Table 1: Hemodynamic variables of malignant hyperthermia susceptible (MHS) and non-susceptible (MHN) pigs following trigger application.
Diagnose
MHSSCh
(n = 9)
MHNSCh
(n = 10)
MHSHalothane
(n = 6)
MHNHalothane
(n = 10)
MHSHalothane+SCh
(n = 12)
MHNHalothane+SCh
(n = 10)
Time
[min|
0 min
15 min
30 min
45 min
0 min
15 min
30 min
45 min
0 min
15 min
30 min
45 min
0 min
15 min
30 min
45 min
0 min
15 min
30 min
45 min
0 min
15 min
30 min
45 min
HR
[bpm]
53 [52-61]
58 [53-65]
73 [63-85]*
70 [68-92]*
67 [63-72]
71 [63-75]
72 [67-75]
66 [61-70]
61 [60-66]
58 [55-66]
61 [59-64]
76 [61-110]
64 [57-70]
64 [55-69]
68 [61-76]
69 [62-73]
65 [55-87]
80 [70-92]*
168 [113-204]*#
200+
71 [61-79]
83 [73-97]*
93 [84-102]*
100 [95-105]*
MAP
[mmHg]
84 [83-89]
85 [82-89]
67 [55-74]*
66 [60-76]*
75 [70-86]
74 [67-81]
72 [68-76]
71 [69-76]
82 [75-84]
82 [76-87]
49 [45-53]*#
41 [38-45]*
72 [70-79]
73 [68-80]
66 [55-72]*
51 [45-56]*
60 [59-72]
60 [55-75]
41 [35-45]*
60+
67 [60-80]
61 [60-78]
57 [53-60]*
52 [48-60]*
SaO2
[%]
98 [98-98]
98 [97-98]
98 [97-98]
98 [97-98]
99 [97-100]
99 [96-100]
99 [98-100]
99 [97-100]
98 [98-99]
98 [97-99]
98 [97-99]
97 [95-98]
98 [98-100]
98 [97-99]
99 [98-100]
99 [97-100]
98 [98-99]
98 [97-99]
96 [95-98]*
98+
99 [97-99]
98 [97-99]
98 [96-98]
96 [95-100]
etCO2
[mmHg]
35 [31-35]
35 [32-36]
48 [42-51]*#
54 [44-62]*#
33 [30-35]
33 [30-35]
34 [31-34]
34 [31-35]
33 [30-35]
33 [30-34]
36 [32-40]*
55 [44-65]*
33 [31-35]
35 [31-35]
33 [31-34]
31 [29-33]*#
31 [30-32]
33 [32-34]*
63 [55-65]*#
79+
33 [31-33]
32 [31-34]
31 [30-32]
32 [30-32]
Temperature
[°C]
37,3 [37,1-37,3]
37,2 [37,0-37,3]
37,5 [37,2-37,5]
37,6 [37,3-37,9]
37,0 [36,8-37,5]
36,9 [36,7-37,4]
37,0 [36,6-37,4]
37,0 [36,6-37,4]
37,4 [36,9-37,5]
37,4 [36,9-37,4]
37,3 [37,0-37,5]
37,5 [37,1-37,9]
36,8 [36,6-37,3]
37,0 [36,8-37,2]
37,1 [36,6-37,2]
37,0 [36,8-37,3]
37,5 [37,4-37,9]
37,5 [37,3-37,8]
38,0 [37,6-38,2]*#
39,5+
37,6 [37,1-37,8]
37,2 [37,1-37,6]*
37,0 [36,8-37,5]*
36,9 [36,7-37,4]*
t = 0 minutes: Baseline values; t = 15 minutes: Application of 4 mg/kg succinylcholine or 0.5 vol% halothane or both; t = 30 minutes: Application of
4 mg/kg succinylcholine or 1 vol% halothane or both.
HR = heart rate; MAP = mean arterial blood pressure; SaO2 = peripheral oxygen saturation; etCO2 = end-tidal carbon dioxide; SCh =
succinylcholine.
Data as median and interquartile range;
* significant changes from baseline values; # significant differences between MHS and MHN; p < 0.05. +: data from only one MHS animal.