HUMAN GENOME PROJECT
1. What was the Human
Genome Project (HGP)?
Project to sequence the _______________ of a human beings to make a map
of every _________ in the human body
Scientist hope to use the information to ___________ and ____________
abnormalities that lead to disease
2. What were two goals of
the HGP?
1. To identify the 30,000 – 40,000 _______________ in human DNA
2. To determine the sequences of the 3 _________________ nitrogen base
pairs that make up human DNA
3. What did scientists do to
complete the HGP?
Scientists sequenced the ___________ in human beings
4. How has technology
played a role in this
project?
Technology increased the ____________________ at which the project was
completed
5. What is a GENOME?
A complete __________ of an organisms ____________
6. How might the map of the
human genome play a
role in preventative
medicine?
7. What are BENEFITS of the
HGP?
Understanding the DNA allows doctors to _______________ potential
diseases and disorders ________________, allowing the patient a better
chance at ________________ and a better quality of life
1. Finding __________________ and treatments for diseases
2. Better understanding human ___________________
3. Advancements in the fields of ________________ and _____________________
8. What are CONCERNS of
the HGP?
1. “Playing God”
2. _________________ and confidentiality of genetic information
3. ___________________ in the use of genetic information by __________________,
employers, courts, schools, adoption agencies, and the military, among
others
4. _______________________ impacts, stigmatization and discrimination due
to an individuals genetic make-up
Human Genome Video Notes:
http://www.youtube.com/watch?v=XuUpnAz5y1g&feature=related
1. What do all of our cells contain?
2. How many pairs of chromosomes are packed into our nucleus?
3. If the DNA was unwound…How long would it stretch?
4. How many letters have scientists read, to understand our molecular selves?
5. Different sets of genes influence what risks? (Name the 2 that were mentioned)
EOC PRACTICE:
Scientists have completed the main phase of the Human Genome Project. What have they
accomplished with this project?
a.
b.
c.
d.
They used a single cell from one organism to create an identical organism.
They created a single pedigree for every genetic disorder.
They created DNA synthetically in a laboratory.
They identified the sequence of base pairs in human DNA.
GENE THERAPY
1. What is it?
Inserting a _________________ or healthy gene into a cell to replace a
_____________ gene
2. How does it work?
1. Use a ____________ to deliver the _____________ version of the gene to the cell
2. Then the cell has the ______________ version of the gene
3. The gene will then be used to make the correct ___________________ for the
individual
3. What are two disorders
that involve defective
genes?
1. ___________________ Fibrosis
4. What is Cystic Fibrosis
(CF)?
Inherited disease that causes the body to make the _________________ protein
2. _________________________ Combined Immunodeficiency
The protein codes for the body to make __________ and sticky ________________
This leads to infections and _________________ death
5. What is one way Cystic
Fibrosis can be TREATED?
Gene Therapy
6. What is Severe Combined A faulty gene affects a persons ability to fight off _______________ and diseases
Immunodeficiency (SCID)?
Severely ___________________ immune system
Can lead to early ___________________
7. What is one way SCID can
be TREATED?
Gene therapy
8. What are BENEFITS of
Gene Therapy?
1. Helps ______________ disease at the _______________________ level
9. What are CONCERNS of
Gene Therapy?
1. Viruses may not insert the gene into the DNA ____________________
2.The technology is _____________________ and only accessible to the rich
3. “Playing God”
Gene Therapy Video Notes
http://www.youtube.com/watch?v=imL1Zmi3mWk&feature=related
1.
What is gene therapy?
2.
What are viruses?
3.
How are viruses used in gene therapy?
EOC PRACTICE
1. How is the process of Gene Therapy used to treat Cystic Fibrosis?
a.
b.
c.
d.
By replacing the abnormal gene with a copy of the normal gene
By removing a portion of the abnormal gene
By adding a nitrogen base to the beginning of the DNA sequence
By inducing a mutation
2. Which process is used to insert normal genes into human cells to correct disorders?
a. Gene therapy
b. Live vector vaccines
c. Molecular cloning
d. Stem cell therapy
3. Which vehicles are often used for gene therapy to carry a healthy gene?
a. Bacteria
b. Plastic capsules
c. Powder balls
d. Viruses
4. What is gene therapy?
a.
b.
c.
d.
Pre-clinical testing for inherited diseases in newborns
Treatment of diseases caused by a genetic defect
Genetic engineering using recombinant DNA technology
Cancer treatment using in vitro cultured stem cells
5. Which of the following is an example of a condition caused by a mutation in a single gene?
a. Colon cancer
b. Heart disease
c. AIDS
d. Cystic Fibrosis