Gastro-intestinal complaints in primary care across Europe
Publications by ESPCG committee members from 2005.
General abdominal complaints
Aro P, Ronkainen J, Talley NJ, Storskrubb T, Bolling-Sternevald E, Agréus L. Body mass
index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population
based study. Gut. 2005;54:1377-83
Van den Heuvel-Janssen HAM, Borghouts JA, Muris JWM, Koes BW, Bouter LM,
Knottnerus JA. Chronic non-specific abdominal complaints in general practice: a
prospective study on management, health status and course of complaints. BMC Family
Practice 2006; 7(1): 12
Seifert B, Lukás K, Charvátová E, Vojtísková J, Koudelka T, Hep A, Bures J, Jirásek V,
Díte P. [Lower dyspeptic syndrome. Recommended diagnostic and therapeutic procedures
for general practitioners 2006]. Cas Lek Cesk. 2007;146(1):17-23.
Wensaas K-A, Langeland N, Rørtveit G. [Uncovering the giardiasis-outbreak in Bergen
2004.] Tidsskr Nor Laegeforen 2007;127:2222-5
Ålander T, Heimer G, Svärdsudd K, Agréus L. Abuse in Women and Men with and without
Functional Gastrointestinal Disorders. Dig Dis Sci. 2008;53:1856-64.
Ålander T, Svärdsudd K, Agréus L. Functional gastrointestinal disorder is associated with
increased non-gastrointestinal healthcare consumption in the general population. Int J Clin
Pract. 2008;62:234-40.
Bolling-Sternevald E, Aro P, Ronkainen J, Storskrubb T, Talley NJ, Junghard O, Agréus L.
Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda study.
Dig Dis. 2008;26:256-63.
Jones R, Rubin G, Berenbaum F, Scheiman J. Gastrointestinal and cardiovascular risks of
nonsteroidal anti-inflammatory drugs. Am J Med. 2008 Jun;121(6):464-74. Review.
McDougall P, Drewett RF, Hungin AP, Wright CM. The detection of early weight faltering at
the 6-8 week check and its association with family factors, feeding and behavioural
development. Arch Dis Child. 2009 Jul;94(7):549-52.
Mørch K, Hanevik K, Rortveit G, Wensaas K-A, Langeland N. High rate of fatigue and
abdominal symptoms two years after an outbreak of giardiasis. Trans R Soc Trop Med Hyg
2009;103:530-2
Wensaas K-A, Langeland N, Rortveit G. Prevalence of recurring symptoms after infection
with Giardia lamblia in a non-endemic area. Scand J Prim Health Care 2009; 27:12-7
Mørch K, Hanevik K, Rortveit G, Wensaas K-A, Eide GE, Hausken T, Langeland N. Risk
factors for fatigue and abdominal symptoms and fatigue two years after Giardia lamblia
infection. BMC Infect Dis. 2009 Dec 15;9:206.
Wensaas K-A, Langeland N, Rortveit G. Post-infectious gastrointestinal symptoms after
acute Giardiasis. A one-year follow-up in general practice. Fam Pract. 2010;27:255-9.
Ungan M;Gastrointestinal Problems Among University Students, are They Different Than
the Population? Turkiye Klinikleri J Fam Med-Special Topics 2010;1(3):49-52
Mørch K, Hanevik K, Rivenes AC, Bødtker J, Næss H, Stubhaug B, Wensaas KA, Rortveit
G, Eide GE, Hausken T, Langeland N. Chronic Fatigue Syndrome 5 years after giardiasis:
differential diagnoses, characteristics and natural course. BMC Gastroenterol. 2013;13:28
E. Oikonomidou, F. Anastasiou, C. Mihas, S. Dimopoulou, A. Glystra, I. Tsiligianni, G.
Kolios, H. Kouroumalis, C. Lionis. Identification and management of patients with upper
gastrointestinal symptoms in the primary care setting. Arch Hellen Med, 30(3), May-June
2013, 309-315
Rajasekhar P, Ritchie M, Rutter M, Clifford G, Waddup G, Dempsey N, Rubin G, Rees C.
Lower gastrointestinal symptoms are prevalent among individuals colonoscoped within the
Bowel Cancer Screening Programme. Colorectal Disease 2012.
Alam SE, Singh RB, Gupta S, Dherange P, De Meester F, Wilczynska A, Dharwadkar S,
Wilson D,Hungin P. Nutritional aspects of epigenetic inheritance. Can J Physiol
Pharmacol. 2012 Aug;90(8):989-994. Review.
Walter SA, Jones MP, Talley NJ, Kjellstrom L, Nyhlin H, Andreasson AN, Agréus L.
Abdominal pain is associated with anxiety and depression scores in a sample of the general
adult population with no signs of organic gastrointestinal disease. Neurogastroenterol Motil.
2013;25:741-e576.
Hunt R, Quigley E, Abbas Z, Eliakim A, Emmanuel A, Goh KL, Guarner F, Katelaris P,
Smout A, Umar M, Whorwell P, Johanson J, Saenz R, Besançon L, Ndjeuda E, Horn
J, Hungin P, Jones R, Krabshuis J, LeMair A; Review Team. Coping with common
gastrointestinal symptoms in the community: a global perspective on heartburn,
constipation, bloating and abdominal pain/discomfort. J Clin Gastroenterol. 2014
Aug;48(7):567-578
Diagnosis
Bolling-Sternevald E, Aro P, Ronkainen J, Storskrubb T, Talley NJ, Junghard O, Agréus L.
Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda study.
Dig Dis. 2008;26:256-63.
Schussele Filliettaz S, Gonvers JJ, Peytremann-Bridevaux I, Arditi C, Delvaux M, Numans
ME, Lorenzo-Zuniga V, Dubois RW, Juillerat P, Burnand B, Pittet V, Vader JP, Froehlich F,
EPAGE II Study Group (Agréus L). Appropriateness of colonoscopy in Europe (EPAGE II).
Functional bowel disorders: pain, constipation and bloating. Endoscopy. 2009;41:234-9.
Peytremann-Bridevaux I, Arditi C, Froehlich F, O'Malley J, Fairclough P, Le Moine O,
Dubois RW, Gonvers JJ, Schussele Filliettaz S, Vader JP, Juillerat P, Pittet V, Burnand B,
EPAGE II Study Group (Agréus L.) Appropriateness of colonoscopy in Europe (EPAGE II).
Iron-deficiency anemia and hematochezia. Endoscopy. 2009;41:227-33.
Schussele Filliettaz S, Juillerat P, Burnand B, Arditi C, Windsor A, Beglinger C, Dubois RW,
Peytremann-Bridevaux I, Pittet V, Gonvers JJ, Froehlich F, Vader JP, EPAGE II Study
Group (Agréus L). Appropriateness of colonoscopy in Europe (EPAGE II). Chronic diarrhea
and known inflammatory bowel disease. Endoscopy. 2009;41:218-26.
Arditi C, Gonvers JJ, Burnand B, Minoli G, Oertli D, Lacaine F, Dubois RW, Vader JP,
Schussele Filliettaz S, Peytremann-Bridevaux I, Pittet V, Juillerat P, Froehlich F, EPAGE II
Study Group (Agréus L.) Appropriateness of colonoscopy in Europe (EPAGE II).
Surveillance after polypectomy and after resection of colorectal cancer. Endoscopy.
2009;41:209-17.
Arditi C, Peytremann-Bridevaux I, Burnand B, Eckardt VF, Bytzer P, Agréus L, Dubois RW,
Vader JP, Froehlich F, Pittet V, Schussele Filliettaz S, Juillerat P, Gonvers JJ.
Appropriateness of colonoscopy in Europe (EPAGE II). Screening for colorectal cancer.
Endoscopy. 2009;41:200-8.
Jones R, Rubin G. Acute diarrhoea in adults. BMJ. 2009 Jun 15;338:b1877.
Molinder HK, Kjellström L, Nylin HB, Agréus LE. Doubtful outcome of the validation of the
Rome II questionnaire: validation of a symptom based diagnostic tool. Health Qual Life
Outcomes. 2009;7:106.
Walter SA, Kjellström L, Talley NJ, Andreasson AN, Nyhlin H, Agréus L. Prospective diary
evaluation of unexplained abdominal pain and bowel dysfunction: a population-based
colonoscopy study. Dig Dis Sci. 2011;56:1444-51.
Kok L, Elias SG, Witteman BJ, Goedhard JG, Muris JW, Moons KG, de Wit NJ. Diagnostic
Accuracy of Point-of-Care Fecal Calprotectin and Immunochemical Occult Blood Tests for
Diagnosis of Organic Bowel Disease in Primary Care: The Cost-Effectiveness of a Decision
Rule for Abdominal Complaints in Primary Care (CEDAR) Study. Clin Chem. 2012
Jun;58(6):989-98.
GORD
General
Quigley EM, Hungin AP. Review article: quality-of-life issues in gastro-oesophageal reflux
disease. Aliment Pharmacol Ther. 2005 Aug;22 Suppl 1:41-7. Review
Mason J, Hungin AP. Review article: gastro-oesophageal reflux disease--the health
economic implications.Aliment Pharmacol Ther. 2005 Aug;22 Suppl 1:20-31. Review
Ronkainen J, Aro P, Storskrubb T, Johansson SE, Lind T, Bolling-Sternevald E, Vieth M,
Stolte M, Talley NJ, Agréus L. Prevalence of Barrett's esophagus in the general population:
an endoscopic study. Gastroenterology. 2005;129:1825-31.
Ronkainen J, Aro P, Storskrubb T, Johansson SE, Lind T, Bolling-Sternevald E, Graffner H,
Vieth M, Stolte M, Engstrand L, Talley NJ, Agréus L. High prevalence of gastroesophageal
reflux symptoms and esophagitis with or without symptoms in the general adult Swedish
population: a Kalixanda study report. Scand J Gastroenterol. 2005;40:275-85.
Ronkainen J, Aro P, Storskrubb T, Lind T, Bolling-Sternevald E, Junghard O, Talley NJ,
Agréus L. Gastro-oesophageal reflux symptoms and health-related quality of life in the
adult general population--the Kalixanda study. Aliment Pharmacol Ther. 2006;23:1725-33.
Roger Jones; Greg Rubin; Niek de Wit; Bohumil Seifert; Lars Agreus Gastrooesophageal reflux redefined ; implications for primary care. Eur J of Gen Pract.2007; (13)
4:: 214-5
Ronkainen J, Talley NJ, Aro P, Storskrubb T, Johansson SE, Lind T, Bolling-Sternevald E,
Vieth M, Stolte M, Walker MM, Agréus L. Prevalence of oesophageal eosinophils and
eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut.
2007;56:615-20.
Dent J, Kahrilas PJ, Vakil N, Van Zanten SV, Bytzer P, Delaney B, Haruma K, Hatlebakk J,
McColl E, Moayyedi P, Stanghellini V, Tack J, Vaezi M. Clinical trial design in adult reflux
disease: a methodological workshop. Aliment Pharmacol Ther. 2008 Jul;28(1):107-26.
AW. van der Velden, NJ. de Wit, AO Quartero DE. Grobbee ME. Numans. Maintenance
treatment for GERD: residual symptoms are associated with psychological distress.
Digestion 2008: 77; 207-13.
Delaney B, Moayyedi P. GORD in adults. Clin Evid (Online). 2008 Jun 13;2008
Åsling B, Jirholt J, Hammond P, Knutsson M, Walentinsson A, Davidson G, Agréus L,
Lehmann A, Lagerstrom-Fermer M. Collagen type III alpha I (COL3A1) is a Gastrooesophageal reflux disease (GORD) susceptibility gene and a male risk factor for hiatus
hernia (HH). Gut. 2009;26:26.
Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Zapardiel J.
Impact of gastroesophageal reflux disease on patients' daily lives: a European
observational study in the primary care setting. Health Qual Life Outcomes. 2009;7:60
Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Tafalla M.
Management of gastro-oesophageal reflux disease in primary care: a European
observational study. Curr Med Res Opin. 2009;25:2777-84.
Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, Tafalla M.
Consultation rates and characteristics of gastro-oesophageal reflux disease in primary care:
A European observational study. Eur J Gen Pract. 2009;15:154-60.
Alike vd Velden, Niek J de Wit, A Otto Quartero, Diederick E Grobbee, Mattijs E Numans.
GORD patients on chronic acid suppressive medication: A population average
psychological state. Scand J Gastroenterol 2009; 44: 380-82.
van der Velden AW, de Wit NJ, Quartero AO, Grobbee DE, Numans E.Pharmacological
Dependency in Chronic Treatment of Gastroesophageal Reflux Disease: A Randomized
Controlled Clinical Trial. Digestion. 2010;81(1):43-52.
Flameling RD, Numans ME, Ter Linde J, de Wit NJ, Siersema PD. Different characteristics
of patients with gastro-oesophageal reflux disease on their path through healthcare: a
population follow-up study. Eur J Gastroenterol Hepatol. 2010 May;22(5):578-822.
Kanwal F, Barkun A, Gralnek IM, Asch SM, Kuipers EJ, Bardou M, Sung J, Enns R, Agréus
L, Armstrong D, Spiegel BM. Measuring quality of care in patients with nonvariceal upper
gastrointestinal hemorrhage: development of an explicit quality indicator set. Am J
Gastroenterol. 2010;105:1710-8.
Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, Sinclair P, Agréus L (in
Collaborators) . International consensus recommendations on the management of patients
with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152:101-13.
Ronkainen J, Talley NJ, Storskrubb T, Johansson SE, Lind T, Vieth M, Agreus L, Aro P.
Erosive esophagitis is a risk factor for Barrett's esophagus: a community-based endoscopic
follow-up study. Am J Gastroenterol. 2011;106:1946-52
Jirholt J, Åsling B, Hammond P, Davidson G, Knutsson M, Walentinsson A, Jensen JM,
Lehmann A, Agréus L, Lagerström-Fermer M. 4-aminobutyrate aminotransferase (ABAT):
genetic and pharmacological evidence for an involvement in gastro esophageal reflux
disease. PLoS One. 2011;6:e19095.
Close H, Mason JM, Wilson D, Hungin AP. Hormone replacement therapy is associated
with gastro- oesophageal reflux disease: a retrospective cohort study. Gastroenterol. 2012
May 29;12:56.
Forssell L, Cnattingius S, Bottai M, Edstedt Bonamy AK, Lagergren J, Agréus L, Akre O.
Increased Risk of Barrett's Esophagus Among Individuals Born Preterm or Small for
Gestational Age. Clin Gastroenterol Hepatol. 2013;11:790-4.
Forssell L, Cnattingius S, Bottai M, Edstedt Bonamy AK, Lagergren J, Agréus L, Akre O.
Risk of oesophageal adenocarcinoma among individuals born preterm or small for
gestational age. Eur J Cancer. 2013 Jun;49(9):2207-13. doi: 10.1016/j.ejca.2013.02.014.
Epub 2013 Mar 13. Erratum in: Eur J Cancer. 2013 Oct;49(15):3385.
Forssell L, Cnattingius S, Bottai M, Lagergren J, Ekbom A, Akre O.Risk of esophagitis
among individuals born preterm or small for gestational age. Clin Gastroenterol Hepatol.
2012 Dec;10(12):1369-75.
Akre O, Forssell L, Kaijser M, Norén-Nilsson I, Lagergren J, Nyrén O, Ekbom A. Perinatal
risk factors for cancer of the oesophagus and gastric cardia: a nested case-control study.
Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):867-71.
Hungin AP, Hill C, Molloy-Bland M, Raghunath A. Systematic review: Patterns of proton
pump inhibitor use and adherence in gaastroesophageal reflux disease. Clin Gastroenterol
Hepatol. 2012 Feb;10(2):109-16.
Ruigómez A, Hungin AP, Lundborg P, Johansson S, Wallander MA, García Rodríguez LA.
Treatment patterns in paediatric patients with a new diagnosis of gastroesophageal reflux
disease. Eur J Gastroenterol Hepatol. 2011 Mar;23(3):232-7.
Hungin AP, Hill C, Raghunath A. Systematic review: frequency and reasons for
consultation for gastro- oesophageal reflux disease and dyspepsia. Aliment Pharmacol
Ther. 2009 Aug 15;30(4):331-42.
Modlin IM, Hunt RH, Malfertheiner P, Moayyedi P, Quigley EM, Tytgat GN, Tack J, Heading
RC, Holtman G, Moss SF; Vevey NERD Consensus Group. Diagnosis and management of
non-erosive reflux disease—the Vevey NERD Consensus Group. Digestion. 2009;80(2):7488.
Hungin AP, Modlin I.NERD: a new approach in managing reflux symptoms. Fam Pract.
2008 Dec;25(6):397-9.
Diagnosis
Jones R, Galmiche JP. Review: what do we mean by GERD?--definition and diagnosis.
Aliment Pharmacol Ther. 2005 Aug;22 Suppl 1:2-10.
Rubin G, Uebel P, Brimo-Hayek A, Hey KH, Doerfler H, Heading RC. Validation of a brief
symptom questionnaire (ReQuest in Practice) for patients with gastro-oesophageal reflux
disease. Aliment Pharmacol Ther. 2008 May;27(9):846-51
Treatment
Raghunath AS, Hungin AP, Mason J, Jackson W.Symptoms in patients on long – term
proton pump inhibitors: Symptoms in patients on long-term proton pump inhibitors:
prevalence and predictors. Aliment Pharmacol Ther. 2009 Feb 15;29(4):431-9.
Tytgat GN, McColl K, Tack J, Holtmann G, Hunt RH, Malfertheiner P, Hungin AP, Batchelor
HK.New algorithm for the treatment of gstro-oesophageal reflux disease. Aliment
Pharmacol Ther. 2008 Feb 1;27(3):249-56.
Dyspepsia
General
Delaney B, Ford AC, Forman D, Moayyedi P, Qume M. Initial management strategies for
dyspepsia. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD001961. Review.
Agréus L, Talley NJ, Sheen A, Johansson SE, Jones MP, Svärdsudd K. Predictors and
non-predictors of symptom relief in dyspepsia consultations in primary care. Dig Dis.
2008;26:248-55.
Storskrubb T, Aro P, Ronkainen J, Sipponen P, Nyhlin H, Talley NJ, Engstrand L, Stolte M,
Vieth M, Walker M, Agréus L. Serum biomarkers provide an accurate method for diagnosis
of atrophic gastritis in a general population: The Kalixanda study. Scand J Gastroenterol.
2008;43:1448-55.
Walker MM, Talley NJ, Prabhakar M, Pennaneac'h CJ, Aro P, Ronkainen J, Storskrubb T,
Harmsen WS, Zinsmeister AR, Agréus L. Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and
functional dyspepsia. Aliment Pharmacol Ther. 2009;17:17.
Agréus L, Storskrubb T, Aro P, Ronkainen J, Talley NJ, Sipponen P. Clinical use of protonpump inhibitors but not H(2)-blockers or antacid/alginates raises the serum levels of
amidated gastrin-17, pepsinogen I and pepsinogen II in a random adult population. Scand J
Gastroenterol. 2009;4:1-7.
Fransen GA, Janssen MJ, Muris JW, Mesters I, Knottnerus JA. Measuring the severity of
upper gastrointestinal complaints: does GP assessment correspond with patients' selfassessment? Fam Pract. 2007;24(3):252-8.
Fransen GA, van Marrewijk CJ, Mujakovic S, Muris JW, Laheij RJ, Numans ME, de Wit
NJ, Samsom M, Jansen JB, Knottnerus JA. Pragmatic trials in primary care. Methodological
challenges and solutions demonstrated by the DIAMOND-study. BMC Med Res Methodol.
2007 Apr 23;7:16. Review.
Fraser A, Delaney BC, Ford AC, Qume M, Moayyedi P. The Short-Form Leeds Dyspepsia
Questionnaire validation study. Aliment Pharmacol Ther. 2007 Feb 15;25(4):477-86.
Hawkey CJ, Jones RH, Yeomans ND, Scheiman JM, Talley NJ, Goldstein JL, Ahlbom, H,
Naesdal J. Efficacy of esomeprazole for resolution of symptoms of heartburn and acid
regurgitation in continuous users of non-steroidal anti-inflammatory drugs. Aliment
Pharmacol Ther. 2007 Apr 1;25(7):813-21.
Hawkey CJ, Talley NJ, Scheiman JM, Jones RH, Långström G, Naesdal J, Yeomans ND;
NASA/SPACE author group. Maintenance treatment with esomeprazole following initial
relief of non-steroidal anti-inflammatory drug-associated upper gastrointestinal symptoms:
the NASA2 and SPACE2 studies. Arthritis Res Ther. 2007;9(1):R17.
Mujakovic S, de Wit NJ, van Marrewijk CJ, Fransen GA, Laheij RJ, Muris JW,
Samsom M, Grobbee DE, Jansen JB, Knottnerus JA, Numans ME. Psychopathology is
associated with dyspeptic symptom severity in primary care patients with a new episode of
dyspepsia. Aliment Pharmacol Ther. 2009; 29(5):580-8.
Van Marrewijk CJ, VAN Oijen MG, Paloheimo LI, Fransen GA, Mujakovic S, Muris JW,
Numans ME, DE Wit NJ, Grobbee DE, Knottnerus JA, Laheij RJ, Jansen JB. Influence of
gastric mucosal status on success of stepwise acid suppressive therapy for dyspepsia.
Aliment Pharmacol Ther. 2009 Mar 21.
Fransen GA, Mesters I, Janssen MJ, Knottnerus JA, Muris JW. Which
patient-related factors determine self-perceived patient adherence to prescribed dyspepsia
medication?. Health Educ Res. 2009 Mar 20.
Aro P, Talley NJ, Ronkainen J, Storskrubb T, Vieth M, Johannsson SE, Bolling-Sternevald
E, Agreus L. Anxiety is associated with uninvestigated and functional dyspepsia (ROME III
criteria) in a Swedish population-based study. Gastroenterology. 2009;26:26.
Oikonomidou E, Anastasiou F, Pilpilidis I, Kouroumalis E, Lionis C; Greek General
Practice Dyspepsia Group*. Upper gastrointestinal endoscopy for dyspepsia: Εxploratory
study of factors influencing patient compliance in Greece. BMC Gastroenterol. 2011 Feb
14;11:11.
Aro P, Talley NJ, Agréus L, Johansson SE, Bolling-Sternevald E, Storskrubb T, Ronkainen
J. Functional dyspepsia impairs quality of life in the adult population. Aliment Pharmacol
Ther. 2011;33:1215-24.
Epidemiology
Aro P, Storskrubb T, Ronkainen J, Bolling-Sternevald E, Engstrand L, Vieth M, Stolte M,
Talley NJ, Agréus L. Peptic ulcer disease in a general adult population: the Kalixanda
study: a random population-based study. Am J Epidemiol. 2006;163:1025-34.
Talley NJ, Walker MM, Aro P, Ronkainen J, Storskrubb T, Hindley LA, Harmsen WS,
Zinsmeister AR, Agréus L. Non-ulcer dyspepsia and duodenal eosinophilia: an adult
endoscopic population-based case-control study. Clin Gastroenterol Hepatol. 2007;5:117583
Mujakovic S, DE Wit NJ, VAN Marrewijk CJ, Fransen GA, Laheij RJ, Muris JW,Samsom
M, Grobbee DE, Jansen JB, Knottnerus JA, Numans ME. Psychopathology is associated
with dyspeptic symptom severity in primary care patients with a new episode of dyspepsia.
Aliment Pharmacol Ther.2009 Mar 1;29(5):580-8
Diagnosis
Anastasiou F, Antonakis N, Chaireti G, Theodorakis PN, Lionis C. Identifying dyspepsia in
the Greek population: translation and validation of a questionnaire. BMC Public Health.
2006 Mar 4;6:56.
Hungin AP, Seifert B. Upper gastrointestinal endoscopy or not, and in whom? Eur J
Gastroenterol Hepatol. 2007 Jul;19(7):527-8. Review.
Mujakovic S, ter Linde JJ, de Wit NJ, van Marrewijk CJ, Fransen GA, Onland-Moret NC,
Laheij RJ, Muris JW, Grobbee DE, Samsom M, Jansen JB, Knottnerus A, Numans ME.
Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia. BMC
Med Genet. 2011 Oct 20;12:140.
Treatment
Moayyedi P, Soo S, Deeks J, Delaney B, Innes M, Forman D. Pharmacological
interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev. 2006 Oct
18;(4):CD001960. Review.
Zijdenbos IL, de Wit NJ, van der Heijden GJ, Rubin G, Quartero AO. Psychological
treatments for the management of irritable bowel syndrome.Cochrane Database Syst Rev.
2009 Jan 21;(1):CD006442.
Bijkerk CJ, de Wit NJ, Muris JW, Whorwell PJ, Knottnerus JA, Hoes AW. Soluble or
insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled
trial. BMJ. 2009 Aug 27;339:
van Marrewijk CJ, Mujakovic S, Fransen GA, Numans ME, de Wit NJ, Muris JW, van Oijen
MG, Jansen JB, Grobbee DE, Knottnerus JA, Laheij RJ. Effect and cost-effectiveness of
step-up versus step-down treatment with antacids, H(2)-receptor antagonists, and proton
pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-carebased randomised controlled trial.Lancet. 2009 Jan 17;373(9659):215-225.
Smeets HM, De Wit NJ, Delnoij DM, Hoes AW.. Patient attitudes towards and experiences
with an intervention programme to reduce chronic acid-suppressing drug intake in primary
care. Eur J Gen Pract. 2009 Dec;15(4):219-25.
Smeets HM, de Wit NJ, Zuithoff NP, van Dijk PC, van der Lee AP, Hoes AW. A health
insurance company-initiated multifaceted intervention for optimizing acid-suppressing drug
prescriptions in primary care: a randomized controlled trial. Arch Intern Med. 2010 Jul
26;170(14):1264-8.
Smeets HM, Hoes AW, Zuithoff NP, van Dijk PC, van der Lee AP, de Wit NJ. A health
insurance company-initiated practice support intervention for optimizing acid-suppressing
drug prescriptions in primary care. Eur J Gastroenterol Hepatol.2011 Jun 13. [Epub ahead
of print]
Fransen GA, Mesters I, Muris JW, Van Marrewijk CJ, Mujakovic S, Laheij RJ,
Numans ME, de Wit NJ, Samsom M, Jansen JB, Knottnerus JA. Patient adherence to
prescribed medication instructions for dyspepsia: the DIAMOND-study. Eur J Gen
Pract. 2012 Jun;18(2):79-85.
H.pylori
General
Storskrubb T, Aro P, Ronkainen J, Vieth M, Stolte M, Wreiber K, Engstrand L, Nyhlin H,
Bolling-Sternevald E, Talley NJ, Agréus L. A negative Helicobacter pylori serology test is
more reliable for exclusion of premalignant gastric conditions than a negative test for
current H. pylori infection: a report on histology and H. pylori detection in the general adult
population. Scand J Gastroenterol. 2005;40:302-11
Storskrubb T, Aro P, Ronkainen J, Wreiber K, Nyhlin H, Bolling-Sternevald E, Talley NJ,
Engstrand L, Agréus L. Antimicrobial Susceptibility of Helicobacter pylori Strains in a
Random Adult Swedish Population. Helicobacter. 2006;11:224-30.
Delaney BC, Moayyedi P, Forman D, McNulty C. Helicobacter pylori infection. Clin Evid
(Online). 2007 Jun 1;2007. pii: 0406.
Ford AC, Moayyedi P, Jarbol DE, Logan RF, Delaney BC. Meta-analysis: Helicobacter
pylori'test and treat' compared with empirical acid suppression for managing dyspepsia.
Aliment Pharmacol Ther. 2008 Sep 1;28(5):534-44
Delaney BC, Qume M, Moayyedi P, Logan RF, Ford AC, Elliott C, McNulty C, Wilson S,
Hobbs FD. Helicobacter pylori test and treat versus proton pump inhibitor in initial
management of dyspepsia in primary care: multicentre randomised controlled trial (MRCCUBE trial). BMJ. 2008 Mar 22; 336(7645): 651-4
Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF,
Gisbert JP, Graham DY, Rokkas T, El-Omar EM, Kuipers EJ; European Helicobacter Study
Group(Hungin P). Management of Helicobacter pylori infection--the Maastricht IV/ Florence
Consensus Report. Gut. 2012 May;61(5):646-64.
Epidemiology
Vorobjova T, Nilsson I, Terjajev S, Granholm M, Lyyra M, Porkka T, Prükk T, Salupere R,
Maaroos HI, Waldström T, Uibo R. Serum antibodies to enterohepatic Helicobacter spp. in
patients with chronic liver diseases and in a population with high prevalence of H. pylori
infection. Digestive and Liver Disease 38 (2006):171–176.
Vorobjova T, Ren Z, Dunkley M, Clancy R, Maaroos HI, Labotkin R, Kull K, Uibo R.
Response of IgG1 and IgG2 subclasses to Helicobacter pylori in subjects with chronic
inflammation of the gastric ucosa, atrophy and gastric cancer in a country with high
Helicobacter pylori infection prevalence. APMIS 2006; 114:372-380.
Ford AC, Delaney BC, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease
in Helicobacter pylori positive patients. Cochrane Database Syst Rev. 2006 Apr
19;(2):CD003840. Review.
Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, Oakes R, Wilson S, Roalfe A,
Bennett C, Forman D. Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane
Database Syst Rev. 2006 Apr 19;(2):CD002096.
Vorobova T, Maaroos HI, Uibo R. Immune response to Helicobacter pylori and its
assocation with the dynamics of chronic gastritis in the antrum and corpus. APMIS 2008;
116(6):465-476.
Bruce MG, Maaroos HI. Epidemiology of Helicobacter pylori infection. Helicobacter
2008;13(Suppl. 1): 1–6
Ferrant L Eradiquer l’HP : traitement séquentiel ou de référence actuel ? Minerva
(Fr)2009 ; 8 (4) :54-55 Analyse de : Jafri NS, Hornung CA,Howden CW. Meta-analysis :
sequential therapy appears superior to standard therapy for Helicobacter pylori infection in
patients naive to treatment. Ann.Intern Med 2008 ;148 :923-31
Maaroos HI. Vorobjova T. Chronic gastritis develops and progresses over the years under
permanent exposure of Helicobacter pylori: is the case different in Mozambican dyspeptic
patients? Helicobacter 2009;14:304-5.
Ferrant L. Helicobacter pylori-eradicatie : sequentiële of standaardtherapie ? Is
een sequentiële therapie beter dan een standaardtherapie voor de eradicatie van
Helicobacter pylori bij patiënten zonder voorafgaande eradicatiebehandeling ?
Minerva(Ned)2009; 8 (4): 42-43
Treatment
Delaney BC. Who benefits from Helicobacter pylori eradication? BMJ. 2006 Jan
28;332(7535):187-8.
Peetsalu M, Valle J, Harkonen M, Maaroos HI, Peetsalu A. Changes in the histology and
function of gastric mucosa and in Helicobacter pylori colonization during a long-term followup period after vagotomy in duodenal ulcer patients. Hepato-Gastroenterology 2005;
52(63): 785-791.
Mason JM, Raghunath AS, Hungin AP, Jackson W . Helicobacter pylori eradication in longterm proton pump inhibitor users is highly cost-effective: economic analysis of the HELPUP
trial. Aliment Pharmacol Ther. 2008 Dec 1;28(11-12):1297-303
Irritable Bowel Syndrome
General
Rubin G, De Wit N, Meineche-Schmidt V, Seifert B, Hall N, Hungin P. The diagnosis of
IBS in primary care: consensus development using nominal group technique. Fam Pract.
2006 Dec;23(6):687-92.
Hungin AP. Self-help interventions in irritable bowel syndrome. Gut. 2006 May;55(5):603-4.
Faresjö A, Anastasiou F, Lionis C, Johansson S, Wallander MA, Faresjö T. Health-related
quality of life of irritable bowel syndrome patients in different cultural settings. Health Qual
Life Outcomes. 2006 Mar 27;4:21.
Jones R, Rubin G. A positive diagnosis in irritable bowel syndrome. Int J Clin Pract. 2006
Jul;60(7):870.
Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P, Jones R, Kumar D,
Rubin G, Trudgill N, Whorwell P; Clinical Services Committee of The British Society of
Gastroenterology. Guidelines on the irritable bowel syndrome: mechanisms and practical
management. Gut. 2007 Dec;56(12):1770-98.
Casiday RE, Hungin AP, Cornford CS, de Wit NJ, Blell MT. Patients' explanatory models
for irritable bowel syndrome: symptoms and treatment more important than explaining
aetiology. Fam Pract. 2009; 26: 40-47.
Casiday RE, Hungin A, Cornford CS, de Wit NJ, Blell MT. GPs' explanatory models for
irritable bowel syndrome: a mismatch with patient models? Fam Pract. 2009; 26: 34-9.
Walter SA, Kjellström L, Nyhlin H, Talley NJ, Agréus L. Assessment of normal bowel habits
in the general adult population: the Popcol study. Scand J Gastroenterol. 2010;45:556-66.
Wensaas K-A, Langeland N, Hanevik K, Mørch K, Eide GE, Rortveit G. Irritable bowel
syndrome and chronic fatigue three years after acute giardiasis: historic cohort study. Gut
2012;61:214-9.
Hunskar GS, Langeland N, Wensaas KA, Hanevik K, Eide GE, Morch K, Rortveit G. The
impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome
3 years after Giardia infection. A historic cohort study. Scand J Gastroenterol. 2012;47:95661. Epub 2012 July 2.
Quigley EM, Abdel-Hamid H, Barbara G, Bhatia SJ, Boeckxstaens G, De Giorgio R,
Delvaux M, Drossman DA, Foxx-Orenstein AE, Guarner F, Gwee KA, Harris
LA, Hungin AP, Hunt RH, Kellow JE, Khalif IL, Kruis W, Lindberg G, Olano C, Moraes-Filho
JP, Schiller LR, Schmulson M, Simrén M, Tzeuton C. A global perspective on irritable bowel
syndrome: a consensus statemetn of the World Gastroenterology Organisation Summit
Task Force on irritable bowel syndrome. J Clin Gastroenterol. 2012 May-Jun;46(5):356-66.
A. P. S. Hungin, M. Molloy‐Bland, R. Claes, J. Heidelbaugh, W. E. Cayley, J. Muris, B.
Seifert, G. Rubin, N. Wit. Systematic review: the perceptions, diagnosis and management
of irritable bowel syndrome in primary care – A Rome Foundation Working Team Report.
Alimentary Pharmacology & Therapeutics 2014; Nov;40(10):1133-45.
Sperber AD, Gwee KA, Hungin AP, Corazziari E, Fukudo S, Gerson C, Ghoshal UC,
Kang JY, Levy RL, Schmulson M, Dumitrascu D, Gerson MJ, Chen M, Myung SJ, Quigley
EM, Whorwell PJ, Zarzar K, Whitehead WE.Conducting multinational, cross- cultural
research in the functional gastrointestinal disorders: issues and recommendations. A
Rome Foundation working team report. Aliment Pharmacol Ther. 2014 Nov;40(9):1094102.
Hanevik K, Wensaas KA, Rortveit G, Eide GE, Morch K, Langeland N. Irritable bowel
syndrome and chronic fatigue six years after Giardia infection: a controlled prospective
cohort study. Clin Infect Dis. 2014;59:1394-400 Epub 2014 Aug 12
Epidemiology
Bijkerk CJ, Muris JW, Knottnerus JA, Hoes AW, de Wit NJ. Randomized patients in IBS
research had different disease characteristics compared to eligible and recruited patients. J
Clin Epidemiol. 2008; 61(11):1176-81
Haagsma JA, Siersema PD, DE Wit NJ, Havelaar AH. Disease burden of post-infectious
irritable bowel syndrome in The Netherlands. Epidemiol Infect.2010 2010
Nov;138(11):1650-6.
Genetics
Zucchelli M, Camilleri M, Andreasson AN, Bresso F, Dlugosz A, Halfvarson J, Torkvist L,
Schmidt PT, Karling P, Ohlsson B, Duerr RH, Simren M, Lindberg G, Agréus L, Carlson P,
Zinsmeister AR, D'Amato M. Association of TNFSF15 polymorphism with irritable bowel
syndrome. Gut. 2011;60:1671-7.
Wouters MM, Lambrechts D, Knapp M, Cleynen I, Whorwell P, Agréus L, Dlugosz A,
Schmidt PT, Halfvarson J, Simren M, Ohlsson B, Karling P, Van Wanrooy S, Mondelaers S,
Vermeire S, Lindberg G, Spiller R, Dukes G, D'Amato M, Boeckxstaens G. Genetic variants
in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant
irritable bowel syndrome. Gut. 2013;16:2013-304570.
Diagnosis
Lionis C, Olsen-Faresjo A, Anastasiou F, Wallander MA, Johansson S, Faresjo T.
Measuring the frequency of functional gastrointestinal disorders in rural Crete: a need for
improving primary care physicians' diagnostic skills. Rural Remote Health. 2005 JulSep;5(3):409.
Rubin G, Wit NJ, Meineche-Schmidt V, Seifert B, Hall N, Hungin P. The diagnosis of IBS
in primary care: consensus development using nominal group technique. Fam Pract. 2006
Dec;23(6):687-92
Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P, Jones R, Kumar D,
Rubin G, Trudgill N, Whorwell P; Clinical Services Committee of The British Society of
Gastroenterology. Guidelines on the irritable bowel syndrome: mechanisms and practical
management. Gut. 2007 Dec;56(12):1770-98
Evans HM, Hungin AP. Uncomfortable implications: placebo equivalence in drug
management of a functional illness. J Med Ethics. 2007 Nov;33(11):635-8.
Anastasiou F, Mouzas IA, Moschandreas J, Kouroumalis E, Lionis C. Exploring the
agreement between diagnostic criteria for IBS in primary care in Greece. BMC Res Notes.
2008 Dec 3;1:127.
Kok L, Elias SG, Witteman BJ, Goedhard JG, Romberg-Camps MJ, Muris JW, Moons KG,
de Wit NJ. Application of the Rome III criteria is not likely to reduce the number of
unnecessary referrals for colonoscopy in primary care. Eur J Gastroenterol Hepatol. 2013;
;25(5):568-574.
Treatment
Kennedy T, Jones R, Darnley S, Seed P, Wessely S, Chalder T. Cognitive behaviour
therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care:
randomised controlled trial. BMJ. 2005 Aug 20;331(7514):435.
Quartero AO, Meineche-Schmidt V, Muris J, Rubin G, de Wit N. Bulking agents,
antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome.
Cochrane Database Syst Rev 2005;(2): CD003460.
Kennedy TM, Chalder T, McCrone P, Darnley S, Knapp M, Jones RH, Wessely S.
Cognitive behavioural therapy in addition to antispasmodic therapy for irritable bowel
syndrome in primary care: randomised controlled trial. Health Technol Assess. 2006
Jun;10(19):iii-iv, ix-x, 1-67.
de Wit N, Rubin G, Jones RH. Irritable bowel syndrome. Clin Evid (Online). 2007 Mar
1;2007. pii: 0410.
C J Bijkerk, N J de Wit, J W M Muris, P J Whorwell, J A Knottnerus, and A W Hoes
Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo
controlled trial. BMJ 2009;339 b3154
Zijdenbos IL, de Wit NJ, van der Heijden GJ, Rubin G, Quartero AO. Psychological
treatments for the management of irritable bowel syndrome.Cochrane Database Syst Rev.
2009 Jan 21;(1):CD006442.
Ruepert L, Quartero AO, de Wit NJ, van der Heijden GJ, Rubin G, Muris JW. Bulking
agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome.
Cochrane Database Syst Rev. 2011 Aug 10;(8):CD003460. doi:
10.1002/14651858.CD003460.pub3.
Giroldi E, Veldhuijzen W, Leijten C, Welter D, van der Weijden T, Muris J, van
der Vleuten C. 'No need to worry': an exploration of general practitioners' reassuring
strategies. BMC Fam Pract. 2014 Jul 7;15:133.
IBD
Hall NJ, Rubin GP, Hungin AP, Dougall A. Medication beliefs among patients with
inflammatory bowel disease who report low quality of life: a qualitative study. BMC
Gastroenterol. 2007 Jun 8;7:20.
Hawthorne AB, Rubin G, Ghosh S. Review article: medication non-adherence in ulcerative
colitis--strategies to improve adherence with mesalazine and other maintenance therapies.
Aliment Pharmacol Ther. 2008 Jun;27(12):1157-66.
Schussele Filliettaz S, Juillerat P, Burnand B, Arditi C, Windsor A, Beglinger C, Dubois RW,
Peytremann-Bridevaux I, Pittet V, Gonvers JJ, Froehlich F, Vader JP, EPAGE II Study
Group (Agréus L.) Appropriateness of colonoscopy in Europe (EPAGE II). Chronic diarrhea
and known inflammatory bowel disease. Endoscopy. 2009;41:218-26.
Schussele Filliettaz S, Gonvers JJ, Peytremann-Bridevaux I, Arditi C, Delvaux M, Numans
ME, Lorenzo-Zuniga V, Dubois RW, Juillerat P, Burnand B, Pittet V, Vader JP, Froehlich F,
EPAGE II Study Group (Agréus L.) Appropriateness of colonoscopy in Europe (EPAGE II).
Functional bowel disorders: pain, constipation and bloating. Endoscopy. 2009;41:234-9.
Peytremann-Bridevaux I, Arditi C, Froehlich F, O'Malley J, Fairclough P, Le Moine O,
Dubois RW, Gonvers JJ, Schussele Filliettaz S, Vader JP, Juillerat P, Pittet V, Burnand B,
EPAGE II Study Group (Agréus L.) Appropriateness of colonoscopy in Europe (EPAGE II).
Iron-deficiency anemia and hematochezia. Endoscopy. 2009;41:227-33
Quince C, Lundin EE, Andreasson AN, Greco D, Rafter J, Talley NJ, Agréus L, Andersson
AF, Engstrand L, D'Amato M. The impact of Crohn's disease genes on healthy human gut
microbiota: a pilot study. Gut. 2013;7:7.
GI Bleeding
Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M,
Gisbert J, Sharma VK, Rostom A, Moayyedi P, Forman D. Systematic reviews of the clinical
effectiveness and cost-effectiveness of proton pump inhibitors in acute upper
gastrointestinal bleeding. Health Technol Assess. 2007 Dec;11(51):iii-iv, 1-164. Review.
Helsper CW, Smeets HM, Numans ME, Knol MJ, Hoes AW, de Wit NJ. Trends and
determinants of adequate gastroprotection in patients chronically using
NSAIDs.Pharmacoepidemiol Drug Saf. 2009 Sep;18(9):800-6.
GI cancer
Seifert B, Zavoral M, Fric P, Bencko V. The role of primary care in colorectal cancer
screening: experience from Czech Republic. Neoplasma. 2008;55(1):74-80.
Rubin G, Hamilton W. Alarm features of colorectal cancer. Gut 2009;58:1026
Arditi C, Peytremann-Bridevaux I, Burnand B, Eckardt VF, Bytzer P, Agréus L, Dubois RW,
Vader JP, Froehlich F, Pittet V, Schussele Filliettaz S, Juillerat P, Gonvers JJ.
Appropriateness of colonoscopy in Europe (EPAGE II). Screening for colorectal cancer.
Endoscopy. 2009;41:200-8.
Arditi C, Gonvers JJ, Burnand B, Minoli G, Oertli D, Lacaine F, Dubois RW, Vader JP,
Schussele Filliettaz S, Peytremann-Bridevaux I, Pittet V, Juillerat P, Froehlich F, EPAGE II
Study Group (Agréus L.) Appropriateness of colonoscopy in Europe (EPAGE II).
Surveillance after polypectomy and after resection of colorectal cancer. Endoscopy.
2009;41:209-17.
Lionis C, Petelos E. Early detection of colorectal cancer: barriers to screening in the
primary care setting. Fam Pract. 2011 Dec;28(6):589-91.
Rubin G, Elliott K, McPhail S. National Audit of Cancer Diagnosis in Primary Care. RCGP
2011
Van Hout AM, de Wit NJ, Rutten FH, Peeters PH. Determinants of patient's and doctor's
delay in diagnosis and treatment of colorectal cancer. Eur J Gastroenterol Hepatol. 2011
Nov;23(11):1056-63
Mitchell E, Rubin G, Macleod U. Improving diagnosis of cancer: a toolkit for general
practice. 2012
Forsberg AM, Kjellström L, Agréus L, Nixon Andreasson A, Nyhlin H, Talley NJ, Björck E.
Prevalence of colonic neoplasia and advanced lesions in the normal population: a
prospective population-based colonoscopy study. Scand J Gastroenterol. 2012;10:10
Rubin G, Lyratzopoulos G, Abel G, Neal R, Walter F, Hamilton W. Cancer detection in
primary care. Lancet Oncol 2012; 13: e325-6
David Meechan, Carolynn Gildea, Louise Hollingworth, Mike Richards, Di Riley, Greg
Rubin. Variation in use of the two week referral pathway for suspected cancer: crosssectional analysis. BJGP 2012; 62: e590-e597
Weller D, Vedsted P, Rubin G, Walter FM, Emery J, Scott S, Campbell C, Andersen RS,
Hamilton W, Olesen F, Rose P, Nafees S, van Rijswijk E, Hiom S, Muth C, Beyer M, Neal
RD. The Aarhus Statement: Improving design and reporting of studies on early cancer
diagnosis Br J Cancer. 2012 Mar 27;106(7):1262-7.
Lyratzopoulos G, Neal RD, Barbiere JM, Rubin GP, Abel GA. Variation in the number of
general practitioner consultations before hospital referral for cancer: findings from a national
patient experience survey. Lancet Oncology 2012. Apr;13(4):353-65.
Lyratzopoulos G, Greenberg DC, Rubin GP, Abel GA, Walter FM, Neal RD. Advanced
stage diagnosis of cancer: who is at greater risk? Expert Rev Anticancer Ther.
2012;12(8):993-6.
Hamilton W, Green T, Martins T, Elliott K, Rubin G, Macleod U. Evaluation of risk
assessment tools for suspected cancer in general practice. Br J Gen Pract 2013; 63: 30-6
Lyratzopoulos G, Abel GA, McPhail S, Neal RD, Rubin G. Measures of promptness of
cancer diagnosis in primary care: Secondary analysis of national audit data on patients with
18 common and rarer cancers. Br J Cancer 2013 Feb 19;108(3):686-90
Rubin G, Weller D. Improving survival in colorectal cancer: what role for general practice.
BJGP 2013; 63: 179-180
Hamilton W, Coleman MG, Rubin G. Easily Missed? Colorectal cancer. BMJ. 2013 May
21;346:f3172.
R D Neal, N U Din, W Hamilton, O C Ukoumunne, B Carter, S Stapley, G Rubin
Comparison of cancer diagnostic intervals before and after implementation of NICE
guidelines: analysis of data from the UK General Practice Research Database. British
Journal of Cancer. 12/2013
Hall NJ, Rubin GP, Dobson C, Weller D, Wardle J, Ritchie M, Rees CJ. Attitudes and
beliefs of non-participants in a population-based screening programme for colorectal
cancer. Health Expect. 2013 Nov 25. DOI:10.1111/hex.12157
Rubin G, Neal R, Abel G, Lyratzopoulos G. Integrated research efforts are needed to better
understand how to reduce the proportion of patients with cancer who are diagnosed as
emergencies. Br J Cancer. 2013 Apr 16;108(7):1550-1.
Lyratzopoulos G, Abel GA, McPhail S, Neal RD, Rubin GP. Timeliness, risk communication
and patient preferences for investigations or referral. Br J Cancer. 2013 May
28;108(10):2187-8.
Keeble S, Abel GA, Saunders CL, McPhail S, Walter FM, Neal RD, Rubin GP,
Lyratzopoulos G.Variation in promptness of presentation among 10,297 patients
subsequently diagnosed with one of 18 cancers: Evidence from a national audit of cancer
diagnosis in primary care. Int J Cancer. 2014 Sep 1;135(5):1220-8.
Brown S, Castelli M, Hunter DJ, Erskine J, Vedsted P, Foot C, Rubin G.How might
healthcare systems influence speed of cancer diagnosis: a narrative review. Soc Sci Med.
2014 Sep;116:56-63.
Bevan R, Lee TJ, Nickerson C, Rubin G, Rees CJ; on behalf of the NHS BCSP Evaluation
Group. Non-neoplastic findings at colonoscopy after positive faecal occult blood testing:
Data from the English Bowel Cancer Screening Programme. J Med Screen. 2014 Mar
18;21(2):89-94.
Rose PW, Hamilton W, Aldersey K, Barisic A, Dawes M, Foot C, Grunfeld E, Hart N, Neal
RD, Pirotta M, Sisler J, Thulesius H, Vedsted P, Young J, Rubin G; ICBP Module 3
Working Group*. Development of a survey instrument to investigate the primary care
factors related to differences in cancer diagnosis between international jurisdictions. BMC
Fam Pract. 2014 Jun 17;15:122.
Bevan R, Rubin G, Sofianopoulou E, Patnick J, Rees CJ. Implementing a national flexible
sigmoidoscopy screening program: results of the English early pilot. Endoscopy. 2014 Sep
30. [Epub ahead of print]
Rubin G, Walter F, Emery J, Neal R, Hamilton W, Wardle J. Research into Practice: prompt
diagnosis of cancer in primary care. Br J Gen Pract. 2014 Aug;64(625):428-30.
Dobson CM, Russelll AJ, Rubin GP. Patient delay in cancer diagnosis: what do we really
mean and can we be more specific? BMC Health Serv Res. 2014 Sep 12;14:387.
Hepatitis
Vorobjova T, Nilsson I, Terjajev S, Granholm M, Lyyra M, Porkka T, Prükk T, Salupere R,
Maaroos HI, Waldström T, Uibo R. Serum antibodies to enterohepatic Helicobacter spp. in
patients with chronic liver diseases and in a population with high prevalence of H. pylori
infection. Digestive and Liver Disease 38 (2006):171–176
Helsper CW, van Essen GA, Bonten MJ, de Wit NJ. A support programme for primary care
leads to substantial improvements in the effectiveness of a public hepatitis C campaign.
Fam Pract. 2010 Jun;27(3):328-32
Helsper CW, Borkent-Raven BA, DE Wit NJ, VAN Essen GA, Bonten MJ, Hoepelman AI,
Janssen MP, DE Wit GA. Cost-effectiveness of targeted screening for hepatitis C in The
Netherlands. Epidemiol Infect. 2011 Feb 16:1-12.
Helsper C, van Essen G, Frijling BD, de Wit NJ. Follow-up of mild alanine aminotransferase
elevation identifies hidden hepatitis C in primary care. Br J Gen Pract. 2012
Mar;62(596):212-6.
Drositis I, Bertsias A, Lionis C, Kouroumalis E. Epidemiology and molecular analysis of
hepatitis A, B and C in a semi-urban and rural area of Crete. Eur J Intern Med. 2013
Dec;24(8):839-45.
Gallbladder disease
Speets AM, Hoes AW, van der Graaf Y, Kalmijn S, de Wit NJ, Montauban van Swijndregt
AD, Gratama JW, Rutten MJ, Mali WP. Upper abdominal ultrasound in general practice:
indications, diagnostic yield and consequences for patient management. Fam Pract. 2006
Oct;23(5):507-11
Speets AM, Van Der Graaf Y, Hoes AW, Kalmijn S, De Wit NJ, Th WP, Mali M. Expected
and unexpected gallstones in primary care. Scand J Gastroenterol. 2007 Mar;42(3):351-5
Celiac disease
Ress K, Harro M, Maaroos HI, Harro J, Uibo R, Uibo O. High prevalence of coeliac
disease: Need for increasing awareness among physician. Digestive and Liver Disease
2007; 39(2):136-139.
Hall NJ, Rubin G, Charnock A. Systematic review: adherence to a gluten-free diet in adult
patients with coeliac disease. Aliment Pharmacol Ther. 2009 Aug 15;30(4):315-30
Kostopoulou O, Devereaux-Walsh C, Delaney BC. Missing celiac disease in family
medicine: the importance of hypothesis generation. Med Decis Making. 2009 MayJun;29(3):282-90.
Hall NJ, Rubin GP, Charnock A. Intentional and inadvertent non-adherence in adult coeliac
disease: a cross sectional survey. Appetite 2013 doi: 10.1016/j.appet.2013.04.016
Ludvigsson JF, Aro P, Walker MM, Vieth M, Agréus L, Talley NJ, Murray JA, Ronkainen J.
Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult
population-based study. Scand J Gastroenterol. 2013;48:808-14.
Walker MM, Murray JA, Ronkainen J, Aro P, Storskrubb T, D'Amato M, Lahr B, Talley NJ,
Agréus L. Detection of celiac disease and lymphocytic enteropathy by parallel serology
and histopathology in a population-based study. Gastroenterology. 2010;139:112-9.
Constipation
Rubin G, Dale A. Chronic constipation in children. BMJ. 2006 Nov 18;333(7577):1051-5.
Review
Mihaylov S, Stark C, McColl E, Steen N, Vanoli A, Rubin G, Curless R, Barton R, Bond J.
Stepped treatment of older adults on laxatives. The STOOL trial. Health Technol Assess.
2008 May;12(13):iii-iv, ix-139
Speed C, Heaven B, Adamson A, Bond J, Corbett S, Lake AA, May C, Vanoli A, McMeekin
P, Moynihan P, Rubin G, Steen IN, McColl E. LIFELAX – diet and LIFEstyle versus
LAXatives in the management of chronic constipation in older people: randomised
controlled trial. Health Technology Assessment 2010 Vol 14: 52
Education in gastroenterology
Berberat PO, de Wit NJ, Bockhorn M, Lundell L, Drenth JP. Training innovations in
gastroenterology and educational resources: a new vision of gastrointestinal education
across Europe. Eur J Gastroenterol Hepatol.2010 Dec;22(12):1393-6
Rubin G. What can education do to improve cancer diagnosis? Education for Primary Care
2013; 24: 234-236
Rajasekhar P, Rees C, Rutter M, Hungin P. Developing a clinical research network; the
Northern Region Endoscopy Group experience. Clin Med. 2014 Apr;14(2):107-12.
Rajasekhar PT, Rutter MD, Bramble MG, Wilson DW, East JE, Greenaway JR, Saunders
BP, Lee TJ, Barton R, Hungin AP, Rees CJ. Achieving high quality colonoscopy: using
graphical representation to measure performance and reset standards. Colorectal Dis. 2012
Dec;14(12):1538-45.
Rajasekhar PT, Rees CJ, Rutter MD, Saunders BP, Bramble MG, Hungin P, East JE;
Improving the quality of colonoscopy. Quality Improvement in Colonoscopy Study Group.
Gastrointest Endosc. 2012 Jan;75(1):229-30; author reply 230.