Name ________________________________________________ Date _________________
DO NOW
1. What is the Central Dogma of DNA?
________________________________________________________________________
2. What is the name of the process that reads the DNA sequence and codes for it’s
message? ___________________________
3. Where does this process occur? ___________________________
4. When does this process occur? ___________________________
5. How many ‘codes’ are created? _____________________________________________
List two ways replication and transcription are similar?
6.________________________________________________________
7.________________________________________________________
List two ways that replication and transcription differ?
8.________________________________________________________
9.________________________________________________________
10. If the DNA sequence read:
T A C A T A T A G C T C G G A A T T
What would the mRNA sequence read? ______________________________________________
Additional Practice:
11. If the DNA sequence read:
T A C C A T G G T A C A A C T A T C
What would the mRNA sequence read? ______________________________________________
12. If the DNA sequence read:
T A C C C C A T G A A G C G T A C T
What would the mRNA sequence read? ______________________________________________
13. If the DNA sequence read:
T A C G A T C G C G A T T A C A T T
What would the mRNA sequence read? ______________________________________________
14. If the DNA sequence read:
T A C T T G C G A A T G C C T A T C
What would the mRNA sequence read? ______________________________________________
15. If the DNA sequence read:
T A C G T T T A C A G A T C G A C T
What would the mRNA sequence read? ______________________________________________
BUT WHAT IF IT ALL GOES WRONG:
If the ‘original’ DNA sequence read:
T A C C A T G G T A C A T C T A T C
The the mRNA sequence would read:
AUG
GUA
CCA
UGU
AGA UAG
The amino acids for each codon would be: ______-______-______-______-______-______
BUT
If the ‘original’ DNA sequence was mutated: T A C C C T G G T A C A T C T A T C
The the mRNA sequence would then read:
______ ______ ______ ______ ______ ______
The amino acids for each codon would be: ______-______-______-______-______-______
Was there a change in this sequence? YES / NO
How many codons/amino acids were changed? __________
Would you consider it a significant change? _________________________________________________
------------------------------------------------------------------------------------------------------------------------------------------
If the ‘original’ DNA sequence read:
T A C C C C A T G A A G C G T A C T
The the mRNA sequence would then read:
AUG
GGG
UAC
UUC
GCA
UGA
The amino acids for each codon would be: ______-______-______-______-______-______
BUT
If the ‘original’ DNA sequence was mutated: T A C C C C A T A A A G C G T A C T
The the mRNA sequence would then read:
______ ______ ______ ______ ______ ______
The amino acids for each codon would be: ______-______-______-______-______-______
Was there a change in this sequence? YES / NO
How many codons/amino acids were changed? __________
Would you consider it a significant change? _________________________________________________
------------------------------------------------------------------------------------------------------------------------------------------
If the ‘original’ DNA sequence read:
The the mRNA sequence would then read:
The amino acids for each codon would be:
T A C G G C A A C A A A C G G A C T
AUG
CCG
UUG
UUU
GCC
UGA
______-______-______-______-______-______
BUT
If the ‘original’ DNA sequence was mutated: T A C G C A A C A A A C G G A C T
The the mRNA sequence would then read:
______ ______ ______ ______ ______ ______
The amino acids for each codon would be: ______-______-______-______-______-______
Was there a change in this sequence? YES / NO
How many codons/amino acids were changed? __________
Would you consider it a significant change? _________________________________________________