Minutes 20140603
I2b2 standardization conference call
Attendees: Jim Campbell(JRC)(GPC-U Nebraska), Nathan Graham(GPC- KUMC),
Firas Wehbe(PCORI-Vanderbilt), Keith Marsolo(KM)(Pedsnet-U Cincinnati), George Hripscak(NYCColumbia), Daniella Meeker(Santa Monica-PScanner) Charles Bailey(CB)(Pedsnet-Childrens Philadelphia)
Shawn Murphy(SM)(Harvard SCILHS, SHRINE), Toan Ong(UColoradoDenver), Michael Buck (NYC) Jeffrey
Klann(SCILHS) Tom Campion(Weill Cornell, Bonnie Westra(BW)(GPC-Minnesota), Stuart Speedie(GPC UMinnesota), Parsa Mirhaj(NYC-CDRN), Steve Johnson(NYC-CDRN)
Apologies: MKahn
1) Discussion of minutes from 5/20
2) Updated report on standard model survey reviewed briefly
3) Workplanning:
a. SMurphy reported on conversations with MKahn and aregued for work focusing on
conversion between models
b. DMeeker suggested matrix approach to model mapping
c. Discussed shared requirements of PCORI V1 mapping
d. DMeeker to deliver matrix prioritization back to group approx. 5 working days
4) Design teams for optimization of data structures:
a. I2b2: SMurphy suggested Chris Eric; Jeff Klann; Keith Marsolo; Mike Buck
b. OMOP: KMarsolo, GHripcsak; Charles Bailey; Daniella Meeker
5) Workteams for ETL development
a. Epic – JRC reported discussions with Epic and their interest on hosting on Userweb.
Workgroup: JCampbell; KMarsolo; Jeff Klann; DMeeker; TCampion;
b. Cerner – Boston Childrens(John Bichtel; Ken Mandl suggested but they were not
present to discuss)
c. Allscripts – Daniella to recruit a team
6) I2b2 Test datasets thought to be necessary KMarsolo will coordinate with SMurphy
7) After delivery of matrix plan, workgroups will convene and plan their efforts; no followup calls
scheduled at this time
Minutes 20140520
Attendees: Jim Campbell(JRC)(GPC-U Nebraska), Nathan Graham(GPC- KUMC),
Firas Wehbe(PCORI-Vanderbilt), Keith Marsolo(KM)(Pedsnet-U Cincinnati), Michael Kahn(PedsnetColorado), George Hripscak(NYC-Columbia), Daniella Meeker(Santa Monica-PScanner) Charles
Bailey(CB)(Pedsnet-Childrens Philadelphia) Shawn Murphy(SM)(Harvard SCILHS, SHRINE),
Toan Ong(UColoradoDenver) Russ Waitman(GPC-KUMC) Michael Buck (NYC) Jeffrey Klann(SCILHS)
Keith Marsolo(Cincinnati)
Apologies: Tom Campion, Nathan Wilson(GPC-UWisonsin), Brittany Zzosche, Bonnie Westra(BW)(GPCMinnesota), Stuart Speedie(GPC -UMinnesota), Lori Phillips(MGH, SHRINE) Parsa Mirhaj(NYC-CDRN)
1) Report and discussion of data domain inventory team: KMarsolo, DMeeker, GHripcsak,
MBuck, CBailey, JCampbell; Michael Buck proposed edits to NYC-DMH which were added to
the grid; GH added requirements of OMOP V5; JK and DM will update grid with reports from
Harvard Shrine and Quality Model by end of day in order to finalize data inventory V1
2) Report of workplan prioritization discussant: SMurphy, MKahn; ShawnM and MichaelK will
draft and circulate for comment a prioritized workplan for data domains and standards to be
deployed into a harmonized i2b2 in support of PCORI; group will comment back to them to
assemble finalized workplan
3) Identification of design teams for optimal data sets deployment:
a. I2b2: SM and i2b2 community to suggest team for data structures discussion
b. OMOP: KM, CM, GH to suggest team for data structures discussion and advice
4) Identification of work teams for ETL development:
a. Epic 28 sites represented: KM and JC to recommend workteam for ETL sharing; Epic
research council to provide forum for discussion of ETL library and mechanisms for
sharing
b. Cerner 5 sites represented
c. Allscripts 5 sites represented
d. NexGen 1 site
5) Vendor ETL library discussion report: not addressed today
6) Extracts to PCORI V1 and OMOP are computable (and scalable): workplan not discussed today
7) Sample data development plan to support transformation: there was lots of discussion
regarding reasons for test data preparation (?testing extract functionality?; visualization and
understanding of i2b2 data structures; testing i2b2 query functionality with model deployment)
and several use cases for deidentified data set development were discussed. There was no
conclusion regarding action items.
8) Next call 6/3/2014 1000AM EDT, 9:00AM CDT, 7:00AM PDT
Minutes 20140514
Discussion Washington DC
Discussants: George Hripcsak, Shawn Murphy, Charles Bailey, Keith Marsolo, Firas Wehbe, Jim Campbell,
Daniella Meeker(phone)
Proposed plan:
1) KM(lead), DM, MBuck, CBailey, GHripscak, JRC to develop for next call draft for discussion of
data domain inventory with associated domain ontologies/reference terminologies including
expectations of OMOP V5;
2) MKahn(lead), SM to convene discussion group to propose draft prioritization plan by domain
for standardization efforts;
3) A) MK and SM should further identify team of i2b2 experts to examine requirements of first
set of data domains. This team is tasked with identification of optimization and specialization
guidelines for deployment of ontologies and modifiers for first data domain. B) identify work
team for customization of OMOP
4) Team of informaticists expert in data structures of host EHRs should be convened to advise on
design of ETLs to populate i2b2 and OMOP standard models
5) Identify sample clinical data for testing of ontology rollouts
6) ETL library and maintenance tasks should be discussed with vendor communities:
a. Epic – JRC
b. Allscripts – KM
c. McKesson – BC
d. Nexgen – DM
e. LMR – DM,SM
f. eClinicalWork - GH
I2b2 standardization discussion
Conference call summary
201405060800 CDT
Attendees: Jim Campbell(JRC)(GPC-U Nebraska), Nathan Wilson(GPC-UWisonsin), Brittany Zzosche,
Bonnie Westra(BW)(GPC-Minnesota), Nathan Graham(GPC-Kansas U), Firas Wehbe(PCORI-Vanderbilt),
Keith Marsolo(KM)(Pedsnet-U Cincinnati), Nathan Wilson(GPC-Wisconsin-Madison), Stuart Speedie(GPC
-UMinnesota), Michael Kahn(Pedsnet-Colorado), George Hripscak(NYC-Columbia), Daniella
Meeker(Santa Monica-PScanner), Charles Bailey(CB)(Pedsnet-Childrens Philadelphia), Shawn
Murphy(SM)(Harvard SCILHS, SHRINE), Lori Phillips(MGH, SHRINE), Toan Ong(UColoradoDenver)
Apologies: Tom Campion, Russ Waitman, Michael Buck, Jeffrey Klann
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
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Deliverables from last call were discussed and group updated
JRC Demonstrated Babel website developed by Dan Connolly/Russ Waitman/GPC. BW commented
on utility for review of other network models. MK offered to upload fact statistics for Colorado
Childrens to site. Colleagues interested in access to site should contact Nathan Graham
(ngraham@kumc.edu) for an account.
KM, DM: Summary of planning for DSSNI face-to-face meeting 5/14 reported to group
KM, DM, MK, JRC: Email thread from past two weeks discussed and workplan proposals were
reviewed: 1) develop a comprehensive model that subsumes the semantic requirements of S&I,
OMOP, SHRINE, Mini-Sentinel or 2) establish workgroups to work on queries to serve CDMV1 from
our existing systems?
o MKahn: we are at a unique moment with PCORI funding and we should seize the
opportunity; an overriding model should be the goal of shared work; CB: The data
management requirements for compliance with PCORI CDMV1 for 7/1 are minimal and
should not drive our standardization efforts
o DM: target ETL developments pragmatically; develop a roadmap that can be pursued
incrementally
o MKahn: PedsNet plans to deploy much more that CDMV1; PedsNet is planning three rounds
of ETL development starting beginning with Obesity requirements and we have to be
responsive; others within discussion group concurred with choice of Obesity as priority
o SMurphy: Is the scope including decisions on i2b2 structures for optimization?
o JRC: Proposed plan: 1) KM(lead), DM, MBuck, CBailey, GHripscak, JRC to develop for next
call draft for discussion of data domain inventory with associated domain
ontologies/reference terminologies; 2) MKahn(lead), SM to convene discussion group to
propose draft prioritization plan by domain for standardization efforts; 3) A)they should
further identify team of i2b2 experts to examine requirements of first set of data domains.
This team is tasked with identification of optimization and specialization guidelines for
deployment of ontologies and modifiers for first data domain. B) identify work team for
customization of OMOP 4) a Team of informaticists expert in data structures of host EHR

should be convened to advise on design of ETLs to populate i2b2 and OMOP standard
models
Next call will be 5/20/14 8AM CDT; ad hoc meeting will be attempted on 5/14 in PCORI Washington
offices
I2b2 standardization discussion
Summary 20140421 1400UTC
1. Introductions; identification of network agendas and reasons for talking
2. Discussion of objectives informed by #1
3. Discussion and elaboration of requirements
Attendees: Jim Campbell(JRC)(GPC-U Nebraska), Steve Johnson(NYC-Cornell), Brittany Zzosche, Bonnie
Westra (GPC-Minnesota), Nathan Graham(GPC-Kansas U), Firas Wehbe(PCORI-Vanderbilt), Keith
Marsolo(KM)(Pedsnet-U Cincinnati), Nathan Wilson(GPC-Wisconsin-Madison), Stuart
Speedie(Minnesota), Matthew Hoag(GPC-Kansas U), Tom Campion(NYC-Cornell), Michael Kahn(PednetColorado), George Hripscak(NYC-Columbia), Charles Bailey(Pedsnet-Childrens Philadelphia)
1)
2)
3)
4)
Deliverables:
JRC to contact Lisa Dahm of UCRex network and Shawn and Lori of Partners to invite to future
discussions
KM to propose presentation on standards and maintenance management to PCORI for 5/14 face-to-face
meeting
JRC to demo Babel website to group at next meeting
Next conference call May 6; doodle poll to group for agreement on time
CDRN i2b2 Model Build
4/21/2014
Goal: develop a standards-based i2b2 data model that can be employed across CDRNs supported by a
sustainable standards distribution process which will maintain standards alignment over time and serve
their data query and analytics requirements from multiple heterogeneous sites
Requirements/Use Case support:
1. Align with S&I data standards from ONC for all data domains originating from or required by the
enterprise EHR
o align other data resources with these standard ontologies and valuesets whenever
possible
o identifying the centerpiece of ONC interoperation as CDA/CCD data extracts, assure that
a the HL7 V3 CCD extract is supported for all CCD data domains when such data are
present in the site EHR
o assure ability to respond to Quality Model query data extracts
2. Support response to PCORI common research data model queries across all sites
o anticipating that additional elements of Mini-Sentinel model are likely to be required as
PCORI CDM expands maximize alignment with deployment of further PCORI data
domains
o analytics platform standardization has not been identified as a requirement by PCORI
3. Support extracts to OMOP common data model analytics datasets for drug surveillance and
adverse event monitoring
4. Scalable business model for obtaining, formulating for i2b2 and distributing to all parties
ontologies identified as domain ontologies
Editorial principles
 Attribute context and source of data for all facts; preferentially with modifier dimension
 Attribute information source when appropriate for data re-use; esp when patient originated
 Assure minimal/no data loss on query between models
Domain
Demographics
Diagnoses
Observables\Clinical findings
Observables\Lab tests
Observables\radiology results
Procedures
Domain ontologies
SNOMED CT
ICD*
LOINC
SNOMED CT
LOINC
LOINC
CPT;HCPCS;ICD*
SNOMED CT
Codesets / Valuesets
OMB/HL7
Clinical findings, events, situations
Clinical LOINC
Observables
Lab LOINC
Procedures
Orders\medications\inpatient
RxNORM
\\Prescriptions
Orders\Procedures
LOINC
SNOMED CT
SubstAdmin\Meds&biologicals
RxNORM
NDC
\Immunizations
CVX
MVX
Enrollment
Registries
LOINC
SNOMED CT
Lab LOINC
Procedures