Faculty & Graduate Institute of Animal Vaccine Technology
Name
CHUN-YEN CHU
Position
Full Time Faculty
Title
Associate Professor
Tel.
Tel.: +886 87703202#5330, 5331
Lab
Vaccinology lab. (VM208)
Blog
http://agriculture.npust.edu.tw/npust_teacher169/intro
E-mail
Lessons
cychu@mail.npust.edu.tw
(1) Vaccinology
(2) Adjuvants
(3) Advance vaccine manufacture operation
(4) Biotechnology and Bioindustry
(5) Inspection Techniques on Biological Products
Diploma
National Sun Yat-sen University,
Department of biological sciences, Ph.D.
Profession
1. Vaccinology
2. Biotechnology and Bioindustry
3. Adjuvants
4. Vaccine Technology
5. Inspection Techniques on Biological Products
Career
 Graduate Institute of Animal Vaccine Technology, National Pingtung
University of Science and Technology, Associate Professor.
 Tzu Hui Institute of technology Department of Nursing,
Assistant Professor.
 Animal vaccine company, R&D department, Manger.
CHUN-YEN CHU, Associate Professor
研究室名稱
Vaccinology lab. (VM208)
主持人
CHUN-YEN CHU, Associate Professor
聯絡方式
Tel.: +886 87703202#5330
fax : +886 87740178
E-mail address: cychu@mail.npust.edu.tw
Address: Department of Veterinary Medicine, National Pingtung University of
Science and Technology. 1, Shuefu Road, Neipu, Pingtung 912, TAIWAN.
(VM208)
個人檔案
學歷
2001/6
—
Department of biological sciences, National Sun Yat-sen University,
Ph.D.
簡歷
2008/8 ~
—
Graduate Institute of Animal Vaccine Technology, National
Pingtung University of Science and Technology, Associate
Professor
2005/8~ 2008/7— Graduate Institute of Animal Vaccine Technology, National
Pingtung University of Science and Technology, Assistant
Professor
1983/7~2005/7— R&D department, Animal vaccine company, Manger
經歷



National Sun Yat-sen University Department of biological sciences, Associate
Professor
Tzu Hui Institute of technology Department of Nursing, Assistant Professor
R&D department, Animal vaccine company, Manger
專長
1. Vaccinology
2. Biotechnology and Bioindustry
3. Adjuvants
4. Vaccine Technology
5. Inspection Techniques on Biological Products
專業背景
專業
Study and establish the platform of production antigens. Transfer the research
results to vaccine industry to increase the output value.
授課課程
Master Students: Vaccinology, Adjuvant, Advance vaccine manufacture operation,
Biotechnology and Bioindustry, Inspection Techniques on
Biological Products
研究介紹
 Current and Pending Support
1. Establishment the 30 Liter Bioreactor to Produce Streptococcus Suis Recombinant
Proteins and Evaluation The Vaccines Efficacy. (NSC99-2324-B020-001-MY2)
2010/08/01~2011/07/31.
2. Commercialization Study of Cattle Pasteurella Recombinant Proteins and
Inactivated Vaccine. (99 AS-5.4.2- BQ -B2) 2010/01/01~2010/12/31.
3. Development of Inactivated Vaccine with Oil Adjuvant Against Bovine
Staphylosoccus aureus and Coliform Bacteria Mastitis (I). (98AS-9.2.4-BQ-B8)
2009/09/01~2009/12/31.
4. The Animal Vaccine & Adjuvant Research Center Plan (4)-(7). (D09800049)
5.
6.
7.
2006/01/01~2009/12/31.
Development of Herpesvirus Type I and Bovine Ephemeral Fever Virus Bivalent
Vaccine in Ruminants (I)(II). (D97-46) 2008/06/01~2009/12/31.
The Immune Regulation Effects of Different Adjuvants with Waterfowl
Parvovirus Antigens. (NSC97-2313-B020-004-MY3) 2008/08/01~2011/07/31.
Development of Cattle Pasteurella Recombinant Membrane Protein and
Inactivated Vaccine(I)(II). (96AS-1.1.5-BQ-B1(4), 97AS-1.1.5-BQ-B1(5)
2007/01/01/~2008/12/31.
8.
9.
Development of Porcine Circovirus Subunit Vaccine(I) (II) (III)
(95AS-6.1.5-BQ-B1(1), 96AS-1.1.5-BQ-B1(1), 97AS-1.1.5-BQ-B1(1)
2006/01/01/~2008/12/31.
The Development of the Streptococcus suis Inactivated Vaccine(I) (II)
(NSC95-2622-B020-002-CC3) 2006/05/01/~2008/10/31.
 Main Research Projects
1. Cloning and expression of viral genes
2. Cloning and expression of bacterial genes
3. Scale up of animal cell culture with bioreactor
4. Formulation of vaccine and adjuvants
 Publications
1. Jai-Wei Lee, Yu-Ming Lin, Ting-Ying Yen, Wen-Jen Yang, Chun-Yen Chu*. 2010.
CpG oligodeoxynucleotides containing GACGTT motifs enhance the immune
responses elicited by a goose parvovirus vaccine in ducks. Vaccine (accepted)
2. Chun-Yen Chu*, Shang-Chun Lee, Chi Yu, Kuo-Hua Lee, Xin Zhao, Jai-Wei Lee.
2010. CpG oligodeoxynucleotides containing GACGTT 1 motifs enhance the
immune responses elicited by keyhole limpet hemocyanin antigen in dairy cattle.
Veterinary Immunology and Immunopathology. (reviced)
3. Jai-Wei Lee, Ji-Ping Huang, Li-Shian Hong, Shih-Fang Shu, Chi Yu, Chun-Yen
Chu*. 2010. Recombinant Hemagglutinin-Neuraminidase Protein Enhances the
Humoral Response and Efficacy of Commercial Newcastle Disease Vaccines in
Chickens. Avian disease. 54:53-58.
4. Hsing-Chieh Wu, Han-Yun Lin , Shih-Fang Shu, Shyh-Shyan Liu, Hso-Chi
Chaung, Chun-Yen Chu*. 2009. Genetic and immunogenic analysis of the
recombinant Lpp 38 outer membrane protein of Mannheimia (Pasteurella)
haemolytica. Taiwan Veterinary Journal 35(4) 273-282.
5. Chi Yu, Zhao-Ru Shi, Chun-Yen Chu*, Kuo-Hua Lee, Jai-Wei Lee. 2009.
Expression of bovine granulocyte chemotactic protein-2 (GCP-2) in neutrophils
and a mammary epithelial cell line (MAC-T) in response to various bacterial cell
wall components. The Veterinary Journal. (Epub ahead of print)
6. Chun-Yen Chu*, Shih-Fang Shu, Jui-Hao Huang, Jung-Pin Hsu, Kai-Ren Xue.
2009. Rapid Detection of Streptococcus suis Serotypes and Virulent factors in
Southern Taiwan by Multiplex Polymerase Chain Reaction. The Veterinary
Journal. 35(2) 107-114.
7. Chun-Yen Chu*, Shiang-Yiu Wang, Zeng-Weng Chen, Maw-Sheng Chienc,
Ji-Ping Huang, Jen-Jin Chen, Li-Shian Hong, Ai-Li Shiau and Chao-Liang Wu.
2007. Heterologous Protection in Pigs Induced by A Plasmid Cured and crp
Gene-Deleted Salmonella choleraesuis Live Vaccine. Vaccine. 25:7031-7040.
8. Chun-Yen Chu*, Jan-Jin Chen, Hunter Chen .2007. Effect of water-in-oil-inwater (w/o/w) Oil Adjuvant on Long-term Antibody Response of Bovine
Ephemeral Fever Vaccine. The Veterinary Journal. 33: 206-211.
9. Yao-Ching Hsieh, Shiang-Yiu Wang, Yen-Feng Lee, Shih-Hui Chen, Paul O.T.
Mak and Chun-Yen Chu*. 2006. DNA sequence analysis of glycoprotein G gene
of Bovine Ephemeral Fever virus and development of a double oil emulsion
vaccine against Bovine Ephemeral Fever. Journals Veterinary Medical Science.
68(6):543-548.
10. Chun-Yen Chu*, Shiang-Yiu Wang, Ji-Ping Huang, Li-Shian Hong, Ai-Li Shiau
and Chao-Liang Wu. 2006. Construction of Salmonella choleraesuis Gene-Deleted
Mutant and Evaluate the Efficacy in mice. J Northwest Sci-Tech Univ of Agri and
For. 34:83-86.
11. Ai-Li Shiau, Chung-Cheng Chen, Yi-Te Yo, Chun-Yen Chu*, Shiang-Yiu Wang ,
Chao-Liang Wu. 2005. Enhancement of humoral and cellular immune responses
by an oral Salmonella choleraesuis vaccine expressing porcine prothymosin
Vaccine 23:5563-5571.
 International Conference Meetings
1. Jai-Wei Lee, S-C Lee, Chun-Yen Chu, H-K Lee. 2010. CpG ligodeoxynucleotides
in a bovine mastitis vaccine enhance the production of IgM and phagocytosis in
milk. 5th IDF Mastitis Conference. March 21-24, New Zealand. (poster)
2. Chun-Yen Chu, Kai-Ren Xue, Jui-Hao Huang, Shih-Fang Shu. 2009. Development
of Streptococcus suis Subunit Vaccine. 4th China Medical Biotech. Augst 7-10,
Dalian, China. (oral)
3. Chun-Yen Chu, Ting-Ying Yen, Yu-Ming Lin, Shih-Fang Shu, Jai-Wei Lee. 2009.
CpG oligodeoxynucleotides enhance the immune responses of a recombinant
parvovirus capsid protein vp2 vaccine in ducks. 11th International Congress
ISDCI. Jun 28-July 3, Prague, Czech. (oral)
4. Chun-Yen Chu, Xiang Yu Wang, Ji-Ping Huang, Li-Xiang Hong, Yuan-Li Xiao,
Zhao-Liang Wu. 2006. Construction of Salmonella Choleraesuis gene-deleted
mutantand evaluation of the efficacy. 第一屆海峽兩岸畜牧獸醫永續發展高新技
術論壇,Augst 21-24, China.(oral)
5. Shih-Fang Hsu, Chun-Yen Chu, and Jiin-Tsuey Cheng. 2004. An upstream
regulatory element confers differential TSG101 promoter activities in primary
thyroid cells and thyroid carcinoma cells. American Association for Cancer
Research, 95th Annual Meeting. (poster)
6. Chun-Yen Chu. 2004. Swine vaccines and Immune Response. International
Symposium on Mutilateral Cooperation in Agricultural Biotechnology Exchange
in Pan-Pacific Area. (oral)