Curriculum Vitae
Name: Paul Kong Thoo Lin
BSc, PhD, CChem; FRSC; FHEA
Current Position: Professor
Date of birth: 21/07/59
Nationality: British
Qualifications and Professional Affiliations:
30/06/1983 BSc (Hons), Chemistry, Robert Gordon’s Institute of Technology
01/12/1986 PhD titled “An investigation into the synthesis and reactivity of 7-azaindolizines,
7-azaindolizinones, dipyrrolo[1,2-a:2,1-c]pyrazines and related nitrogen
bridgehead structures”, Robert Gordon Institute of Technology
21/03/1984 Graduate Member of the Royal Society of Chemistry
13/03/1987 Member of the Royal Society of Chemistry, Chartered Chemist
01/05/2007 Fellow of the Higher Education Academy
27/01/2006 Fellow of the Royal Society of Chemistry
2003-2005
Committee Member of the Aberdeen and North Scotland Section of the Royal
Society of Chemistry.
Science and Engineering Ambassador (SETNET)
Previous Positions and Employment Experience
1986-1987
Part-time Lecturer, RGIT
1987-1992
Post Doctoral Fellow, Medical Research Council, Laboratory of Molecular
Biology, Cambridge
1992-1999
Lecturer, School of Applied Sciences, Robert Gordon University
1999-2010
Reader, School of Pharmacy and Life Sciences), Robert Gordon University
Current Roles at School and University level
Pharmaceutical Science Teaching Group Leader
European Coordinator for the School
Member of the Research and Knowledge Transfer Committee
Research Interests
Design, Synthesis and Biological Activity of Novel Compounds
Medicinal Chemistry, NMR spectroscopy, Organic and Bio-organic chemistry, Biological
Chemistry, Bioanalysis. Novel anti-cancer Products derived from plant sources. Synthesis of
novel compounds with potential therapeutic properties. Regulation of apoptosis in cancer cells.
Public Output
Book Chapters
P. Kong Thoo Lin and D. M. Brown (1994)
Oligonucleotides Containing Degenerate Bases: Synthesis and Uses from Methods in
Molecular Biology, vol.26, chapter 7: Protocols for Oligonucleotide Conjugates (Ed. S.
Agrawal), The Humana Press Inc., Totowa, New Jersey.
P. Kong Thoo Lin and V. A. Kuksa (1999)
Oxa-Polyamine Analogues: Synthesis and Biological Activity in Polyamine in Health and
Nutrition Chapter 9, 105-115. Eds. Bardocz, S. and White, A. Kulver Academic, Boston,
USA.
PATENTS
D. M. Brown and P. Kong Thoo Lin, (WO/1993/005175) Improvements in oligonucleotide
primers and probes, Publication date: 18.03.1993.
Patent WO 02/099409 A1 (PCT/GB02/02292), IP title: Method and application. Inventors: Paul
Kong Thoo Lin, Alabert N. Araujo, Maria C.B.S.M. Montenegro. International filing date 5 June
2002.
Portuguese Patent Application filed on the 19/6/06.
IP Title: Bisnaphthalimidopropyl derivative compounds with anti-parasite and anti-cancer
activity. Patent number 103 503
Anabela Cordeira da Silva , Paul kong Thoo Lin and Joana Tavares.
British Patent Application filed on 21/11/ 2006. IP Title: Compounds Application number
0623174.0. PCT application submitted. Inventors: Paul Kong Thoo Lin and Charles
Bestwick.
SELECTION OF PUBLICATIONS
Vladimir A. Kuksa, Valentin Pavlov, Paul Kong Thoo Lin (2000), The Synthesis and In vitro
Cytotoxic Studies of Novel Oxa-spermidine Derivatives and Homologues. Bioorganic and
Medicinal Chemistry Letters, 10, 1265-1267.
Paul Kong Thoo Lin and Valentin A. Pavlov (2000), The Synthesis and Invitro Cytotoxic Studies
of Novel Bis-naphthalimidopropyl Polyamine Derivatives. Bioorganic and Medicinal Chemistry
Letters, 10, 1609-1612.
Valentin Pavlov, Paul Kong Thoo Lin, Vicente Rodilla (2001), Cytotoxic and DNA binding and
localisation of novel Bis-naphthalimidopropyl polyamine derivatives. Chemico-Biological
Interactions, 137, 15-34.
Vladimir A. Kuksa, Valentin Pavlov, Paul Kong Thoo Lin (2002), Novel Oxa-spermine
Homologues: Synthesis and Cytotoxic Properties. Bioorganic & Medicinal Chemistry, 10, 692697.
Valentin Pavlov, Vicente Rodilla and Paul Kong Thoo Lin (2002). Biochemical effects and
growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives.
Cellular and Molecular Life Sciences, 59, 715-723.
V. Pavlov, V. Rodilla and P. Kong Thoo Lin (2002). Growth, morphological and biochemical
changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells. Life Sciences, 71,
1161-1173.
P. Kong Thoo Lin, A. M. Dance, C. Bestwick and L. Milne (2003), The biological activities of
new polyamine derivatives as potential therapeutic agents. Biochemical Society Transactions, 31,
407-410.
Anne-Marie Dance, Lynda Ralton, Zoe Fuller, Charles Bestwick, Lesley Milne, Susan Duthie and
Paul Kong Thoo Lin (2005)Synthesis and Biological Activities of Bisnaphthalimido Polyamines
Derivatives: Cytotoxicity,DNA Binding, DNA Damage and Drug Localization in Breast Cancer
MCF 7 Cells. Biochemical Pharmacology, 69, 19-27.
Joana Tavares, Ali Ouaissi , Paul Kong Thoo Lin, , Ana Tomás, and Anabela Cordeiro-da-Silva
(2005), Differential effects of Polyamine Derivatives Compounds against Leishmania Infantum
Promastigotes and Axenic Amastigotes. International Journal for Parasitology, 35, 637-646.
Mohammad Shoeb, Sezgin Celik, Marcel Jaspars, Yashodharan Kumarasamy, Stephen M.
MacManus, Lutfun Nahar, Paul Kong Thoo-Lin and Satyajit D. Sarker (2005) Isolation, structure
elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea
schischkinii. Tetrahedron, 61, 9001-9006.
Paul Kong Thoo Lin, Alabert N. Araujo, Maria C.B.S.M. Montenegro and R. Pérez-Olmos
(2005). New PVC nitrate-selective electrode: Application to vegetables and mineral waters.
Journal of Agricultural and Food Chemistry, 53, 211 – 215.
Mohammad Shoeb, Stephen M. MacManus, Marcel Jaspars, Jioji Trevidu, Lutfun Nahar, Paul
Kong-Thoo-Lin and Satyajit D. Sarker (2006), Montamine, a unique dimeric indole alkaloid,
from the seeds of Centaurea montana (Asteraceae), and its in vitro cytotoxic activity against
CaCo-2 colon cancer cells. Tetrahedron, 62, 11172-11177.
Mohammad Shoeb, Sezgin Celik, Lutfun Nahar, Stephen M. MacManus, Paul Kong-Thoo-Lin,
Marcel Jaspars, and Satyajit D. Sarker (2007), Two Salonitenolide Derivatives from Aerial Parts
of Centaurea gigantea Inhibit the Growth of Colorectal Cancer Cells in vitro. Natural Products
Communications, 2, 121-125.
João Oliveira, Lynda Ralton, Joana Tavares, Anabela Codeiro-da-Silva, Charles S. Bestwick,
Anne McPherson and Paul Kong Thoo Lin (2007), The Synthesis and the in vitro Cytotoxicity
studies of Bisnaphthalimidopropyl Polyamine Derivatives against Colon Cancer Cells and
Parasite Leishmania infantum. Bioorganic & Medicinal Chemistry, 15, 541-545.
Lynda Ralton, Charles S. Bestwick, and Paul Kong Thoo Lin (2007). Polyamine analogues and
derivatives as potential anticancer agents. Current Bioactive Compounds, 3 (3), 179-191.
Satyajit D. Sarker , Mohammad Shoeb, , Sezgin Celik , Marcel Jaspars, Lutfun Nahar, , Paul
Kong-Thoo-Lin and Stephen M. MacManus (2007). Extracts of Centaurea bornmuelleri and
Centaurea huber-morathii inhibit the growth of colon cancer cells in vitro. Oriental Pharmacy
and Experimental Medicine, 7(4), 336-340.
Lynda Ralton, Charles S. Bestwick, and Paul Kong Thoo Lin (2007), Polyamine analogues and derivatives
as potential anticancer agents. Current Bioactive Compounds, 3 (3), 179-191.
Lynda Ralton, Charles S. Bestwick, Lesley Milne, Susan Duthie, Paul Kong Thoo Lin (2009). The study
of Bisnaphthalimidopropyl Spermidine and Spernine on DNA damage and repair within Colon Carcinoma
Cells. Chemico-Biological Interactions, 177, 1–6
Joana Tavares, Ali Ouaissi, Paul Kong Thoo Lin, Ines Loureiro, Simranjeet Kaur,Nilanjan Roy, and
Anabela Cordeiro-da-Silva (2010). Bisnaphthalimidopropyl derivatives as inhibitors of
Leishmania SIR2 related protein 1, ChemMedChem., 5, 140-7.
Gemma A Barron, Giovanna Bermano, Amanda Gordon, and Paul Kong Thoo Lin (2010). Synthesis,
cytotoxicity and DNA binding of novel bisnaphthalimidopropyl polyamine derivatives in breast cancer
MDA-MB-231 cells. European Journal of Medicinal Chemistry, 45, 1430-1437.
Clare Hoskins, Mehdi Ouaissi, Sofia Costa Lima, Woei Ping Cheng, Inês Loureirio, Eric Mas,
Dominique Lombardo, Anabela Cordeiro, Ali Ouaissi and Paul Kong Thoo Lin (2010)
In Vitro and in Vivo Anticancer Activity of a Novel nano-sized Formulation based on self-assembling
polymers against Pancreatic Cancer. Pharmaceutical Research, 27, 2694-2703.