Supplemental Table 1. Patients with pre-existing cardiomyopathy and stable or normal cardiac function during pregnancy
Patient Cancer
Age at
Total Dose
Mitoxantrone/
Total
Previous h/o CMP
diagnosis
anthracyclines Ifosfamide/
number of
before pregnancy
and race
(mg/m2)
Cyclophosphamide/
pregnancies
Radiation therapy
4947
Neuroblastoma
1 yr
363
Cyclophosphamide,
1
Subclinical CMP
Caucasian
(14,784 mg/m2)
(EF24%)
7102
AML
9 yrs
310
None
2
Subclinical CMP (EF
Caucasian
22%)
7144
Osteosarcoma
9 yrs
450
Cyclophosphamide
2
CMP requiring
Caucasian
(5405 mg/m2 )
meds
CMP
resolved
before
pregnancy
Yes
Yes
No, stable
function
during
pregnancy
7462
Soft Tissue Sarcoma
13 yrs
Black
450
Cyclophosphamide
(6000 mg/m2 )
4
Subclinical CMP (EF
26%)
No, stable
subclinical
CMP
7535
AML
480
9353
Osteosarcoma
290
Cyclophosphamide
(5988 mg/m2 )
3
CMP requiring
meds (EF 20%)
CMP requiring
meds
CMP requiring
meds
Yes
ALL
Cyclophosphamide
(7923 mg/m2 )
+radiation
2
8465
9 yrs
Caucasian
11 yrs
Caucasian
15 yrs
Black
9676
Osteosarcoma
12 yrs
Black
260
Cyclophosphamide
(5400 mg/m2 )
2
Subclinical CMP (EF
27%)
No, stable
subclinical
CMP)
9727
Osteosarcoma
170
Subclinical CMP (EF
25%)
Subclinical CMP
Yes
ALL
Cyclophosphamide
(4650 mg/m2 )
Cyclophosphamide
(10,095 mg/m2 ,
+radiation)
2
9728
12 yrs
Caucasian
3 yrs
Caucasian
None
42
2
1
Yes
Yes
Yes
Outcome
No other CMP
events
No other CMP
events
No
documentation
of further
problems with
2nd pregnancy
Subclinical CMP
during first 3
pregnancies
with resolution
of CMP before
4th pregnancy
No other CMP
events
No other CMP
events
Later
developed CHF
unrelated to
pregnancy
Persistent
subclinical CMP
prior to 2nd
pregnancy
No other CMP
events
No other CMP
events
9945
Osteosarcoma
17 yrs
Caucasian
8 yrs
Caucasian
129
10101
Osteosarcoma
10833
ALL
10 yrs
Caucasian
411
10909
Non-Hodgkin
Lymphoma
15 yrs
Black
101
11288
AML
18 yrs
Black
11434
Rhabdomyosarcoma
12236
Ewing Sarcoma
12690
Hodgkin Lymphoma
389
Ifosfamide
(38,324 mg/m2 )
Ifosfamide
(40,109 mg/m2)
2
1
CMP requiring dose
change in chemo
Subclinical CMP (EF
27%)
Yes
No, stable
subclinical
CMP
Yes
Mitoxantrone
(87.5 mg/m2;
Cyclophosphamide
11,750 mg/m2)
Cyclophosphamide
(6404 mg/m2)
1
Subclincial CMP
(EF25%)
4
CMP requiring
meds
None
None
5
CMP requiring
meds
10 yrs
Caucasian
8 yrs
Caucasian
441
Cyclophosphamide
(11,022 mg/m2 )
Cyclophosphamide
(56,279 mg/m2 )
Ifosfamide
(16,472 mg/m2 )
1
CMP requiring
meds
CMP requiring
meds
Yes
15 yrs
Caucasian
300
+radiation
2
Subclinical CMP
(EF 27%)
Yes
377
2
No, stable
subclinical
CMP
Yes
Yes
CMP – Cardiomyopathy; ICD – Intra-cardiac defibrillator; yrs – years; AML – Acute myelogenous leukemia; ALL – Acute lymphoblastic leukemia
No other CMP
events
Resolution of
subclinical CMP
No other CMP
events
No other CMP
events
Later
developed CMP
requiring ICD
No other CMP
events
Subclinical CMP
prior to 2nd
pregnancy
without
peripartum
complications
CMP requiring
meds after
pregnancies