CURRICULUM VITAE FABIO SONVICO Date of birth: 9 December 1974 Citizenship: Italian Private Viale Milazzo, 29 43100 – Parma, Italy Tel. ++39-0521-252790 Cell. ++39-339-5019016 E-mail : fabio.sonvico@unipr.it Buisness Dipartimento Farmaceutico Viale G.P. Usberti, 27a 43100 – Parma Tel. ++39-0521-905087 Fax. ++39-0521-905006 Curriculum vitae – Fabio Sonvico pag. 2 di 21 EDUCATION 2005 Since November 2005 Assistant Professor at the Faculty of Pharmacy of the University of Parma 2004 Researcher at the National Institute for the Physics of the Matter (INFM), Research Unit of Parma, on the project: “Development of biopolymeric nanosystems suitable for the controlled delivery of drugs” 2003 French Ph.D. degree in Pharmaceutical Technology and Physicochemistry Italian Ph.D. degree in Biopharmaceutics and Pharmacokinetics Awarded with a Ph.D. grant by the French Assotiation for Cancer Research (ARC) 2000 Awarded with a grant for France-Italy cotutorial Ph.D. thesis by the Italian Minster for Instruction, University and Research Awarded with a Socrates/Erasmus Scholarship Attribution of the equivalence of the Italian Master’s Degree with the French Diplome d’Etudes Avancés (DEA) 2000-2003 Università degli Studi di Parma - Université de Paris Sud Ph.D. Thesis in Biopharmaceutics and Pharmacokinetics Co-tutorial project between Italy and France: “Functionalised metallic nanoparticles for the treatment of solid tumours” Tutors Prof. P.Colombo (Italy), Prof. P.Couvreur (France) 2000 Italian national qualification as Pharmacist (Pharm.D.) 1993-1999 Università degli Studi di Pavia Laurea (equivalent Master’s Degree) in Chemistry and Pharmaceutical Technologies. Experimental project carried out in Bayer laboratories in Garbagnate Milanese (Italy): “Applications on Near Infrared Spectroscopy to Quality Control of solid pharmaceutical dosage forms” Tutors Prof. C.Caramella, Dr. A.Schiavi (BAYER) Curriculum vitae – Fabio Sonvico pag. 3 di 21 Secondary school: Liceo Classico “T.Gallio”, Como 1988-1993 PROFESSIONAL EXPERIENCE March-July 1999 BAYER - Garbagnate milanese (Italy) Work experience placement at PH-Quality Assurance CONTINUOUS EDUCATION AND QUALIFICATION 2009 Workshop “Giornata di studio con aggiornamento regolatorio per studi clinici di Fase 1” I.P.A.S., Ligornetto, Switzerland Workshop on “Quality by Design: Theory and tools made easy” University of Parma, Italy 2007 Collaboration with the Consortium TEFARCO Innova as reviewer of drug products Common Technical Document for the Italian Medicines Agency (AIFA) 2007 Workshop on Bioencapsulation and COST865 meeting, Lisbon, Portugal 2006 Aitun, AAPS Italian Student Chapter Workshop, “Pharmaceutical nanotechnology” – Università di Ferrara, Italy 2005 CRS Italian Chapter Workshop on “Controlled release of oral therapeutics” – Università degli Studi di Pavia, Italy 2004 Socrates course on Innovative therapeutics: from molecules to medicines – Università degli Studi di Parma, Italy 2003 3rd Ph.D. School on “Polymers of pharmaceutical interest” – Università della Calabria, Arcavacata di Rende, Italy 2003 Workshop on “Nanohybrids” – Carry Le Rouet, France 2002 4th International Intensive Course and Workshop on Cell Culture and in vitro Models for Drug Absorption and Delivery – Saarland Universitat, Saarbrucken, Germany 2001 1st Socrates Course on Innovative therapeutics: from molecules to drugs – Université de Paris Sud, Paris, France Curriculum vitae – Fabio Sonvico pag. 4 di 21 LANGUAGE SKILLS ItaIian Mother tongue English Fluent French Fluent German Beginner level Spanish Intermediate level CONGRESS COMMUNICATIONS Colombo G., Rimessi A., De Corcelli A., Menegatti E., Bortolotti F., Sonvico F., Colombo P. Combination of alginate and cells for skin regeneration PharmaTech 2010 - International Conference and Exhibition on Pharmaceutical, Nutraceutical and Cosmeceutical Technology: Formulation and Applications, 25-26 May 2010, KLCC, Kuala Lumpur, Malaysia Miozzi M., Sonvico F., Colombo P., Buttini F. Construction of ciprofloxacin dy microparticles for lung infection treatment 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 8-11 March 2010, Valletta, Malta - Abstract 68 Senyigit T., Sonvico F., Barbieri S., Ozer O., Santi P., Colombo P. Preparation and characterization of clobetasol-17-propionate loaded lecithinchitosan nanoparticles for topical use 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 8-11 March 2010, Valletta, Malta - Abstract 68? Balducci A.G., Colombo P., Cavallari C., Rodriguez L., Sonvico F., Rossi A. Gastro-resistant multiparticulate dosage form for mesalazine colon delivery in paediatric patients 17th International Symposium on Microincapsulation, 29 September - 1 October 2009 Curriculum vitae – Fabio Sonvico pag. 5 di 21 Sonvico F., Ampollini L., Barbieri S., Marcotti E., Colombo G., Carbognani P., Colombo P. Polysaccharide films loaded with anticancer drugs for locoregional therapy of malignant pleural mesothelioma 17th International Symposium on Microincapsulation, 29 September - 1 October 2009 Raffin R., Haas S.E., Colomé L.M., Hoffmeister C.R.D., Colombo P., Sonvico F., Colmè L.M., Natalini C.C., Pohlmann A., Dalla Costa T., Guterres, S. Pharmacokinetics evaluation of soft agglomerates containing pantoprazole-loaded microparticles in dogs 36th Annual Meeting & Exposition of the Controlled Release Society, 18-22 July 2009, Copenhagen, Danemark Raffin R., Colomé l., Hoffmeister C., Dalla Costa T., Pohlmann A., Colombo P., Sonvico F., Rossi A., Colmè l., Guterres, S. Soft agglomerates of pantoprazole gastro-resistant microparticles for oral administration: pharmacokinetics evaluation 2nd PharmSciFair, 8-12 June 2009, Nice, France Conti C., Rossi A., Sonvico F., Scarpignato C., Colombo P. Influence of HPMC polymer content on clarithromycin release from module assembled system 2nd PharmSciFair, 8-12 June 2009, Nice, France Barbieri S., Marcotti E., Sonvico F., Rossi A., Colombo P. Tamoxifen loaded autoassembled nanoparticles: cellular uptake and enzymatic degradation 2nd PharmSciFair, 8-12 June 2009, Nice, France Coelho P., Santos D., Bettini R., Colombo P., Sonvico F., Strusi O.L. Development of a ranitidine controlled release gastroretentive oral dosage form 68th International Congress of FIP - Reengineering Pharmacy Practice in a Changing World, 29 August - 4 September 2008, Basel, Switzerland Curriculum vitae – Fabio Sonvico pag. 6 di 21 Sonvico F., Sacchetti G., Gussago F., Barbieri S., Rossi A., Colombo P., Carbognani P. Polysaccahrdic films loaded with cisplatin for the locoregional therapy of pleural malignant mesothelioma 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 7-10, 2008, Barcelona, Spain Rossi A., De Haan B., Sonvico F., De Vos p., Colombo P. Study of human protein adsorption onto sodium alginate/poly-L-lysine beads by micro fourier transformed infrared spectroscopy 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 7-10, 2008, Barcelona, Spain Como C., Sonvico F., Rossi A., Corradini E., Colombo P. Lecithin/Chitosan Based Nanosystem for Tamoxifen Citrate Oral Delivery 2007 AAPS Annual Meeting, November 11-15, 2007, San Diego, USA Strusi O. L., Sonvico F., Rossi A., Bettini R., Majori G., Colombo P. Clindamycin-Artesunate Combined Multi-Kinetics Drug Delivery System for Malaria Therapy 2007 AAPS Annual Meeting, November 11-15, 2007, San Diego, USA Raffin R., Colombo P., Sonvico F., Rossi A., Pohlmann A., Gutierrez S. Preparation and Characterization of a Pantoprazole New Drug Delivery System for Oral Administration Based on Soft Agglomerates 2007 AAPS Annual Meeting, November 11-15, 2007, San Diego, USA Buttini F., Vitale A., Rossi A., Sonvico F., Colombo P. High Respirable Insulin Dry Powder for Pulmonary Administration 2007 AAPS Annual Meeting, November 11-15, 2007, San Diego, USA Sonvico F., Colombo G., Gallina L., Bortolotti F., Colombo P., Menegatti E., Scagliarini A. Use of Sucralfate Gel as a Vehicle for Topical Administration of the Antiviral Drug Cidofovir 2007 AAPS Annual Meeting, November 11-15, 2007, San Diego, USA Curriculum vitae – Fabio Sonvico pag. 7 di 21 Colombo G., Russo P., Sonvico F., Hesse E., Ferraro L., Bortolotti F., Colombo P. Desmopressin dry powder for nasal administration Innovation in drug delivery : from biomaterials to devices, September 30 – October 3, 2007, Naples, Italy Sonvico F., Barbieri S., Rossi A., Gerelli Y., Deriu A., Colombo P., Colombo G. Progesterone-loaded lechitin/chitosan/isopropyl myristate nanoparticles for transmucosal delivery Innovation in drug delivery : from biomaterials to devices, September 30 – October 3, 2007, Naples, Italy Colombo G., Bortolotti F., Colombo P., Menegatti E., Sonvico F., Soft agglomerates containing microincapsulated levothyroxine for buccal oral delivery 16th International Symposium on Microencapsulation, September 9 - 12, 2007, Lexington, USA Parlati C., Buttini F., Sonvico F., Colombo P. Innovtive tobramycin dry powder for pulmonary administration 16th International Symposium on Microencapsulation, September 9 - 12, 2007, Lexington, USA Deriu A., Gerelli Y., Como C., Sonvico F., Di Bari M.T., Colombo P., May R. Neutron investigation of the structure and organization of phospholipid/polysaccharide nanoparticles 4th European Conference on Neutron Scattering, 25-29 June 2007, Lund, Sweden. Deriu A., Chiapponi C., Di Bari M.T., Sonvico F., Santi P., Nicoli S., Padula C. Water diffusivity in PVA-based transdermal patches 4th European Conference on Neutron Scattering, 25-29 June 2007, Lund, Sweden Coelho P., Bettini R., Colombo P., Sonvico F., Strusi L., Oliveira A., Sosa Lobo J.M., Delfim S., Ferreira D. Curriculum vitae – Fabio Sonvico pag. 8 di 21 Gamma scintigraphy evaluation of floating Dome matrix gastric residence in humans 3rd Pharmaceutical Science World Congress, 22-25 April 2007, Amsterdam, The Netherlands Barata P., Colombo P., Bettini R., Sonvico F., Strusi L., Sousa Lobo J.M., Delfim S., Ferreira D. Plataforma Dome Matrix : un sistema farmaceutico inovador Congresso Nacional dos Farmaceuticos, 8-10 March 2007, Lisbon, Portugal Rossi A., Colombo P., Sonvico F., Colombo G., Buttini F., Russo P. Agglomerates of morphine microcrystals for nasal or buccal admnistration AAPS 2006 Annual Meeting, October 29 - November 2, 2006, San Antonio, USA Colombo G., Gallina L., Sonvico F., Colombo P., Bortolotti F., Menegatti E., Scatturin A., Scagliarini A. Biohadesive sucralfate gel based suspension containing cidofovir for spray treatment of viral infections in lamb and sheep AAPS 2006 Annual Meeting, October 29 - November 2, 2006, San Antonio, USA Losi E., Jimenez-Kairuz A., Strusi O.L., Sonvico F., Colombo G., Bettini R., Colombo P. Dome Matrix® technology : effect of drug solubility on release kinetics of swellable delivery modules AAPS 2006 Annual Meeting, October 29 - November 2, 2006, San Antonio, USA Como C., SonvicoF., Rossi A., Corradini E., Colombo P. Influence of tamoxifen citrate loading on lecithin/chitosan nanoparticles AAPS 2006 Annual Meeting, October 29 - November 2, 2006, San Antonio, USA Gallina L., Colombo G., Sonvico F., Dal Pozzo F., Borlotti F. Menegatti E., Scatturin A., Colombo P., Scagliarini A. Cidofovir spray formulation for the topical treatment of orf virus infected sheep 8th Congress of Chemotherapy and Infection (EEC8) – 4th European Conference on Viral Diseases (ConVir 4), 26-28 October 2006, Budapest, Hungary Curriculum vitae – Fabio Sonvico pag. 9 di 21 Sonvico F., Barbieri S., Rossi A., Motta S., Bettini R., Deriu A., Colombo P. Lecithin/chitosan self-organized nanoparticles as drug carriers for lipophilic drugs XIV International Workshop on Bioencapsulation & COST 865 Meeting, 5-7 October 2006, Lausanne, Switzerland Colombo P., Rossi A., Russo P., Sonvico F., Colombo G., Buttini F. Nasal powders of morphine microcrystal agglomerates Respiratory Drug Delivery X, 23 – 27 April 2006, Boca Raton, USA Sonvico F., Bove L., Deriu A., Cavatorta F., Di Bari M.T., Albanese G. Mean square hydrogen fluctuations in chitosan/lecithinnanoparticles from elastic neutron scattering experiments International Conference on Neutron Scattering 2005, 27 November – 2 December 2005, Sydney, Australia Sonvico F., Deriu A., Di Bari M.T., Albanese G., Cavatorta F., Calandrini V., May R. Small angle scattering investigation of chitosan/lecithin nanoparticles, potential carriers for drug delivery International Conference on Neutron Scattering 2005, 27 November – 2 December 2005, Sydney, Australia Jimenez-Kairuz A., Bettini R., Sonvico F., Como C., Strusi O. L., Colombo P. Riboflavin release from hydrophilic matrices using Dome Matrix® technology 2nd EUFEPS Conference on Optimising Drug Delivery and Formulation : Evaluation of Drug Delivery Systems Issues and Perspectives, 20-23 November 2005, Versailles, France Sonvico F., Rizzi A., Rossi A., Motta S., Cavatorta F., Santi P., Deriu A., Colombo P. Progesterone loading in lecithin/chitosan nanoparticles for transmucosal delivery AAPS 2005 Annual Meeting, 6-10 November 2005, Nashville, USA Sonvico F., Rossi A., Motta S., Cavatorta F., Bettini R., Deriu A., Colombo P. Curriculum vitae – Fabio Sonvico pag. 10 di 21 Lecithin-chitosan nanoparticles for the transmucosal delivery of progesterone via chimerical agglomerates 15th Symposium on Microincapsulation, 18-21 September 2005, Parma, Italy Russo P. Colombo P. Bettini R. Sonvico F. Buttini F. Chimeral agglomerates of microparticles for nasal administration of analgesic powders Respiratory Drug Delivery IX, 25-29 April 2004, Palm Desert, USA Cagnani A., Sonvico F., Colombo P., Bettini R., Alonso M.J., Colombo G., Rossi A. Chimerical agglomerates of lecithin/chitosan nanoparticles for powder nasal delivery AAPS 2004 Annual meeting, 7-11 November 2004, Baltimore, USA Sonvico F., Mornet S., Dubernet C., Appel M., Chacun H., Duguet E., Colombo P., Couvreur P. In vitro uptake of folate targeted nanohybrids in a folate receptor expressing cellular model International Conference on Drug Delivery and Pharmaceutical Technology, 10-12 May 2004, Seville, Spain Sonvico F., Mornet S., Dubernet C., Appel M., Chacun H., Jaillard D., Degrouard J., Hoebecke J., Duguet E., Colombo P., Couvreur P. Folate targeted nanohybrids for the treatment of solid tumors AAPS 2003 Annual meeting, 26-30 October 2003, Salt Lake City, USA Caliceti P., Salmaso S., Carofiglio T., Fornasier R., Sonvico F., Couvreur P., Hoebeke J. New cyclodextrin bioconjugates for active drug targeting Controlled Release Society 30th Annual Meeting, Glasgow, Scotland, 19 – 23 July 2003 Sonvico F., Mornet S., Vasseur S., Appel M., Chacun H., Dubernet C., Colombo P., Duguet E., Couvreur P. In vitro uptake of folate-targeted VUSPIO in a folate-receptor expressing model 5th Magnetic Carrier Meeting, 20-22 May 2003, Lyon, France Curriculum vitae – Fabio Sonvico pag. 11 di 21 Sonvico F., Salmaso S., Caliceti P., Dubernet C., Colombo P., Couvreur P. Evaluation in vitro d’un nouveau vecteur conjugué à l’acide folique pour le ciblage de tumeurs solides, XVIIièmes Journées scientifiques du G.T.R.V., 12-13 December 2002, Paris, France X.Jurvilliers, R Schneider, Y Fort, S Begin-Colin, J.M. Dubois, F.Sonvico, C.Dubernet, P.Couvreur, O. Tillement Functionalised nanoparticles for medicinal applications, XXXV I.C.C.C., 21-26 July 2002, Heidelberg, Germany Sonvico F., Dubernet C.,Appel M., Chacun H., Jurvilliers X., Schneider R., Fort Y., Tillement O., Colombo P., Couvreur P. Folate linked metallic nanoparticles targeting tumor cells, 4th World meeting ADRITELF/APGI/APV, 8-11 April 2002, Florence, Italy Sonvico F., Dubernet C., Appel M., Chacun H., Colombo P., Couvreur P. Développement d'un modèle in vitro de cellules tumorales hyperexprimant le récepteur à l'acide folique en vue de l'étude de la capture spécifique de vecteurs pilotés , XVIièmes Journées scientifiques du G.T.R.V., 9-10 December 2001, Lyon, France ORAL COMMUNICATIONS Sonvico F., Ampollini L., Rossi A., Carbognani P., Colombo P. Cisplatin-loaded polymeric films for the intrapleural treatment of mlignant pleural mesothelioma PharmaTech 2010 - International Conference and Exhibition on Pharmaceutical, Nutraceutical and Cosmeceutical Technology: Formulation and Applications, 25-26 May 2010, KLCC, Kuala Lumpur, Malaysia Sonvico F. Lecithin/chitosan nanosystems for the delivery of lipophilic drugs One day seminar on “New advances in drug delivery systems”, 24 May 2010, Universiti Sains Malaysia, Penang, Malaysia Curriculum vitae – Fabio Sonvico pag. 12 di 21 Strusi O.L., Sonvico F., Barata P., Mercuri S., Colombo G., Buttini F., Bettini R., Colombo P. Multi-kinetics and site specific oral delivery system of artesunate-clindamycin combination for malaria treatment 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 8-11 March 2010, Valletta, Malta Colombo G., Scagliarini A., Gallina L., Bortolotti F., Rossi A., Colombo P., Menegatti E., Sonvico F. Therapeutic paint for simultaneous delivery of sucralfate gel and cidofovir in the treatment of veterinary viral skin infections 17th International Symposium on Microincapsulation, 29 September - 1 October 2009, Nagoya, Japan Sonvico F., Barbieri S., Ampollini L., Rossi A., Carbognani P., Colombo P. Polysaccharide films loaded with cisplatin for lung mesothelioma loco-regional therapy XX Simposio A.D.R.I.T.E.L.F., 10-13 September 2009, Cagliari, Italy Colombo G., Gallina L., Rossi A., Colombo P., Bortolotti F., Menegatti E., Scagliarini A., Sonvico F. Study of a sucralfate gel-based therapeutic paint for antiviral drug topcla application by spraying XX Simposio A.D.R.I.T.E.L.F., 10-13 September 2009, Cagliari, Italy Strusi O.L., Mercuri S., Sonvico F., Bettini R., Colombo P., Heng P.W. Influence of granule dimension on the mechanical characteristics of Dome Matrix modules 2nd PharmSciFair, 8-12 June 2009, Nice, France Sonvico F., Colombo P., Scagliarini A., Gallina L., Colombo G. Curriculum vitae – Fabio Sonvico pag. 13 di 21 Spray therapeutic paint for topical treatment of orf virus skin infections in breeding sheep 2nd PharmSciFair, 8-12 June 2009, Nice, France Ampollini L., Sonvico F., Bilancia R., Barbieri S., Stavroulias D., Cavazzoni A., Petronini P.G., Cantoni A.M., Rusca M., Carbognani P. Intrapleural polymeric devices containing cisplatin for malignant pleural mesothelioma in a rat tumor model: a preliminary study 17th European Conference on General Thoracic Surgery, 31 May - 3 June 2009, Krakow, Poland Barbieri S., Marcotti E., Sonvico F., Colombo P. Chitosan/Lecithin autoassembled nanoparticles: a new carrier for oral delivery of tamoxifen 9th International Conference of the European Chitin Society, 23-26 May 2009, Venice, Italy Sonvico F., Como C., Barbieri S., Gereli Y., Deriu A., Colombo P. Lecithin/chitosan nanosystems for tamoxifen oral deliery Anticancer drug delivery: new perspectives in tumor targeting - Thematic workshop of Controlled Release Society Italian Chapter, 28-29 November 2008, Padua, Italy Sonvico F., Como C., Barbieri S., Gereli Y., Deriu A., Colombo P. Lecithin/chitosan nanosystems for the oral and transmucosal deliery of lipophilic drugs 14th International Pharmaceutical Technology Symposium, 6-10 September 2008, Antalya, Turkey Sonvico F. Pharmaceutical nanotechnology in tumor targeting Advances in pharmaceutical technology : development of controlled release formulations and implement of new techniques, April 3, 2008, Madrid, Spain Curriculum vitae – Fabio Sonvico pag. 14 di 21 Coelho P., Strusi L., Sonvico F., Bettini R, Colombo P., Ribeiro L., Santos D., Sousa Lobo, J.M., Ferreira D. Gastric retention and bioavailability determination of ranitidine immediate and controlled release Dome Matrix formulation in dogs Innovation in drug delivery : from biomaterials to devices, September 30 – October 3, 2007, Naples, Italy Colombo G., Russo P., Sonvico F., Ferraro, L., Bortolotti F. Soft chimera agglomerates for desmopression nasal administration : an in vitro and in vivo study The 5th International Postgradute Research Symposium on Pharmaceutics IPORSIP – 2007, September 13-15, 2007, Istanbul, Turkey C. Como, F. Sonvico, A. Rossi, E. Corradini and P. Colombo A new nanosystem for tamoxifen citrate oral delivery 16th International Symposium on Microencapsulation, September 9 -12, 2007, Lexington, Kentucky, USA Sonvico F., Colombo P., Como C. “Nanoparticelle ottenute dall’interazione tra lecitina e chitosano per la veicolazione di farmaci lipofili” 47° Simposio AFI, 13-15 June 2007, Rimini, Italy Coelho P., Bettini R., Colombo P., Sonvico F., Strusi L., Sosa Lobo J.M., Delfim S., Ferreira D., Soares M.E., Ribeiro L. “Gastric retention and bioavailability determination of ranitidine Dome Matrix formulations in dogs” Young Pharmaceutical Scientists meet in Amsterdam, Pre-satellite meeting of the 3rd Pharmaceutical Science World Congress, 20-21 April 2007, Amsterdam, The Netherlands Colombo G., Buttini F., Sonvico F., Colombo P., Russo P., Scatturin A., Menegatti E. Respiratory drug delivery Curriculum vitae – Fabio Sonvico pag. 15 di 21 International school on advanced material science and technology, 6-9 September 2005, Jesi, Italy Colombo P., Sonvico F., Losi E., Bettini R. The geometrical approach for modulation of drug delivery from swallebale matrix tablets: the Dome Matrix technology FMC Biopolymer - Controlled release Seminar/Tablet Tech, 25-26 May 2004, Brussels, Belgium PUBLICATIONS 1) Salmaso S., Semenzato A., Caliceti P., Hoebecke J., Sonvico F., Dubernet C., Couvreur P. Specific anti-tumor targetable -cyclodextrin-PEG-folate drug delivery system Bioconjugate Chem 15, 997-1004 (2004) 2) Russo P, Buttini F., Sonvico F., Bettini R., Massimo G., Sacchetti C., Colombo P., Santi P. Chimeral agglomerates of microparticles for administration of caffeine nasal powders J Drug Del Sci Tech, 14, 449-454 (2004) 3) Gainotti A., Losi E., Bettini R., Colombo P., Sonvico F., Baroni D., Santi P., Colombo G. Effect of microwave drying and residual water content on the physico-chemical properties of sucralfate humid gel Drug Dev Ind Pharm, 31, 645-652 (2005) 4) Sonvico F., Dubernet C., Colombo P., Couvreur P. Metallic based nanotechnology: applications in diagnosis and therapeutics Curr Pharm Des, 11(16), 2091-2105 (2005) 5) Del Gaudio P, Colombo P., Colombo G., Russo P., Sonvico F. Mechanisms of formation and disintegration of alginate beads obtained by prilling Int J Pharm, 302, 1-9 (2005) Curriculum vitae – Fabio Sonvico pag. 16 di 21 6) Sonvico F., Dubernet C., Appel M., Chacun H., Colombo P., Couvreur P. Set-up and validation of an appropriate in viro model for the evasluation of folate targeted vectors and conjugates J Drug Del Sci Tech, 15, 407-410 (2005) 7) Sonvico F., Mornet S., Vasseur S., Dubernet C., Jaillard D., Degrouard J., Hoebecke J., Duguet E., Colombo P., Couvreur P. Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments Bioconj Chem, 16, 1181-1188 (2005) 8) Colombo P., Sonvico F. Les formes pharmaceutiques du futur J Pharm Bel, 60, 1-4 (2005) 9) Gainotti A., Losi E., Colombo P., Sonvico F., Massimo G., Colombo G., Del Gaudio P. The effect of residual water content on antacid properties of sucralfate gel dried by microwaves AAPS PharmSciTech (on line) 7 : article 9 (2006) 10) Losi E., Bettini R., Santi P., Sonvico F., Colombo G., Lofthus K., Colombo P., Peppas N.A. Assemblage of novel release modules for the development of adaptable drug delivery systems J Control Rel, 111, 212-218 (2006) 11) Sonvico F., Cagnani A., Rossi A., Motta S., Di Bari M.T., Cavatorta F., Alonso M.J., Deriu A., Colombo P. Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction Int. J. Pharm., 314, 66-73 (2006) Curriculum vitae – Fabio Sonvico pag. 17 di 21 12) Sonvico F., Di Bari M.T., Bove L., Deriu A., Cavatorta F., Albanese G. Mean square hydrogen fluctuations in chitosan/lecithin nanoparticles from elastic neutron scattering experiments Physica B, 385, 725–727 (2006) 13) Raffin R.P., Colombo P., Sonvico F., Polleto F.S., Colombo G., Rossi A., Polhmann A.R., Guterres S.S. Soft agglomerates of pantoprazole gastro-resistant microparticles for oral administration and intestinal release J Drug Del Sci Tech, 17, 407-413 (2007) 14) Di Bari M.T., Gerelli Y., Sonvico F., Deriu A., Cavatorta F., Albanese G., Colombo P. and Fernandez-Alonso F. Dynamics of lipid–saccharide nanoparticles by quasielastic neutron scattering Chem Phys, 345, 239-244 (2008) 15) Gerelli Y., Di Bari M.T., Deriu A., Cantù L., Colombo P., Como C., Motta S., Sonvico F., May R. Structure and organization of phospholipid/polysaccharide nanoparticles J Phys: Condens Matter, 20 (10), 104211 (8pp) (2008) 16) Strusi O.L., Sonvico F., Bettini R., Santi P., Colombo G., Barata P., Oliveira A., Santos D., Colombo P. Module assemblage technology for floating systems: in vitro flotation and in vivo gastro-retention J Control Release, 129 (2), 88-92 (2008) doi: 10.1016/j.conrel.2008.04.015 17) Gerelli Y., Barbieri S., Di Bari M.T., Deriu A., Cantù L., Brocca P., Sonvico F., Colombo P., Motta S., May R. Structure of self-organized multilayer nanoparticles for drug delivery Langmuir, 24, 11378-11384 (2008) doi: 10.1021/la801992t Curriculum vitae – Fabio Sonvico pag. 18 di 21 18) Colombo P., Sonvico F., Colombo G., Bettini R. Novel Platforms for Oral Drug Delivery Pharm Res, 26(3), 601-611 (2009) doi: 10.1007/s11095-008-9803-0 19) Bortolotti F., Balducci A.G, Sonvico F., Russo P., Colombo G. In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays: the enhancing effect of potassium sorbate. Eur J Pharm Sci, 37, 36-42 (2009) doi: 10.1016/j.eps.2008.12.015 20) Sonvico F., Colombo G., Gallina L., Bortolotti F., Rossi A., McInnes C.J., Massimo G., Colombo P., Scagliarini A. Therapeutic paint of cidofovir/sucralfate gel combination topically administered by spraying for treatment of orf virus infections. AAPS J, 11(2), 242-249 (2009) doi: 10.1208/s12248-009-9101-8 21) Raffin R., Colombo P., Sonvico F., Rossi A., Jornada D.S., Pohlmann A.R., Guterres S.S. Agglomerates containing pantoprazole microparticles: modulating the drug release. AAPS PharmSciTech, 10(2), 335-345 (2009) doi: 10.1208/s12249-009-9214-5 22) Gerelli Y., Di Bari M.T., Barbieri S., Sonvico F., Colombo P., Natali F., Deriu A. Flexibility and drug release features of lipid/saccharide nanoparticles Soft Matter, 6, 685 – 691 (2010) doi:10.1039/b916139b 23) Huynh T.T.N., Padois K., Sonvico F., Rossi A., Zani F., Pirot F., Doury J., Falson F. Characterization of a polyurethane-based controlled release system for local delivery of chlorhexidine diacetate Curriculum vitae – Fabio Sonvico pag. 19 di 21 Eur J Pharm Biopharm, 74, 255-264 (2010) doi:10.1016/j.ejpb.2009.11.002 24) Raffin R., Colomé L.M, Hoffmeister C.R.D., Colombo P., Rossi A., Sonvico F., Colomé L.M., Natalini C.C., Polhmann A.R., Dalla Costa T., Guterres S.S. Pharmacokinetics evaluation of soft agglomerates for prompt delivery of enteric pantoprazole-loaded microparticles Eur J Pharm Biopharm, 74, 275-280 (2010) doi:10.1016/j.ejpb.2009.11.015 25) Ampollini L., Sonvico F., Barocelli E., Cavazzoni A., Bilancia R., Mucchino C., Cantoni A.M., Carbognani P. Intrapleural polymeric films containing cisplatin for malignant pleural mesothelioma in a rat tumour model: a preliminary study Eur J Cardiothorac Surg, 37, 557-565 (2010) doi: 10.1016/j.ejcts.2009.08.012 26) Senyigit T., Sonvico F., Barbieri S., Ozer O., Santi P., Colombo P. Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin J Control Rel, 142, 368-373 (2010) doi: 10.1016/j.jconrel.2009.11.013 27) Strusi O.L., Barata P., Traini D., Young P.M., Mercuri S., Colombo G., Sonvico F., Bettini R., Paolo Colombo Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products J Control Rel, XXX, XXX-xxx (2010) doi: 10.1016/j.jconrel.2010.05.001 28) Padula C., Chiapponi C., DiBari M.T., Deriu A., Sonvico F., Barbieri S., Ollivier J., Santi P. Single layer transdermal film containing lidocaine: water and lidocaine mobility determined using neutron scattering J Pharm Sci, XXX, XXX-xxx (2010) Curriculum vitae – Fabio Sonvico pag. 20 di 21 doi: 10.1002/jps.22152 BOOK CHAPTERS Colombo P., Sonvico F Les formes pharmaceutiques du futur in Histoire de la Pharmacie Galénique, Preat V., Roland-Marcelle N. and Van den Abeele B. Editors; UCL Presses Universitaires de Louvain - Louvain-la-Neuve, 279299 (2006) ISBN: 2-87463-049-7 Colombo P., Cagnani S., Sonvico F., Santi P., Russo P., Colombo G. Biological in vitro models for absorption by nonoral routes in Comprehensive Medicinal Chemistry II, Taylor J.B. and Triggle D.J. Editors-inChief; Volume 5, ADME-Tox Approaches, Testa B. and van de Waterbeemd H. Volume Editors; Elsevier - Oxford, 279-299 (2007) ISBN: 978-0-08-044513-7 Colombo P., Santi P., Siepmann J., Colombo G., Sonvico F., Rossi A., Strusi O.L. Swellable and rigid matrices: controlled release matrices with cellulose ethers in Pharmaceutical Dosage Forms: Tablets, Edited by Augsburger L.L. and Hoag S.W.; Informa Healthcare - New York, 433-468 (2008) ISBN: 978-0-8493-9015-9 PATENTS Colombo P., Santi P., Bettini R., Strusi O.L., Sonvico F., Colombo G. New modules, new assemblage kits and new assemblies for the controlled release of substances PCT/EP2006/011661, filing date 05/12/2006 Raffin R., Colombo P., Sonvico F., Colombo G., Rossi A., Buttini F. Compositions in powder form made of soft agglomerates of a micronized drug and of a two-components excipient, and process for their prearation PCT/EP2007/061599, filing date 26/10/2007 Curriculum vitae – Fabio Sonvico pag. 21 di 21 Colombo G., Colombo P., Gallina L., Sonvico F., Scagliarini A. Sprayable pharmaceutical compositions comprising sucralfate gel for treating skin or mucosa lesions PCT/EP2008/064528, filing date 27/10/2008 Associtations American Association of Pharmaceutical Scientists (AAPS), member since 2002 Associazione Docenti e Ricetcatori Italiani di Tecnologie e Legislazione Farmaceutiche (Adritelf), member since 2008 International Society for Pharmaceutical Engineering (ISPE), member since 2008 European Chitin Society (Euchis), active member since 2009 Controlled Release Society (CRS), member since ?