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AUTONOMIC
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ACCLIMATION
NERVOUS
SYSTEM
ADAPTATION
TO
PROGRESSIVE
HEAT
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Andreas D. Flouris,1 Martin Poirier,2 Andrea Bravi,3 Heather E. Wright,2 Geoffrey Green,3
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Andrew J. Seely,3 Glen P. Kenny2
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School of Human Kinetics, University of Ottawa, Ottawa, Canada, K1N 6N5.
FAME Laboratory, Centre for Research and Technology Hellas, Trikala, Greece, 42100.
Human and Environmental Physiology Research Unit, Faculty of Health Sciences,
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Campus, Ottawa Health Research Institute, Ontario, Canada, K1H 8L6.
Divisions of Thoracic Surgery and Critical Care Medicine, Ottawa Hospital-General
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MATERIALS AND METHODS
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Heart Rate Variability
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R-R interval data were extracted from 175Hz ECG waveforms throughout all heat
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tolerance tests using a 5-lead Holter DigiTrak XT (Philips, Andover, USA) and those
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deemed to be normal-to-normal (NN) were retained for further analysis. Using the NN
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interval time series of each subject (total of three NN interval series), HRV analyses
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were performed employing the Continuous Individualized Variability Analysis – CIMVATM
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software (http://ohridal.org/cimva/CIMVA-Core-Description.pdf) to extract a total of 102
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measures of variability computed from the statistical, geometric, informational, energetic,
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and invariant domains. The list of all 102 variability measures computed is provided in
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Supplementary Table 1. We used a 5-min window analysis with 30 seconds time step to
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effectively assess the transients between the different phases of the protocol.
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LIST OF TABLES
Supplementary Table 1. The list of all 102 variability measures computed.
Variability
#
Variability measure
domain
1 Mean
Statistical
2 Mean rate
Statistical
3 Standard deviation
Statistical
4 Coefficient of variation
Statistical
5 Poincaré plot SD1
Geometric
6 Poincaré plot SD2
Geometric
7 Root mean square of successive differences
Statistical
8 Sample entropy
Informational
9 LF/HF ratio computed with Lomb-Scargle periodogram
Energetic
10 LF power computed with Lomb-Scargle periodogram
Energetic
11 HF power computed with Lomb-Scargle periodogram
Energetic
12 Wavelet area under the curve
Energetic
13 Detrended fluctuation analysis: a1
Invariant
14 Detrended fluctuation analysis: a2
Invariant
15 Largest Lyapunov exponent
Invariant
16 Correlation dimension global exponent
Invariant
17 Skewness
Statistical
18 Kurtosis
Statistical
19 Power Law Slope computed with Welch's method
Invariant
20 Power Law Y-Intercept computed with Welch's method
Invariant
21 Power Law X-Intercept computed with Welch's method
Invariant
22 Power Law Goodness of Fit computed with Welch's method
Invariant
23 Power Law Slope computed with Lomb-Scargle periodogram
Invariant
24 Power Law Y-Intercept computed with Lomb-Scargle periodogram
Invariant
25 Power Law X-Intercept computed with Lomb-Scargle periodogram
Invariant
Power Law Goodness of Fit computed with Lomb-Scargle
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Invariant
periodogram
27 Power Law Slope computed with histogram
Invariant
28 Power Law Y-Intercept computed with histogram
Invariant
29 Power Law X-Intercept computed with histogram
Invariant
30 Power Law Goodness of Fit computed with histogram
Invariant
31 Detrended fluctuation analysis area under the curve
Invariant
32 Multiscale Entropy
Informational
33 LF/HF ratio computed with Welch's method
Energetic
34 VLF power computed with Welch's method
Energetic
35 LF power computed with Welch's method
Energetic
36 HF power computed with Welch's method
Energetic
37 VLF power computed with Lomb-Scargle periodogram
Energetic
38 Hjorth parameter: activity
Energetic
39 Hjorth parameter: mobility
Energetic
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Supplementary Table 1 cont. The list of all 102 variability measures computed.
Variability
#
Variability measure
domain
40. Hjorth parameter: complexity
Energetic
41. Embedding scaling exponent
Invariant
42. Recurrence quantification analysis: percentage of recurrences
Geometric
43. Recurrence quantification analysis: percentage of determinism
Geometric
44. Recurrence quantification analysis: maximum diagonal line
Geometric
45. Recurrence quantification analysis: average diagonal line
Geometric
Recurrence quantification analysis: Shannon entropy of the
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Geometric
diagonals
47. Recurrence quantification analysis: determinism/recurrences
Geometric
48. Recurrence quantification analysis: percentage of laminarity
Geometric
49. Recurrence quantification analysis: maximum vertical line
Geometric
50. Recurrence quantification analysis: trapping time
Geometric
Recurrence quantification analysis: Shannon entropy of the
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Geometric
vertical lines
52. Shannon entropy
Geometric
53. Plotkin and Swamy energy operator average energy
Energetic
54. Teager energy operator average energy
Energetic
Symbolic dynamics: percentage of 0 variations sequences,
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Statistical
uniform case
Symbolic dynamics: percentage of 1 variations sequences,
56.
Statistical
uniform case
Symbolic dynamics: percentage of 2 variations sequences,
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Statistical
uniform case
Symbolic dynamics: percentage of 0 variations sequences, non58.
Statistical
uniform case
Symbolic dynamics: percentage of 1 variations sequences, non59.
Statistical
uniform case
Symbolic dynamics: percentage of 2 variations sequences, non60.
Statistical
uniform case
61. Symbolic dynamics: forbidden words, uniform case
Statistical
62. Symbolic dynamics: forbidden words, non-uniform case
Statistical
63. Symbolic dynamics: Shannon entropy, uniform case
Informational
64. Symbolic dynamics: Shannon entropy, non-uniform case
Informational
65. Symbolic dynamics: modified conditional entropy, uniform case
Informational
Symbolic dynamics: modified conditional entropy, non-uniform
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Informational
case
67. Form factor
Statistical
68. Fuzzy entropy
Informational
69. Grid transformation feature: grid count
Geometric
70. Grid transformation feature: AND similarity index
Informational
71. Grid transformation feature: time delay similarity index
Informational
72. Grid transformation feature: weighted similarity index
Informational
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Supplementary Table 1 cont. The list of all 102 variability measures computed.
Variability
#
Variability measure
domain
73. Correlation dimension local exponent
Invariant
74. Rescaled detrended range analysis
Invariant
75. Higuchi scaling exponent
Invariant
76. Allan factor distance from a Poisson distribution
Informational
77. Fano factor distance from a Poisson distribution
Informational
78. Index of variability distance from a Poisson distribution
Informational
79. Finite growth rate
Invariant
80. Scaled windowed variance
Invariant
81. Kullback-Leibler permutation entropy
Informational
82. Multiscale time irreversibility asymmetry index
Energetic
83. Lee parameter
Statistical
84. Poincaré plot cardiac sympathetic index
Geometric
85. Poincaré plot cardiac vagal index
Geometric
86. Mean of the differences
Statistical
87. Standard deviation of the differences
Statistical
88. Interquartile range
Statistical
89. Predictive feature: error from an Autoregressive model
Informational
90. Similarity index of the distributions
Informational
91. Multifractal spectrum cumulant of the first order
Invariant
92. Multifractal spectrum cumulant of the second order
Invariant
93. Multifractal spectrum cumulant of the third order
Invariant
94. Kolmogorov-Sinai entropy
Invariant
95. Scale dependent Lyapunov exponent slope
Invariant
96. Scale dependent Lyapunov exponent mean value
Invariant
97. Dynamical moment of the second order
Geometric
98. Dynamical moment of the third order along the principal bisector
Geometric
99. Dynamical moment of the third order along the secondary bisector
Geometric
100. Dynamical moment of the third order along the x axes
Geometric
101. Dynamical moment of the third order along the y axes
Geometric
102. Diffusion entropy
Informational
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