitamin D receptor and β-catenin cross regulation? Invited Speaker at the NIH
Symposium “Vitamin D and Cancer: Current Dilemmas/Future Needs”. May 7-8, 2007.
-catenin specific regulation of the vitamin D receptor pathway. Thomas Jefferson University February 2007
The effect of timing of exposure on the chemopreventative effects of vitamin D. Plenary speaker, American
Institute for Cancer Research, July 2005
Molecular Basis of Vitamin D-receptor and -catenin interactions. Invited Speaker, Gordon Conference on Cell
Adhesion. June 2005
Cell signaling: Bionetworks verses the regulated assembly of protein machines. Computational Orchestra of
Philadelphia. Drexel University, September, 2004
Beta catenin and nuclear receptor interactions. Marshall University, Huntingdon, WVA. April 2004
Beta catenin and nuclear receptor interactions. The Prostate Center, University of British Columbia,
Vancouver. October 2003
Bioinformatics meets “best guess”. Drexel University, November 2002
Cadherin-11 and carcinoma cell invasion and metastasis. Urology Department, McGill University, October,
2002
Cadherin-11 and carcinoma cell invasion and metastasis. Cell Biology Department, Georgetown University,
October, 2001
Mesenchymal cadherins and breast cancer. Invited speaker at Hormonal Carcinogenesis Gordon Conference.
New Hampshire. July 2001.
The IKK complex regulates -catenin signaling. Wnt meeting. New York, May 2001 (Christy Jarrett gave the
talk).
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Stephen Byers August 2012
Cross regulation of -catenin, retinoid and NF kappa B pathways. Department of Pathology, USUHSC,
Bethesda. April 2001
Cross-regulation of LEF/TCF and retinoid signaling pathways. Department of Dermatology, NYU, New York.
August 2000
Cross-regulation of LEF/TCF and retinoid signaling pathways. Biochemistry and Molecular Biology
Department, Georgetown University, April 2000
Cross-regulation of LEF/TCF and retinoid signaling pathways. Differentiation Control Section, LCCTP, DBS,
NCI, NIH. March 2000
-catenin mediates cross-regulation of LEF/TCF and retinoid signaling pathways. Speaker at Wnt Meeting
(Vijay Easwaran gave the talk). Stanford, CA, July, 1999.
-catenin and cancer. Oncology Rounds, University of Texas, Southwestern, Dallas July, 1999
-catenin and cancer. Ariad Corporation, Boston, May, 1999
-catenin and cancer. Chiron Corporation, San Francisco, April, 1999
Cadherins, Catenins and Cancer, Laboratory of Chemoprevention, NCI, NIH. November, 1998
Cadherins, Catenins and Cancer. Department of Microbiology and Molecular Biology, University of Memphis,
October, 1998
-catenin/LEF regulated genes in breast cancer. Komen Foundation Symposium. Dallas, October, 1998
Cadherins, Catenins and Cancer. H. Lee Moffitt Cancer Research Institute, Tampa, FL, September, 1998
Regulation of -catenin signaling.
February, 1998
Strang Cancer Research Laboratories.
Cornell University, New York.
-catenin signaling and cancer. NIDR, NIH. January, 1998.
New directions in cell adhesion research. Becton-Dickinson, Franklin, NJ December, 1997
-catenin and contact inhibition. Department of Pathology, Columbia University, New York. March 1997.
Serine phosphorylation targets -catenin for ubiquitination and proteosomal degradation: A role in signaling by
cytoplasmic -catenin. Speaker at the Molecular Cell Biology Gordon Conference, Tilton School, NH.
June 1996
Serine phosphorylation targets -catenin for ubiquitination and proteosomal degradation.: A role in signaling by
cytoplasmic -catenin. DNAX Research Institute, Palo Alto, CA. August 1996
Serine phosphorylation targets -catenin for ubiquitination and proteosomal degradation.: A role in signaling by
cytoplasmic -catenin. Speaker at Wnt Meeting. Stanford, CA, August 1996.
-catenin and contact inhibition. Division of Cancer Biology and Diagnosis, NCI, NIH. October 1996.
Cadherins, catenins and cancer. Pathology Department, Yale University, April 1995
Cadherins and catenins in development.
Molecular Biology, June 1995
Special lecturer at The Woods Hole Program in Cellular and
Cadherins, catenins and cancer. Laboratory of Viral Carcinogenesis, NCI, NIH. October, 1995.
Adhesion molecules and collective organization. NIH Workshop "A new look at spermatogenesis" March 1993
Cell-cell adhesion, hepatocyte growth factor and epithelial differentiation. European Tissue Culture
Association. Rennes, France, July 1993.
Carcinoma, a collective disorder. Bucknell University, October 1993
Cell adhesion molecules, growth factors and carcinoma. Department of Cell Biology, NYU. January 1992.
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Stephen Byers August 2012
The role of homotypic cell adhesion in tumor cell proliferation and invasion. Medical College of Pennsylvania,
January 1991.
Cell surface molecules in the male reproductive tract. Environmental Protection Agency. February 1991
The role of homotypic cell adhesion in tumor cell invasion. Grand Rounds, Department of Surgery, McGill
University. April 1991.
The role of homotypic cell adhesion and hepatocyte growth factor in carcinoma cell proliferation and
tumor/stroma interactions. Department of Oncology, McGill University. April 1991.
The role of homotypic cell adhesion and hepatocyte growth factor in carcinoma cell proliferation and
tumor/stroma interactions. University of Texas Health Science Center, Tyler. May 1991.
Calcium, cadherins and cancer. Lady Davis Institute, Montreal. August 1991
Epithelial barriers, mucosal immunity and cell-cell adhesion in the male reproductive tract. Invited speaker for
the WHO Symposium on Local Immunity in Reproductive Tract Tissues, New Dehli. November 1990
Epithelial barriers in the reproductive system: A re-examination using polarized cell culture systems. Invited
speaker at the ASCB/ASBMB meetings, San Francisco, February 1989.
Epithelial barriers in the male reproductive system. A re-examination. Harvard University Medical School.
February 1989.
Isolation and characterization of Sertoli cell plasma membranes and junctional specializations.
symposium speaker American Association of Anatomists Meeting, New Orleans, April 1989
Invited
Cell Biology of the testis and epididymis; a re-examination of epithelial barriers. MRC Unit for Reproductive
Biology, Edinburgh, Scotland. May 1989
The Sertoli cell plasma membrane and plasminogen independent proteases in seminiferous epithelium
remodeling. Poster selected for the presidential poster session at the International Andrology Meeting,
Florence, Italy. May 1989.
Epithelial barriers in the testis and epididymis. Millipore Corporation. April 1988.
Molecular and cellular aspects of reproductive tract epithelial cell function.
Georgetown University. November 1988.
Physiology Department,
In vitro studies of the male reproductive system. Invited colloquium speaker. American Society of Andrology.
March 1987.
Polarized epithelial cells in the male reproductive tract. Population Council, Rockefeller University. October
1987.
Polarized functions of epididymal epithelial cells and Sertoli cells in vivo and in vitro. Georgetown University
Biology Department. January 1986.
The role of extracellular matrix and polarity in Sertoli cell function. Monash University, Department of Anatomy,
Australia. September 1986.
Factors affecting epithelial cell polarity. Millipore Corporation. October 1986.
Localization and possible function of alpha-lactalbumin in the testis and epididymis. National Cancer Institute,
NIH. May 1983
Alpha-lactalbumin-like proteins in the male reproductive tract. Symposium speaker at the VIII Testis Workshop,
October 1983.
Alpha-lactalbumin-like proteins in the male reproductive tract. Johns Hopkins University, Department of
Population Dynamics. December 1983.
The regulation of testosterone production in the heated testis. Male Reproductive Function Symposium of the
VI International Congress of Endocrinology. Surfers Paradise. February 1980.
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Stephen Byers August 2012
The pituitary-testicular axis in rams. Harvard University, December 1979.
19
Stephen Byers August 2012
Active Support FY 2013:
NIH R01CA129813-01 Principal Investigator Stephen Byers “Beta catenin specific regulation of the vitamin D
pathway in colon cancer”:
03/01/08-02/28/14 (NCE)
(2.4 calendar months)
Direct Costs $207,000/yr
The overall goal of this grant is to investigate the hypothesis that beta catenin specific vitamin D analogues and
vitamin D receptors can regulate colorectal cancer.
W81XWH-10-1-0437 DOD Synergistic IDEA award. Cadherin-11 as a therapeutic target in basal-like breast
cancers. Stephen Byers and Milton Brown PIs
09/01/10-08/30/12
(2.4 calendar months)
Direct costs $275,000/yr
NIH P30 CA51008-17 Cancer Center Support Grant. Louis Weiner PI. Stephen Byers, Director of Shared
Resources:
05/01/10-04/30/14
(3.0 calendar months)
Direct costs $3,124,216/yr
Administrative position which oversees the operation of the Lombardi Shared Resources
NIH Clinical and Translational Science Award (CTSA) (Verbalis and Mellman PIs). I am co-director (with John
Massari) of the Translational Technologies Resource Component.
07/01/10-06/30/15
(2.4 calendar months)
Direct costs TTR component $296,000/yr
Administrative position which oversees the operation of all GU and Howard University Shared Resources
W81XWH-12-0424 DOD Synergistic IDEA award (Byers and Kumar PIs) Tumor Suppressor RARRES1/TIG1
in Prostate Cancer-biomarker to therapeutic target.
09/01/12-08/30/15
(3.0 calendar months)
Direct costs $250,000/yr
The aims of this proposal are: (1) Study the role of RARRES1/TIG1 in human and mouse prostate cancer (PC)
development; (2) Investigate the role of RARRES1/TIG1 on experimental PC; and Investigate the genetic and
epigenetic regulation of RARRES1/TIG1
NIH R01 CA170653 in Response to Provocative Question RFA . Cadherin-11 in poor prognosis cancers and
rheumatoid arthritis-common target common therapies? (Byers PI, subcontracts to Drs Shapiro
(crystallography) and Brenner (arthritis) at Columbia and Harvard respectively)
09/01/12-08/31/16
(3.0 calendar months)
Direct costs $384,000/yr
NIH R21CA156188 (Bong PI, Byers mentor) The role of the vitamin D pathway in Gardner syndrome. Dr. Bong
is junior faculty in the Byers laboratory
09/01/12-08/31/14
(0.0 calendar months)
Direct costs $125,000/yr
Pending/planned:
NIH R01 (Byers PI, subcontract to Dr. Shapiro, Columbia (crystallography)) Development of therapeutics for
tubulin tyrosine carboxypeptidase CCP2/AGBL2
07/01/13-06/30/18
(3.0 calendar months)
Direct costs $350,000/yr
NIH R01CA129813 Principal Investigator Stephen Byers “Beta catenin specific regulation of the vitamin D
pathway in colon cancer”:
03/01/13-02/28/18
(2.4 calendar months)
Direct Costs $250,000/yr
The overall goal of this grant is to investigate the hypothesis that beta catenin specific vitamin D analogues and
vitamin D receptors can regulate colorectal cancer.
20
Stephen Byers August 2012
Completed last 10 years:
NIH 1 P01 CA130821-01. Cellular and molecular mechanisms of gastrointestinal cancers. Lopa Mishra PI,
Stephen Byers Project Leader of Project 2. Cross regulation of TGF, -catenin and vitamin D pathways in
foregut cancers.
09/01/08-08/31/11
(3.0 calendar months)
Direct costs $196,314/yr
DOD BC062416-01 Synergistic IDEA Award. (Stephen Byers and Milton Brown PIs) Cadherin-11 in breast
cancer growth, invasion, lymphangiogenesis and lymph node metastasis. 10/01/07-09/31/09 (3.0 calendar
months) Direct Costs $250,000/year
DOD W81XWH- 06-1-0764. DOD Graduate Student Fellowship. Cadherin-11 and Its Potential Role in Breast
Cancer Bone Metastasis. Jaime Guidry PI, Stephen Byers-Mentor 1 Sep 2006 - 30 Sep 2009 Direct costs
$33,300/year
ORNL/GUMC Partnership. Stephen Byers and Gary van Berkel (ORNL) PIs. Surface spray mass spectrometry
for metabolomics of paraffin embedded tissue. 04/01/08-06/01/09 (no salary support). Direct costs to GUMC
$68,583/yr
NIH U56 LCCC/UDC Partnership. Stephen Byers and Deepak Kumar PIs. Pilot Project. Role of TIG1 in breast
cancer.10/01/07-09/30/08 (no salary support) Direct costs $53,816/yr
DOD W81XWH-05-1-0559. DOD Graduate Student Fellowship. Regulation of Cadherin-11 Expression in
Prostate Cancer Cells. Anne Kawczenski PI, Stephen Byers-Mentor 1 Sep 2005 - 30 Sep 2008. Direct costs
$33,300/yr
DOD W81XWH-06-1-0786. DOD Graduate Student Fellowship.The Effect of the Vitamin D Receptor on the
Wnt Signaling Pathway in Breast Cancer. Marcy Beildeck PI, Stephen Byers-Mentor 22 Sep 2006 - 22 Oct
2008. Direct costs $33,300/yr
DOD W81XWH-08-1-0103.DOD Graduate Student Fellowship. Retinioc acid regulation of vascular mimicry in
breast cancer. Priya Prahahad PI, Stephen Byers-Mentor 03/01/08-02/28/10.
Direct costs $33,300/yr
NIH 5U54CA100970-05 Nutrition Program Project Timing of dietary exposure and breast cancer risk (HilakiviClarke PI) Byers Project Leader of Project 2 “Timing of exposure to vitamins A and D, mechanisms of action”:
10/01/03-09/30/08 (2.4 calendar months). Project Direct Costs $187,000/yr
NIH 2 R01DK52626-05 (Principal Investigator: Dan Djakiew, Stephen Byers CoI) NGF Receptor Regulation of
Prostate Growth: 05/01/03-04/30/08 (0.6 calendar months) Total Direct costs: $656,003
R01 DK58196 (Byers PI) Cross regulation of -catenin and retinoid signaling 04/01/02-03/31/06
Adherex Technologies (Byers PI) Adhesion disrupting peptides 03/01/98- 07/01/06.
3R01 DK58196-02S1 (Byers PI, Deonauth) Cross regulation of -catenin and retinoid signaling. Minority
supplement to DK58196. 04/01/03-03/31/06
DAMD17-01-1-0245 IDEA award (Byers PI) 03/1/01-02/28/04. Cadherin-11 and N-cadherin and breast cancer
R21 (Byers PI) APC2 and -catenin signaling in breast cancer 04/01/01-03/31/03
21