Table S1- List of organisms and the corresponding sequences used as seed to perform the similarity searches. The corresponding Gene ID numbers are presented.
Escherichia coli Bacillus subtilis
str. K-12 substr. subsp. subtilis
MG1655
str. 168
Direct repair
photolyase
SplB
ada
alkB
alt
aidB
BER
DNA glyco monofunction
alkA
alkC
alkD
MutY
tag
ung
MutT-Nudix motif
Bacillus cereus
ATCC 10987
Mycobacteriu Caulobacter
m tuberculosis crescentus
H37Rv
CB15
947005
939248
946710
946708
948710
947371
4584144
4584089
947447
947137
947067
944824
bifunctional DNA glycosylase
endonuclease VIII (nei)
MutM (fpg)
endonuclease III (nth)
945320
946765
947122
AP endonuclease
endonuclease IV (nfo)
endonuclease V (nfi)
exonuclease III (xth)
946669
948502
946254
1
NER
uvrA
uvrB
uvrC
uvrD
mfd
pcrA
repA
2716946
MMR
dam
mutH
mutL
mutS
947893
947299
948691
947206
HHR
RecA
RecB
RecC
RecD
RecF
RecG
RecJ
RecO
RecR
RecQ
RecS
RuvA
RuvB
RuvC
ssb
RecX
948559
945385
947203
948347
945681
938747
947170
947286
947294
947287
948209
948162
947367
947038
945100
948318
885442
939671
938969
946369
946371
946378
948570
947172
2
addA
AddB
SMC
Mre11
Rad50
RecN
939793
936341
945049
949076
947105
NHEJ
Ku
ATP dependent ligase
TLS
DNA pol II
DNA pol IV
DNA pol V/umuC
DNA pol V/umuD
imuA
imuB
dnaEII
939375
939372
885050
885561
944779
944922
946359
945746
943830
940967
940962
3
Table S2 – Abbreviation of species names investigated in the phylogenetic analysis. The organisms are listed in alphabetic order within the taxa.
Organisms
Abbreviation
CENARSY
Archaea/ incertae sedis
Haladaptatus paucihalophilus
Halalkalicoccus jeotgali
Haloferax volcanii
Methanococcus maripaludis S2
Methanosarcina barkeri fusaro_1
HALADA
Archaea/Halobacteria*
gi|322368774
HALAL
Archaea/Halobacteria*
gi|300711140
HALOFE
Archaea/Halobacteria*
gi|292656929
MARIPA
Methanosarcina mazei Go1
MAZEI
Methanothermobacter thermautotrophicus str. Delta H
METHE
Archaea/ Euryarchaeota
Archaea/ Methanomicrobia
Archaea/ Methanomicrobia
Archaea/ Methanomicrobia
Nitrosopumilus maritimus
Picrophilus torridus
Pyrobaculum aerophilum
Chlamydophila pneumoniae
Deinococcus geothermalis
Deinococcus maricopensis
Deinococcus proteolyticus
Deinococcus radiodurans R1
Thermus thermophilus
Leptospirillum rubarum
Planctomyces maris
Thermobaculum terrenum
Chitinophaga pinensis
Flavobacterium branchiophilum
Flavobacterium johnsoniae
Mucilaginibacter paludis
Niabella soli
Niastella koreensis
Pedobacter sp.
NITROMA
Archaea/ incertae sedis
PICRO
Archaea/ Thermoplasmata
Archaea/ Thermoprotei
Chlamydiae
Deinococcus-Themus*
Deinococcus-Thermus*
Deinococcus-Thermus*
Deinococcus-Thermus
Deinococcus-Thermus
Nitrospira
Planctomycetes
Thermobaculum
Bacteroidetes/Sphingobacteria
Bacteroidetes/Flavobacteria*
Bacteroidetes/Flavobacteria*
Bacteroidetes/ Sphingobacteria*
Bacteroidetes/ Sphingobacteria *
Bacteroidetes/Sphingobacteria
Bacteroidetes/Sphingobacteria*
Cenarchaeum symbiosum
MEBAR
PYROPHI
CHLAMY
DEIGEO
DEIMA
DEIPRO
DEIRA
THETHE
RUBARU
PLAMA
BACULU
CHITINO
FLABRAN
FLAJO
MUCIPA
NIABE
NIATE
PEDOBA
Division
Acession code
gi|94984215
gi|320335587
gi|325284136
gi|347535508
gi|146299237
gi|371989056
gi|374372927
gi|149278419
4
Organisms
Chloroflexus aggregans
Chloroflexus aurantiacus
Sphaerobacter thermophilus
Cyanothece
Microcoleus chthonoplastes
Nostoc punctiforme PCC 73102
Oscillatoria
Synechococcus sp. WH 8102
Synechocystis sp. PCC 6803
Akkermansia muciniphila ATCC BAA-835
Methylacidiphilum infernorum
Acholeplasma laidlawii
Acidaminococcus fermentans
Alkaliphilus metalliredigens
Bacillus cereus ATCC 10987
Bacillus subtilis
Caloramator australicus
Clostridium carboxidivorans
Clostridium hathewayi
Desulfitobacterium dichloroeliminans
Desulfitobacterium metallireducens
Desulfosporosinus orientis
Lactobacillus johnsonii
Listeria monocytogenes
Staphylococcus aureus
Thermosediminibacter oceani
Gemmatimonas aurantiaca
Borrelia burgdorferi B31
Leptonema illini DSM 21528
Abbreviation
AGGRE
AURAN
SPHAERO
CYANO
MICROCO
NOSTOC
OSCILLA
SYNECHO
SYNECY
AKKER
MEFER
ACHOLE
ACIDA
ALKAME
Division
Chloroflexi*
Chloroflexi*
Chloroflexi
Cyanobacteria*
Cyanobacteria*
Cyanobacteria
Cyanobacteria*
Cyanobacteria
Cyanobacteria
Verrucomicrobia
Verrucomicrobia
Firmicutes/Mollicutes
Firmicutes/Negativicutes
Firmicutes/Clostridia
Acession code
gi|219850496
gi|163845842
gi|172037923
gi|254417495
gi|300866658
BACERE
BACSU
Firmicutes/Bacilli
CALORA
Firmicutes/Clostridia
CLOSCA
Firmicutes/Clostridia*
gi|255527407
CLOSHA
Firmicutes/Clostridia*
gi|358065198
DESULDI
Firmicutes/Clostridia*
gi|374383563
DESULME
Firmicutes/Clostrida*
gi|354559127
DESORI
Firmicutes/Clostridia*
gi|374993782
LACJO
Firmicutes/Bacilli
LISTERIA
Firmicutes/Bacilli
STAPAU
SEDIMI
Firmicutes/Bacilli
GEMMA
Gemmatimonadetes
BORGE
Spirochaetes
Spirochaetes
LEPTO
Firmicutes/Bacilli
Firmicutes/Clostridia
5
Organisms
Leptospira alexanderi
Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)'
Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'
Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
Leptospira borgpetersenii serovar Hardjo-bovis str. L550
Leptospira broomii
Leptospira inadai
Leptospira interrogans serovar Bulgarica
Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
Leptospira interrogans serovar Lai str. 56601
Leptospira interrogans serovar Pomona
Leptospira kirschneri
Leptospira kmetyi
Leptospira noguchii
Leptospira santarosai
Leptospira weilii
Spirochaeta smaragdinae
Treponema pallidum
Turneriella parva
Kocuria rhizophila
Kribbella flavida DSM 17836
Abbreviation
LEPTOA
Division
Spirochaetes
LBF
LEPBI
LBJ
LBL
LEBRO
Spirochaetes
Spirochaetes
Spirochaetes
Spirochaetes
LEDAI
Spirochaetes
LEPI
Spirochaetes
LIC
LA
LICPO
Spirochaetes
Spirochaetes
LEKIR
Spirochaetes
LETYI
Spirochaetes
LECHII
Spirochaetes
LESAN
Spirochaetes
LEWEI
Spirochaetes
SMARA
Spirochaetes
Spirochaetes
Mycobacterium tuberculosis
MYCTU
Propionibacterium acnes K
PROPIO
Streptomyces coelicolor
STRECO
Spirochaetes
Spirochaetes
Spirochaetes
Actinobacteria
Actinobacteria
Actinobacteria
Actinobacteria
Actinobacteria
Sebaldella termitidis
Streptobacillus moniliformis DSM 12112
Beijerinckia indica
Brucella melitensis M28
SEBAL
Fusobacteria
MONILI
Fusobacteria
BEIJE
Alpha- proteobacteria
BRUCE
Alpha- proteobacteria
Caulobacter crescentus
CAULO
Alpha- proteobacteria
TPADAL
TURPA
KOCU
KRIBBE
Acession code
6
Organisms
Citromicrobium bathyomarinum
Dinoroseobacter shibae
Erythrobacter litoralis
Gluconacetobacter diazotrophicus
Granulibacter bethesdensis
Novosphingobium aromaticivorans
Novosphingobium pentaromativorans
Pelagibaca bermudensis
Puniceispirillum marinum
Rhizobium leguminosarum
Rhodobacter sphaeroides
Rhodospirillum rubrum
Roseomonas cervicalis
Ruegeria pomeroyi
Sphingobium chlorophenolicum
Sphingobium japonicum
Sphingomonas wittichii
Sphingopyxis alaskensis
Achromobacter arsenitoxydans
Achromobacter piechaudii
Achromobacter xylosoxidans A8
Advenella kashmirensis
Bordetella pertussis
Bordetella petrii
Burkholderia pseudomallei
Burkholderia rhizoxinica
Burkholderia xenovorans
Chromobacterium violaceum
Neisseria meningitidis
Abbreviation
CITROBA
Division
Alpha- proteobacteria*
Acession code
gi|296284512
DINORO
Alpha- proteobacteria*
gi|159044238
ERYLITO
Alpha- proteobacteria*
gi|85373171
GLUZO
Alpha- proteobacteria
GRANU
Alpha- proteobacteria
NOVOAR
Alpha –proteobacteria*
gi|87199138
NOVOPEN
Alpha –proteobacteria*
gi|359398457
PELAGI
Alpha -proteobacteria
PUNICE
Alpha- proteobacteria
RHIZO
Alpha –proteobacteria*
RHODO
Alpha -proteobacteria
RHORU
Alpha -proteobacteria
ROSEO
Alpha –proteobacteria*
gi|296535256
RUEGE
Alpha –proteobacteria*
gi|56696993
SPHINCLO
Alpha –proteobacteria*
gi|334345210
SPHINJA
Alpha –proteobacteria*
gi|294010788
SPHINWI
Alpha –proteobacteria*
gi|148555342
SPHINLA
Alpha –proteobacteria*
gi|103486334
ACHRO
Beta-proteobacteria*
gi|359799492
ACHROPI
Beta-proteobacteria*
gi|400197007
AXYLO
Beta-proteobacteria*
gi|311107716
ADVENE
Beta-proteobacteria*
gi|389872885
BORDE
BORPE
Beta-proteobacteria*
gi|33592951
gi|163857763
BURKHO
BURHIZO
Beta-proteobacteria*
Beta-proteobacteria*
gi|167816495
gi|312796648
BURXO
Beta-proteobacteria*
gi|91784174
CHROMO
NEIMA
Beta-proteobacteria
Beta-proteobacteria
Beta-proteobacteria*
gi|393168254
7
Organisms
Nitrosomonas eutropha
Nitrosospira multiformis
Polynucleobacter necessarius
Ralstonia eutropha H16
Desulfobacterium autotrophicum
Geobacter sulfurreducens
Pelobacter propionicus
Citrobacter freundii
Escherichia coli.
Francisella novicida U112
Haemophilus influenzae
Legionella drancourtii
Marinobacter adhaerens
Marinobacter sp.
Pantoea sp. AS-PWVM4
Pasteurella multocida
Pseudomonas aeruginosa
Pseudomonas chlororaphis
Pseudomonas entomophila
Pseudomonas fluorescens
Psychromonas ingrahamii 37
Salmonella typhimurium LT2
Shigella flexneri
Vibrio cholerae
Vibrio parahaemolyticus AQ3810
Xanthomonas axonopodis
Yersinia enterocolitica
Helicobacter pylori
Mycoplasma gallisepticum
Abbreviation
NITRO
Division
Beta-proteobacteria
Acession code
NIMU
Beta-proteobacteria
POLYNO
Beta-proteobacteria*
RALSTO
Beta-proteobacteria
DESUAU
Delta-proteobacteria
GEOSU
PELOBA
Delta-proteobacteria
CIFREU
Gamma-proteobacteria
ECOLI
FRANCI
Gamma-proteobacteria
HAEMO
Gamma-proteobacteria
LEGIDRA
Gamma-proteobacteria*
MARIAD
Gamma-proteobacteria
MARINO
Gamma-proteobacteria
PANTOEA
Gamma-proteobacteria
PASTEU
PSEUDO
PSEUCHO
Gamma-proteobacteria
Gamma-proteobacteria
Gamma-proteobacteria*
gi|389683838
PENTOMO
Gamma-proteobacteria*
gi|104780072
PSEUFLU
Gamma-proteobacteria
PSYGRA
Gamma-proteobacteria
SALMO
SHIGUE
VICHO
VIPARA
Gamma-proteobacteria
Gamma-proteobacteria
Gamma-proteobacteria
XANTHO
Gamma-proteobacteria
YERSINA
Gamma-proteobacteria
HELPY
Epsilon-proteobacteria
MYCOGA
Mollicutes
gi|171463665
Delta-proteobacteria
Gamma-proteobacteria
gi|374262978
Gamma-proteobacteria
8
Organisms
Mycoplasma penetrans HF-2
Mycoplasma synoviae
Amsacta moorei entomopoxvirus 'L']
Anopheles darlingi
Aphrocallistes vastus
Arabidopsis lyrata
Arabidopsis thaliana
Aspergillus nidulans
Camponotus floridanus
Danio rerio
Drosophila melanogaster
Glicine max
Harpegnathos saltator
Homo sapiens
Medicago truncatula
Physcomitrella patens
Pisum sativum
Populus trichocarpa
Ricinus communis
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Trichoderma atroviride
Trichomonas vaginalis G3
Vitis vinifera
Abbreviation
MYCOPE
Division
Acession code
Mollicutes
MYCOSY
Mollicutes
AMSACTA
ANOPHE
Virus
APHRO
Eukaryote
ARALY
Eukaryote - Viriplantae*
gi|297844924
ARATHA
ASPER
Eukaryote - Viriplantae*
gi|18394744
CAMPO
Eukaryote
DANIO
Eukaryote
DROSO
GLIMAX
Eukaryote
HARPE
Eukaryote
HOMO
MEDICAGO
Eukaryote
PHYSCO
PISUM
POTRI
Eukaryote
Eukaryote
Eukaryote –Viriplantae*
gi|224082864
RICINU
Eukaryote - Viriplanae*
gi|255538662
SACCHA
Eukaryote
SCHIZO
TRICHO
TRIVA
Eukaryote
Eukaryote
VITIS
Eukaryote - Viriplantae*
Eukaryote
Eukaryote
Eukaryote - Viriplantae*
Eukaryote - Viriplantae*
gi|356510199
gi|357483447
Eukaryote
gi|302142502
XENOP
Eukaryote
Xenopus laevis
* indicates the organisms in condensed branches in the Figure 2. The accession codes refer to genes from these organisms in the condensed
branches in this aforementioned phylogenetic tree. Other accession codes are indicated in the Figures.
9
Table S3- Oligonucleotides employed in this work.
gene ID/LIC Nameb
Sequence oligonucleotide
a
NR_074524
LIC11774
LIC13389
LIC13476
LIC10420
LIC13402
LIC12677
LIC11620
LIC11745
LIC10238
LIC12305
LIC13064
16S-F
16S-R
mutS1-F
mutS1-R
mutS3-F
mutS3-R
recR-F
recR-R
S-uvrDF
S-uvrDR
ada-F
ada-R
DNA ligF
DNA ligR
recN-F
recN-R
recA-F
recA-R
alkA1-F
alkA1-R
lexA1-F
lexA1-R
tag-F
tag-F
TTCAGTTGGGCACTCGTAAG
CGTGTGTTGCCCTAGACATAA
AGACAAATCGCCCTCAATCA
CCCGCTCCGATTCTAGTAAATAA
CGGGTTCGAATATGTCTGGAAA
CCACCCGCCATAGAAAGAATAG
CAAACGTTGCGGCTCTTATG
AATGTCTTCCGGTTGCTCTAC
ACGACAGCCAAGCGATTTA
Amplicon
(pb)c
97
mean efficiency d
107
1,950 ± 0,057
76
1,998 ± 0,127
103
1,990 ± 0,070
121
1,965 ± 0,085
107
2,088 ± 0,162
106
1,93 ± 0,026
104
1,971 ± 0,062
101
2,024 ± 0,115
133
2,019 ± 0,108
129
2,000 ± 0,890
140
2,066 ± 0,160
1,970 ± 0,088
TCCGGAAGAGATCGGTAATTTG
TTCTCTCTAAACCTCAAACCACTT
CGGAGTCATCCCTTCAATCTTTA
AGCTCTCTTCAAACCGGAAC
CTGTGTATCCTTTCGCCATCT
GAGAATGTGGGCGGGATGGA
GTTGTGAACTTCGGCGAGCA
TTGATTCTGTGGCGGCTTTGG
TCTAAGCGCCTGGGACATGAG
GAAACGCGCAAAATCATTCATGT
CAGCCGAAACAACCGATCTACTATT
TTGTGGCCTGAACGGGAAGT
GGCAAAGGGTGCCTACGATC
GTAATCCAAGAAAGCCCAGCCT
AAACGTTGTGCTTGGGTTACCG
10
LIC11717
LIC12362
uvrA-F
uvrA-R
alkA2-F
alkA2-R
GTTTCACAACGTCCACCGCT
ACGCCGATCCGAGAGATGTT
CCAGTTATGTTCGAGACCTTGC
CTACGGTCCAATTTCCAATCCC
101
1,950 ± 0,092
132
1,977 ± 0,297
a
Locus tag of the corresponding gene used for primer design
F- and R, forward and reverse primer sequences, respectively.
c
PCR product size (in base pairs).
d
Efficiency for PCR (determined by the software LinRegPCR, as described in Materials and Methods). The data represent the average of the
values obtained by LinRegPCR for each reaction. All oligonucleotides had the correlation coefficient squared (R2) superior or equal to 0,998.
b
11
Table S4- Putative DNA repair of Leptospira spp for direct repair. Each ORF is identified by the corresponding locus tag.
Genes
phra-like photolyase *
photolyase b *
splB
ada *
alkB
atl *
L. biflexa
Ames
LBF_2420
LBF_2340
LBF_0608
LBF_4131
LBF_3071
LBF_0549
L. biflexa
Paris
LEPBI_I2494
LEPBI_I2409
LEPBI_I0633
LEPBI_II0134
LEPBI_I3182
LEPBI_I0568
L.interrogans
Copenhageni
−−−
LIC_11339
LIC_10195
LIC_13402
−−−
LIC_10119
L. interrogans
Lai
−−−
LA_2649
LA_0226
LA_4250
−−−
LA_0131
L.borgpetersenii
JB197
−−−
−−−
LBJ_0162
LBJ_2922
−−−
LBJ_0115
L. borgpetersenii
L550
−−−
−−−
LBL_2921
LBL_0141
−−−
LBL_2962
* Genes that had their identity confirmed by phylogenetic analysis.
12
Table S5- Genes encoding putative repair proteins for Excision Repair in Leptospira spp. Each ORF is identified by the corresponding locus
tag.
Genes
L. biflexa
Ames
Base excision repair
DNA glyco monofunction
−−−
alkA *
alkC
LBF_0595
alkD
LBF_2342
mutY
LBF_1233
−−−
Tag
ung or udg *
LBF_0791
Bifunctional DNA
glycosylase
endonuclease III (nth) LBF_0987
AP endonuclease
exonuclease III (xth)
LBF_1776
Others
−−−
MutT-Nudix motif
−−−
MutT-Nudix motif
MutT-Nudix motif
LBF_0166
MutT-Nudix motif
pseudo
MutT-Nudix motif
LBF_2015
MutT-Nudix motif
LBF_3172
MutT-Nudix motif
LBF_3212
Nucleotide excision repair
uvrA
LBF_1784
uvrB
LBF_0814
uvrC
LBF_2022
mfd
LBF_1770
uvrD *
LBF_1683
pcrA *
LBF_1584
L. biflexa
L. interrogans
Paris Copenhageni
L. interrogans
Lai
L. borgpetersenii JB197 L. borgpetersenii L550
−−−
LEPBI_I0619
LEPBI_I2411
LEPBI_I1287
−−−
LEPBI_I0821
LIC_10238; LIC_12362
LIC_11639
LIC_12552; LIC_11252
LIC_11614
LIC_13064
LIC_10548; LIC_13102
LA_0281; LA_1370
LA_2298
LA_1129; LA_2767
LA_2328
LA_3832
LA_3668; LA_3883
LBJ_0662
−−−
LBJ_1745
LBJ_1296
−−−
LBJ_2712; LBJ_0598
LBL_2417
−−−
LBL_1964
LBL_1521
−−−
LBL_0362; LBL_2482
LEPBI_I1021
LIC_11759
LA_2163
LBJ_1856
LBL_1428
LEPBI_I1829
LIC_11452
LA_2516
LBJ_1669
LBL_1888
−−−
−−−
LEPBI_I0171
LEPBI_I2583
LEPBI_I2068
LEPBI_I3287
LEPBI_I3326
LIC_12191
LIC_10257
LIC_13264
LIC_20067
LIC_12589
LIC_10106
LIC_13180
LA_1589
LA_0300
LA_4093
LB_085
LA_1082
LA_0119
LA_3977
−−−
LBJ_2602
LBJ_0192
pseudo
LBJ_2308
LBJ_0097
LBJ_0418
−−−
LBL_0510
LBL_2891
LBL_0941
LBL_0799
LBL_0038
LBL_2659
LEPBI_I1837
LEPBI_I0845
LEPBI_I2076
LEPBI_I1823
LEPBI_I1736
LEPBI_I1634
LIC_11717
LIC_12941
LIC_11756
LIC_11455
LIC_11732
LIC_11624
LA_2212
LA_0649
LA_2166
LA_2513
LA_2193
LA_2317
LBJ_1403
LBJ_2353
LBJ_1853
LBJ_1666
LBJ_1356
LBJ_1306
LBL_1629
LBL_0755
LBL_1431
LBL_1885
LBL_1581
LBL_1531
13
repA *
small uvrD *
LBF_2013
LBF_2310
LEPBI_12066
LEPBI_I237
LIC_12588
LIC_10420
LA_1085
LA_0488
LBL_2305
−−−
LBL_0802
−−−
Mismatch repair
mutL
mutS1
mutS3 **
Dam
LBF_2096
LBF_0802
LBF_0324
−−−
LEPBI_12151
LEPBI_I0833
LEPBI_I0334
−−−
LIC_12514
LIC_11774
LIC_13389
−−−
LA_1175
LA_2146
LA_4235
−−−
LBJ_2225
LBJ_1867
LBJ_2911
LBJ_1937
LBL_2218
LBL_1417
LBL_0152
LBL_1347
* Genes that had their identity confirmed by phylogenetic analysis. Bold: Genes possibly obtained by LGT events. **Genes specific to Leptospiraceae.
Table S6- Putative proteins related to recombinational repair in Leptospira spp. Each ORF is identified by the corresponding locus tag.
Genes
HR
recA
recB
recC
recD
recF
recG
recJ
Reco
recR
recQ
recS
ruvA
ruvB
ruvC
ssb1
ssb2
Saprophytic
L. biflexa
L. biflexa
Ames
Paris
Pathogen
L. interrogans
L. interrogans
Copenhageni
Lai
Host-dependent
L. borgpetersenii
L. borgpetersenii
JB197
L550
LBF_2374
LBF_5019
LBF_5020
LBF_5018
LBF_0006
LBF_0338
LBF_1255
LBF_2037
LBF_3348
LBF_0300
LBF_2428
LBF_1447
LBF_0505
LBF_3203
LBF_2873
LBF_2045
LIC_11745
LIC_12686
LIC_12688
LIC_12685
LIC_10003
LIC_13150
LIC_11066
LIC_12104
LIC_13476
LIC_12961
LIC_12689
LIC_11148
LIC_12811
LIC_12885
LIC_10564
LIC_12112
LBJ_1344
LBJ_0684
LBJ_0685
LBJ_0683
LBJ_0006
LBJ_0400
LBJ_1989
LBJ_1202
LBJ_3003
LBJ_0296
LBJ_0686
LBJ_1987
LBJ_0761
LBJ_0544
pseudo
LBJ_1194
LEPBI_I2446
LEPBI_p0020
LEPBI_p0021
LEPBI_p0019
LEPBI_I0003
LEPBI_I0349
LEPBI_I1309
LEPBI_I2091
LEPBI_I3463
LEPBI_I0309
LEPBI_I2503
LEPBI_I1501
LEPBI_I0524
LEPBI_I3318
LEPBI_I2975
LEPBI_I2099
LA_2179
LA_0966
LA_0965
LA_0967
LA_0003
LA_3945
LA_2999
LA_1685
LA_4333
LA_0625
LA_0964
LA_2903
LA_0810
LA_0723
LA_3645
LA_1676
LBL_1569
LBL_2395
LBL_2394
LBL_2396
LBL_0006
LBL_2677
LBL_1061
LBL_1254
LBL_0066
LBL_2780
LBL_2393
LBL_1063
LBL_2317
LBL_2536
LBL_2444
LBL_1246
14
SMC
recN
mre11
rad50
LBF_1580
LBF_2807
LBF_2806
LEPBI_I1630
LEPBI_I2906
LEPBI_I2905
LIC_11620
LIC_10252
LIC_10251
LA_2321
LA_0294
LA_0293
LBJ_1302
LBJ_0659
LBJ_0658
LBL_1527
LBL_2420
LBL_2421
NHEJ
ATP dependent
ligase
−−−
−−−
LIC_12677
LA_0984
−−−
−−−
Bold: Genes possibly obtained by LGT events.
Table S7- Leptospira spp genes related to DNA damage tolerance. Each ORF is identified by the corresponding locus tag.
Genes
L. biflexa
Ames
L. biflexa
Paris
L. interrogans
Copenhageni
L. interrogans L. borgpetersenii
Lai
JB197
L. borgpetersenii
L550
Y-family TLS
dinP
LBF_4145
LEPBI_II0150
LIC_13052
LA_0503
−−−
−−−
B-family
DNA pol II
LBF_2104
LEPBI_I2161
−−−
−−−
−−−
−−−
Bold: possibly obtained by LGT events.
15