Pharmacology I: CHEMICAL BIOLOGY 2008
Lectures: MWF, Sep 3 to Nov 12, 2008, 1:30 – 3:00 PM, Weill Auditorium
Course Directors
Anthony Sauve
aas2004@med.cornell.edu
Derek Tan
tand@mskcc.org
212-746-6224
646-888-2234
LC 216
ZRC 2165
Teaching Assistants
Eleanor Allen
eka2003@med.cornell.edu
Elissaveta Petrova elp2003@med.cornell.edu
212-746-6312
212-639-2551
LC216
RRL641
Grading
40% Problem Sets (due before class one week following each lecture)
20% Student Presentation
16% Examination #1 (Lectures 1–10)
24% Examination #2 (Lectures 11–25)
Examinations
closed book, in class
1) Wednesday, October 8, 1:30 – 3:00 pm
2) Wednesday, November 12, 1:30 – 3:00 pm
Goals
Students should develop an understanding of the chemical reactions used in biological
and laboratory synthesis and manipulation of proteins, nucleic acids, lipids, and
carbohydrates. Students should also develop an understanding for the chemical
principles that underlie enzyme function. By the end of the course, students should be
comfortable reading journal articles on chemical biology and will be expected to give an
oral presentation and written report on a topic in the field.
Lecture Schedule (** = class moved to A-250)
Wed 9/3
1. Reaction Kinetics
Anthony Sauve
Fri 9/5
2. Thermodynamics
Anthony Sauve
Mon 9/8**
3. Receptor Binding Assays and Pharmacology
Gavril Pasternak
Wed 9/10** 4. Purification of Small Molecule Receptors
Jochen Buck
Fri 9/12
5. Receptor–Ligand Interactions
Anthony Sauve
Mon 9/15
6. Enzyme Kinetics
Anthony Sauve
Wed 9/17
7. Organic Reaction Mechanisms I
David Gin
Fri 9/19
8. Organic Reaction Mechanisms II
David Gin
Mon 9/22
9. Primary Metabolite Synthesis I:
Derek Tan
Peptides
Wed 9/24** 10. Primary Metabolite Synthesis II:
Derek Tan
Oligonucleotides and carbohydrates
Fri 9/26
11. Peptide Chemistry I:
Samie Jaffrey
Amino acid and peptide structure
Mon 9/29
12. Peptide Chemistry II:
Samie Jaffrey
Acidic residues
Wed 10/1
13. Peptide Chemistry III:
Samie Jaffrey
Basic residues
Fri 10/3
14. Peptide Chemistry IV:
Samie Jaffrey
Sulfur-containing residues
Mon 10/6** EXAMINATION #1: Lectures 1–10
Wed 10/8
15. Chemical Genetics and Drug Discovery I:
Gabriela Chiosis
Fundamentals and techniques
Fri 10/10
16. Chemical Genetics and Drug Discovery II:
Gabriela Chiosis
Case study
Mon 10/13
17. Chemical Genetics and Drug Discovery III:
Minkui Luo
Affinity-based chemical probes
Wed 10/15
18. Secondary Metabolite Synthesis I:
Derek Tan
Non-ribosomal peptides
Fri 10/17
19. Secondary Metabolite Synthesis II:
Derek Tan
Fatty acids and polyketides
Mon 10/20
20. Secondary Metabolite Synthesis III:
Derek Tan
Steroids and terpenes
Wed 10/22
21. Glycopeptides and Glycoproteins
David Gin
Structure, reactivity, and function
Fri 10/24
22. Proteases I:
Yueming Li
Enzymology
Mon 10/27
23. Proteases II:
Yueming Li
Mechanism-based inhibitors
Wed 10/29
24. Oligonucletide Chemistry I:
Luca Cartegni
DNA structure and reactivity
Fri 10/31
25. Oligonucleotide Chemistry II:
Scott Blanchard
RNA reactivity and enzymology
Mon 11/3
STUDENT PRESENTATIONS
STUDENTS
Wed 11/5
STUDENT PRESENTATIONS
STUDENTS
Fri 11/7
STUDENT PRESENTATIONS
STUDENTS
Wed 11/12
Examination #2: Lectures 11–25