Supplementary Table 1 . Characteristics of early onset pancreatic cancer cases and healthy controls by 5-year increments under age
60.
N
Study Center
Italy 1
Ontario 1
SEARCH
1
LSU
2
MD Anderson 2
UCSF 2
Yale 2
Mayo Clinic
3
Family History of PC (1 st degree)
Unknown
No
Yes
Diabetes Mellitus (DM)
Unknown
Non-DM
DM (≥ 3 years)
Sex
Female
Male
Smoking (pack-years)
Unknown
0
1-19
20-39
40+
Alcohol (g ethanol/day)
Unknown
< 26
26+
Usual BMI (kg/m 2 )
Unknown
Early-Onset Cases
<45 years 45 to 49 years 50 to 54 years 55 to 59 years
226
N %
38 17
171 76
17 8
27 12
193 85
6 3
103 46
123 54
16 7
79 35
78 35
39 17
14 6
55 24
146 65
25 11
13 6
40
30
26
3
12
21
7
87
318
N %
78 25
230 72
10 3
48 15
253 80
17 5
132 42
186 58
37 12
89 28
91 29
66 21
35 11
93 29
192 60
33 10
31 10
52
29
44
5
16
25
17
130
N %
109 19
426 73
45 8
62 11
478 82
40 7
243 42
337 58
48 8
176 30
137 24
131 23
88 15
139 24
375 65
66 11
36 6
580
79
98
65
8
35
54
31
210
N %
184 22
578 70
68 8
103 12
653 79
74 9
335 40
495 60
71 9
225 27
211 25
168 20
155 19
197 24
544 66
89 11
47 6
830
129
118
113
4
38
65
46
317
Controls
<45 years
589
300
0
91
2
0
87
34
75
N %
116 20
464 79
9 2
31 5
547 93
11 2
222 38
367 62
25 4
239 41
201 34
100 17
24 4
27 5
530 90
32 5
31 5
45 to 49 years 50 to 54 years 55 to 59 years
528
219
0
100
6
0
77
29
97
N %
129 24
390 74
9 2
35 7
475 90
18 3
214 41
314 59
29 5
238 45
134 25
98 19
29 5
30 6
461 87
37 7
40 8
< 30
30+
Personal History of Pancreatitis (≥ 3 years)
170 75
43 19
63 28
210 66
77 24
100 31
400 69
144 25
147 25
586 71
197 24
228 27
491 83
67 11
324 55
410 78
78 15
251 48 Unknown
No 160 71 216 68 426 73 579 70 264 45
Yes 3 1 2 1 7 1 23 3 1 0
Site as grouped for analysis: 1-Non-Mayo Clinic outside USA; 2-Non-Mayo Clinic inside USA; 3-Mayo Clinic (MC)
277 52
0 0
N %
226 23
743 75
17 2
78 8
871 88
37 4
397 40
589 60
68 7
405 41
270 27
158 16
85 9
73 7
822 83
91 9
86 9
748 76
152 15
361 37
623 63
2 0
986
291
0
153
22
0
226
58
236
1175
387
0
218
16
0
212
72
270
N %
293 25
855 73
27 2
85 7
1022 87
68 6
462 39
713 61
74 6
470 40
295 25
178 15
158 13
87 7
957 81
131 11
87 7
906 77
182 15
467 40
703 60
5 0