中文 CV 姓名: 陳念榮 出生日期: 民國六十ㄧ年六月十四日 國籍: 台灣 聯絡地址: 台北市北投區立農街二段 155 號 陽明大學微免所 電子郵件: nienjung.chen@gmail.com 學歷: 1995.9-2000.7 陽明大學微免所 博士 1994.9-1995.7 陽明大學微免所 碩士班直升 1990.9-1994.6 私立台北醫學院醫技系 學士 研究經歷: 2007.12-now 陽明大學微免所 助理教授 2002.3-2007.12 加拿大多倫多大學安大略腫瘤研究所 博士後研究 及助理研究員 2000.8-2002-1 陽明大學微免所 博士後研究 Curriculum Vitae Name: CHEN, NIEN-JUNG Gender: Date of birth: Nationality: Citizenship: Male June 14th, 1972 Taiwan, Republic of China Taiwan Office Address: Institute of Microbiology and Immunology National Yang-Ming University No. 155, Sec. 2, Linong St., Beitou District, Taipei city 112, Taiwan R.O.C. E-mail: nienjung.chen@gmail.com Education: 1995.9 - 2000.7 Ph.D. Microbiology and Immunology National Yang-Ming University 1994.9 - 1995.7 Master Microbiology and Immunology National Yang-Ming University 1990.9 - 1994.6 BS Medical Technology Taipei Medical College Research Experience: 2007.12 – present Assistant professor Institute of Microbiology and Immunology National Yang-Ming University, Taipei, Taiwan 2006.2 – 2007.12 Post-doctoral fellow The Campbell family Institute for Breast Cancer Research, University Health Network, Toronto, Canada 2004.7 – 2006.1 Scientific associate The Campbell family Institute for Breast Cancer Research, University Health Network, Toronto, Canada 2002.3 – 2004.6 Post-doctoral fellow Advanced Medical Discovery Institute University Health Network, Toronto, Canada 2000.8 - 2002.1 Post-doctoral fellow Microbiology and Immunology National Yang-Ming University, Taipei, Taiwan Publications: (A)Papers in Journals 1. Hao Z, Duncan G, Su YW, Seagal J, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola A, Rajewsky K and Mak TW. Fas expression in germinal center B cells is essential for T and B lymphocyte homeostasis. (2008 Oct), Immunity 29:1-13. SCI 2. Chen NJ, Chio IIC, Lin WJ, Duncan G, Chau H, Katz D, Huang HL, Pike KA, Hao Z, Su YW, Yamamoto K, de Pooter RF, Zu´ n˜ iga-Pflu¨ cker JC, Wakeham A, Yeh WC and Mak TW. Beyond tumor necrosis factor receptor: TRADDsignaling in toll-like receptors. (2008 Aug), Proceedings of the National Academy of Sciences USA 105:12429-12434. SCI 3. Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC. C5L2/GPR77 is critical for the biological activities of the anaphylatoxins C5a and C3a. (2007 Mar), Nature 446, 203-207. SCI 4. Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, Yamasaki S, Yokosuka T, Chen NJ, Elford AR, Suzuki JI, Takeuchi A, Mirtsos C, Bouchard D, Ohashi PS, Yeh WC, Saito T. Acritical role for the innateimmune signaling molecular IRAK-4 in T cell activation (2006 Mar), Science 311, 1927-1932. SCI 5. Chau H, Wong V, Chen NJ, Lin WJ, Huang HL, Mirtsos C, Bonnard M, Elford AR, Wakeham A, Itie YTA, Lemmers B, Salmena L, Pellegrini M, Hakem R, Mak TW, Ohashi PS, Yeh WC. Cellular FLICE-inhibitory protein (cFLIP) is required for T cell survival and cycling. (2005 Aug) Journal of Experimental Medicine 202, 405-413. SCI 6. Cheung H, Chen NJ, Cao Z, Ono N, Ohashi PS, Yeh WC. Accessory protein-like is essential for IL-18-mediated signaling. (2005 May) Journal of Immunology 174, 5351-5357. SCI (shared first author) 7. Chang YC, Hsu TL, Lin HH, Chio CC, Chiu AW, Chen NJ, Lin CH, Hsieh SL. Modulation of macrophage differentiation and activation by decoy receptor 3. (2004 Mar) Journal of Leukocyte Biology 75, 486-494. SCI 8. Suzuki N, Suzuki S, Eriksson U, Hara H, Mirtosis C, Chen NJ, Wada T, Bouchard D, Hwang I, Takeda K, Fujita T, Der S, Penninger JM, Akira S, Saito T, Yeh WC. IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. (2003) Journal of Immunology 171, 6065-6071. SCI 9. Yeh WC, Chen NJ. Immunology: another toll road. (2003) Nature 424, 736-737. SCI 10. Takada H, Chen NJ, Mirtsos C, Suzuki S, Suzuki N, Wakeham A, Mak TW, Yeh WC. Role of SODD in regulation of tumor necrosis factor responses. (2003) Molecular and Cellular Biolology 23, 4026-4033. SCI 11. Suzuki N, Chen NJ, Millar DG, Suzuki S, Horacek T, Hara H, Bouchard D, Nakanishi K, Penninger JM, Ohashi PS, Yeh WC. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. (2003) Journal of Immunology 170, 4031-4035. SCI 12. Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH. Isolation and characterization of size-sieved stem cells from human bone marrow. (2002) Stem Cells 20, 249-258. SCI 13. Hsu PN, Lin HH, Tu CF, Chen NJ, Wu KM, Tsai HF, Hsieh SL. Human FasL gene does not induce inflammation in pancreas but is unable to protect islet graft from transplantation rejection in pancreas-specific hFasL transgeneic mice. (2001) Journal of Biomedical Science 8, 262-269. SCI 14. Chen NJ, Huang MW, Hsieh SL. Enhanced Secretion of Interferon-gamma by Activated Th1 Cells Occurs via Reverse Signaling through TRANCE. (2001) Journal of Immunology 166, 270-276. SCI 15. Yang S, Huang C, Chen NJ, Chou C, Lin C. Functional implication of human Serine/ Threonine kinase, hAIK, in cell cycle progression. (2000) Journal of Biomedical Science 7, 484-493. SCI 16. Hsieh SL, Chen NJ, Tarbell K, Liao NS, Lee KS, Lai YG, Lee KM., Lee KH, Wu SC, Sytwu HK, Han SH, McDevitt H. Transgenic Mice Expressing Surface Markers for IFN- and IL-4 Producing Cells. (2000) Molecular Immunology 37, 281-293. SCI (shared first author) (B)Chapter in book 1. Chen NJ, Yeh WC. Adaptor proteins in death receptor signaling. (2005) Death Receptors in Cancer Therapy, Chapter 5, 93-109. (Humana Press, Totota, NJ, ISBN 1-58829-172-3 E-ISBN; 1-59259-851-X) (B)Meeting 1. 2. 3. Chen NJ. (2008 Oct) Beyond TNFR signaling: the multifunctionality of TRADD. The 4th Congress of the Federation of Immunology Societies of Asia-Oceania, Taipei, Taiwan Chen NJ. (2007 Nov) Non-TLR Receptors in Inflammation Regulation. 9th NHRI Conference on Immunology, Miaoli, Taiwan Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC. (2007 Jun) C5L2/GPR77 is critical for the biological activities of the anaphylatoxins C5a and C3a. 4th workshop on Complement Associated Diseases, Animal Models and Therapeutics, Porto Heli, Greece