Graduate Curriculum Committee Course Proposal Form
Graduate Curriculum Committee
Course Proposal Form for
Courses Numbered 5000 and Higher
Note: Before completing this form, please carefully read the accompanying instructions.
PHAR 7609
1.
Course Prefix and Number:
3.
Requested Action (check only one box):
X
2. Date:
January 09, 2009
New Course
Revision of Active Course
Revision & Unbanking of a Banked Course
Renumbering of an Existing Course from
X
from
#6609
to
#7609
4.
Justification (assessment or accreditation based) for new course or course revision or
course renumbering:
The proposed revision and renumbering of the course follows a recent assessment of the graduate
curriculum by the graduate faculty of the department. Based on the recommendations of the
faculty, this course needs some restructuring so as to incorporate an in-depth discussion of the
theory of dose-response concepts. The faculty recommendations also included that the course
teach therapeutic aspects of the pharmacodynamic principles being discussed. Consequently,
such a revision necessitates an upward renumbering of the course to better reflect its level.
5.
Course description exactly as it should appear in the next catalog:
7609. Introduction to Pharmacology (3) Formerly PHAR 6609 P: Previous admission to
graduate program in biomedical sciences in Brody School of Medicine and concurrent
registration in graduate biochemistry or consent of chair. History and scope of pharmacology;
pharmacokinetics including the quantitative principles of uptake, distribution,
biotransformation and elimination of drugs; and pharmacodynamics including theory of doseresponse relationships, and cellular mechanisms of drug action.
6.
If this is a course revision, briefly describe the requested change:
The revised course includes an in-depth information about drug dose-response
concepts as well as therapeutic aspects of the pharmacodynamic principles
discussed.
7. Graduate Catalog Page Number from current Graduate catalog:
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Graduate Curriculum Committee Course Proposal Form
Course Credit:
Lecture Hours
3
3
Weekly OR
Per Term Credit Hours
s.h.
Lab
Weekly OR
Per Term Credit Hours
s.h.
Studio
Weekly OR
Per Term Credit Hours
s.h.
Practicum
Weekly OR
Per Term Credit Hours
s.h.
Internship
Weekly OR
Per Term Credit Hours
s.h.
Other (e.g., independent study) Please explain.
Total Credit Hours
9.
3
s.h.
Anticipated annual student enrollment:
5-6
10.
Affected Degrees or Academic Programs:
Degree(s)/Course(s)
Current
Catalog Page
Ph.D. in Pharmacology and Toxicology
11.
Changes in Degree Hours
None
Overlapping or Duplication with Affected Units or Programs:
X
Not Applicable
Notification & response from affected units is attached
12.
Approval by the Council for Teacher Education (required for courses affecting teacher
education programs):
X
Not Applicable
Applicable and CTE has given their approval.
13.
Statements of Support:
a. Staff
X
Current staff is adequate
Additional Staff is needed (describe needs in the box below):
b. Facilities
X
Current facilities are adequate
Additional Facilities are needed (describe needs in the box below):
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Graduate Curriculum Committee Course Proposal Form
c. Library
X
Initial library resources are adequate
Initial resources are needed (in the box below, give a brief explanation
and an estimate for the cost of acquisition of required initial resources):
d. Computer resources
X
Unit computer resources are adequate
Additional unit computer resources are needed (in the box below, give a
brief explanation and an estimate for the cost of acquisition):
X
14.
ITCS Resources are not needed
The following ITCS resources are needed (put a check beside each need):
Mainframe computer system
Statistical services
Network connections
Computer lab for students
Approval from the Director of ITCS attached
Course information: see Instructions for Completing the Graduate Curriculum
Committee Course Proposal Form for more detail
a. TEXTBOOK(S): Pharmacology (5th Edition; 2004); Edited by Rang, Dale, Ritter and Moore.
Optional text: Goodman and Gilman’s “The Pharmacological Basis of Therapeutics”, 11th
Edition (2006); Laurence L. Brunton, editor-in-chief; John S. Lazo and Keith L. Parker,
Associate Editors. Additional reading provided from the historical and primary literature.
b. Course objectives student –centered behavioral objectives for the course –
Upon completion of this course the students should be able to:

Examine the history of the discipline of pharmacology.

Recognize how the science contributes to the development of therapeutic agents to
treat a disease.

Explain the principles of pharmacokinetics and how the body acts on drugs.

Describe the actions of drugs on the body including the molecular targets of drugs.

Identify the concepts underlying the dose (concentration)-response relationship as
well as the mechanisms by which drugs produce their effects.

Critically analyze the current and historical literature about pharmacological
principles in pharmacokinetics and pharmacodynamics.
c. A course content outline.
History and Overview
Heritage of Pharmacology:
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Graduate Curriculum Committee Course Proposal Form
Ancient use of drugs,
History of biomedical science
New Drug Development,Testing and Marketing
Principles of Pharmacokinetics
Administration of drug moleculespH and ionization
Drug absorption and distribution
Calculation of Bioavailability and Volume of Distribution
The Cytochrome P450 superfamily
Drug Metabolism
Excretion of drugs
Clearance, half life and maintenance dosages
Pharmacokinetics
Pharmacogenomics
Principles of Pharmacodynamics
Introduction
Mechanisms of drug action: Types of receptors
Drug-receptor interactions: Kd and Bmax
Cell Signaling Pathways
Dose-Response Relationships
Models of Drug Efficacy
Functional Selectivity
Factors Modifying Drug Action
d. A list of course assignments and weighting of each assignment and the
grading/evaluation system for determining a grade.
Examinations and grading. Attendance of all sessions is mandatory. There are two written
exams. Active student involvement in the presentation and discussion of the course material,
the student’s performance will be evaluated by the faculty throughout the course. The final
grade will be the average of the grades on the midterm and the final with 75% provided from
the examination scores and 25% based upon student participation and presentation according
to the following grading scale:
A letter grade will be assigned using the following scale:
A = 90-100%
B = 80-89%
C = 70-79%
F = Below 70%
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