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Supplementary Tables Supplementary Table S1. Sample characteristics. Diagnosis WHO grade Ki-67 p53 MGMT a 1p & 19q Radiotherapy Recurrent AO III 10% positive <1% negative 1p deletion CCRT b 55.8 Gy a MGMT, O6-methylguanine–DNA methyltransferase. b CCRT, Concurrent chemoradiotherapy, temozolomide based. Supplementary Table S3. The proteins of anti-apoptosis identified in recurrent AO. Accesions Gene_Symbol Gene product IPI00000760 DDAH2 dimethylarginine dimethylaminohydrolase 2 IPI00003362 HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) IPI00003815 ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha IPI00007765 HSPA9 heat shock 70kDa protein 9 (mortalin) IPI00012011 CFL1 cofilin 1 (non-muscle) IPI00021263 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide IPI00021369 CRYAB crystallin, alpha B IPI00021842 APOE apolipoprotein E IPI00022314 SOD2 superoxide dismutase 2, mitochondrial IPI00025512 HSPB1 heat shock 27kDa protein 1 IPI00027230 HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 IPI00027350 PRDX2 peroxiredoxin 2 IPI00071059 BAX BCL2-associated X protein IPI00218733 SOD1 superoxide dismutase 1, soluble IPI00219757 GSTP1 glutathione S-transferase pi 1 IPI00220740 NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) IPI00220766 GLO1 glyoxalase I IPI00329801 ANXA5 annexin A5 Supplementary Table S4. The proteins of cell proliferation identified in recurrent AO. Accesions Gene_Symbol Gene product IPI00000874 PRDX1 peroxiredoxin 1 IPI00003479 MAPK1 mitogen-activated protein kinase 1 IPI00007926 C6orf108 chromosome 6 open reading frame 108 IPI00013004 PDXK pyridoxal (pyridoxine, vitamin B6) kinase IPI00015148 RAP1B RAP1B, member of RAS oncogene family IPI00021304 KRT2 keratin 2 IPI00021347 UBE2L3 ubiquitin-conjugating enzyme E2L 3 IPI00021841 APOA1 apolipoprotein A-I IPI00022744 CSE1L CSE1 chromosome segregation 1-like (yeast) IPI00027350 PRDX2 peroxiredoxin 2 IPI00215747 FABP7 fatty acid binding protein 7, brain IPI00218493 HPRT1 hypoxanthine phosphoribosyltransferase 1 IPI00299399 S100B S100 calcium binding protein B IPI00784154 HSPD1 heat shock 60kDa protein 1 (chaperonin) Supplementary Table S5. The protein of cell adhesion identified in recurrent AO. Accesions Gene_Symbol Gene product IPI00013303 LSAMP limbic system-associated membrane protei IPI00019502 MYH9 myosin, heavy chain 9, non-muscle IPI00022892 THY1 Thy-1 cell surface antigen IPI00159927 NCAN neurocan IPI00160552 TNR tenascin R (restrictin, janusin) IPI00177817 ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 IPI00215629 VCAN versican IPI00298994 TLN1 talin 1 IPI00376427 NCAM2 neural cell adhesion molecule 2 IPI00411478 NCAM1 neural cell adhesion molecule 1 IPI00456623 BCAN brevican Supplementary Table S6. The protein of cell migration identified in recurrent AO. Accesions Gene_Symbol Gene product IPI00019502 MYH9 myosin, heavy chain 9, non-muscle IPI00021304 KRT2 keratin 2 IPI00021841 APOA1 apolipoprotein A-I IPI00025512 HSPB1 heat shock 27kDa protein 1 IPI00027493 SLC3A2 IPI00031370 TUBB2B tubulin, beta 2B class IIb IPI00160552 TNR tenascin R (restrictin, janusin) IPI00419585 PPIA peptidylprolyl isomerase A (cyclophilin A) IPI00974544 YWHAE solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Supplementary Table S7. The proteins associated with EGFR signaling identified in recurrent Accesions Gene_Symbol Gene product IPI00004838 CRK v-crk sarcoma virus CT10 oncogene homolog (avian) IPI00012011 CFL1 cofilin 1 (non-muscle) IPI00014230 C1QBP complement component 1, q subcomponent binding protein IPI00021369 CRYAB crystallin, alpha B IPI00021439 ACTB actin, beta IPI00024067 CLTC clathrin, heavy chain (Hc) IPI00071059 BAX BCL2-associated X protein IPI00289499 ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IPI00395769 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 IPI00414123 CRMP1 collapsin response mediator protein 1 IPI00456623 BCAN brevican IPI00456969 DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 AO. PI00465436 CAT catalase IPI00465439 ALDOA aldolase A, fructose-bisphosphate IPI00844578 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9