Table 1 (online supplement): Order and Proximity of medication pairs
Pair
Mean
Experts classification
Match
Rank
Fluticasone/Albuterol
8.9
Pulmonary/Pulmonary
Y
Alprazolam/Paroxetine
10.4
Psychiatric /Psychiatric
Y
Atorvastatin/Diltiazem
12.9
Cardiovascular or Neurological
/Cardiovascular
Y
Digoxin/Diltiazem
15.2
Cardiovascular /Cardiovascular
Y
Home oxygen/Albuterol
16.1
Pulmonary /Pulmonary
Y
Fluticasone/Home oxygen
17.0
Pulmonary/Pulmonary
Y
Clopidogrel/Digoxin
17.4
Cardiovascular or Neurological
/Cardiovascular
Y
Aspirin/Atorvastatin
17.9
Cardiovascular or Neurological
/Cardiovascular or Neurological
Y
Atorvastatin/Digoxin
17.9
Cardiovascular or Neurological
/Cardiovascular
Y
Clopidogrel/Aspirin
18.6
Cardiovascular or Neurological
/Cardiovascular or Neurological
Y
Clopidogrel/Atorvastatin
19.3
Cardiovascular or Neurological
/Cardiovascular or Neurological
Y
Aspirin/Diltiazem
20.0
Cardiovascular or Neurological
/Cardiovascular
Y
Clopidogrel/Diltiazem
20.0
Cardiovascular or Neurological
/Cardiovascular
Y
Potassium Chloride/Aspirin
21.5
Cardiovascular /Cardiovascular or
Neurological
Y
Potassium Chloride/Digoxin
23.0
Cardiovascular /Cardiovascular
Y
Aspirin/Digoxin
23.6
Cardiovascular or Neurological
/Cardiovascular
Y
Clopidogrel/Potassium Chloride
24.4
Cardiovascular or Neurological
/Cardiovascular
Y
Fluticasone/Digoxin
25.0
Pulmonary/Cardiovascular
N
Potassium Chloride/Diltiazem
25.8
Cardiovascular /Cardiovascular
Y
Potassium Chloride/Atorvastatin
25.9
Cardiovascular /Cardiovascular or
Neurological
Y
Paroxetine/Albuterol
26.8
Psychiatric /Pulmonary
N
Fluticasone/Diltiazem
27.5
Pulmonary/Cardiovascular
N
Digoxin/Albuterol
27.6
Cardiovascular /Pulmonary
N
Fluticasone/Alprazolam
28.1
Pulmonary/Psychiatric
N
Fluticasone/Potassium Chloride
28.6
Pulmonary/Cardiovascular
N
Fluticasone/Paroxetine
28.8
Pulmonary/Psychiatric
N
Home oxygen/Digoxin
29.3
Pulmonary /Cardiovascular
N
Albuterol./Diltiazem
29.6
Pulmonary. /Cardiovascular
N
Fluticasone/Clopidogrel
29.8
Pulmonary/Cardiovascular or
Neurological
N
Clopidogrel/Albuterol
30.1
Cardiovascular or Neurological
/Pulmonary
N
Aspirin/Albuterol
30.6
Cardiovascular or Neurological
/Pulmonary
N
Fluticasone/Atorvastatin
30.6
Pulmonary/Cardiovascular or
Neurological
N
Alprazolam/Albuterol
30.9
Psychiatric /Pulmonary
N
Potassium Chloride/Albuterol
31.0
Cardiovascular /Pulmonary
N
Atorvastatin/Albuterol
31.0
Cardiovascular or Neurological
/Pulmonary
N
Clopidogrel/Alprazolam
32.1
Cardiovascular or Neurological
/Psychiatric
N
Fluticasone/Aspirin
32.8
Pulmonary/Cardiovascular or
N
Neurological
Alprazolam/Home oxygen
33.0
Psychiatric /Pulmonary
N
Home oxygen/Diltiazem
33.1
Pulmonary /Cardiovascular
N
Potassium Chloride/Home oxygen
33.1
Cardiovascular /Pulmonary
N
Home oxygen/Paroxetine
33.8
Pulmonary /Psychiatric
N
Alprazolam/Diltiazem
35.1
Psychiatric /Cardiovascular
N
Potassium Chloride/Alprazolam
35.3
Cardiovascular /Psychiatric
N
Clopidogrel/Home oxygen
35.5
Cardiovascular or Neurological
/Pulmonary
N
Alprazolam/Atorvastatin
36.0
Psychiatric /Cardiovascular or
Neurological
N
Home oxygen/Atorvastatin
36.0
Pulmonary /Cardiovascular or
Neurological
N
Paroxetine/Diltiazem
36.1
Psychiatric /Cardiovascular
N
Clopidogrel/Paroxetine
37.6
Cardiovascular or Neurological
/Psychiatric
N
Potassium Chloride/Paroxetine
37.9
Cardiovascular /Psychiatric
N
Aspirin/Home oxygen
37.9
Cardiovascular or Neurological
/Pulmonary
N
Alprazolam/Digoxin
38.6
Psychiatric /Cardiovascular
N
Atorvastatin/Paroxetine
38.7
Cardiovascular or Neurological
/Psychiatric
N
Paroxetine/Digoxin
38.7
Psychiatric /Cardiovascular
N
Aspirin/Paroxetine
38.9
Cardiovascular or Neurological
/Psychiatric
N
Alprazolam/Aspirin
39.0
Psychiatric /Cardiovascular or
Neurological
N