Online Appendix
Mitral Valve Academic Research Consortium Organization
MVARC Physician Members
William T. Abraham, MD, David H. Adams, MD, Stefan Anker, MD, PHD, Michael
Argenziano, MD, Helmut Baumgartner, MD, Jeroen J. Bax, MD, PHD, Eugene H. Blackstone,
MD, Steven F. Bolling, MD, Robert O. Bonow, MD, Jeffrey S. Borer, MD, J. Matthew Brennan,
MD, MPH, Donald E. Cutlip, MD, Robert A. Dion, MD, PHD, Ted E. Feldman, MD, Gerasimos
Filippatos, MD, Philippe Généreux, MD, Paul A. Grayburn, MD, Stuart J. Head, PHD, Arie
Pieter Kappetein, MD, PHD, Mitchell W. Krucoff, MD, Karl-Heinz Kuck, MD, Patrizio
Lancellotti, MD, PHD, Martin B. Leon, MD, JoAnn Lindenfeld, MD, Michael J. Mack, MD,
Patrick M. McCarthy, MD, Roxana Mehran, MD, Nicolo Piazza, MD, PHD, Maurice EnriquezSarano, MD, Joachim Schofer, MD, Allan Schwartz, MD, Robert J. Siegel, MD, Gregg W.
Stone, MD, Alec S. Vahanian, MD, Pascal Vranckx, MD, PHD
Dr. Anker has received grants and personal fees from Abbott Vascular; and has received
personal fees from Sorin. Dr. Baumgartner has received support for travel to scientific meetings
from Abbott Vascular. Dr. Blackstone has received grants from Edwards Lifesciences. Dr.
Bolling has received intellectual property/royalties from Edwards Lifesciences. Dr. Borer has
served as a consultant for Amgen, ARMGO, BioMarin, Boehringer Ingelheim, Celgene,
Cleveland Biolabs, JenaValve, Salix, Sanofi, and Servier; and serves as a committee member for
Cardiorentis, Celladon, the National Heart, Lung, and Blood Institute, Novartis, Pfizer,
Somahlution, and Takeda USA. Dr. Dion has received grants from Edwards Lifesciences,
Johnson & Johnson, Sorin Biomedica, and St. Jude Medical; has received personal fees from
Edwards Lifesciences and Sorin Biomedica; and has received nonfinancial support from
Edwards Lifesciences, Sorin Biomedica, and St. Jude Medical. Dr. Feldman has received grants
and personal fees from Abbott Vascular, Boston Scientific, and Edwards Lifesciences. Dr.
Grayburn has served as a consultant for Abbott Vascular, Bracco Diagnostics, and Tendyne
Holdings; has received grants from Abbott Vascular, Edwards Lifesciences, Guided Delivery
Systems, Medtronic, Tendyne Holdings, and Valtech Cardio; and has received personal fees
from Abbott Vascular, Bracco Diagnostics, and Tendyne Holdings. Dr. Krucoff has received
grants from, served as a consultant to, and received personal fees from Abbott Vascular, Boston
Scientific, and Medtronic. Dr. Lindenfeld has received personal fees from Abbott Vascular,
Boston Scientific, Cardiokinetix, Pfizer, Relypsa, Sorin, and St. Jude. Dr. Mack has served as a
coprincipal investigator of trials on transcatheter mitral valve replacement and MitraClip therapy.
Dr. McCarthy has served as a consultant for Abbott Vascular, Edwards Lifesciences, and
MiCardia; and has a patent with Edwards Lifesciences with royalties paid.
MVARC Coordinating Chairmen
William T. Abraham, The Ohio State University, Columbus, Ohio; David H. Adams, Mount
Sinai Health System, New York, New York; Gerasimos Filippatos, Athens University Hospital
Attikon, Athens, Greece; Arie Pieter Kappetein, Erasmus University Medical Center, Rotterdam,
Netherlands; Gregg W. Stone, Columbia University Medical Center/New York-Presbyterian
Hospital and Cardiovascular Research Foundation, New York, New York; Alec S. Vahanian,
Hôpital Bichat, Paris, France.
Writing Group Chairs
William T. Abraham, The Ohio State University, Columbus, Ohio; David H. Adams, Mount
Sinai Health System, New York, New York; Eugene H. Blackstone, Cleveland Clinic,
Cleveland, Ohio; Steven F. Bolling, University of Michigan, Ann Arbor, Michigan; Jeffrey S.
Borer, SUNY Downstate Medical Center, Brooklyn, New York; Jeroen J. Bax, Leiden
University Medical Center, Leiden, Netherlands; Donald E. Cutlip, Beth Israel Deaconess
Medical Center, Boston, Massachusetts; Philippe Généreux, Hôpital du Sacré-Coeur de
Montréal, Montreal, Canada and Cardiovascular Research Foundation New York, New York;
Arie Pieter Kappetein, Erasmus University Medical Center, Rotterdam, Netherlands; Karl-Heinz
Kuck, Asklepios Hospital St. Georg, Hamburg, Germany; Martin B. Leon, Columbia University
Medical Center/New York-Presbyterian Hospital and Cardiovascular Research Foundation, New
York, New York; Roxana Mehran, Mount Sinai Medical Center and Cardiovascular Research
Foundation, New York, New York; Nicolo Piazza, McGill University Health Center, Montreal,
Canada; Joachim Schofer, Hamburg University Cardiovascular Center, Hamburg, Germany;
Gregg W. Stone, Columbia University Medical Center/New York-Presbyterian Hospital and
Cardiovascular Research Foundation, New York, New York; Alec S. Vahanian, Hôpital Bichat,
Paris, France; Pascal Vranckx, Hartcentrum Hasselt, Hasselt, Belgium.
Physician Participants
William T. Abraham, The Ohio State University, Columbus, Ohio; David H. Adams, Mount
Sinai Health System, New York, New York; Stefan Anker, Charité, Campus Virchow-Klinikum,
Berlin, Germany Michael Argenziano, Columbia University Medical Center/New YorkPresbyterian Hospital, New York, New York; Helmut Baumgartner, Universitaetsklinikum
Muenster, Muen, Germany; Jeroen J. Bax, Leiden University Medical Center, Leiden,
Netherlands; Eugene H. Blackstone, Cleveland Clinic, Cleveland, Ohio; Steven F. Bolling,
University of Michigan, Ann Arbor, Michigan; Robert O. Bonow, Northwestern University,
Chicago, Illinois; Jeffrey S. Borer, SUNY Downstate Medical Center, Brooklyn, New York; J.
Matthew Brennan, Duke University Medical Center, Durham, North Carolina; Donald E. Cutlip,
Beth Israel Deaconess Medical Center, Boston, Massachusetts; Robert A. Dion, Ziekenhuis
Oost-Limburg, Genk, Belgium; Ted E. Feldman, Evanston Hospital, Evanston, Illinois;
Gerasimos Filippatos, Athens University Hospital Attikon, Athens, Greece; Philippe Généreux,
Hôpital du Sacré-Coeur de Montréal, Montreal, Canada and Cardiovascular Research Foundation
New York, New York; Paul A. Grayburn, Baylor University Medical Center, Dallas, TX; Stuart
J. Head, Erasmus University Medical Center, Rotterdam, Netherlands; Arie Pieter Kappetein,
Erasmus University Medical Center, Rotterdam, Netherlands; Mitchell W. Krucoff, Duke
University Medical Center, Durham, North Carolina; Karl-Heinz Kuck, Asklepios Hospital St.
Georg, Hamburg, Germany; Patrizio Lancellotti, University Hospital of Liège, Liège, Belgium;
Martin B. Leon, Columbia University Medical Center/New York-Presbyterian Hospital and
Cardiovascular Research Foundation, New York, New York; JoAnn Lindenfeld, University of
Colorado Health Sciences Center, Aurora, Colorado; Michael J. Mack, The Heart Hospital
Baylor Plano, Plano, Texas; Patrick M. McCarthy, Northwestern University, Chicago, Illinois;
Roxana Mehran, Mount Sinai Medical Center and Cardiovascular Research Foundation, New
York, New York; Nicolo Piazza, McGill University Health Center, Montreal, Canada; Maurice
Enriquez-Sarano, Mayo Clinic, Rochester, Minnesota; Joachim Schofer, Hamburg University
Cardiovascular Center, Hamburg, Germany; Allan Schwartz, Columbia University Medical
Center/New York-Presbyterian Hospital, New York, New York; Robert J. Siegel, Cedars-Sinai
Medical Center, Los Angeles, California; Gregg W. Stone, Columbia University Medical
Center/New York-Presbyterian Hospital and Cardiovascular Research Foundation, New York,
New York; Alec S. Vahanian, Hôpital Bichat, Paris, France; Pascal Vranckx, Hartcentrum
Hasselt, Hasselt, Belgium.
Participating Academic Research Organizations
Cardiovascular Research Foundation, New York, New York (administrative lead; Roxana
Mehran, Philippe Généreux, Dominic P. Francese, Monique Sylvester, Denise Tong, Colleen
Whelan, Johnnie White, Lisa Hathaway, Tara Donegan, Jason Kahn, Fun Lee, Caitlin Cox);
Cardialysis, Rotterdam, Netherlands (Nicolo Piazza, Stuart J. Head); Duke Clinical Research
Institute, Durham, North Carolina (Mitchell W. Krucoff, J. Matthew Brennan); Harvard Clinical
Research Institute, Boston, Massachusetts (Donald E. Cutlip)
U.S. Food and Drug Administration Center for Devices and Radiological Health (advisory
role) Industry Sponsors
Abbott Vascular, Menlo Park, California; Boston Scientific, Marlborough, Massachusetts;
Cardiac Dimensions, Kirkland, Washington; Cordis, Warren, New Jersey; Edwards Lifesciences,
Irvine, California; Guided Delivery Systems Inc., Santa Clara, California; Mitralign, Tewksbury,
Massachusetts; Medtronic, Santa Rosa, California; Valtech, Tel Aviv, Israel