S5 Table. TNFA haplotype combinations. Number and frequency (in brackets) of CD cases and controls are reported. Odds Ratios were calculated
by binary logistic regression analysis adjusted for age, gender and H. pylori infection.
Classification (OR; 95% CI)
TNFA Haplotypes combinations
Number
Group A (Ref.)
H1/H1
H1/H2
H1/H3
H2/H2
H2/H3
H3/H3
H1/H4
H2/H4
H2/H5
H1/H5
H3/H4
H3/H5
H4/H5
H4/H4
H5/H5
H3/H6
H6/H6
17
27
72
11
65
83
11
9
33
35
16
96
8
2
22
3
1
Group B (11.2; 2.6-48.6) *
Group C (21.2; 4.5-100.3) *
Group D (55.7; 12.5-247.8) *
Group E (188.7; 30.6-1165.2) *
*: p<0.0001
CCGG/CCGG
CCGG/TTGG
CCGG/TCGG
TTGG/TTGG
TTGG/TCGG
TCGG/TCGG
CCGG/CCAG
TTGG/CCAG
TTGG/TCGA
CCGG/TCGA
TCGG/CCAG
TCGG/TCGA
CCAG/TCGA
CCAG/CCAG
TCGA/TCGA
TCGG/CCGA
CCGA/CCGA
CD Nr.
(frequency)
1 (0.06)
1 (0.04)
23 (0.32)
3 (0.27)
24 (0.37)
32 (0.39)
5 (0.45)
5 (0.56)
15 (0.45)
23 (0.66)
11 (0.69)
69 (0.72)
7 (0.88)
2 (1.00)
19 (0.86)
3 (1.00)
1 (1.00)
Controls Nr.
(frequency)
16 (0.94)
26 (0.96)
49 (0.68)
8 (0.73)
41 (0.63)
51 (0.61)
6 (0.55)
4 (0.44)
18 (0.55)
12 (0.34)
5 (0.31)
27 (0.28)
1 (0.12)
0 (-)
3 (0.14)
0 (-)
0 (-)
CD/Controls
ratio
0.06
0.04
0.47
0.40
0.59
0.64
0.82
1.27
0.82
1.94
2.23
2.57
7.33
6.14
-