Table S1: Clinical data for enrolled patients (n=18) Patient # Gender 1 2 3 4 5 6 7 M M M M M F F 8 Age on study Histology Metastatic site 70 41 76 64 72 61 50 cc cc cc cc s cc cc M 56 cc 9 M 69 cc 10 11 12 13 14 15 16 17 M M M M M F F M 64 53 61 64 42 69 65 47 cc cc cc cc cc m cc s 18 F 64 cc Lung, adrenal Lung LN Lung, LN Lung Bone Lung, Adrenal, LN Lung, bones, LN Lung, liver, LN Bone, LN Lung,LN Lung,LN Lung Lung Lung,liver Lung, LN Skin, LN, Lung Bone, LN, Lung, Adrenal MSKCI /UISS Best Overall Response to Treatment Int/Int Int/Int L/Int Int/Int L/Int L/Int Int/Int SD: PR: SD: CR: PD: PD: PR: Stable Disease Partial Response Stable Disease Complete Response Progressive Disease Progressive Disease Partial Response Int/Int CR: Complete Response Int/High PR: Partial Response Int/Int L/L L/Int L/High Int/Int L/Int Int/Int Int/Int SD: SD: PR: SD: SD: SD: PR: CR: Int/Int PD: Progressive Disease Stable Disease Stable Disease Partial Response Stable Disease Stable Disease Stable Disease Partial Response Complete Response Abbreviations: M= male, F= female, cc= clear cell, s= sarcomatoid, m= medullary, LN= lymph node, MSKCI/UISS= Memorial Sloan Kettering Cancer Institute/UCLA Integrated Staging System, L= Low, Int= Intermediate 1