Appendix A: VASQIP Adverse Event Definition and POEM Algorithm VASQIP Clinical Definition POEM Definition POEM Algorithm Sources of Evidence Acute Renal Failure In a patient who did not Postoperative “Dialysis” as a keyword search, require dialysis preSNOMED “Acute SNOMED CT concept search, operatively, worsening of Renal Failure” or or string search in general renal dysfunction postdialysis in clinical notes or discharge operatively requiring hospitalization summaries hemodialysis, peritoneal documentation or “Acute Renal Failure” as a dialysis, hemofiltration, discharge summary string search or SNOMED CT hemodiafiltration or concept search in general ultrafiltration. Exclude preclinical notes or discharge operative chronic renal summaries failure. The absence of cardiac rhythm or presence of chaotic cardiac rhythm that results in loss of consciousness requiring the initiation of any component of basis and/or advanced cardiac life support. The identification of a new blood clot or thrombus within the venous system, which may be coupled with inflammation. This diagnosis is confirmed by a duplex, venogram, or CT scan. Cardiac Arrest Post operative evidence of cardiac arrest, and/or resuscitation. “Code” (as in “pt coded”) as a string search in general clinical notes or discharge summaries “Resuscitation,” “cardiac arrest,” and “absent pulse” as a SNOMED CT concept search in general clinical notes “Called” and “code” in the same sentence as a string search in general clinical notes. Deep Vein Thrombosis Postoperative Intravenous anticoagulant drugs SNOMED “Venous in structured data. thrombosis” or “Phlebitis,” “venous thrombosis,” “Phlebitis” in or “thrombus” as a SNOMED CT hospitalization concept search in imaging notes documentation or “Phlebitis,” “venous thrombosis,” discharge summary and “thrombus” or “blood clot” but not “carotid” as a SNOMED CT concept search and “dopper,” “ultrasound” as a SNOMED CT concept search, or string search in the same sentence in general clinical notes or discharge summaries “Vena cava filter” as a SNOMED CT concept search in general clinical notes A new transmural acute myocardial infarction occurring during surgery or within 30 days following surgery as manifested by new Q-waves on ECG. Myocardial Infarction Postoperative “Myocardial infarction” (excluding SNOMED “Q-wave q-wave) as a SNOMED CT Concept” and concept search in general clinical “Myocardial notes Infarction” in “Finding of ECG Q wave” or hospitalization “myocardial infarction” (q-wave documentation or only) as a SNOMED CT concept discharge summary search in general clinical notes Creatine kinase (CK) and troponins with abnormal laboratory results in structured data Inflammation of the lungs caused primarily by bacteria, viruses, and/or chemical irritants, usually manifested by chills, fever, pain in the chest, cough, purulent, bloody sputum. Report as an occurrence if the patient has pneumonia meeting the definition of pneumonia below AND pneumonia not present preoperatively. 1. Rales or dullness to percussion on physical examination of chest AND any of the following: a. New onset of purulent sputum or change in character of sputum b. Organism isolate from blood culture c. Isolation of pathogen from specimen obtained by transtracheal aspirate, bronchial brushing, or biopsy. Pneumonia Postoperative SNOMED “Lung Consolidation” in hospitalization documentation or discharge summary Positive blood culture from regular expression parsed microbiology report “Lung consolidation” or “pneumonitis” as a SNOMED CT concept search in general clinical notes or discharge summaries OR 2. Chest radiographic examination shows new or progressive infiltrate, consolidation, cavitation, or pleural effusion AND any of the following: a. New onset of purulent sputum or change in character of sputum b. Organism isolated from the blood c. Isolation of pathogen from specimen obtained by transtracheal aspirate, bronchial brushing, or biopsy d. Isolation of virus or detection of viral antigen in respiratory secretions e. Diagnostic single antibody titer (IgM) or fourfold increase in paired serum samples (IgG) for pathogen f. Histopathologic evidence of pneumonia.” Exclude pre-operative pneumonia. Lodging of a blood clot in a pulmonary artery with subsequent obstruction of blood supply to the lung parenchyma. Pulmonary embolism is diagnosed by a V-Q scan interpreted as high probability of pulmonary embolism or a positive pulmonary arteriogram or positive CT angiogram or positive Spiral CT exam. Pulmonary Embolism Postoperative “Embolus” or “pulmonary SNOMED embolism” as a SNOMED CT “Pulmonary concept search in imaging notes, Embolism” or discharge summaries, or general “Embolus” in clinical notes hospitalization documentation or discharge summary Sepsis Sepsis is the systemic response to infection. This syndrome is clinically recognized by the presence of two or more of the following: 1) Temp >38 degrees C or <36 degrees C; 2) HR >90 bpm; 3) RR >20 breaths/min or PaCO2 <32 mmHg(<4.3 kPa); 4) WBC >12,000 cell/mm3, <4000 cells/mm3, or >10% immature forms; 5) Anion gap acidosis AND one of the following: 1) positive blood culture; 2) clinical documentation of purulence; 3) positive culture from any site thought to be causative Postoperative symptomactic urinary tract infection with symptoms and culture or symptoms and physician’s diagnosis. Exclude preoperative infection. Postoperative SNOMED “Systemic Infection” in hospitalization documentation “Systemic infection” as a SNOMED CT concept search in general clinical notes or discharge summaries Positive blood culture in regular expression parsed microbiology reports “Septic shock” or “multi-system organ failure” as a SNOMED CT concept search in general clinical notes or discharge summaries Urinary Tract Infection Post operative White blood cells (>=3) in urine findings of a urinary laboratory results structured data track infection in the “Urinary tract infection” or clinical notes, or an “urosepsis” as a SNOMED CT organism in urine, or concept search in general white blood cells in clinical notes or discharge urine. summaries Positive urine culture in regular expression parsed microbiology reports Superficial incisional, deep incisional, or organ/space surgical site infection that occurs within 30 days after operation and the infection appears to be related to the operation. Exclude preoperative infection. Wound Infection Post operative documentation of a wound infection including cellulitis “Infection of wound,” “inflammatory morphology,” “cellulitis,” “culture,” “debridement,” “organism growth,” or “necrosis” as a SNOMED CT concept search in general clinical notes or discharge summaries “Wound” as a SNOMED CT concept search and “cellulitis” as a SNOMED CT concept search occuring in the same document in general clinical notes or discharge summaries “Wound” as a SNOMED CT concept search and “infection of skin subcutaneous tissue” as a SNOMED CT concept search occurring in the same sentence in general clinical notes or discharge summaries Positive culture (excluding specimen types of blood, urine, sputum, stool and unlikely sites) in regular expression parsed microbiology reports “Wound infection” as a string search in general clinical notes or discharge summaries Exclude case if positive for “purulent discharge” as a SNOMED CT concept search found in operative reports