Supplementary Table 1. BCT candidacy, surgical procedure and BCT success 1A. Total sample (N=404) Pre-NST Post-NST Candidate N=197 (of 219 or 90%) Candidate N=219 (of 404, 54%) Noncandidate N=185 (of 404, 46%) TOTAL BCT attempted If BCT attempted, successful * Final Surgery BCT 138 (of 197, 70%) 130 (of 138, 94%) Mastectomy N= 59 (of 197, 30%) Non-candidate N=22 (of 219 or 10%) BCT Candidate N=78 (of 185 or 42%) BCT N= 0 (of 22, 0%) Mastectomy N=22 (of 22, 100%) 53 (of 78, 68%) 48 (of 53, 91%) Non-candidate N=107 (of 185 or 58%) Candidate N=275 (of 404, 68%) Non-Candidate N=151 (of 404, 37%) N=138 (of 197, 70%) N=53 (of 78, 70%) Mastectomy N=25 (of 78, 30%) BCT N= 0 (of 107, 0%) Mastectomy N=107 (of 107, 100%) 191 (of 275, 69%) 178 (of 191, 93%) BCT N=191 (of 404, 47%) Mastectomy N=213 (of 404, 53%) 1 1B. Arm 1: P (N=101) Pre-NST Post-NST Candidate N=47 (of 56, 84%) Candidate N=56 (of 101, 55%) Noncandidate N=45 (of 101, 45%) TOTAL BCT attempted If BCT attempted, successful Final Surgery BCT 32 (of 47, 68%) 31 (of 32, 97%) Mastectomy N=15 (of 47, 32%) Non-candidate N=9 (of 56, 16%) BCT Candidate N=15 (of 45, 33%) BCT N=0 (of 9, 0%) Mastectomy N=9 (of 9, 100%) 12 (of 15, 80%) 12 (of 12, 100%) Non-candidate N=30 (of 45, 67%) Candidate N=62 (of 101, 61%) Non-Candidate N=39 (of 101, 39%) N=32 (of 47, 68%) N=12 (of 15, 80%) Mastectomy N= 3 (of 15, 20%) BCT N= 0 (of 30, 0%) Mastectomy N=30 (of 30, 100%) 44 (of 62, 71%) 43 (of 44, 98%) BCT N=44 (of 101, 44%) Mastectomy N=57 (of 404, 56%) 2 1C. Arm 2: P+B->B (N=100) Pre-NST Post-NST Candidate N=59 (of 63, 94%) Candidate N=63 (of 100, 63%) Noncandidate N=37 (of 100, 37%) TOTAL BCT attempted If BCT attempted, successful Final Surgery BCT 41 (of 59, 69%) 37 (of 41, 90%) Mastectomy N=18 (of 59, 31%) Non-candidate N=4 (of 63, 6%) BCT Candidate N=14 (of 37, 38%) BCT N=0 (of 4, 0%) Mastectomy N=4 (of 4, 100%) 8 (of 14, 57%) 8 (of 8, 100%) Non-candidate N=23 (of 37, 62%) Candidate N=73 (of 100, 73%) Non-Candidate N=27 (of 100, 27%) N=41 (of 59, 69%) N=8 (of 14, 57%) Mastectomy N=6 (of 14, 43%) BCT N= 0 (of 23, 0%) Mastectomy N=23 (of 23, 100%) 49 (of 73, 67%) 45 (of 44, 92%) BCT N=49 (of 100, 49%) Mastectomy N=51 (of 100, 51%) 3 1D. Arm 3: P+Cb (N=101) Pre-NST Post-NST Candidate N=50 (of 54, 93%) Candidate N=54 (of 101, 53%) Noncandidate N=47 (of 101, 47%) TOTAL BCT attempted If BCT attempted, successful Final Surgery BCT 38 (of 50, 76%) 35 (of 38, 92%) Mastectomy N=12 (of 50, 24%) Non-candidate N=4 (of 50, 7%) BCT Candidate N=21 (of 47, 45%) BCT N=0 (of 4, 0%) Mastectomy N=4 (of 4, 100%) 13 (of 21, 62%) 12 (of 13, 92%) Non-candidate N=26 (of 47, 55%) Candidate N=71 (of 101, 70%) Non-Candidate N=30 (of 101, 30%) N=38 (of 50, 76%) N=13 (of 21, 62%) Mastectomy N= 8 (of 21, 38%) BCT N= 0 (of 26, 0%) Mastectomy N=26 (of 26, 100%) 51 (of 71, 72%) 47 (of 51, 92%) BCT N=51 (of 101, 50%) Mastectomy N=50 (of 101, 50%) 4 1E. Arm 4: P+Cb+B->B (N=102) Pre-NST Post-NST Candidate N=41 (of 46, 89%) Candidate N=46 (of 102, 45%) Noncandidate N=56 (of 102, 55%) TOTAL BCT attempted If BCT attempted, successful Final Surgery BCT 27 (of 41, 66%) 27 (of 27, 100%) Mastectomy N=14 (of 41, 34%) Non-candidate N=5 (of 46, 11%) BCT Candidate N=28 (of 56, 50%) BCT N=0 (of 5, 0%) Mastectomy N=5 (of 5, 100%) 20 (of 28, 71%) 16 (of 20, 80%) Non-candidate N=28 (of 56, 50%) Candidate N=69 (of 102, 68%) Non-Candidate N=33 (of 102, 32%) N=27 (of 41, 66%) N=20 (of 28, 71%) Mastectomy N= 8 (of 28, 29%) BCT N= 0 (of 28, 0%) Mastectomy N=28 (of 28, 100%) 47 (of 69, 68%) 43 (of 47, 91%) BCT N=47 (of 102, 46%) Mastectomy N=55 (of 102, 54%) 5